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Entry version 126 (16 Oct 2019)
Sequence version 3 (20 Feb 2007)
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Protein

Transmembrane protein 87A

Gene

TMEM87A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 87ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM87AImported
ORF Names:PSEC0094Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24522 TMEM87A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBN3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 225LumenalCuratedAdd BLAST204
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei226 – 246Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini247 – 257CytoplasmicCuratedAdd BLAST11
Transmembranei258 – 278Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini279 – 305LumenalCuratedAdd BLAST27
Transmembranei306 – 322Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini323 – 325CytoplasmicCurated3
Transmembranei326 – 346Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini347 – 361LumenalCuratedAdd BLAST15
Transmembranei362 – 382Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini383 – 403CytoplasmicCuratedAdd BLAST21
Transmembranei404 – 424Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini425 – 437LumenalCuratedAdd BLAST13
Transmembranei438 – 458Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini459 – 555CytoplasmicCuratedAdd BLAST97

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25963

Open Targets

More...
OpenTargetsi
ENSG00000103978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670739

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBN3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM87A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027075122 – 555Transmembrane protein 87AAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi160N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei540PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBN3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NBN3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NBN3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBN3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NBN3

PeptideAtlas

More...
PeptideAtlasi
Q8NBN3

PRoteomics IDEntifications database

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PRIDEi
Q8NBN3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
72799 [Q8NBN3-1]
72800 [Q8NBN3-2]
72801 [Q8NBN3-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1854

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NBN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBN3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NBN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103978 Expressed in 240 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NBN3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBN3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018104
HPA018189

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117453, 39 interactors

Protein interaction database and analysis system

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IntActi
Q8NBN3, 21 interactors

Molecular INTeraction database

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MINTi
Q8NBN3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374484

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi476 – 482Poly-Glu7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LU7TM family. TMEM87 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2568 Eukaryota
ENOG410XS1Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231789

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NBN3

Identification of Orthologs from Complete Genome Data

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OMAi
TWYLRYS

Database of Orthologous Groups

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OrthoDBi
1448608at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBN3

TreeFam database of animal gene trees

More...
TreeFami
TF314452

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009637 GPR107/GPR108-like

The PANTHER Classification System

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PANTHERi
PTHR21229 PTHR21229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06814 Lung_7-TM_R, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAWLQVL PVILLLLGAH PSPLSFFSAG PATVAAADRS KWHIPIPSGK
60 70 80 90 100
NYFSFGKILF RNTTIFLKFD GEPCDLSLNI TWYLKSADCY NEIYNFKAEE
110 120 130 140 150
VELYLEKLKE KRGLSGKYQT SSKLFQNCSE LFKTQTFSGD FMHRLPLLGE
160 170 180 190 200
KQEAKENGTN LTFIGDKTAM HEPLQTWQDA PYIFIVHIGI SSSKESSKEN
210 220 230 240 250
SLSNLFTMTV EVKGPYEYLT LEDYPLMIFF MVMCIVYVLF GVLWLAWSAC
260 270 280 290 300
YWRDLLRIQF WIGAVIFLGM LEKAVFYAEF QNIRYKGESV QGALILAELL
310 320 330 340 350
SAVKRSLART LVIIVSLGYG IVKPRLGVTL HKVVVAGALY LLFSGMEGVL
360 370 380 390 400
RVTGAQTDLA SLAFIPLAFL DTALCWWIFI SLTQTMKLLK LRRNIVKLSL
410 420 430 440 450
YRHFTNTLIL AVAASIVFII WTTMKFRIVT CQSDWRELWV DDAIWRLLFS
460 470 480 490 500
MILFVIMVLW RPSANNQRFA FSPLSEEEEE DEQKEPMLKE SFEGMKMRST
510 520 530 540 550
KQEPNGNSKV NKAQEDDLKW VEENVPSSVT DVALPALLDS DEERMITHFE

RSKME
Length:555
Mass (Da):63,430
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ED560B42FA01076
GO
Isoform 2 (identifier: Q8NBN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-181: AMHEPLQTWQDAP → IQMPFLKKHFLDC
     182-555: Missing.

Show »
Length:181
Mass (Da):20,529
Checksum:iE484518255201436
GO
Isoform 3 (identifier: Q8NBN3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MAAAAWLQVL...FRNTTIFLKF → MAHSDTVV

Show »
Length:494
Mass (Da):56,774
Checksum:iA4DA96F31ABD0AA2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMU0H3BMU0_HUMAN
Transmembrane protein 87A
TMEM87A
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPJ4H3BPJ4_HUMAN
Transmembrane protein 87A
TMEM87A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTS6H3BTS6_HUMAN
Transmembrane protein 87A
TMEM87A
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRG0H3BRG0_HUMAN
Transmembrane protein 87A
TMEM87A
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUZ1H3BUZ1_HUMAN
Transmembrane protein 87A
TMEM87A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM87H3BM87_HUMAN
Transmembrane protein 87A
TMEM87A
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSZ0H3BSZ0_HUMAN
Transmembrane protein 87A
TMEM87A
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11598 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117 – 118KY → NI in AAF66444 (Ref. 1) Curated2
Sequence conflicti313I → S in AAF66444 (Ref. 1) Curated1
Sequence conflicti424 – 425MK → KG in CAB43218 (PubMed:17974005).Curated2
Sequence conflicti485E → V in CAB43218 (PubMed:17974005).Curated1
Sequence conflicti518L → S in BAC11598 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0222071 – 69MAAAA…IFLKF → MAHSDTVV in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_022208169 – 181AMHEP…WQDAP → IQMPFLKKHFLDC in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_022209182 – 555Missing in isoform 2. 1 PublicationAdd BLAST374

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132733 mRNA Translation: AAF66444.1
AK074870 mRNA Translation: BAC11256.1
AK075403 mRNA Translation: BAC11598.1 Different initiation.
BC005335 mRNA Translation: AAH05335.1
BC069240 mRNA Translation: AAH69240.1
AL049944 mRNA Translation: CAB43218.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32205.1 [Q8NBN3-1]
CCDS45243.1 [Q8NBN3-2]
CCDS66742.1 [Q8NBN3-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08676

NCBI Reference Sequences

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RefSeqi
NP_001103973.1, NM_001110503.2 [Q8NBN3-2]
NP_001273416.1, NM_001286487.1 [Q8NBN3-3]
NP_056312.2, NM_015497.4 [Q8NBN3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307216; ENSP00000305894; ENSG00000103978 [Q8NBN3-2]
ENST00000389834; ENSP00000374484; ENSG00000103978 [Q8NBN3-1]
ENST00000448392; ENSP00000405379; ENSG00000103978 [Q8NBN3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25963

UCSC genome browser

More...
UCSCi
uc001zpg.4 human [Q8NBN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132733 mRNA Translation: AAF66444.1
AK074870 mRNA Translation: BAC11256.1
AK075403 mRNA Translation: BAC11598.1 Different initiation.
BC005335 mRNA Translation: AAH05335.1
BC069240 mRNA Translation: AAH69240.1
AL049944 mRNA Translation: CAB43218.1
CCDSiCCDS32205.1 [Q8NBN3-1]
CCDS45243.1 [Q8NBN3-2]
CCDS66742.1 [Q8NBN3-3]
PIRiT08676
RefSeqiNP_001103973.1, NM_001110503.2 [Q8NBN3-2]
NP_001273416.1, NM_001286487.1 [Q8NBN3-3]
NP_056312.2, NM_015497.4 [Q8NBN3-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117453, 39 interactors
IntActiQ8NBN3, 21 interactors
MINTiQ8NBN3
STRINGi9606.ENSP00000374484

PTM databases

GlyConnecti1854
iPTMnetiQ8NBN3
PhosphoSitePlusiQ8NBN3
SwissPalmiQ8NBN3

Polymorphism and mutation databases

BioMutaiTMEM87A
DMDMi126302609

Proteomic databases

EPDiQ8NBN3
jPOSTiQ8NBN3
MassIVEiQ8NBN3
MaxQBiQ8NBN3
PaxDbiQ8NBN3
PeptideAtlasiQ8NBN3
PRIDEiQ8NBN3
ProteomicsDBi72799 [Q8NBN3-1]
72800 [Q8NBN3-2]
72801 [Q8NBN3-3]

Genome annotation databases

EnsembliENST00000307216; ENSP00000305894; ENSG00000103978 [Q8NBN3-2]
ENST00000389834; ENSP00000374484; ENSG00000103978 [Q8NBN3-1]
ENST00000448392; ENSP00000405379; ENSG00000103978 [Q8NBN3-3]
GeneIDi25963
KEGGihsa:25963
UCSCiuc001zpg.4 human [Q8NBN3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
25963
DisGeNETi25963

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM87A
HGNCiHGNC:24522 TMEM87A
HPAiHPA018104
HPA018189
neXtProtiNX_Q8NBN3
OpenTargetsiENSG00000103978
PharmGKBiPA142670739

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2568 Eukaryota
ENOG410XS1Q LUCA
GeneTreeiENSGT00940000159481
HOGENOMiHOG000231789
InParanoidiQ8NBN3
OMAiTWYLRYS
OrthoDBi1448608at2759
PhylomeDBiQ8NBN3
TreeFamiTF314452

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM87A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25963
PharosiQ8NBN3

Protein Ontology

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PROi
PR:Q8NBN3

Gene expression databases

BgeeiENSG00000103978 Expressed in 240 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8NBN3 baseline and differential
GenevisibleiQ8NBN3 HS

Family and domain databases

InterProiView protein in InterPro
IPR009637 GPR107/GPR108-like
PANTHERiPTHR21229 PTHR21229, 1 hit
PfamiView protein in Pfam
PF06814 Lung_7-TM_R, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM87A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBN3
Secondary accession number(s): Q6NT77
, Q8NCA4, Q9BS46, Q9P103, Q9Y3Y7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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