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UniProtKB - Q8NBP0 (TTC13_HUMAN)

Protein

Tetratricopeptide repeat protein 13

Gene

TTC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 13
Short name:
TPR repeat protein 13
Gene namesi
Name:TTC13
ORF Names:PSEC0076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143643.12
HGNCiHGNC:26204 TTC13
neXtProtiNX_Q8NBP0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143643
PharmGKBiPA134931681

Polymorphism and mutation databases

BioMutaiTTC13
DMDMi212276494

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063981 – 860Tetratricopeptide repeat protein 13Add BLAST860

Proteomic databases

EPDiQ8NBP0
MaxQBiQ8NBP0
PaxDbiQ8NBP0
PeptideAtlasiQ8NBP0
PRIDEiQ8NBP0
ProteomicsDBi72804
72805 [Q8NBP0-2]

PTM databases

iPTMnetiQ8NBP0
PhosphoSitePlusiQ8NBP0

Expressioni

Gene expression databases

BgeeiENSG00000143643 Expressed in 202 organ(s), highest expression level in corpus callosum
CleanExiHS_TTC13
ExpressionAtlasiQ8NBP0 baseline and differential
GenevisibleiQ8NBP0 HS

Organism-specific databases

HPAiHPA018022
HPA051558

Interactioni

Protein-protein interaction databases

BioGridi122720, 3 interactors
IntActiQ8NBP0, 5 interactors
MINTiQ8NBP0
STRINGi9606.ENSP00000355621

Structurei

3D structure databases

ProteinModelPortaliQ8NBP0
SMRiQ8NBP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati143 – 176TPR 1Add BLAST34
Repeati216 – 248TPR 2Add BLAST33
Repeati249 – 282TPR 3Add BLAST34
Repeati284 – 316TPR 4Add BLAST33
Repeati317 – 350TPR 5Add BLAST34
Repeati352 – 384TPR 6Add BLAST33
Repeati386 – 418TPR 7Add BLAST33

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4626 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110941
HOGENOMiHOG000007934
HOVERGENiHBG057893
InParanoidiQ8NBP0
OMAiYETPGFL
OrthoDBiEOG091G08C6
PhylomeDBiQ8NBP0
TreeFamiTF332283

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8NBP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAGCCCCC CFWGGAVAAA GAARRVLLLL LLGVLSAGLR PGALATEHYS 
        60         70         80         90        100
PLSLLKQELQ HRQQQEAPAG GGGCSPQSGD WGDQYSAECG ESSFLNFHDS 
       110        120        130        140        150
DCEPKGSSPC DSLLSLNTEK ILSQAKSIAE QKRFPFATDN DSTNEELAIA 
       160        170        180        190        200
YVLIGSGLYD EAIRHFSTML QEEPDLVSAI YGRGIAYGKK GLHDIKNAEL 
       210        220        230        240        250
ALFELSRVIT LEPDRPEVFE QRAEILSPLG RINEAVNDLT KAIQLQPSAR 
       260        270        280        290        300
LYRHRGTLYF ISEDYATAHE DFQQSLELNK NQPIAMLYKG LTFFHRGLLK 
       310        320        330        340        350
EAIESFKEAL KQKVDFIDAY KSLGQAYREL GNFEAATESF QKALLLNQNH 
       360        370        380        390        400
VQTLQLRGMM LYHHGSLQEA LKNFKRCLQL EPYNEVCQYM KGLSHVAMGQ 
       410        420        430        440        450
FYEGIKAQTK VMLNDPLPGQ KASPEYLKVK YLREYSRYLH AHLDTPLTEY 
       460        470        480        490        500
NIDVDLPGSF KDHWAKNLPF LIEDYEEQPG LQPHIKDVLH QNFESYKPEV 
       510        520        530        540        550
QELICVADRL GSLMQYETPG FLPNKRIHRA MGLAALEVMQ AVQRTWTNSK 
       560        570        580        590        600
VRMNGKTRLM QWRDMFDIAV KWRRIADPDQ PVLWLDQMPA RSLSRGFNNH 
       610        620        630        640        650
INLIRGQVIN MRYLEYFEKI LHFIKDRILV YHGANNPKGL LEVREALEKV 
       660        670        680        690        700
HKVEDLLPIM KQFNTKTKDG FTVNTKVPSL KDQGKEYDGF TITITGDKVG 
       710        720        730        740        750
NILFSVETQT TEERTQLYHA EIDALYKDLT AKGKVLILSS EFGEADAVCN 
       760        770        780        790        800
LILSLVYYFY NLMPLSRGSS VIAYSVIVGA LMASGKEVAG KIPKGKLVDF 
       810        820        830        840        850
EAMTAPGSEA FSKVAKSWMN LKSISPSYKT LPSVSETFPT LRSMIEVLNT 
       860
DSSPRCLKKL
Length:860
Mass (Da):96,813
Last modified:November 4, 2008 - v3
Checksum:i75747278086D7160
GO
Isoform 2 (identifier: Q8NBP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-224: Missing.
     662-662: Missing.

Show »
Length:806
Mass (Da):90,718
Checksum:i158BE03F91CBB8B0
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBV3H0YBV3_HUMAN
Tetratricopeptide repeat protein 13
TTC13
186Annotation score:
E5RG15E5RG15_HUMAN
Tetratricopeptide repeat protein 13
TTC13
255Annotation score:
E5RHB3E5RHB3_HUMAN
Tetratricopeptide repeat protein 13
TTC13
166Annotation score:
E5RJP6E5RJP6_HUMAN
Tetratricopeptide repeat protein 13
TTC13
150Annotation score:
H0YB10H0YB10_HUMAN
Tetratricopeptide repeat protein 13
TTC13
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → R in BAC11700 (PubMed:16303743).Curated1
Sequence conflicti438Y → H in BAC11586 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011644172 – 224Missing in isoform 2. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_035660662Missing in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075386 mRNA Translation: BAC11586.1
AK075561 mRNA Translation: BAC11700.1
AL834453 mRNA Translation: CAD39113.1
AL844165 Genomic DNA No translation available.
FO393421 Genomic DNA No translation available.
BC042683 mRNA Translation: AAH42683.1
CCDSiCCDS1588.1 [Q8NBP0-1]
CCDS44332.2 [Q8NBP0-2]
RefSeqiNP_001116307.2, NM_001122835.2 [Q8NBP0-2]
NP_078801.3, NM_024525.4 [Q8NBP0-1]
UniGeneiHs.424788

Genome annotation databases

EnsembliENST00000366661; ENSP00000355621; ENSG00000143643 [Q8NBP0-1]
ENST00000366662; ENSP00000355622; ENSG00000143643 [Q8NBP0-2]
GeneIDi79573
KEGGihsa:79573
UCSCiuc001huf.5 human [Q8NBP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTTC13_HUMAN
AccessioniPrimary (citable) accession number: Q8NBP0
Secondary accession number(s): B1AQI1
, B1AQI2, Q8IVP8, Q8NBI0, Q8ND20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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