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UniProtKB - Q8NBP5 (MFSD9_HUMAN)
Protein
Major facilitator superfamily domain-containing protein 9
Gene
MFSD9
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8NBP5 |
SignaLinki | Q8NBP5 |
Protein family/group databases
TCDBi | 2.A.1.2.105, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 9 |
Gene namesi | Name:MFSD9 ORF Names:PSEC0066 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28158, MFSD9 |
neXtProti | NX_Q8NBP5 |
VEuPathDBi | HostDB:ENSG00000135953 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 45 – 65 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 80 – 100 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 116 – 136 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 288 – 308 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 323 – 343 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 436 – 456 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84804 |
OpenTargetsi | ENSG00000135953 |
PharmGKBi | PA162395873 |
Miscellaneous databases
Pharosi | Q8NBP5, Tdark |
Genetic variation databases
BioMutai | MFSD9 |
DMDMi | 158706133 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305025 | 1 – 474 | Major facilitator superfamily domain-containing protein 9Add BLAST | 474 |
Proteomic databases
EPDi | Q8NBP5 |
jPOSTi | Q8NBP5 |
MassIVEi | Q8NBP5 |
MaxQBi | Q8NBP5 |
PaxDbi | Q8NBP5 |
PeptideAtlasi | Q8NBP5 |
PRIDEi | Q8NBP5 |
ProteomicsDBi | 72806 |
PTM databases
iPTMneti | Q8NBP5 |
PhosphoSitePlusi | Q8NBP5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135953, Expressed in tendon of biceps brachii and 186 other tissues |
ExpressionAtlasi | Q8NBP5, baseline and differential |
Genevisiblei | Q8NBP5, HS |
Organism-specific databases
HPAi | ENSG00000135953, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124268, 7 interactors |
IntActi | Q8NBP5, 1 interactor |
STRINGi | 9606.ENSP00000258436 |
Miscellaneous databases
RNActi | Q8NBP5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT01040000241234 |
HOGENOMi | CLU_001265_10_12_1 |
InParanoidi | Q8NBP5 |
OMAi | IVGSWSD |
OrthoDBi | 1090653at2759 |
PhylomeDBi | Q8NBP5 |
TreeFami | TF314512 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q8NBP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY
60 70 80 90 100
LVGFLDLFGV SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG
110 120 130 140 150
CWSDVVGRRS SLLACILLSA LGYLLLGAAT NVFLFVLARV PAGIFKHTLS
160 170 180 190 200
ISRALLSDVV PEKERPLVIG HFNTASGVGF ILGPVVGGYL TELEDGFYLT
210 220 230 240 250
AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL LGRSHDTVQE
260 270 280 290 300
AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM
310 320 330 340 350
LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS
360 370 380 390 400
QALLLHSSIL TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL
410 420 430 440 450
TVGGAQASGT LIGVGQSVTA VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL
460 470
VAIFIMSLNK RHSSGDGNSK LKSE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WE00 | F8WE00_HUMAN | Major facilitator superfamily domai... | MFSD9 | 66 | Annotation score: | ||
F2Z2A2 | F2Z2A2_HUMAN | Major facilitator superfamily domai... | MFSD9 | 92 | Annotation score: | ||
H7C3S7 | H7C3S7_HUMAN | Major facilitator superfamily domai... | MFSD9 | 79 | Annotation score: | ||
F8WDV5 | F8WDV5_HUMAN | Major facilitator superfamily domai... | MFSD9 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | L → P in BAC11577 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 278 | K → R in BAC11577 (PubMed:16303743).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035966 | 59 | G → A in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035967 | 84 | V → A in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035152 | 129 | A → S. Corresponds to variant dbSNP:rs7601509EnsemblClinVar. | 1 | |
Natural variantiVAR_035153 | 288 | I → T. Corresponds to variant dbSNP:rs33993717Ensembl. | 1 | |
Natural variantiVAR_061383 | 376 | A → T. Corresponds to variant dbSNP:rs34096572EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075376 mRNA Translation: BAC11577.1 AC007239 Genomic DNA Translation: AAX88847.1 AC007251 Genomic DNA Translation: AAY14910.1 CH471127 Genomic DNA Translation: EAX01787.1 BC006242 mRNA Translation: AAH06242.1 BC009310 mRNA Translation: AAH09310.2 |
CCDSi | CCDS2063.1 |
RefSeqi | NP_001309009.1, NM_001322080.1 NP_001309010.1, NM_001322081.1 NP_116107.3, NM_032718.4 |
Genome annotation databases
Ensembli | ENST00000258436; ENSP00000258436; ENSG00000135953 |
GeneIDi | 84804 |
KEGGi | hsa:84804 |
MANE-Selecti | ENST00000258436.10; ENSP00000258436.5; NM_032718.5; NP_116107.3 |
UCSCi | uc002tcb.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075376 mRNA Translation: BAC11577.1 AC007239 Genomic DNA Translation: AAX88847.1 AC007251 Genomic DNA Translation: AAY14910.1 CH471127 Genomic DNA Translation: EAX01787.1 BC006242 mRNA Translation: AAH06242.1 BC009310 mRNA Translation: AAH09310.2 |
CCDSi | CCDS2063.1 |
RefSeqi | NP_001309009.1, NM_001322080.1 NP_001309010.1, NM_001322081.1 NP_116107.3, NM_032718.4 |
3D structure databases
SMRi | Q8NBP5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124268, 7 interactors |
IntActi | Q8NBP5, 1 interactor |
STRINGi | 9606.ENSP00000258436 |
Protein family/group databases
TCDBi | 2.A.1.2.105, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | Q8NBP5 |
PhosphoSitePlusi | Q8NBP5 |
Genetic variation databases
BioMutai | MFSD9 |
DMDMi | 158706133 |
Proteomic databases
EPDi | Q8NBP5 |
jPOSTi | Q8NBP5 |
MassIVEi | Q8NBP5 |
MaxQBi | Q8NBP5 |
PaxDbi | Q8NBP5 |
PeptideAtlasi | Q8NBP5 |
PRIDEi | Q8NBP5 |
ProteomicsDBi | 72806 |
Protocols and materials databases
Antibodypediai | 65316, 8 antibodies from 4 providers |
DNASUi | 84804 |
Genome annotation databases
Ensembli | ENST00000258436; ENSP00000258436; ENSG00000135953 |
GeneIDi | 84804 |
KEGGi | hsa:84804 |
MANE-Selecti | ENST00000258436.10; ENSP00000258436.5; NM_032718.5; NP_116107.3 |
UCSCi | uc002tcb.3, human |
Organism-specific databases
CTDi | 84804 |
DisGeNETi | 84804 |
GeneCardsi | MFSD9 |
HGNCi | HGNC:28158, MFSD9 |
HPAi | ENSG00000135953, Low tissue specificity |
neXtProti | NX_Q8NBP5 |
OpenTargetsi | ENSG00000135953 |
PharmGKBi | PA162395873 |
VEuPathDBi | HostDB:ENSG00000135953 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2615, Eukaryota |
GeneTreei | ENSGT01040000241234 |
HOGENOMi | CLU_001265_10_12_1 |
InParanoidi | Q8NBP5 |
OMAi | IVGSWSD |
OrthoDBi | 1090653at2759 |
PhylomeDBi | Q8NBP5 |
TreeFami | TF314512 |
Enzyme and pathway databases
PathwayCommonsi | Q8NBP5 |
SignaLinki | Q8NBP5 |
Miscellaneous databases
BioGRID-ORCSi | 84804, 11 hits in 1053 CRISPR screens |
ChiTaRSi | MFSD9, human |
GenomeRNAii | 84804 |
Pharosi | Q8NBP5, Tdark |
PROi | PR:Q8NBP5 |
RNActi | Q8NBP5, protein |
Gene expression databases
Bgeei | ENSG00000135953, Expressed in tendon of biceps brachii and 186 other tissues |
ExpressionAtlasi | Q8NBP5, baseline and differential |
Genevisiblei | Q8NBP5, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MFSD9_HUMAN | |
Accessioni | Q8NBP5Primary (citable) accession number: Q8NBP5 Secondary accession number(s): Q4ZG89 Q9BRI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families