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Protein

Thioredoxin domain-containing protein 5

Gene

TXNDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: GO_Central
  • cell redox homeostasis Source: InterPro
  • negative regulation of apoptotic process Source: UniProtKB
  • neutrophil degranulation Source: Reactome

Enzyme and pathway databases

BRENDAi5.3.4.1 2681
ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name:
ER protein 46
Short name:
ERp46
Thioredoxin-like protein p46
Gene namesi
Name:TXNDC5
Synonyms:TLP46
ORF Names:UNQ364/PRO700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000239264.8
HGNCiHGNC:21073 TXNDC5
MIMi616412 gene
neXtProtiNX_Q8NBS9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi81567
OpenTargetsiENSG00000239264
PharmGKBiPA134992492

Polymorphism and mutation databases

BioMutaiTXNDC5
DMDMi29839560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000003418333 – 432Thioredoxin domain-containing protein 5Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 92Redox-activePROSITE-ProRule annotation
Disulfide bondi217 ↔ 220Redox-activePROSITE-ProRule annotation
Disulfide bondi350 ↔ 353Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8NBS9
MaxQBiQ8NBS9
PaxDbiQ8NBS9
PeptideAtlasiQ8NBS9
PRIDEiQ8NBS9
ProteomicsDBi72817

PTM databases

iPTMnetiQ8NBS9
PhosphoSitePlusiQ8NBS9
SwissPalmiQ8NBS9

Expressioni

Gene expression databases

BgeeiENSG00000239264 Expressed in 93 organ(s), highest expression level in lymph node
CleanExiHS_TXNDC5
ExpressionAtlasiQ8NBS9 baseline and differential
GenevisibleiQ8NBS9 HS

Organism-specific databases

HPAiHPA034677
HPA034678

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123529, 81 interactors
DIPiDIP-53700N
IntActiQ8NBS9, 22 interactors
MINTiQ8NBS9
STRINGi9606.ENSP00000369081

Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8NBS9
SMRiQ8NBS9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NBS9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 169Thioredoxin 1PROSITE-ProRule annotationAdd BLAST134
Domaini170 – 295Thioredoxin 2PROSITE-ProRule annotationAdd BLAST126
Domaini304 – 429Thioredoxin 3PROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi429 – 432Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000007899
HOVERGENiHBG058611
InParanoidiQ8NBS9
KOiK13984
OMAiHVSSGNH
OrthoDBiEOG091G08PT
PhylomeDBiQ8NBS9
TreeFamiTF106379

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
SUPFAMiSSF52833 SSF52833, 3 hits
TIGRFAMsiTIGR01126 pdi_dom, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8NBS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP
60 70 80 90 100
AADGEDGQDP HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN
110 120 130 140 150
DLGDKYNSME DAKVYVAKVD CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK
160 170 180 190 200
YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE PPSAPELKQG LYELSASNFE
210 220 230 240 250
LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV KIGKVDCTQH
260 270 280 290 300
YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
310 320 330 340 350
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC
360 370 380 390 400
GHCKTLAPTW EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL
410 420 430
LFRGGKKVSE HSGGRDLDSL HRFVLSQAKD EL
Length:432
Mass (Da):47,629
Last modified:April 11, 2003 - v2
Checksum:i85E398008D6DB98C
GO
Isoform 2 (identifier: Q8NBS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,178
Checksum:i93FE17E484F5EFC9
GO

Sequence cautioni

The sequence AAH01199 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354K → R in BAC11526 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451811 – 108Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358646 mRNA Translation: AAQ89009.1
AK075291 mRNA Translation: BAC11526.1
AK315598 mRNA Translation: BAG37969.1
AL023694 Genomic DNA No translation available.
AL096800 Genomic DNA No translation available.
AL133541 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55221.1
AJ440721 mRNA Translation: CAD29430.1
BC001199 mRNA Translation: AAH01199.1 Different initiation.
AL834423 mRNA Translation: CAD39084.1
CCDSiCCDS4505.1 [Q8NBS9-1]
CCDS47369.1 [Q8NBS9-2]
RefSeqiNP_001139021.1, NM_001145549.3 [Q8NBS9-2]
NP_110437.2, NM_030810.4 [Q8NBS9-1]
UniGeneiHs.150837
Hs.635352

Genome annotation databases

EnsembliENST00000379757; ENSP00000369081; ENSG00000239264 [Q8NBS9-1]
ENST00000473453; ENSP00000420784; ENSG00000239264 [Q8NBS9-2]
GeneIDi81567
KEGGihsa:81567
UCSCiuc003mxv.4 human [Q8NBS9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358646 mRNA Translation: AAQ89009.1
AK075291 mRNA Translation: BAC11526.1
AK315598 mRNA Translation: BAG37969.1
AL023694 Genomic DNA No translation available.
AL096800 Genomic DNA No translation available.
AL133541 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55221.1
AJ440721 mRNA Translation: CAD29430.1
BC001199 mRNA Translation: AAH01199.1 Different initiation.
AL834423 mRNA Translation: CAD39084.1
CCDSiCCDS4505.1 [Q8NBS9-1]
CCDS47369.1 [Q8NBS9-2]
RefSeqiNP_001139021.1, NM_001145549.3 [Q8NBS9-2]
NP_110437.2, NM_030810.4 [Q8NBS9-1]
UniGeneiHs.150837
Hs.635352

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIZNMR-A323-432[»]
3UJ1X-ray2.65A323-432[»]
3UVTX-ray2.00A/B/C/D/E323-428[»]
3WGDX-ray2.50A/B/C/D/E/F/G/H/I62-170[»]
3WGEX-ray0.95A190-298[»]
3WGXX-ray0.92A/B190-298[»]
ProteinModelPortaliQ8NBS9
SMRiQ8NBS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123529, 81 interactors
DIPiDIP-53700N
IntActiQ8NBS9, 22 interactors
MINTiQ8NBS9
STRINGi9606.ENSP00000369081

PTM databases

iPTMnetiQ8NBS9
PhosphoSitePlusiQ8NBS9
SwissPalmiQ8NBS9

Polymorphism and mutation databases

BioMutaiTXNDC5
DMDMi29839560

Proteomic databases

EPDiQ8NBS9
MaxQBiQ8NBS9
PaxDbiQ8NBS9
PeptideAtlasiQ8NBS9
PRIDEiQ8NBS9
ProteomicsDBi72817

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379757; ENSP00000369081; ENSG00000239264 [Q8NBS9-1]
ENST00000473453; ENSP00000420784; ENSG00000239264 [Q8NBS9-2]
GeneIDi81567
KEGGihsa:81567
UCSCiuc003mxv.4 human [Q8NBS9-1]

Organism-specific databases

CTDi81567
DisGeNETi81567
EuPathDBiHostDB:ENSG00000239264.8
GeneCardsiTXNDC5
HGNCiHGNC:21073 TXNDC5
HPAiHPA034677
HPA034678
MIMi616412 gene
neXtProtiNX_Q8NBS9
OpenTargetsiENSG00000239264
PharmGKBiPA134992492
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000150840
HOGENOMiHOG000007899
HOVERGENiHBG058611
InParanoidiQ8NBS9
KOiK13984
OMAiHVSSGNH
OrthoDBiEOG091G08PT
PhylomeDBiQ8NBS9
TreeFamiTF106379

Enzyme and pathway databases

BRENDAi5.3.4.1 2681
ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiTXNDC5 human
EvolutionaryTraceiQ8NBS9
GeneWikiiTXNDC5
GenomeRNAii81567
PROiPR:Q8NBS9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239264 Expressed in 93 organ(s), highest expression level in lymph node
CleanExiHS_TXNDC5
ExpressionAtlasiQ8NBS9 baseline and differential
GenevisibleiQ8NBS9 HS

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
SUPFAMiSSF52833 SSF52833, 3 hits
TIGRFAMsiTIGR01126 pdi_dom, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTXND5_HUMAN
AccessioniPrimary (citable) accession number: Q8NBS9
Secondary accession number(s): B2RDM2
, Q5TCQ0, Q8ND33, Q8TCT2, Q9BVH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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