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UniProtKB - Q8NBN7 (RDH13_HUMAN)

Entry version 158 (07 Apr 2021)
Sequence version 2 (29 Mar 2005)
Previous versions | rss
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Protein

Retinol dehydrogenase 13

Gene

RDH13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency (PubMed:18039331). Has no activity toward steroids (PubMed:18039331).1 Publication

Caution

Was originally thought to lack retinol dehydrogenase (RDH) activity. However, a more recent publication demonstrates a retinol dehydrogenase activity for RDH13.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.2 µM for all-trans-retinal1 Publication
  2. KM=3 µM for all-trans-retinol1 Publication
  3. KM=1.5 µM for NADPH1 Publication
  4. KM=6000 µM for NAD1 Publication
  1. Vmax=230 nmol/min/mg enzyme with all-trans-retinal as substrate1 Publication
  2. Vmax=5 nmol/min/mg enzyme with all-trans-retinol as substrate1 Publication
  3. Vmax=230 nmol/min/mg enzyme with NADPH as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei174SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei200Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi45 – 51NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.300, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NBN7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5365859, RA biosynthesis pathway

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00912

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001877

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinol dehydrogenase 13Curated (EC:1.1.1.3001 Publication)
Alternative name(s):
Short chain dehydrogenase/reductase family 7C member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RDH13
Synonyms:SDR7C3
ORF Names:PSEC0082, UNQ736/PRO1430
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19978, RDH13

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NBN7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160439.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		112724

Open Targets

More...OpenTargetsi		ENSG00000160439

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134897935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NBN7, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00162, Vitamin A

DrugCentral

More...DrugCentrali		Q8NBN7

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RDH13

Domain mapping of disease mutations (DMDM)

More...DMDMi		62298570

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000547682 – 331Retinol dehydrogenase 13Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NBN7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NBN7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NBN7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NBN7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NBN7

PeptideAtlas

More...PeptideAtlasi		Q8NBN7

PRoteomics IDEntifications database

More...PRIDEi		Q8NBN7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72802 [Q8NBN7-1]
72803 [Q8NBN7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NBN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NBN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:18039331). In the retina, detected in the inner segment of the photoreceptor cells. Weak signals are observed in a small population of inner nuclear neurons and the inner plexiform layer (PubMed:12226107).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160439, Expressed in placenta and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NBN7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NBN7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160439, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125200, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q8NBN7, 27 interactors

Molecular INTeraction database

More...MINTi		Q8NBN7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000391121

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NBN7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NBN7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1208, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010194_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NBN7

Identification of Orthologs from Complete Genome Data

More...OMAi		WQKRKYN

Database of Orthologous Groups

More...OrthoDBi		921996at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NBN7

TreeFam database of animal gene trees

More...TreeFami		TF105429

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106, adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081, GDHRDH
PR00080, SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00061, ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRYLLPLSA LGTVAGAAVL LKDYVTGGAC PSKATIPGKT VIVTGANTGI 
        60         70         80         90        100
GKQTALELAR RGGNIILACR DMEKCEAAAK DIRGETLNHH VNARHLDLAS 
       110        120        130        140        150
LKSIREFAAK IIEEEERVDI LINNAGVMRC PHWTTEDGFE MQFGVNHLGH 
       160        170        180        190        200
FLLTNLLLDK LKASAPSRII NLSSLAHVAG HIDFDDLNWQ TRKYNTKAAY 
       210        220        230        240        250
CQSKLAIVLF TKELSRRLQG SGVTVNALHP GVARTELGRH TGIHGSTFSS 
       260        270        280        290        300
TTLGPIFWLL VKSPELAAQP STYLAVAEEL ADVSGKYFDG LKQKAPAPEA 
       310        320        330 
EDEEVARRLW AESARLVGLE APSVREQPLP R
Length:331
Mass (Da):35,932
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC5C1A6E54F1E6CC
GO
Isoform 2 (identifier: Q8NBN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:260
Mass (Da):28,794
Checksum:i12C82526B01A3174
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLA1G8JLA1_HUMAN
Retinol dehydrogenase 13
RDH13
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMY5K7EMY5_HUMAN
Retinol dehydrogenase 13
RDH13
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQB5K7EQB5_HUMAN
Retinol dehydrogenase 13
RDH13
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERV1K7ERV1_HUMAN
Retinol dehydrogenase 13
RDH13
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106E → V in BAC11591 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0403831 – 71Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358473 mRNA Translation: AAQ88837.1
AK075392 mRNA Translation: BAC11591.1
AC011476 Genomic DNA No translation available.
BC009881 mRNA Translation: AAH09881.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42627.1 [Q8NBN7-2]
CCDS54320.1 [Q8NBN7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001139443.1, NM_001145971.1 [Q8NBN7-1]
NP_612421.1, NM_138412.3 [Q8NBN7-2]
XP_005258530.1, XM_005258473.1 [Q8NBN7-1]
XP_011524709.1, XM_011526407.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396247; ENSP00000379547; ENSG00000160439 [Q8NBN7-2]
ENST00000415061; ENSP00000391121; ENSG00000160439 [Q8NBN7-1]
ENST00000610356; ENSP00000477732; ENSG00000160439 [Q8NBN7-2]
ENST00000613257; ENSP00000479552; ENSG00000276341 [Q8NBN7-2]
ENST00000613935; ENSP00000482809; ENSG00000274504 [Q8NBN7-2]
ENST00000615256; ENSP00000477512; ENSG00000276684 [Q8NBN7-1]
ENST00000615688; ENSP00000482782; ENSG00000275474 [Q8NBN7-2]
ENST00000616348; ENSP00000477884; ENSG00000276826 [Q8NBN7-2]
ENST00000620423; ENSP00000482051; ENSG00000278149 [Q8NBN7-2]
ENST00000621614; ENSP00000484637; ENSG00000276684 [Q8NBN7-2]
ENST00000621849; ENSP00000480095; ENSG00000273944 [Q8NBN7-2]
ENST00000622200; ENSP00000484111; ENSG00000274418 [Q8NBN7-2]
ENST00000622572; ENSP00000484246; ENSG00000278284 [Q8NBN7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		112724

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:112724

UCSC genome browser

More...UCSCi		uc002qio.4, human [Q8NBN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358473 mRNA Translation: AAQ88837.1
AK075392 mRNA Translation: BAC11591.1
AC011476 Genomic DNA No translation available.
BC009881 mRNA Translation: AAH09881.1
CCDSiCCDS42627.1 [Q8NBN7-2]
CCDS54320.1 [Q8NBN7-1]
RefSeqiNP_001139443.1, NM_001145971.1 [Q8NBN7-1]
NP_612421.1, NM_138412.3 [Q8NBN7-2]
XP_005258530.1, XM_005258473.1 [Q8NBN7-1]
XP_011524709.1, XM_011526407.1

3D structure databases

SMRiQ8NBN7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125200, 53 interactors
IntActiQ8NBN7, 27 interactors
MINTiQ8NBN7
STRINGi9606.ENSP00000391121

Chemistry databases

DrugBankiDB00162, Vitamin A
DrugCentraliQ8NBN7
SwissLipidsiSLP:000001877

PTM databases

iPTMnetiQ8NBN7
PhosphoSitePlusiQ8NBN7

Genetic variation databases

BioMutaiRDH13
DMDMi62298570

Proteomic databases

EPDiQ8NBN7
jPOSTiQ8NBN7
MassIVEiQ8NBN7
MaxQBiQ8NBN7
PaxDbiQ8NBN7
PeptideAtlasiQ8NBN7
PRIDEiQ8NBN7
ProteomicsDBi72802 [Q8NBN7-1]
72803 [Q8NBN7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32994, 134 antibodies

Genome annotation databases

EnsembliENST00000396247; ENSP00000379547; ENSG00000160439 [Q8NBN7-2]
ENST00000415061; ENSP00000391121; ENSG00000160439 [Q8NBN7-1]
ENST00000610356; ENSP00000477732; ENSG00000160439 [Q8NBN7-2]
ENST00000613257; ENSP00000479552; ENSG00000276341 [Q8NBN7-2]
ENST00000613935; ENSP00000482809; ENSG00000274504 [Q8NBN7-2]
ENST00000615256; ENSP00000477512; ENSG00000276684 [Q8NBN7-1]
ENST00000615688; ENSP00000482782; ENSG00000275474 [Q8NBN7-2]
ENST00000616348; ENSP00000477884; ENSG00000276826 [Q8NBN7-2]
ENST00000620423; ENSP00000482051; ENSG00000278149 [Q8NBN7-2]
ENST00000621614; ENSP00000484637; ENSG00000276684 [Q8NBN7-2]
ENST00000621849; ENSP00000480095; ENSG00000273944 [Q8NBN7-2]
ENST00000622200; ENSP00000484111; ENSG00000274418 [Q8NBN7-2]
ENST00000622572; ENSP00000484246; ENSG00000278284 [Q8NBN7-2]
GeneIDi112724
KEGGihsa:112724
UCSCiuc002qio.4, human [Q8NBN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		112724
DisGeNETi112724

GeneCards: human genes, protein and diseases

More...GeneCardsi		RDH13
HGNCiHGNC:19978, RDH13
HPAiENSG00000160439, Low tissue specificity
neXtProtiNX_Q8NBN7
OpenTargetsiENSG00000160439
PharmGKBiPA134897935
VEuPathDBiHostDB:ENSG00000160439.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1208, Eukaryota
GeneTreeiENSGT00940000159641
HOGENOMiCLU_010194_44_5_1
InParanoidiQ8NBN7
OMAiWQKRKYN
OrthoDBi921996at2759
PhylomeDBiQ8NBN7
TreeFamiTF105429

Enzyme and pathway databases

UniPathwayiUPA00912
BRENDAi1.1.1.300, 2681
PathwayCommonsiQ8NBN7
ReactomeiR-HSA-5365859, RA biosynthesis pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		112724, 5 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RDH13, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		112724
PharosiQ8NBN7, Tdark

Protein Ontology

More...PROi		PR:Q8NBN7
RNActiQ8NBN7, protein

Gene expression databases

BgeeiENSG00000160439, Expressed in placenta and 217 other tissues
ExpressionAtlasiQ8NBN7, baseline and differential
GenevisibleiQ8NBN7, HS

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PRINTSiPR00081, GDHRDH
PR00080, SDRFAMILY
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061, ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDH13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBN7
Secondary accession number(s): Q6UX79, Q96G88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 29, 2005
Last modified: April 7, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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