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Entry version 151 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Golgi membrane protein 1

Gene

GOLM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Unknown. Cellular response protein to viral infection.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NBJ4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi membrane protein 1
Alternative name(s):
Golgi membrane protein GP73
Golgi phosphoprotein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLM1
Synonyms:C9orf155, GOLPH2
ORF Names:PSEC0242, UNQ686/PRO1326
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135052.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15451, GOLM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606804, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBJ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini36 – 401LumenalSequence analysisAdd BLAST366

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51280

Open Targets

More...
OpenTargetsi
ENSG00000135052

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28811

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBJ4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000213561 – 401Golgi membrane protein 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei187PhosphoserineCombined sources1
Modified residuei309Phosphoserine; by FAM20C1 Publication1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.4 Publications
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBJ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBJ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBJ4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBJ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBJ4

PeptideAtlas

More...
PeptideAtlasi
Q8NBJ4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBJ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72776 [Q8NBJ4-1]
72777 [Q8NBJ4-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1281, 33 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8NBJ4, 10 sites, 2 O-linked glycans (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBJ4

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q8NBJ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135052, Expressed in prostate gland and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBJ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBJ4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135052, Tissue enhanced (gallbladder, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DYM.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8NBJ4
With#Exp.IntAct
ABI3 [Q9P2A4]3EBI-712073,EBI-742038
AIG1 - isoform 2 [Q9NVV5-2]3EBI-712073,EBI-11957045
ANKRD46 - isoform 1 [Q86W74-2]3EBI-712073,EBI-12109402
ASPH - isoform 6 [Q12797-6]3EBI-712073,EBI-12092171
BCL2L1 [Q07817]3EBI-712073,EBI-78035
C1QL4 [Q86Z23]3EBI-712073,EBI-12062109
CDIPT [O14735]3EBI-712073,EBI-358858
CLDN4 [O14493]3EBI-712073,EBI-9316372
CLDND2 [Q8NHS1]3EBI-712073,EBI-11959453
CNPY3 [Q9BT09]3EBI-712073,EBI-2835965
DESI1 [Q6ICB0]3EBI-712073,EBI-2806959
EGFR [P00533]13EBI-712073,EBI-297353
FUT9 [Q9Y231]3EBI-712073,EBI-3922408
GALNT15 [Q8N3T1]3EBI-712073,EBI-3925203
GAST [P01350]3EBI-712073,EBI-3436637
GET3 [O43681]3EBI-712073,EBI-2515857
GLB1 [P16278]3EBI-712073,EBI-989638
GUCA2A [Q02747]3EBI-712073,EBI-12244272
HGFAC [Q04756]3EBI-712073,EBI-1041722
HSD17B13 [Q7Z5P4]3EBI-712073,EBI-18053395
IGFBP5 [P24593]3EBI-712073,EBI-720480
INSIG2 [Q9Y5U4]3EBI-712073,EBI-8503746
JAGN1 [Q8N5M9]3EBI-712073,EBI-10266796
LAT - isoform 2 [O43561-2]3EBI-712073,EBI-8070286
MIP [P30301]3EBI-712073,EBI-8449636
NDUFV2 [P19404]3EBI-712073,EBI-713665
NEU1 [Q99519]3EBI-712073,EBI-721517
NINJ1 [Q92982]3EBI-712073,EBI-2802124
PGRMC1 [O00264]3EBI-712073,EBI-1045534
RIPPLY2 [Q5TAB7]3EBI-712073,EBI-10246897
SFTPC [P11686]3EBI-712073,EBI-10197617
SLC13A5 [Q86YT5]3EBI-712073,EBI-12002412
SLC30A3 [Q99726]3EBI-712073,EBI-10294651
SLC35B2 [Q8TB61]3EBI-712073,EBI-1054782
SLC5A4 [Q9NY91]3EBI-712073,EBI-12409133
SLCO3A1 - isoform 2 [Q9UIG8-2]3EBI-712073,EBI-13041931
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-712073,EBI-12908338
STRIT1 [P0DN84]3EBI-712073,EBI-12200293
TF [P02787]3EBI-712073,EBI-714319
THSD7A [Q9UPZ6]3EBI-712073,EBI-310962
TMEM109 [Q9BVC6]3EBI-712073,EBI-1057733
TMEM140 [Q9NV12]3EBI-712073,EBI-2844246
TMEM147 [Q9BVK8]3EBI-712073,EBI-348587
TMEM176A [Q96HP8]3EBI-712073,EBI-2800645
TMEM86B [Q8N661]3EBI-712073,EBI-2548832
TMEM98 [Q9Y2Y6]3EBI-712073,EBI-7333781
TMPO [P42167]3EBI-712073,EBI-455283
TMUB1 [Q9BVT8]3EBI-712073,EBI-11425701
TMUB2 [Q71RG4]3EBI-712073,EBI-2820477
TSG101 [Q99816]3EBI-712073,EBI-346882
VSTM1 - isoform 3 [Q6UX27-3]3EBI-712073,EBI-12190699

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119432, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBJ4, 121 interactors

Molecular INTeraction database

More...
MINTi
Q8NBJ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373364

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NBJ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBJ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili40 – 205Sequence analysisAdd BLAST166

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLM family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S080, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_055640_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBJ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QREKRNH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBJ4

TreeFam database of animal gene trees

More...
TreeFami
TF331127

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026143, GOLM1
IPR026139, GOLM1/CASC4

The PANTHER Classification System

More...
PANTHERi
PTHR15896, PTHR15896, 1 hit
PTHR15896:SF8, PTHR15896:SF8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02084, GOLM1CASC4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE
60 70 80 90 100
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ
110 120 130 140 150
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER
160 170 180 190 200
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL
210 220 230 240 250
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV
260 270 280 290 300
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP
310 320 330 340 350
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD
360 370 380 390 400
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT

L
Length:401
Mass (Da):45,333
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24C1DC31E47B5B77
GO
Isoform 2 (identifier: Q8NBJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:391
Mass (Da):44,273
Checksum:i5BCF2B6097DFA458
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J941C9J941_HUMAN
Golgi membrane protein 1
GOLM1
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYM4C9JYM4_HUMAN
Golgi membrane protein 1
GOLM1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAT9F8WAT9_HUMAN
Golgi membrane protein 1
GOLM1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti249Q → R in CAG33482 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053922217H → R. Corresponds to variant dbSNP:rs2297002Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187821 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF236056 mRNA Translation: AAF44663.1
AY358593 mRNA Translation: AAQ88956.1
CR457201 mRNA Translation: CAG33482.1
AK075542 mRNA Translation: BAC11685.1
BC001740 mRNA Translation: AAH01740.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35054.1 [Q8NBJ4-1]

NCBI Reference Sequences

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RefSeqi
NP_057632.2, NM_016548.3 [Q8NBJ4-1]
NP_808800.1, NM_177937.2 [Q8NBJ4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000388711; ENSP00000373363; ENSG00000135052 [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052 [Q8NBJ4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51280

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51280

UCSC genome browser

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UCSCi
uc004aol.4, human [Q8NBJ4-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236056 mRNA Translation: AAF44663.1
AY358593 mRNA Translation: AAQ88956.1
CR457201 mRNA Translation: CAG33482.1
AK075542 mRNA Translation: BAC11685.1
BC001740 mRNA Translation: AAH01740.1
CCDSiCCDS35054.1 [Q8NBJ4-1]
RefSeqiNP_057632.2, NM_016548.3 [Q8NBJ4-1]
NP_808800.1, NM_177937.2 [Q8NBJ4-1]

3D structure databases

SMRiQ8NBJ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119432, 43 interactors
IntActiQ8NBJ4, 121 interactors
MINTiQ8NBJ4
STRINGi9606.ENSP00000373364

PTM databases

GlyConnecti1281, 33 N-Linked glycans (3 sites)
GlyGeniQ8NBJ4, 10 sites, 2 O-linked glycans (5 sites)
iPTMnetiQ8NBJ4
MetOSiteiQ8NBJ4
PhosphoSitePlusiQ8NBJ4

Polymorphism and mutation databases

BioMutaiGOLM1
DMDMi51316027

Proteomic databases

EPDiQ8NBJ4
jPOSTiQ8NBJ4
MassIVEiQ8NBJ4
MaxQBiQ8NBJ4
PaxDbiQ8NBJ4
PeptideAtlasiQ8NBJ4
PRIDEiQ8NBJ4
ProteomicsDBi72776 [Q8NBJ4-1]
72777 [Q8NBJ4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2449, 684 antibodies

The DNASU plasmid repository

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DNASUi
51280

Genome annotation databases

EnsembliENST00000388711; ENSP00000373363; ENSG00000135052 [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052 [Q8NBJ4-1]
GeneIDi51280
KEGGihsa:51280
UCSCiuc004aol.4, human [Q8NBJ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51280
DisGeNETi51280
EuPathDBiHostDB:ENSG00000135052.16

GeneCards: human genes, protein and diseases

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GeneCardsi
GOLM1
HGNCiHGNC:15451, GOLM1
HPAiENSG00000135052, Tissue enhanced (gallbladder, stomach)
MIMi606804, gene
neXtProtiNX_Q8NBJ4
OpenTargetsiENSG00000135052
PharmGKBiPA28811

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S080, Eukaryota
GeneTreeiENSGT00530000063675
HOGENOMiCLU_055640_0_0_1
InParanoidiQ8NBJ4
OMAiQREKRNH
PhylomeDBiQ8NBJ4
TreeFamiTF331127

Enzyme and pathway databases

PathwayCommonsiQ8NBJ4
ReactomeiR-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51280, 3 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GOLM1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GOLM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51280
PharosiQ8NBJ4, Tbio

Protein Ontology

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PROi
PR:Q8NBJ4
RNActiQ8NBJ4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135052, Expressed in prostate gland and 221 other tissues
ExpressionAtlasiQ8NBJ4, baseline and differential
GenevisibleiQ8NBJ4, HS

Family and domain databases

InterProiView protein in InterPro
IPR026143, GOLM1
IPR026139, GOLM1/CASC4
PANTHERiPTHR15896, PTHR15896, 1 hit
PTHR15896:SF8, PTHR15896:SF8, 1 hit
PRINTSiPR02084, GOLM1CASC4

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOLM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBJ4
Secondary accession number(s): Q6IAF4, Q9NRB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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