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Entry version 165 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

Inactive C-alpha-formylglycine-generating enzyme 2

Gene

SUMF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.3 Publications

Caution

Although strongly similar to formylglycine-generating enzyme, lacks the catalytic Cys residues at positions 261 and 266 that bind the catalytic copper. The catalytic copper is required to activate oxygen and catalyze oxidative C-H activation.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi194Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi195Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi208Calcium 11 Publication1
Metal bindingi210Calcium 1; via carbonyl oxygen1 Publication1
Metal bindingi229Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi232Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi234Calcium 2; via carbonyl oxygen1 Publication1
Metal bindingi236Calcium 21 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive C-alpha-formylglycine-generating enzyme 2Curated
Alternative name(s):
Paralog of formylglycine-generating enzyme3 Publications
Short name:
pFGE3 Publications
Sulfatase-modifying factor 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUMF21 PublicationImported
ORF Names:PSEC01711 Publication, UNQ1968/PRO45001 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20415 SUMF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607940 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBJ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi156C → A: Abolishes interaction with and inhibition of SUMF1. Can still form homodimers. 1 Publication1
Mutagenesisi290C → A: Abolishes interaction with and inhibition of SUMF1. Can still form homodimers. 1 Publication1
Mutagenesisi298 – 301Missing : Abolishes endoplasmic reticulum retention. 1 Publication4
Mutagenesisi298 – 299PG → KD: Does not affect endoplasmic reticulum retention. 1 Publication2
Mutagenesisi298P → S: Does not affect endoplasmic reticulum retention. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
25870

Open Targets

More...
OpenTargetsi
ENSG00000129103

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134921869

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBJ7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUMF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452916

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003345926 – 301Inactive C-alpha-formylglycine-generating enzyme 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi156 ↔ 2902 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBJ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBJ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBJ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBJ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBJ7

PeptideAtlas

More...
PeptideAtlasi
Q8NBJ7

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBJ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72779 [Q8NBJ7-1]
72780 [Q8NBJ7-2]
72781 [Q8NBJ7-3]
72782 [Q8NBJ7-4]
72783 [Q8NBJ7-5]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00171412

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1773

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBJ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBJ7

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q8NBJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129103 Expressed in 196 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBJ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBJ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025743
HPA024040
HPA074892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer with SUMF1.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117386, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBJ7, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8NBJ7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341938

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBJ7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8NBJ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi298 – 301Non-canonical ER retention motif1 Publication4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The non-canonical ER retention motif mediates retention of the protein in the endoplasmic reticulum.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfatase-modifying factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFQ0 Eukaryota
COG1262 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008983

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBJ7

Database of Orthologous Groups

More...
OrthoDBi
835112at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBJ7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1580.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016187 CTDL_fold
IPR005532 SUMF_dom
IPR042095 SUMF_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03781 FGE-sulfatase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARHGLPLLP LLSLLVGAWL KLGNGQATSM VQLQGGRFLM GTNSPDSRDG
60 70 80 90 100
DGPVREATVK PFAIDIFPVT NKDFRDFVRE KKYRTEAEMF GWSFVFEDFV
110 120 130 140 150
SDELRNKATQ PMKSVLWWLP VEKAFWRQPA GPGSGIRERL EHPVLHVSWN
160 170 180 190 200
DARAYCAWRG KRLPTEEEWE FAARGGLKGQ VYPWGNWFQP NRTNLWQGKF
210 220 230 240 250
PKGDKAEDGF HGVSPVNAFP AQNNYGLYDL LGNVWEWTAS PYQAAEQDMR
260 270 280 290 300
VLRGASWIDT ADGSANHRAR VTTRMGNTPD SASDNLGFRC AADAGRPPGE

L
Length:301
Mass (Da):33,843
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E834CEA56922755
GO
Isoform 2 (identifier: Q8NBJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:213
Mass (Da):24,117
Checksum:iE8AF9A2220AEE11D
GO
Isoform 3 (identifier: Q8NBJ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-301: LYDLLGNVWE...ADAGRPPGEL → WATLQIQPQT...QVFLLEAKYY

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):37,395
Checksum:i74E1DA4C9B85F276
GO
Isoform 5 (identifier: Q8NBJ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-197: Missing.

Show »
Length:217
Mass (Da):23,902
Checksum:i80822E9067E4E5C2
GO
Isoform 4 (identifier: Q8NBJ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-301: SVLWWLPVEK...ADAGRPPGEL → VKFTHGGTGS...QVFLLEAKYY

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):34,187
Checksum:iA4B285CB52C41407
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PG02E9PG02_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WES7F8WES7_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEX5F8WEX5_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MXB9A8MXB9_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBT8E9PBT8_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEV7F8WEV7_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1B1A0A494C1B1_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J660C9J660_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JL30C9JL30_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
274Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3B2H7C3B2_HUMAN
Inactive C-alpha-formylglycine-gene...
SUMF2
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00224 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB43247 differs from that shown. Reason: Frameshift.Curated
The sequence CAB43247 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04695151D → ECombined sources6 PublicationsCorresponds to variant dbSNP:rs4245575Ensembl.1
Natural variantiVAR_080774228Y → C Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs778487055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0078781 – 88Missing in isoform 2. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_007880114 – 301SVLWW…PPGEL → VKFTHGGTGSSQTAPTCGRE SSPRETKLRMASMESPQMLS PPRTTTGSMTSWGTCGSGQH HRTRLLSRTCASSGGHPGST QLMALPITGPGSPPGWATLQ IQPQTTSVSAVLQTQAGRQG SCKQPGGDKEKSLLGSLSFP GHVANSAIPSSRASASGKNF PFPVSHPSVAGASHQGRRGL SLLCFGEGAQCVLTMAGGQV FLLEAKYY in isoform 4. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_040878114 – 197Missing in isoform 5. CuratedAdd BLAST84
Alternative sequenceiVSP_007879227 – 301LYDLL…PPGEL → WATLQIQPQTTSVSAVLQTQ AGRQGSCKQPGGDKEKSLLG SLSFPGHVANSAIPSSRASA SGKNFPFPVSHPSVAGASHQ GRRGLSLLCFGEGAQCVLTM AGGQVFLLEAKYY in isoform 3. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY323911 mRNA Translation: AAP86218.1
AY359103 mRNA Translation: AAQ89461.1
AK300488 mRNA Translation: BAG62203.1
AK301627 mRNA Translation: BAG63112.1
AK075477 mRNA Translation: BAC11643.1
AL050037 mRNA Translation: CAB43247.1 Sequence problems.
CH471140 Genomic DNA Translation: EAX07980.1
BC000224 mRNA Translation: AAH00224.1 Different initiation.
BC006159 mRNA Translation: AAH06159.1
BC015600 mRNA Translation: AAH15600.2
BC084539 mRNA Translation: AAH84539.1
BC111092 mRNA Translation: AAI11093.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43589.2 [Q8NBJ7-5]
CCDS47589.1 [Q8NBJ7-3]
CCDS55111.1 [Q8NBJ7-2]
CCDS5524.2 [Q8NBJ7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T08715

NCBI Reference Sequences

More...
RefSeqi
NP_001035934.2, NM_001042469.1
NP_001035935.2, NM_001042470.1 [Q8NBJ7-5]
NP_001123541.1, NM_001130069.2 [Q8NBJ7-3]
NP_001139805.1, NM_001146333.1 [Q8NBJ7-2]
NP_056226.2, NM_015411.2 [Q8NBJ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275607; ENSP00000275607; ENSG00000129103 [Q8NBJ7-2]
ENST00000342190; ENSP00000341938; ENSG00000129103 [Q8NBJ7-3]
ENST00000395435; ENSP00000378823; ENSG00000129103 [Q8NBJ7-5]
ENST00000434526; ENSP00000400922; ENSG00000129103 [Q8NBJ7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25870

UCSC genome browser

More...
UCSCi
uc003trt.4 human [Q8NBJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323911 mRNA Translation: AAP86218.1
AY359103 mRNA Translation: AAQ89461.1
AK300488 mRNA Translation: BAG62203.1
AK301627 mRNA Translation: BAG63112.1
AK075477 mRNA Translation: BAC11643.1
AL050037 mRNA Translation: CAB43247.1 Sequence problems.
CH471140 Genomic DNA Translation: EAX07980.1
BC000224 mRNA Translation: AAH00224.1 Different initiation.
BC006159 mRNA Translation: AAH06159.1
BC015600 mRNA Translation: AAH15600.2
BC084539 mRNA Translation: AAH84539.1
BC111092 mRNA Translation: AAI11093.1
CCDSiCCDS43589.2 [Q8NBJ7-5]
CCDS47589.1 [Q8NBJ7-3]
CCDS55111.1 [Q8NBJ7-2]
CCDS5524.2 [Q8NBJ7-1]
PIRiT08715
RefSeqiNP_001035934.2, NM_001042469.1
NP_001035935.2, NM_001042470.1 [Q8NBJ7-5]
NP_001123541.1, NM_001130069.2 [Q8NBJ7-3]
NP_001139805.1, NM_001146333.1 [Q8NBJ7-2]
NP_056226.2, NM_015411.2 [Q8NBJ7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y4JX-ray1.86A/B27-301[»]
SMRiQ8NBJ7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi117386, 14 interactors
IntActiQ8NBJ7, 8 interactors
MINTiQ8NBJ7
STRINGi9606.ENSP00000341938

PTM databases

GlyConnecti1773
iPTMnetiQ8NBJ7
PhosphoSitePlusiQ8NBJ7

Polymorphism and mutation databases

BioMutaiSUMF2
DMDMi296452916

2D gel databases

REPRODUCTION-2DPAGEiIPI00171412

Proteomic databases

EPDiQ8NBJ7
jPOSTiQ8NBJ7
MassIVEiQ8NBJ7
MaxQBiQ8NBJ7
PaxDbiQ8NBJ7
PeptideAtlasiQ8NBJ7
PRIDEiQ8NBJ7
ProteomicsDBi72779 [Q8NBJ7-1]
72780 [Q8NBJ7-2]
72781 [Q8NBJ7-3]
72782 [Q8NBJ7-4]
72783 [Q8NBJ7-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25870

Genome annotation databases

EnsembliENST00000275607; ENSP00000275607; ENSG00000129103 [Q8NBJ7-2]
ENST00000342190; ENSP00000341938; ENSG00000129103 [Q8NBJ7-3]
ENST00000395435; ENSP00000378823; ENSG00000129103 [Q8NBJ7-5]
ENST00000434526; ENSP00000400922; ENSG00000129103 [Q8NBJ7-1]
GeneIDi25870
KEGGihsa:25870
UCSCiuc003trt.4 human [Q8NBJ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25870
DisGeNETi25870

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SUMF2
HGNCiHGNC:20415 SUMF2
HPAiCAB025743
HPA024040
HPA074892
MIMi607940 gene
neXtProtiNX_Q8NBJ7
OpenTargetsiENSG00000129103
PharmGKBiPA134921869

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFQ0 Eukaryota
COG1262 LUCA
GeneTreeiENSGT00390000008983
InParanoidiQ8NBJ7
OrthoDBi835112at2759
PhylomeDBiQ8NBJ7

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SUMF2 human
EvolutionaryTraceiQ8NBJ7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SUMF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25870
PharosiQ8NBJ7
PMAP-CutDBiQ8NBJ7

Protein Ontology

More...
PROi
PR:Q8NBJ7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129103 Expressed in 196 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ8NBJ7 baseline and differential
GenevisibleiQ8NBJ7 HS

Family and domain databases

Gene3Di3.90.1580.10, 1 hit
InterProiView protein in InterPro
IPR016187 CTDL_fold
IPR005532 SUMF_dom
IPR042095 SUMF_sf
PfamiView protein in Pfam
PF03781 FGE-sulfatase, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUMF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBJ7
Secondary accession number(s): B4DU41
, B4DWQ0, Q14DW5, Q53ZE3, Q96BH2, Q9BRN3, Q9BWI1, Q9Y405
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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