UniProtKB - Q8NBJ4 (GOLM1_HUMAN)
Protein
Golgi membrane protein 1
Gene
GOLM1
Organism
Homo sapiens (Human)
Status
Functioni
Unknown. Cellular response protein to viral infection.
Caution
It is uncertain whether Met-1 or Met-2 is the initiator.Curated
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- nucleus organization Source: Ensembl
- post-translational protein modification Source: Reactome
- regulation of lipid metabolic process Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8NBJ4 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Golgi membrane protein 1Alternative name(s): Golgi membrane protein GP73 Golgi phosphoprotein 2 |
Gene namesi | Name:GOLM1 Synonyms:C9orf155, GOLPH2 ORF Names:PSEC0242, UNQ686/PRO1326 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15451, GOLM1 |
MIMi | 606804, gene |
neXtProti | NX_Q8NBJ4 |
VEuPathDBi | HostDB:ENSG00000135052.16 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 2 Publications; Single-pass type II membrane protein 2 Publications
Note: Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular space Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 13 – 35 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 36 – 401 | LumenalSequence analysisAdd BLAST | 366 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51280 |
OpenTargetsi | ENSG00000135052 |
PharmGKBi | PA28811 |
Miscellaneous databases
Pharosi | Q8NBJ4, Tbio |
Genetic variation databases
BioMutai | GOLM1 |
DMDMi | 51316027 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000021356 | 1 – 401 | Golgi membrane protein 1Add BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 | |
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 187 | PhosphoserineCombined sources | 1 | |
Modified residuei | 309 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 398 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.4 Publications
Phosphorylation sites are present in the extracellular medium.
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8NBJ4 |
jPOSTi | Q8NBJ4 |
MassIVEi | Q8NBJ4 |
MaxQBi | Q8NBJ4 |
PaxDbi | Q8NBJ4 |
PeptideAtlasi | Q8NBJ4 |
PRIDEi | Q8NBJ4 |
ProteomicsDBi | 72776 [Q8NBJ4-1] 72777 [Q8NBJ4-2] |
PTM databases
GlyConnecti | 1281, 33 N-Linked glycans (3 sites) |
GlyGeni | Q8NBJ4, 10 sites, 2 O-linked glycans (5 sites) |
iPTMneti | Q8NBJ4 |
MetOSitei | Q8NBJ4 |
PhosphoSitePlusi | Q8NBJ4 |
Expressioni
Tissue specificityi
Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications
Inductioni
Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication
Gene expression databases
Bgeei | ENSG00000135052, Expressed in prostate gland and 221 other tissues |
ExpressionAtlasi | Q8NBJ4, baseline and differential |
Genevisiblei | Q8NBJ4, HS |
Organism-specific databases
HPAi | ENSG00000135052, Tissue enhanced (gallbladder, stomach) |
Interactioni
Subunit structurei
Interacts with DYM.
1 PublicationBinary interactionsi
Q8NBJ4
Protein-protein interaction databases
BioGRIDi | 119432, 95 interactors |
IntActi | Q8NBJ4, 124 interactors |
MINTi | Q8NBJ4 |
STRINGi | 9606.ENSP00000373364 |
Miscellaneous databases
RNActi | Q8NBJ4, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 40 – 205 | Sequence analysisAdd BLAST | 166 |
Sequence similaritiesi
Belongs to the GOLM family.Curated
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S080, Eukaryota |
GeneTreei | ENSGT00530000063675 |
HOGENOMi | CLU_055640_0_0_1 |
InParanoidi | Q8NBJ4 |
OMAi | QREKRNH |
PhylomeDBi | Q8NBJ4 |
TreeFami | TF331127 |
Family and domain databases
InterProi | View protein in InterPro IPR026143, GOLM1 IPR026139, GOLM1/CASC4 |
PANTHERi | PTHR15896, PTHR15896, 1 hit PTHR15896:SF8, PTHR15896:SF8, 1 hit |
PRINTSi | PR02084, GOLM1CASC4 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE
60 70 80 90 100
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ
110 120 130 140 150
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER
160 170 180 190 200
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL
210 220 230 240 250
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV
260 270 280 290 300
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP
310 320 330 340 350
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD
360 370 380 390 400
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT
L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J941 | C9J941_HUMAN | Golgi membrane protein 1 | GOLM1 | 80 | Annotation score: | ||
C9JYM4 | C9JYM4_HUMAN | Golgi membrane protein 1 | GOLM1 | 121 | Annotation score: | ||
F8WAT9 | F8WAT9_HUMAN | Golgi membrane protein 1 | GOLM1 | 105 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 249 | Q → R in CAG33482 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053922 | 217 | H → R. Corresponds to variant dbSNP:rs2297002Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018782 | 1 – 10 | Missing in isoform 2. Curated | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236056 mRNA Translation: AAF44663.1 AY358593 mRNA Translation: AAQ88956.1 CR457201 mRNA Translation: CAG33482.1 AK075542 mRNA Translation: BAC11685.1 BC001740 mRNA Translation: AAH01740.1 |
CCDSi | CCDS35054.1 [Q8NBJ4-1] |
RefSeqi | NP_057632.2, NM_016548.3 [Q8NBJ4-1] NP_808800.1, NM_177937.2 [Q8NBJ4-1] |
Genome annotation databases
Ensembli | ENST00000388711; ENSP00000373363; ENSG00000135052 [Q8NBJ4-1] ENST00000388712; ENSP00000373364; ENSG00000135052 [Q8NBJ4-1] |
GeneIDi | 51280 |
KEGGi | hsa:51280 |
UCSCi | uc004aol.4, human [Q8NBJ4-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF236056 mRNA Translation: AAF44663.1 AY358593 mRNA Translation: AAQ88956.1 CR457201 mRNA Translation: CAG33482.1 AK075542 mRNA Translation: BAC11685.1 BC001740 mRNA Translation: AAH01740.1 |
CCDSi | CCDS35054.1 [Q8NBJ4-1] |
RefSeqi | NP_057632.2, NM_016548.3 [Q8NBJ4-1] NP_808800.1, NM_177937.2 [Q8NBJ4-1] |
3D structure databases
SMRi | Q8NBJ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119432, 95 interactors |
IntActi | Q8NBJ4, 124 interactors |
MINTi | Q8NBJ4 |
STRINGi | 9606.ENSP00000373364 |
PTM databases
GlyConnecti | 1281, 33 N-Linked glycans (3 sites) |
GlyGeni | Q8NBJ4, 10 sites, 2 O-linked glycans (5 sites) |
iPTMneti | Q8NBJ4 |
MetOSitei | Q8NBJ4 |
PhosphoSitePlusi | Q8NBJ4 |
Genetic variation databases
BioMutai | GOLM1 |
DMDMi | 51316027 |
Proteomic databases
EPDi | Q8NBJ4 |
jPOSTi | Q8NBJ4 |
MassIVEi | Q8NBJ4 |
MaxQBi | Q8NBJ4 |
PaxDbi | Q8NBJ4 |
PeptideAtlasi | Q8NBJ4 |
PRIDEi | Q8NBJ4 |
ProteomicsDBi | 72776 [Q8NBJ4-1] 72777 [Q8NBJ4-2] |
Protocols and materials databases
Antibodypediai | 2449, 694 antibodies |
DNASUi | 51280 |
Genome annotation databases
Ensembli | ENST00000388711; ENSP00000373363; ENSG00000135052 [Q8NBJ4-1] ENST00000388712; ENSP00000373364; ENSG00000135052 [Q8NBJ4-1] |
GeneIDi | 51280 |
KEGGi | hsa:51280 |
UCSCi | uc004aol.4, human [Q8NBJ4-1] |
Organism-specific databases
CTDi | 51280 |
DisGeNETi | 51280 |
GeneCardsi | GOLM1 |
HGNCi | HGNC:15451, GOLM1 |
HPAi | ENSG00000135052, Tissue enhanced (gallbladder, stomach) |
MIMi | 606804, gene |
neXtProti | NX_Q8NBJ4 |
OpenTargetsi | ENSG00000135052 |
PharmGKBi | PA28811 |
VEuPathDBi | HostDB:ENSG00000135052.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S080, Eukaryota |
GeneTreei | ENSGT00530000063675 |
HOGENOMi | CLU_055640_0_0_1 |
InParanoidi | Q8NBJ4 |
OMAi | QREKRNH |
PhylomeDBi | Q8NBJ4 |
TreeFami | TF331127 |
Enzyme and pathway databases
PathwayCommonsi | Q8NBJ4 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 51280, 4 hits in 872 CRISPR screens |
ChiTaRSi | GOLM1, human |
GeneWikii | GOLM1 |
GenomeRNAii | 51280 |
Pharosi | Q8NBJ4, Tbio |
PROi | PR:Q8NBJ4 |
RNActi | Q8NBJ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135052, Expressed in prostate gland and 221 other tissues |
ExpressionAtlasi | Q8NBJ4, baseline and differential |
Genevisiblei | Q8NBJ4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026143, GOLM1 IPR026139, GOLM1/CASC4 |
PANTHERi | PTHR15896, PTHR15896, 1 hit PTHR15896:SF8, PTHR15896:SF8, 1 hit |
PRINTSi | PR02084, GOLM1CASC4 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GOLM1_HUMAN | |
Accessioni | Q8NBJ4Primary (citable) accession number: Q8NBJ4 Secondary accession number(s): Q6IAF4, Q9NRB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families