Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol dehydrogenase 13

Gene

RDH13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not exhibit retinol dehydrogenase (RDH) activity in vitro.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei174SubstrateBy similarity1
Active sitei200Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 51NAD or NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.300 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway

Chemistry databases

SwissLipidsiSLP:000001877

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol dehydrogenase 13 (EC:1.1.1.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 7C member 3
Gene namesi
Name:RDH13
Synonyms:SDR7C3
ORF Names:PSEC0082, UNQ736/PRO1430
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160439.15
HGNCiHGNC:19978 RDH13
neXtProtiNX_Q8NBN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160439
PharmGKBiPA134897935

Chemistry databases

DrugBankiDB00162 Vitamin A

Polymorphism and mutation databases

BioMutaiRDH13
DMDMi62298570

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000547682 – 331Retinol dehydrogenase 13Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NBN7
MaxQBiQ8NBN7
PaxDbiQ8NBN7
PeptideAtlasiQ8NBN7
PRIDEiQ8NBN7
ProteomicsDBi72802
72803 [Q8NBN7-2]

PTM databases

iPTMnetiQ8NBN7
PhosphoSitePlusiQ8NBN7

Expressioni

Tissue specificityi

Expressed mostly in eye, pancreas, placenta and lung. In the retina, detected in the inner segment of the photoreceptor cells. Weak signals were observed in a small population of inner nuclear neurons and the inner plexiform layer.1 Publication

Gene expression databases

BgeeiENSG00000160439 Expressed in 202 organ(s), highest expression level in placenta
CleanExiHS_RDH13
ExpressionAtlasiQ8NBN7 baseline and differential
GenevisibleiQ8NBN7 HS

Organism-specific databases

HPAiHPA042006

Interactioni

Protein-protein interaction databases

BioGridi125200, 43 interactors
IntActiQ8NBN7, 8 interactors
MINTiQ8NBN7
STRINGi9606.ENSP00000391121

Structurei

3D structure databases

ProteinModelPortaliQ8NBN7
SMRiQ8NBN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ8NBN7
KOiK11161
OMAiRHTGLHQ
OrthoDBiEOG091G0FGA
PhylomeDBiQ8NBN7
TreeFamiTF105429

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRYLLPLSA LGTVAGAAVL LKDYVTGGAC PSKATIPGKT VIVTGANTGI
60 70 80 90 100
GKQTALELAR RGGNIILACR DMEKCEAAAK DIRGETLNHH VNARHLDLAS
110 120 130 140 150
LKSIREFAAK IIEEEERVDI LINNAGVMRC PHWTTEDGFE MQFGVNHLGH
160 170 180 190 200
FLLTNLLLDK LKASAPSRII NLSSLAHVAG HIDFDDLNWQ TRKYNTKAAY
210 220 230 240 250
CQSKLAIVLF TKELSRRLQG SGVTVNALHP GVARTELGRH TGIHGSTFSS
260 270 280 290 300
TTLGPIFWLL VKSPELAAQP STYLAVAEEL ADVSGKYFDG LKQKAPAPEA
310 320 330
EDEEVARRLW AESARLVGLE APSVREQPLP R
Length:331
Mass (Da):35,932
Last modified:March 29, 2005 - v2
Checksum:iDC5C1A6E54F1E6CC
GO
Isoform 2 (identifier: Q8NBN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:260
Mass (Da):28,794
Checksum:i12C82526B01A3174
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLA1G8JLA1_HUMAN
Retinol dehydrogenase 13
RDH13
220Annotation score:
K7ERV1K7ERV1_HUMAN
Retinol dehydrogenase 13
RDH13
35Annotation score:
K7EQB5K7EQB5_HUMAN
Retinol dehydrogenase 13
RDH13
29Annotation score:
K7EMY5K7EMY5_HUMAN
Retinol dehydrogenase 13
RDH13
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → V in BAC11591 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0403831 – 71Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358473 mRNA Translation: AAQ88837.1
AK075392 mRNA Translation: BAC11591.1
AC011476 Genomic DNA No translation available.
BC009881 mRNA Translation: AAH09881.1
CCDSiCCDS42627.1 [Q8NBN7-2]
CCDS54320.1 [Q8NBN7-1]
RefSeqiNP_001139443.1, NM_001145971.1 [Q8NBN7-1]
NP_612421.1, NM_138412.3 [Q8NBN7-2]
XP_005258530.1, XM_005258473.1 [Q8NBN7-1]
XP_011524709.1, XM_011526407.1
UniGeneiHs.327631
Hs.731615

Genome annotation databases

EnsembliENST00000396247; ENSP00000379547; ENSG00000160439 [Q8NBN7-2]
ENST00000415061; ENSP00000391121; ENSG00000160439 [Q8NBN7-1]
ENST00000610356; ENSP00000477732; ENSG00000160439 [Q8NBN7-2]
ENST00000613257; ENSP00000479552; ENSG00000276341 [Q8NBN7-2]
ENST00000613935; ENSP00000482809; ENSG00000274504 [Q8NBN7-2]
ENST00000615256; ENSP00000477512; ENSG00000276684 [Q8NBN7-1]
ENST00000615688; ENSP00000482782; ENSG00000275474 [Q8NBN7-2]
ENST00000616348; ENSP00000477884; ENSG00000276826 [Q8NBN7-2]
ENST00000620423; ENSP00000482051; ENSG00000278149 [Q8NBN7-2]
ENST00000621614; ENSP00000484637; ENSG00000276684 [Q8NBN7-2]
ENST00000621849; ENSP00000480095; ENSG00000273944 [Q8NBN7-2]
ENST00000622200; ENSP00000484111; ENSG00000274418 [Q8NBN7-2]
ENST00000622572; ENSP00000484246; ENSG00000278284 [Q8NBN7-2]
GeneIDi112724
KEGGihsa:112724
UCSCiuc002qio.4 human [Q8NBN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358473 mRNA Translation: AAQ88837.1
AK075392 mRNA Translation: BAC11591.1
AC011476 Genomic DNA No translation available.
BC009881 mRNA Translation: AAH09881.1
CCDSiCCDS42627.1 [Q8NBN7-2]
CCDS54320.1 [Q8NBN7-1]
RefSeqiNP_001139443.1, NM_001145971.1 [Q8NBN7-1]
NP_612421.1, NM_138412.3 [Q8NBN7-2]
XP_005258530.1, XM_005258473.1 [Q8NBN7-1]
XP_011524709.1, XM_011526407.1
UniGeneiHs.327631
Hs.731615

3D structure databases

ProteinModelPortaliQ8NBN7
SMRiQ8NBN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125200, 43 interactors
IntActiQ8NBN7, 8 interactors
MINTiQ8NBN7
STRINGi9606.ENSP00000391121

Chemistry databases

DrugBankiDB00162 Vitamin A
SwissLipidsiSLP:000001877

PTM databases

iPTMnetiQ8NBN7
PhosphoSitePlusiQ8NBN7

Polymorphism and mutation databases

BioMutaiRDH13
DMDMi62298570

Proteomic databases

EPDiQ8NBN7
MaxQBiQ8NBN7
PaxDbiQ8NBN7
PeptideAtlasiQ8NBN7
PRIDEiQ8NBN7
ProteomicsDBi72802
72803 [Q8NBN7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396247; ENSP00000379547; ENSG00000160439 [Q8NBN7-2]
ENST00000415061; ENSP00000391121; ENSG00000160439 [Q8NBN7-1]
ENST00000610356; ENSP00000477732; ENSG00000160439 [Q8NBN7-2]
ENST00000613257; ENSP00000479552; ENSG00000276341 [Q8NBN7-2]
ENST00000613935; ENSP00000482809; ENSG00000274504 [Q8NBN7-2]
ENST00000615256; ENSP00000477512; ENSG00000276684 [Q8NBN7-1]
ENST00000615688; ENSP00000482782; ENSG00000275474 [Q8NBN7-2]
ENST00000616348; ENSP00000477884; ENSG00000276826 [Q8NBN7-2]
ENST00000620423; ENSP00000482051; ENSG00000278149 [Q8NBN7-2]
ENST00000621614; ENSP00000484637; ENSG00000276684 [Q8NBN7-2]
ENST00000621849; ENSP00000480095; ENSG00000273944 [Q8NBN7-2]
ENST00000622200; ENSP00000484111; ENSG00000274418 [Q8NBN7-2]
ENST00000622572; ENSP00000484246; ENSG00000278284 [Q8NBN7-2]
GeneIDi112724
KEGGihsa:112724
UCSCiuc002qio.4 human [Q8NBN7-1]

Organism-specific databases

CTDi112724
EuPathDBiHostDB:ENSG00000160439.15
GeneCardsiRDH13
H-InvDBiHIX0158529
HGNCiHGNC:19978 RDH13
HPAiHPA042006
neXtProtiNX_Q8NBN7
OpenTargetsiENSG00000160439
PharmGKBiPA134897935
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00760000119068
HOVERGENiHBG078800
InParanoidiQ8NBN7
KOiK11161
OMAiRHTGLHQ
OrthoDBiEOG091G0FGA
PhylomeDBiQ8NBN7
TreeFamiTF105429

Enzyme and pathway databases

BRENDAi1.1.1.300 2681
ReactomeiR-HSA-5365859 RA biosynthesis pathway

Miscellaneous databases

ChiTaRSiRDH13 human
GenomeRNAii112724
PROiPR:Q8NBN7

Gene expression databases

BgeeiENSG00000160439 Expressed in 202 organ(s), highest expression level in placenta
CleanExiHS_RDH13
ExpressionAtlasiQ8NBN7 baseline and differential
GenevisibleiQ8NBN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRDH13_HUMAN
AccessioniPrimary (citable) accession number: Q8NBN7
Secondary accession number(s): Q6UX79, Q96G88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 29, 2005
Last modified: October 10, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again