We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8NBP0 (TTC13_HUMAN)
Protein
Tetratricopeptide repeat protein 13
Gene
TTC13
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Tetratricopeptide repeat protein 13Short name: TPR repeat protein 13 |
Gene namesi | Name:TTC13 ORF Names:PSEC0076 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26204, TTC13 |
neXtProti | NX_Q8NBP0 |
VEuPathDBi | HostDB:ENSG00000143643 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79573 |
OpenTargetsi | ENSG00000143643 |
PharmGKBi | PA134931681 |
Miscellaneous databases
Pharosi | Q8NBP0, Tdark |
Genetic variation databases
BioMutai | TTC13 |
DMDMi | 212276494 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106398 | 1 – 860 | Tetratricopeptide repeat protein 13Add BLAST | 860 |
Proteomic databases
EPDi | Q8NBP0 |
jPOSTi | Q8NBP0 |
MassIVEi | Q8NBP0 |
MaxQBi | Q8NBP0 |
PaxDbi | Q8NBP0 |
PeptideAtlasi | Q8NBP0 |
PRIDEi | Q8NBP0 |
ProteomicsDBi | 72804 [Q8NBP0-1] 72805 [Q8NBP0-2] |
PTM databases
iPTMneti | Q8NBP0 |
PhosphoSitePlusi | Q8NBP0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143643, Expressed in granulocyte and 213 other tissues |
ExpressionAtlasi | Q8NBP0, baseline and differential |
Genevisiblei | Q8NBP0, HS |
Organism-specific databases
HPAi | ENSG00000143643, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122720, 67 interactors |
IntActi | Q8NBP0, 7 interactors |
MINTi | Q8NBP0 |
STRINGi | 9606.ENSP00000355621 |
Miscellaneous databases
RNActi | Q8NBP0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 143 – 176 | TPR 1Add BLAST | 34 | |
Repeati | 216 – 248 | TPR 2Add BLAST | 33 | |
Repeati | 249 – 282 | TPR 3Add BLAST | 34 | |
Repeati | 284 – 316 | TPR 4Add BLAST | 33 | |
Repeati | 317 – 350 | TPR 5Add BLAST | 34 | |
Repeati | 352 – 384 | TPR 6Add BLAST | 33 | |
Repeati | 386 – 418 | TPR 7Add BLAST | 33 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG4626, Eukaryota |
GeneTreei | ENSGT00940000158461 |
HOGENOMi | CLU_014101_1_0_1 |
InParanoidi | Q8NBP0 |
OMAi | SWHDVYS |
OrthoDBi | 118570at2759 |
PhylomeDBi | Q8NBP0 |
TreeFami | TF332283 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF00515, TPR_1, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NBP0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPAGCCCCC CFWGGAVAAA GAARRVLLLL LLGVLSAGLR PGALATEHYS
60 70 80 90 100
PLSLLKQELQ HRQQQEAPAG GGGCSPQSGD WGDQYSAECG ESSFLNFHDS
110 120 130 140 150
DCEPKGSSPC DSLLSLNTEK ILSQAKSIAE QKRFPFATDN DSTNEELAIA
160 170 180 190 200
YVLIGSGLYD EAIRHFSTML QEEPDLVSAI YGRGIAYGKK GLHDIKNAEL
210 220 230 240 250
ALFELSRVIT LEPDRPEVFE QRAEILSPLG RINEAVNDLT KAIQLQPSAR
260 270 280 290 300
LYRHRGTLYF ISEDYATAHE DFQQSLELNK NQPIAMLYKG LTFFHRGLLK
310 320 330 340 350
EAIESFKEAL KQKVDFIDAY KSLGQAYREL GNFEAATESF QKALLLNQNH
360 370 380 390 400
VQTLQLRGMM LYHHGSLQEA LKNFKRCLQL EPYNEVCQYM KGLSHVAMGQ
410 420 430 440 450
FYEGIKAQTK VMLNDPLPGQ KASPEYLKVK YLREYSRYLH AHLDTPLTEY
460 470 480 490 500
NIDVDLPGSF KDHWAKNLPF LIEDYEEQPG LQPHIKDVLH QNFESYKPEV
510 520 530 540 550
QELICVADRL GSLMQYETPG FLPNKRIHRA MGLAALEVMQ AVQRTWTNSK
560 570 580 590 600
VRMNGKTRLM QWRDMFDIAV KWRRIADPDQ PVLWLDQMPA RSLSRGFNNH
610 620 630 640 650
INLIRGQVIN MRYLEYFEKI LHFIKDRILV YHGANNPKGL LEVREALEKV
660 670 680 690 700
HKVEDLLPIM KQFNTKTKDG FTVNTKVPSL KDQGKEYDGF TITITGDKVG
710 720 730 740 750
NILFSVETQT TEERTQLYHA EIDALYKDLT AKGKVLILSS EFGEADAVCN
760 770 780 790 800
LILSLVYYFY NLMPLSRGSS VIAYSVIVGA LMASGKEVAG KIPKGKLVDF
810 820 830 840 850
EAMTAPGSEA FSKVAKSWMN LKSISPSYKT LPSVSETFPT LRSMIEVLNT
860
DSSPRCLKKL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBV3 | H0YBV3_HUMAN | Tetratricopeptide repeat protein 13 | TTC13 | 186 | Annotation score: | ||
E5RJP6 | E5RJP6_HUMAN | Tetratricopeptide repeat protein 13 | TTC13 | 150 | Annotation score: | ||
E5RHB3 | E5RHB3_HUMAN | Tetratricopeptide repeat protein 13 | TTC13 | 166 | Annotation score: | ||
E5RG15 | E5RG15_HUMAN | Tetratricopeptide repeat protein 13 | TTC13 | 255 | Annotation score: | ||
H0YB10 | H0YB10_HUMAN | Tetratricopeptide repeat protein 13 | TTC13 | 123 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | G → R in BAC11700 (PubMed:16303743).Curated | 1 | |
Sequence conflicti | 438 | Y → H in BAC11586 (PubMed:16303743).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011644 | 172 – 224 | Missing in isoform 2. 3 PublicationsAdd BLAST | 53 | |
Alternative sequenceiVSP_035660 | 662 | Missing in isoform 2. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075386 mRNA Translation: BAC11586.1 AK075561 mRNA Translation: BAC11700.1 AL834453 mRNA Translation: CAD39113.1 AL844165 Genomic DNA No translation available. FO393421 Genomic DNA No translation available. BC042683 mRNA Translation: AAH42683.1 |
CCDSi | CCDS1588.1 [Q8NBP0-1] CCDS44332.2 [Q8NBP0-2] |
RefSeqi | NP_001116307.2, NM_001122835.2 [Q8NBP0-2] NP_078801.3, NM_024525.4 [Q8NBP0-1] |
Genome annotation databases
Ensembli | ENST00000366661; ENSP00000355621; ENSG00000143643 ENST00000366662; ENSP00000355622; ENSG00000143643 [Q8NBP0-2] |
GeneIDi | 79573 |
KEGGi | hsa:79573 |
MANE-Selecti | ENST00000366661.9; ENSP00000355621.4; NM_024525.5; NP_078801.3 |
UCSCi | uc001huf.5, human [Q8NBP0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK075386 mRNA Translation: BAC11586.1 AK075561 mRNA Translation: BAC11700.1 AL834453 mRNA Translation: CAD39113.1 AL844165 Genomic DNA No translation available. FO393421 Genomic DNA No translation available. BC042683 mRNA Translation: AAH42683.1 |
CCDSi | CCDS1588.1 [Q8NBP0-1] CCDS44332.2 [Q8NBP0-2] |
RefSeqi | NP_001116307.2, NM_001122835.2 [Q8NBP0-2] NP_078801.3, NM_024525.4 [Q8NBP0-1] |
3D structure databases
SMRi | Q8NBP0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122720, 67 interactors |
IntActi | Q8NBP0, 7 interactors |
MINTi | Q8NBP0 |
STRINGi | 9606.ENSP00000355621 |
PTM databases
iPTMneti | Q8NBP0 |
PhosphoSitePlusi | Q8NBP0 |
Genetic variation databases
BioMutai | TTC13 |
DMDMi | 212276494 |
Proteomic databases
EPDi | Q8NBP0 |
jPOSTi | Q8NBP0 |
MassIVEi | Q8NBP0 |
MaxQBi | Q8NBP0 |
PaxDbi | Q8NBP0 |
PeptideAtlasi | Q8NBP0 |
PRIDEi | Q8NBP0 |
ProteomicsDBi | 72804 [Q8NBP0-1] 72805 [Q8NBP0-2] |
Protocols and materials databases
Antibodypediai | 2494, 62 antibodies from 13 providers |
DNASUi | 79573 |
Genome annotation databases
Ensembli | ENST00000366661; ENSP00000355621; ENSG00000143643 ENST00000366662; ENSP00000355622; ENSG00000143643 [Q8NBP0-2] |
GeneIDi | 79573 |
KEGGi | hsa:79573 |
MANE-Selecti | ENST00000366661.9; ENSP00000355621.4; NM_024525.5; NP_078801.3 |
UCSCi | uc001huf.5, human [Q8NBP0-1] |
Organism-specific databases
CTDi | 79573 |
DisGeNETi | 79573 |
GeneCardsi | TTC13 |
HGNCi | HGNC:26204, TTC13 |
HPAi | ENSG00000143643, Low tissue specificity |
neXtProti | NX_Q8NBP0 |
OpenTargetsi | ENSG00000143643 |
PharmGKBi | PA134931681 |
VEuPathDBi | HostDB:ENSG00000143643 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4626, Eukaryota |
GeneTreei | ENSGT00940000158461 |
HOGENOMi | CLU_014101_1_0_1 |
InParanoidi | Q8NBP0 |
OMAi | SWHDVYS |
OrthoDBi | 118570at2759 |
PhylomeDBi | Q8NBP0 |
TreeFami | TF332283 |
Enzyme and pathway databases
PathwayCommonsi | Q8NBP0 |
SignaLinki | Q8NBP0 |
Miscellaneous databases
BioGRID-ORCSi | 79573, 6 hits in 1045 CRISPR screens |
ChiTaRSi | TTC13, human |
GenomeRNAii | 79573 |
Pharosi | Q8NBP0, Tdark |
PROi | PR:Q8NBP0 |
RNActi | Q8NBP0, protein |
Gene expression databases
Bgeei | ENSG00000143643, Expressed in granulocyte and 213 other tissues |
ExpressionAtlasi | Q8NBP0, baseline and differential |
Genevisiblei | Q8NBP0, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits |
InterProi | View protein in InterPro IPR011990, TPR-like_helical_dom_sf IPR001440, TPR_1 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF00515, TPR_1, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 6 hits PS50293, TPR_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TTC13_HUMAN | |
Accessioni | Q8NBP0Primary (citable) accession number: Q8NBP0 Secondary accession number(s): B1AQI1 Q8ND20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | November 4, 2008 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM