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Entry version 149 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Estradiol 17-beta-dehydrogenase 11

Gene

HSD17B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei172SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei185Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193144 Estrogen biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 11 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 11
Short name:
17-beta-HSD 11
Short name:
17bHSD11
Short name:
17betaHSD11
17-beta-hydroxysteroid dehydrogenase XI
Short name:
17-beta-HSD XI
Short name:
17betaHSDXI
Cutaneous T-cell lymphoma-associated antigen HD-CL-03
Short name:
CTCL-associated antigen HD-CL-03
Dehydrogenase/reductase SDR family member 8
Retinal short-chain dehydrogenase/reductase 2
Short name:
retSDR2
Short chain dehydrogenase/reductase family 16C member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD17B11
Synonyms:DHRS8, PAN1B, SDR16C2
ORF Names:PSEC0029, UNQ207/PRO233
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22960 HSD17B11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612831 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBQ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51170

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391655

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02854 Aetiocholanolone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSD17B11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439374

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003197020 – 300Estradiol 17-beta-dehydrogenase 11Add BLAST281

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBQ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBQ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBQ5

PeptideAtlas

More...
PeptideAtlasi
Q8NBQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBQ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72809

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBQ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NBQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198189 Expressed in 224 organ(s), highest expression level in colonic mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBQ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021608

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119349, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBQ5, 59 interactors

Molecular INTeraction database

More...
MINTi
Q8NBQ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351035

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NBQ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NBQ5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1201 Eukaryota
COG1028 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBQ5

Database of Orthologous Groups

More...
OrthoDBi
1373099at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBQ5

TreeFam database of animal gene trees

More...
TreeFami
TF312837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106 adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NBQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR
60 70 80 90 100
LTAYEFAKLK SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI
110 120 130 140 150
YSSAKKVKAE IGDVSILVNN AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW
160 170 180 190 200
TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP FLLAYCSSKF AAVGFHKTLT
210 220 230 240 250
DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE EVVNRLMHGI
260 270 280 290 300
LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKQKISVKFD AVIGYKMKAQ
Length:300
Mass (Da):32,936
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51DE633A205EBE86
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCD0D6RCD0_HUMAN
Estradiol 17-beta-dehydrogenase 11
HSD17B11
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23V → E in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti38I → T in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti106K → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti107V → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti228N → K in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti229P → M in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti263I → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti264A → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti265F → I in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAF06939 (PubMed:10800688).Curated1
Sequence conflicti283Q → R in AAM44459 (PubMed:14996095).Curated1
Sequence conflicti283Q → R in AAQ88917 (PubMed:12975309).Curated1
Sequence conflicti283Q → R in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti283Q → R in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH14327 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH16367 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH21673 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH36001 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF126780 mRNA Translation: AAF06939.1
AF273056 mRNA Translation: AAM44459.1
AY358553 mRNA Translation: AAQ88917.1
AK075348 mRNA Translation: BAC11560.1
AC108516 Genomic DNA No translation available.
BC008650 mRNA Translation: AAH08650.1
BC014327 mRNA Translation: AAH14327.1
BC016367 mRNA Translation: AAH16367.1
BC021673 mRNA Translation: AAH21673.1
BC036001 mRNA Translation: AAH36001.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3619.1

NCBI Reference Sequences

More...
RefSeqi
NP_057329.3, NM_016245.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358290; ENSP00000351035; ENSG00000198189

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51170

UCSC genome browser

More...
UCSCi
uc003hqp.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126780 mRNA Translation: AAF06939.1
AF273056 mRNA Translation: AAM44459.1
AY358553 mRNA Translation: AAQ88917.1
AK075348 mRNA Translation: BAC11560.1
AC108516 Genomic DNA No translation available.
BC008650 mRNA Translation: AAH08650.1
BC014327 mRNA Translation: AAH14327.1
BC016367 mRNA Translation: AAH16367.1
BC021673 mRNA Translation: AAH21673.1
BC036001 mRNA Translation: AAH36001.1
CCDSiCCDS3619.1
RefSeqiNP_057329.3, NM_016245.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB1X-ray1.95A/B28-275[»]
SMRiQ8NBQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119349, 9 interactors
IntActiQ8NBQ5, 59 interactors
MINTiQ8NBQ5
STRINGi9606.ENSP00000351035

Chemistry databases

DrugBankiDB02854 Aetiocholanolone

PTM databases

iPTMnetiQ8NBQ5
PhosphoSitePlusiQ8NBQ5
SwissPalmiQ8NBQ5

Polymorphism and mutation databases

BioMutaiHSD17B11
DMDMi296439374

Proteomic databases

EPDiQ8NBQ5
jPOSTiQ8NBQ5
MaxQBiQ8NBQ5
PaxDbiQ8NBQ5
PeptideAtlasiQ8NBQ5
PRIDEiQ8NBQ5
ProteomicsDBi72809

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51170
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358290; ENSP00000351035; ENSG00000198189
GeneIDi51170
KEGGihsa:51170
UCSCiuc003hqp.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51170
DisGeNETi51170

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HSD17B11

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004358
HGNCiHGNC:22960 HSD17B11
HPAiHPA021608
MIMi612831 gene
neXtProtiNX_Q8NBQ5
PharmGKBiPA162391655

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
InParanoidiQ8NBQ5
OrthoDBi1373099at2759
PhylomeDBiQ8NBQ5
TreeFamiTF312837

Enzyme and pathway databases

ReactomeiR-HSA-193144 Estrogen biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HSD17B11 human
EvolutionaryTraceiQ8NBQ5

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HSD17B11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51170

Protein Ontology

More...
PROi
PR:Q8NBQ5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198189 Expressed in 224 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiQ8NBQ5 baseline and differential
GenevisibleiQ8NBQ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBQ5
Secondary accession number(s): Q96HF6, Q9UKU4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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