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Protein

Synaptotagmin-8

Gene

SYT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca2+-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca2+-regulation of exocytosis in insulin secreted cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-8
Alternative name(s):
Synaptotagmin VIII
Short name:
SytVIII
Gene namesi
Name:SYT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149043.16
HGNCiHGNC:19264 SYT8
MIMi607719 gene
neXtProtiNX_Q8NBV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini70 – 401CytoplasmicSequence analysisAdd BLAST332

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi90019
OpenTargetsiENSG00000149043
PharmGKBiPA134993261

Polymorphism and mutation databases

BioMutaiSYT8
DMDMi327478607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839591 – 401Synaptotagmin-8Add BLAST401

Proteomic databases

EPDiQ8NBV8
PaxDbiQ8NBV8
PeptideAtlasiQ8NBV8
PRIDEiQ8NBV8
ProteomicsDBi72828
72829 [Q8NBV8-1]

PTM databases

iPTMnetiQ8NBV8
PhosphoSitePlusiQ8NBV8

Expressioni

Gene expression databases

BgeeiENSG00000149043 Expressed in 101 organ(s), highest expression level in skin of leg
CleanExiHS_SYT8
ExpressionAtlasiQ8NBV8 baseline and differential
GenevisibleiQ8NBV8 HS

Organism-specific databases

HPAiHPA052700

Interactioni

Subunit structurei

Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca2+. Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5-tetrakisphosphate (IP4). Binds to AP2 in a Ca2+-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124654, 1 interactor
STRINGi9606.ENSP00000371394

Structurei

3D structure databases

ProteinModelPortaliQ8NBV8
SMRiQ8NBV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 217C2 1PROSITE-ProRule annotationAdd BLAST99
Domaini247 – 346C2 2PROSITE-ProRule annotationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 74Cys-rich10

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
The second C2 domain/C2B is responsible for SYNCRIP and inositol 1,3,4,5-tetrakisphosphate (IP4)-binding.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG108531
InParanoidiQ8NBV8
KOiK19908
OMAiHARRPIA
OrthoDBiEOG091G07O9
PhylomeDBiQ8NBV8
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR030540 SYT8
PANTHERiPTHR10024:SF249 PTHR10024:SF249, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q8NBV8-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLHLHGWQTM QGRKMGHPPV SPSAPAPAGT TAIPGLIPDL VAGTPWPRWA
60 70 80 90 100
LIAGALAAGV LLVSCLLCAA CCCCRRHRKK PRDKESVGLG SARGTTTTHL
110 120 130 140 150
VQPDVDGLES SPGDAQQWGC LQLSLEFDFG SQEIRVGLRQ AADLRPGGTV
160 170 180 190 200
DPYARVSVST QAGHRHETKV HRGTLCPVFD ETCCFHIPQA ELPGATLQVQ
210 220 230 240 250
LFNFKRFSGH EPLGELRLPL GTVDLQHVLE HWYLLGPPAA TQPEQVGELC
260 270 280 290 300
FSLRYVPSSG RLTVVVLEAR GLRPGLAEPY VKVQLMLNQR KWKKRKTATK
310 320 330 340 350
KGTAAPYFNE AFTFLVPFSQ VQNVDLVLAV WDRSLPLRTE PVGKVHLGAR
360 370 380 390 400
ASGQPLQHWA DMLAHARRPI AQRHPLRPAR EVDRMLALQP RLRLRLPLPH

S
Note: No experimental confirmation available.
Length:401
Mass (Da):44,138
Last modified:April 5, 2011 - v4
Checksum:i1D23C587E2259A5D
GO
Isoform 1 (identifier: Q8NBV8-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-172: IRVGLRQAAD...GHRHETKVHR → VKGPAAQDQR...WGADRAGALG
     173-401: Missing.

Show »
Length:172
Mass (Da):18,150
Checksum:iE83E26BC7DBCDF21
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCR4A6NCR4_HUMAN
Synaptotagmin-8
SYT8
387Annotation score:
H0Y3G9H0Y3G9_HUMAN
Synaptotagmin-8
SYT8
400Annotation score:
C9J253C9J253_HUMAN
Synaptotagmin-8
SYT8
102Annotation score:
C9K032C9K032_HUMAN
Synaptotagmin-8
SYT8
99Annotation score:
F8WBL4F8WBL4_HUMAN
Synaptotagmin-8
SYT8
129Annotation score:

Sequence cautioni

The sequence AAQ57209 differs from that shown. May be due to an intron retention.Curated
The sequence CAB70885 differs from that shown. The sequence differs from that shown because it is a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35G → W in AAQ57209 (Ref. 3) Curated1
Sequence conflicti46Missing in CAB70885 (PubMed:17974005).Curated1
Sequence conflicti71C → R in AAQ57209 (Ref. 3) Curated1
Sequence conflicti100L → LV in CAB70885 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06183417H → Q. Corresponds to variant dbSNP:rs57344881Ensembl.1
Natural variantiVAR_046952120C → R2 PublicationsCorresponds to variant dbSNP:rs564271Ensembl.1
Natural variantiVAR_046953129F → I. Corresponds to variant dbSNP:rs34141314Ensembl.1
Isoform 1 (identifier: Q8NBV8-1)
Natural varianti143R → Q. Corresponds to variant dbSNP:rs907608Ensembl.1
Natural varianti152T → M. Corresponds to variant dbSNP:rs907609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040846134 – 172IRVGL…TKVHR → VKGPAAQDQRFCEFPERVTG EGQTPCPGWWGADRAGALG in isoform 1. 3 PublicationsAdd BLAST39
Alternative sequenceiVSP_040847173 – 401Missing in isoform 1. 3 PublicationsAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137708 Transcribed RNA Translation: CAB70885.2 Sequence problems.
AK075202 mRNA Translation: BAC11467.1
AY353087 mRNA Translation: AAQ57209.1 Sequence problems.
AC051649 Genomic DNA No translation available.
CCDSiCCDS7726.2 [Q8NBV8-4]
PIRiT46410
RefSeqiNP_612634.3, NM_138567.4
UniGeneiHs.161031
Hs.738918

Genome annotation databases

EnsembliENST00000381968; ENSP00000371394; ENSG00000149043 [Q8NBV8-4]
GeneIDi90019
KEGGihsa:90019
UCSCiuc001lue.2 human [Q8NBV8-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137708 Transcribed RNA Translation: CAB70885.2 Sequence problems.
AK075202 mRNA Translation: BAC11467.1
AY353087 mRNA Translation: AAQ57209.1 Sequence problems.
AC051649 Genomic DNA No translation available.
CCDSiCCDS7726.2 [Q8NBV8-4]
PIRiT46410
RefSeqiNP_612634.3, NM_138567.4
UniGeneiHs.161031
Hs.738918

3D structure databases

ProteinModelPortaliQ8NBV8
SMRiQ8NBV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124654, 1 interactor
STRINGi9606.ENSP00000371394

PTM databases

iPTMnetiQ8NBV8
PhosphoSitePlusiQ8NBV8

Polymorphism and mutation databases

BioMutaiSYT8
DMDMi327478607

Proteomic databases

EPDiQ8NBV8
PaxDbiQ8NBV8
PeptideAtlasiQ8NBV8
PRIDEiQ8NBV8
ProteomicsDBi72828
72829 [Q8NBV8-1]

Protocols and materials databases

DNASUi90019
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381968; ENSP00000371394; ENSG00000149043 [Q8NBV8-4]
GeneIDi90019
KEGGihsa:90019
UCSCiuc001lue.2 human [Q8NBV8-4]

Organism-specific databases

CTDi90019
DisGeNETi90019
EuPathDBiHostDB:ENSG00000149043.16
GeneCardsiSYT8
H-InvDBiHIX0009351
HGNCiHGNC:19264 SYT8
HPAiHPA052700
MIMi607719 gene
neXtProtiNX_Q8NBV8
OpenTargetsiENSG00000149043
PharmGKBiPA134993261
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG108531
InParanoidiQ8NBV8
KOiK19908
OMAiHARRPIA
OrthoDBiEOG091G07O9
PhylomeDBiQ8NBV8
TreeFamiTF315600

Enzyme and pathway databases

ReactomeiR-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

GenomeRNAii90019
PROiPR:Q8NBV8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149043 Expressed in 101 organ(s), highest expression level in skin of leg
CleanExiHS_SYT8
ExpressionAtlasiQ8NBV8 baseline and differential
GenevisibleiQ8NBV8 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR030540 SYT8
PANTHERiPTHR10024:SF249 PTHR10024:SF249, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT8_HUMAN
AccessioniPrimary (citable) accession number: Q8NBV8
Secondary accession number(s): A6NFJ4, Q9NSV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: April 5, 2011
Last modified: October 10, 2018
This is version 135 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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