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Entry version 145 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Ubiquitin-associated domain-containing protein 2

Gene

UBAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 2
Short name:
UBA domain-containing protein 2
Alternative name(s):
Phosphoglycerate dehydrogenase-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBAC2
Synonyms:PHGDHL1
ORF Names:PSEC0110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20486 UBAC2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBM4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 91ExtracellularSequence analysisAdd BLAST56
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 125CytoplasmicSequence analysisAdd BLAST13
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 163ExtracellularSequence analysisAdd BLAST17
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 344CytoplasmicSequence analysisAdd BLAST160

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
337867

MalaCards human disease database

More...
MalaCardsi
UBAC2

Open Targets

More...
OpenTargetsi
ENSG00000134882

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
117 Behcet disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407839

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBM4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBAC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028075436 – 344Ubiquitin-associated domain-containing protein 2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NBM4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBM4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBM4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBM4

PeptideAtlas

More...
PeptideAtlasi
Q8NBM4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBM4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72792 [Q8NBM4-1]
72793 [Q8NBM4-2]
72794 [Q8NBM4-3]
72795 [Q8NBM4-4]
72796 [Q8NBM4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBM4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8NBM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134882 Expressed in 187 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NBM4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBM4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013448

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FAF2 (PubMed:23297223).

Interacts with LMBR1L (PubMed:31073040).

Interacts with AMFR and VCP (By similarity).

By similarity1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-724045,EBI-739580

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130617, 71 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBM4, 30 interactors

Molecular INTeraction database

More...
MINTi
Q8NBM4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383911

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBM4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini304 – 344UBAPROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4463 Eukaryota
ENOG4111CBK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182999

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBM4

Identification of Orthologs from Complete Genome Data

More...
OMAi
KEDFQIW

Database of Orthologous Groups

More...
OrthoDBi
975575at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBM4

TreeFam database of animal gene trees

More...
TreeFami
TF333335

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14305 UBA_UBAC2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041928 UBA_UBAC2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00627 UBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN
60 70 80 90 100
DFQIWRLICG RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW
110 120 130 140 150
VLSALFDFLL IEAMQYFFGI TAASNLPSGF LAPVFALFVP FYCSIPRVQV
160 170 180 190 200
AQILGPLSIT NKTLIYILGL QLFTSGSYIW IVAISGLMSG LCYDSKMFQV
210 220 230 240 250
HQVLCIPSWM AKFFSWTLEP IFSSSEPTSE ARIGMGATLD IQRQQRMELL
260 270 280 290 300
DRQLMFSQFA QGRRQRQQQG GMINWNRLFP PLRQRQNVNY QGGRQSEPAA
310 320 330 340
PPLEVSEEQV ARLMEMGFSR GDALEALRAS NNDLNVATNF LLQH
Length:344
Mass (Da):38,964
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8C5D4D68B64CEB3
GO
Isoform 2 (identifier: Q8NBM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-130: HCQKLFVYDL...TAASNLPSGF → MCFFFSLQEE...TFTQSRTTSS

Show »
Length:309
Mass (Da):34,876
Checksum:i8DBCCCADAB551956
GO
Isoform 3 (identifier: Q8NBM4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Show »
Length:231
Mass (Da):26,097
Checksum:i0BFAA7849E602840
GO
Isoform 4 (identifier: Q8NBM4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:157
Mass (Da):18,055
Checksum:iF87E4C44784F0876
GO
Isoform 5 (identifier: Q8NBM4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-141: IWRLICGRII...APVFALFVPF → PGTCVCSVCT...LDGKILFLDT
     142-344: Missing.

Show »
Length:141
Mass (Da):15,426
Checksum:i93054CCD541AEDFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JUH4Q5JUH4_HUMAN
Ubiquitin-associated domain-contain...
UBAC2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXT1A0A087WXT1_HUMAN
Ubiquitin-associated domain-contain...
UBAC2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6R5E5X6R5E5_HUMAN
Ubiquitin-associated domain-contain...
UBAC2
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH72674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI21139 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0239091 – 187Missing in isoform 4. 2 PublicationsAdd BLAST187
Alternative sequenceiVSP_0239101 – 113Missing in isoform 3. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0239111 – 35Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_02391236 – 130HCQKL…LPSGF → MCFFFSLQEEFLDKHTLMRV LSSGGKLGSRGEGAQLCCWM LLFSWRVSGGQQTRRLCRRA FCWSPVPSPSCSPSSCLTAR SSLCMTFTQSRTTSS in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_02391354 – 141IWRLI…LFVPF → PGTCVCSVCTILLLHTKSPS GTNSGSVVHHKQDIDLYIGT AAFHLWFLHLDCSHKWTYVR SVLRQQNVPGASGALHPQLD GKILFLDT in isoform 5. CuratedAdd BLAST88
Alternative sequenceiVSP_023914142 – 344Missing in isoform 5. CuratedAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK054563 mRNA Translation: BAB70757.1
AK055110 mRNA Translation: BAG51469.1
AK075419 mRNA Translation: BAC11609.1
AK075516 mRNA Translation: BAC11665.1
AL136961 Genomic DNA No translation available.
AL159981 Genomic DNA No translation available.
AL160155 Genomic DNA No translation available.
BC063559 mRNA Translation: AAH63559.1
BC072674 mRNA Translation: AAH72674.1 Different initiation.
BC121138 mRNA Translation: AAI21139.1 Different initiation.
BC121139 mRNA Translation: AAI21140.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45064.1 [Q8NBM4-1]
CCDS9490.1 [Q8NBM4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001137544.1, NM_001144072.1 [Q8NBM4-1]
NP_808882.1, NM_177967.3 [Q8NBM4-2]
XP_006720011.1, XM_006719948.3 [Q8NBM4-3]
XP_011519386.1, XM_011521084.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376440; ENSP00000365623; ENSG00000134882 [Q8NBM4-2]
ENST00000403766; ENSP00000383911; ENSG00000134882 [Q8NBM4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
337867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:337867

UCSC genome browser

More...
UCSCi
uc001voa.5 human [Q8NBM4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054563 mRNA Translation: BAB70757.1
AK055110 mRNA Translation: BAG51469.1
AK075419 mRNA Translation: BAC11609.1
AK075516 mRNA Translation: BAC11665.1
AL136961 Genomic DNA No translation available.
AL159981 Genomic DNA No translation available.
AL160155 Genomic DNA No translation available.
BC063559 mRNA Translation: AAH63559.1
BC072674 mRNA Translation: AAH72674.1 Different initiation.
BC121138 mRNA Translation: AAI21139.1 Different initiation.
BC121139 mRNA Translation: AAI21140.1
CCDSiCCDS45064.1 [Q8NBM4-1]
CCDS9490.1 [Q8NBM4-2]
RefSeqiNP_001137544.1, NM_001144072.1 [Q8NBM4-1]
NP_808882.1, NM_177967.3 [Q8NBM4-2]
XP_006720011.1, XM_006719948.3 [Q8NBM4-3]
XP_011519386.1, XM_011521084.2

3D structure databases

SMRiQ8NBM4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130617, 71 interactors
IntActiQ8NBM4, 30 interactors
MINTiQ8NBM4
STRINGi9606.ENSP00000383911

PTM databases

iPTMnetiQ8NBM4
PhosphoSitePlusiQ8NBM4
SwissPalmiQ8NBM4

Polymorphism and mutation databases

BioMutaiUBAC2
DMDMi74751173

Proteomic databases

EPDiQ8NBM4
jPOSTiQ8NBM4
MassIVEiQ8NBM4
MaxQBiQ8NBM4
PaxDbiQ8NBM4
PeptideAtlasiQ8NBM4
PRIDEiQ8NBM4
ProteomicsDBi72792 [Q8NBM4-1]
72793 [Q8NBM4-2]
72794 [Q8NBM4-3]
72795 [Q8NBM4-4]
72796 [Q8NBM4-5]

Genome annotation databases

EnsembliENST00000376440; ENSP00000365623; ENSG00000134882 [Q8NBM4-2]
ENST00000403766; ENSP00000383911; ENSG00000134882 [Q8NBM4-1]
GeneIDi337867
KEGGihsa:337867
UCSCiuc001voa.5 human [Q8NBM4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
337867
DisGeNETi337867

GeneCards: human genes, protein and diseases

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GeneCardsi
UBAC2
HGNCiHGNC:20486 UBAC2
HPAiHPA013448
MalaCardsiUBAC2
neXtProtiNX_Q8NBM4
OpenTargetsiENSG00000134882
Orphaneti117 Behcet disease
PharmGKBiPA162407839

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4463 Eukaryota
ENOG4111CBK LUCA
GeneTreeiENSGT00950000182999
InParanoidiQ8NBM4
OMAiKEDFQIW
OrthoDBi975575at2759
PhylomeDBiQ8NBM4
TreeFamiTF333335

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UBAC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
337867
PharosiQ8NBM4

Protein Ontology

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PROi
PR:Q8NBM4

Gene expression databases

BgeeiENSG00000134882 Expressed in 187 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ8NBM4 baseline and differential
GenevisibleiQ8NBM4 HS

Family and domain databases

CDDicd14305 UBA_UBAC2, 1 hit
InterProiView protein in InterPro
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041928 UBA_UBAC2
PfamiView protein in Pfam
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBAC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBM4
Secondary accession number(s): B3KNV7
, Q0VAB5, Q5W0W6, Q5W0W9, Q6GQR2, Q6P4B0, Q8N2E8, Q96NW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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