Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 135 (26 Feb 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Aquaporin-11

Gene

AQP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating to the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432047 Passive transport by Aquaporins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.8.4.1 the major intrinsic protein (mip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aquaporin-111 Publication
Short name:
AQP-111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AQP11Imported
Synonyms:AQPX1
ORF Names:PSEC0027
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19940 AQP11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609914 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14Cytoplasmic1 PublicationAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini36 – 41Extracellular1 Publication6
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 74Cytoplasmic1 PublicationAdd BLAST12
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini96 – 163Extracellular1 PublicationAdd BLAST68
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini185 – 194Cytoplasmic1 Publication10
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 234Extracellular1 PublicationAdd BLAST19
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 271Cytoplasmic1 PublicationAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi227C → A: Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Increases osmotic water permeability. Decreases homomultimerization. 1 Publication1
Mutagenesisi227C → S: Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Reduces protein expression. Increases osmotic water permeability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
282679

Open Targets

More...
OpenTargetsi
ENSG00000178301

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134949682

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBQ7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AQP11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47115841

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000639681 – 271Aquaporin-11Add BLAST271

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Not glycosylated.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBQ7

PeptideAtlas

More...
PeptideAtlasi
Q8NBQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72810

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in the sperm head and tail (at protein level) (PubMed:28042826). Expressed in subcutaneous adipocytes (PubMed:24845055). Expressed in testis, kidney and ejaculated spermatozoa (PubMed:19812234).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178301 Expressed in duodenum and 114 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042879

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (By similarity). Can also form homomultimer (PubMed:24918044, PubMed:31546170).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129399, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8NBQ7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000318770

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NBQ7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi99 – 101NPCBy similarity3
Motifi216 – 218NPABy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NPC motif is essential for oligomerization and water permeability function.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHUS Eukaryota
ENOG4111GCP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063816

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_074449_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBQ7

KEGG Orthology (KO)

More...
KOi
K09870

Identification of Orthologs from Complete Genome Data

More...
OMAi
CACTNEL

Database of Orthologous Groups

More...
OrthoDBi
1086803at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBQ7

TreeFam database of animal gene trees

More...
TreeFami
TF320251

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271 Aquaporin-like
IPR023266 Aquaporin_11
IPR016697 Aquaporin_11/12
IPR000425 MIP

The PANTHER Classification System

More...
PANTHERi
PTHR21191:SF7 PTHR21191:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00230 MIP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017529 Aquaporin_11/12, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02024 AQUAPORIN11
PR00783 MINTRINSICP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81338 SSF81338, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NBQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE
60 70 80 90 100
FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP
110 120 130 140 150
CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE
160 170 180 190 200
RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM
260 270
ILMFSFFLPW LHNNHTINKK E
Length:271
Mass (Da):30,203
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4CB292B544C5A40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020446102G → S. Corresponds to variant dbSNP:rs2276415Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028147 mRNA Translation: BAC45004.1
AK075346 mRNA Translation: BAC11558.1
BC040443 mRNA Translation: AAH40443.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8251.1

NCBI Reference Sequences

More...
RefSeqi
NP_766627.1, NM_173039.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313578; ENSP00000318770; ENSG00000178301

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282679

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:282679

UCSC genome browser

More...
UCSCi
uc001oyj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA Translation: BAC45004.1
AK075346 mRNA Translation: BAC11558.1
BC040443 mRNA Translation: AAH40443.1
CCDSiCCDS8251.1
RefSeqiNP_766627.1, NM_173039.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129399, 1 interactor
IntActiQ8NBQ7, 1 interactor
STRINGi9606.ENSP00000318770

Protein family/group databases

TCDBi1.A.8.4.1 the major intrinsic protein (mip) family

Polymorphism and mutation databases

BioMutaiAQP11
DMDMi47115841

Proteomic databases

MassIVEiQ8NBQ7
MaxQBiQ8NBQ7
PaxDbiQ8NBQ7
PeptideAtlasiQ8NBQ7
PRIDEiQ8NBQ7
ProteomicsDBi72810

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
282679

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301
GeneIDi282679
KEGGihsa:282679
UCSCiuc001oyj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
282679
DisGeNETi282679

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AQP11
HGNCiHGNC:19940 AQP11
HPAiHPA042879
MIMi609914 gene
neXtProtiNX_Q8NBQ7
OpenTargetsiENSG00000178301
PharmGKBiPA134949682

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHUS Eukaryota
ENOG4111GCP LUCA
GeneTreeiENSGT00530000063816
HOGENOMiCLU_074449_0_0_1
InParanoidiQ8NBQ7
KOiK09870
OMAiCACTNEL
OrthoDBi1086803at2759
PhylomeDBiQ8NBQ7
TreeFamiTF320251

Enzyme and pathway databases

ReactomeiR-HSA-432047 Passive transport by Aquaporins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AQP11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
282679
PharosiQ8NBQ7 Tbio

Protein Ontology

More...
PROi
PR:Q8NBQ7
RNActiQ8NBQ7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000178301 Expressed in duodenum and 114 other tissues
GenevisibleiQ8NBQ7 HS

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023266 Aquaporin_11
IPR016697 Aquaporin_11/12
IPR000425 MIP
PANTHERiPTHR21191:SF7 PTHR21191:SF7, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PIRSFiPIRSF017529 Aquaporin_11/12, 1 hit
PRINTSiPR02024 AQUAPORIN11
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAQP11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: February 26, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again