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Entry version 129 (02 Jun 2021)
Sequence version 2 (22 Jul 2008)
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Protein

Ubiquitin carboxyl-terminal hydrolase MINDY-2

Gene

MINDY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798).

Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312).

May play a regulatory role at the level of protein turnover (PubMed:27292798).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei266NucleophileBy similarity1
Active sitei448Proton acceptorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei542Ubiquitin-bindingBy similarity1
Sitei545 – 546Ubiquitin-bindingBy similarity2
Sitei549Ubiquitin-bindingBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NBR6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase MINDY-21 Publication (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme MINDY-21 Publication
Protein FAM63B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MINDY2Imported
Synonyms:FAM63B, KIAA1164
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26954, MINDY2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618408, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBR6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000128923.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi519A → G: Strongly decreased binding to 'Lys-48' or 'Lys-63'-tetraubiquitin chains. 1 Publication1
Mutagenesisi546A → G: No effect on binding to 'Lys-48'- or 'Lys-63'-tetraubiquitin chains. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54629

Open Targets

More...
OpenTargetsi
ENSG00000128923

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671873

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBR6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MINDY2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205831477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003440421 – 621Ubiquitin carboxyl-terminal hydrolase MINDY-2Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBR6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBR6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBR6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBR6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBR6

PeptideAtlas

More...
PeptideAtlasi
Q8NBR6

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBR6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72812 [Q8NBR6-1]
72813 [Q8NBR6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBR6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBR6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128923, Expressed in cerebellum and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBR6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBR6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128923, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120085, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBR6, 17 interactors

Molecular INTeraction database

More...
MINTi
Q8NBR6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000452885

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NBR6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBR6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 106DisorderedSequence analysisAdd BLAST106
Regioni119 – 179DisorderedSequence analysisAdd BLAST61
Regioni507 – 559Ubiquitin-binding domain (UBD)1 PublicationAdd BLAST53
Regioni556 – 621DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi145 – 179Polar residuesSequence analysisAdd BLAST35
Compositional biasi561 – 594Polar residuesSequence analysisAdd BLAST34
Compositional biasi595 – 621Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2427, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016607

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022566_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBR6

Identification of Orthologs from Complete Genome Data

More...
OMAi
EYTPECV

Database of Orthologous Groups

More...
OrthoDBi
1601180at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBR6

TreeFam database of animal gene trees

More...
TreeFami
TF314589

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007518, MINDY
IPR033979, MINDY_domain

The PANTHER Classification System

More...
PANTHERi
PTHR18063, PTHR18063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04424, MINDY_DUB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG
60 70 80 90 100
GNGLGAAAAR RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA
110 120 130 140 150
PLRGQYKVTA SPETAVAGVG HELGTAGDAG ARPDLAGTCQ AELTAAGSEE
160 170 180 190 200
PSSAGGLSSS CSDPSPPGES PSLDSLESFS NLHSFPSSCE FNSEEGAENR
210 220 230 240 250
VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ SVYHIKWIQW
260 270 280 290 300
KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG
310 320 330 340 350
DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE
360 370 380 390 400
YTPECIVFDL LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS
410 420 430 440 450
DNSELVSEGF VAEQFLNNTA TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS
460 470 480 490 500
TMTKYKGQLY LLVTDQGFLT EEKVVWESLH NVDGDGNFCD SEFHLRPPSD
510 520 530 540 550
PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI SDLELAKKLQ
560 570 580 590 600
EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK
610 620
RKEPREKDKE KEKEKNSCVI L
Length:621
Mass (Da):67,106
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED97D0BBCA6DC421
GO
Isoform 2 (identifier: Q8NBR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: Missing.

Show »
Length:620
Mass (Da):66,978
Checksum:iC74C054E51FE3F3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM15H0YM15_HUMAN
Ubiquitin carboxyl-terminal hydrola...
MINDY2 FAM63B, hCG_40045
379Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNL7J3KNL7_HUMAN
Ubiquitin carboxyl-terminal hydrola...
MINDY2 FAM63B, hCG_40045
422Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAW77545 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034719580Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471082 Genomic DNA Translation: EAW77545.1 Sequence problems.
CH471082 Genomic DNA Translation: EAW77546.1
BC140811 mRNA Translation: AAI40812.1
BC144616 mRNA Translation: AAI44617.1
AK075319 mRNA Translation: BAC11545.1
AB032990 mRNA Translation: BAA86478.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42046.1 [Q8NBR6-1]
CCDS45268.1 [Q8NBR6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035540.1, NM_001040450.2 [Q8NBR6-1]
NP_001035543.1, NM_001040453.2 [Q8NBR6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000450403; ENSP00000393231; ENSG00000128923 [Q8NBR6-2]
ENST00000559228; ENSP00000452885; ENSG00000128923 [Q8NBR6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54629

UCSC genome browser

More...
UCSCi
uc002afi.4, human [Q8NBR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471082 Genomic DNA Translation: EAW77545.1 Sequence problems.
CH471082 Genomic DNA Translation: EAW77546.1
BC140811 mRNA Translation: AAI40812.1
BC144616 mRNA Translation: AAI44617.1
AK075319 mRNA Translation: BAC11545.1
AB032990 mRNA Translation: BAA86478.1
CCDSiCCDS42046.1 [Q8NBR6-1]
CCDS45268.1 [Q8NBR6-2]
RefSeqiNP_001035540.1, NM_001040450.2 [Q8NBR6-1]
NP_001035543.1, NM_001040453.2 [Q8NBR6-2]

3D structure databases

SMRiQ8NBR6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120085, 27 interactors
IntActiQ8NBR6, 17 interactors
MINTiQ8NBR6
STRINGi9606.ENSP00000452885

PTM databases

iPTMnetiQ8NBR6
PhosphoSitePlusiQ8NBR6

Genetic variation databases

BioMutaiMINDY2
DMDMi205831477

Proteomic databases

EPDiQ8NBR6
jPOSTiQ8NBR6
MassIVEiQ8NBR6
MaxQBiQ8NBR6
PaxDbiQ8NBR6
PeptideAtlasiQ8NBR6
PRIDEiQ8NBR6
ProteomicsDBi72812 [Q8NBR6-1]
72813 [Q8NBR6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
63975, 60 antibodies

The DNASU plasmid repository

More...
DNASUi
54629

Genome annotation databases

EnsembliENST00000450403; ENSP00000393231; ENSG00000128923 [Q8NBR6-2]
ENST00000559228; ENSP00000452885; ENSG00000128923 [Q8NBR6-1]
GeneIDi54629
KEGGihsa:54629
UCSCiuc002afi.4, human [Q8NBR6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54629
DisGeNETi54629

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MINDY2
HGNCiHGNC:26954, MINDY2
HPAiENSG00000128923, Low tissue specificity
MIMi618408, gene
neXtProtiNX_Q8NBR6
OpenTargetsiENSG00000128923
PharmGKBiPA142671873
VEuPathDBiHostDB:ENSG00000128923.10

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2427, Eukaryota
GeneTreeiENSGT00390000016607
HOGENOMiCLU_022566_3_1_1
InParanoidiQ8NBR6
OMAiEYTPECV
OrthoDBi1601180at2759
PhylomeDBiQ8NBR6
TreeFamiTF314589

Enzyme and pathway databases

PathwayCommonsiQ8NBR6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54629, 100 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MINDY2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54629
PharosiQ8NBR6, Tbio

Protein Ontology

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PROi
PR:Q8NBR6
RNActiQ8NBR6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000128923, Expressed in cerebellum and 243 other tissues
ExpressionAtlasiQ8NBR6, baseline and differential
GenevisibleiQ8NBR6, HS

Family and domain databases

InterProiView protein in InterPro
IPR007518, MINDY
IPR033979, MINDY_domain
PANTHERiPTHR18063, PTHR18063, 1 hit
PfamiView protein in Pfam
PF04424, MINDY_DUB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMINY2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBR6
Secondary accession number(s): B2RTT8, Q9ULQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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