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Protein

Xyloside xylosyltransferase 1

Gene

XXYLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869). Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869).2 Publications

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Has the highest in vitro activity with 20 mM Mn2+, a concentration entirely out of the physiological range. Can also utilize Mg2+, suggesting this may be the physiological cofactor.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.28 mM for UDP-alpha-D-xylose1 Publication

    pH dependencei

    Optimum pH is 7.2.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi226ManganeseBy similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei227UDP-alpha-D-xylose; via amide nitrogenBy similarity1
    Metal bindingi228ManganeseBy similarity1
    Binding sitei290UDP-alpha-D-xyloseBy similarity1
    Binding sitei328UDP-alpha-D-xylose; via carbonyl oxygenBy similarity1
    Binding sitei331Substrate glycopeptideBy similarity1
    Binding sitei331UDP-alpha-D-xyloseBy similarity1
    Binding sitei360Substrate glycopeptideBy similarity1
    Metal bindingi383ManganeseBy similarity1
    Binding sitei385Substrate glycopeptideBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    LigandMagnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q8NBI6

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GT8 Glycosyltransferase Family 8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Xyloside xylosyltransferase 11 Publication (EC:2.4.2.n32 Publications)
    Alternative name(s):
    UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:XXYLT1
    Synonyms:C3orf21
    ORF Names:PSEC0251
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000173950.15

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:26639 XXYLT1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    614552 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8NBI6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23Cytoplasmic1 PublicationAdd BLAST23
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
    Topological domaini45 – 393Lumenal1 PublicationAdd BLAST349

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000173950

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134925222

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    XXYLT1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74751171

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002344271 – 393Xyloside xylosyltransferase 1Add BLAST393

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi350 ↔ 375By similarity
    Disulfide bondi357 ↔ 386By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8NBI6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8NBI6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8NBI6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8NBI6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8NBI6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    72773
    72774 [Q8NBI6-2]
    72775 [Q8NBI6-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8NBI6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8NBI6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000173950 Expressed in 134 organ(s), highest expression level in oocyte

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_C3orf21

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8NBI6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8NBI6 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:22117070). Dimer formation may be essential for the retention in endoplasmic reticulum (Probable).Curated1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    127415, 28 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8NBI6, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000309640

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q8NBI6

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8NBI6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 106UDP-alpha-D-xylose bindingBy similarity3
    Regioni263 – 266Interaction with target proteinsBy similarity4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyltransferase 8 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3765 Eukaryota
    ENOG410XRNY LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000158154

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000007690

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG061240

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8NBI6

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LMMFTKV

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0GY6

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8NBI6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323210

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.550.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002495 Glyco_trans_8
    IPR029044 Nucleotide-diphossugar_trans

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01501 Glyco_transf_8, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53448 SSF53448, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8NBI6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGLLRGGLPC ARAMARLGAV RSHYCALLLA AALAVCAFYY LGSGRETFSS
    60 70 80 90 100
    ATKRLKEARA GAPAAPSPPA LELARGSVAP APGAKAKSLE GGGAGPVDYH
    110 120 130 140 150
    LLMMFTKAEH NAALQAKARV ALRSLLRLAK FEAHEVLNLH FVSEEASREV
    160 170 180 190 200
    AKGLLRELLP PAAGFKCKVI FHDVAVLTDK LFPIVEAMQK HFSAGLGTYY
    210 220 230 240 250
    SDSIFFLSVA MHQIMPKEIL QIIQLDLDLK FKTNIRELFE EFDSFLPGAI
    260 270 280 290 300
    IGIAREMQPV YRHTFWQFRH ENPQTRVGGP PPEGLPGFNS GVMLLNLEAM
    310 320 330 340 350
    RQSPLYSRLL EPAQVQQLAD KYHFRGHLGD QDFFTMIGME HPKLFHVLDC
    360 370 380 390
    TWNRQLCTWW RDHGYSDVFE AYFRCEGHVK IYHGNCNTPI PED
    Length:393
    Mass (Da):43,807
    Last modified:October 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C788AFDF933A23D
    GO
    Isoform 2 (identifier: Q8NBI6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.
         204-217: IFFLSVAMHQIMPK → MWPPRCKDPGRQSA

    Note: No experimental confirmation available.
    Show »
    Length:190
    Mass (Da):22,304
    Checksum:i8E76B9CC7AFB4FD5
    GO
    Isoform 3 (identifier: Q8NBI6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-203: Missing.
         204-206: Missing.
         207-262: LSVAMHQIMP...IAREMQPVYR → MNGMSVLMKE...WSWTSQPLEL

    Note: No experimental confirmation available.
    Show »
    Length:187
    Mass (Da):21,817
    Checksum:i9A49152D460573D2
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A140T9D0A0A140T9D0_HUMAN
    Xyloside xylosyltransferase 1
    XXYLT1
    247Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C2F4H7C2F4_HUMAN
    Xyloside xylosyltransferase 1
    XXYLT1
    114Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WEN6F8WEN6_HUMAN
    Xyloside xylosyltransferase 1
    XXYLT1
    84Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH19036 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183151 – 203Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST203
    Alternative sequenceiVSP_018317204 – 217IFFLS…QIMPK → MWPPRCKDPGRQSA in isoform 2. 1 PublicationAdd BLAST14
    Alternative sequenceiVSP_018316204 – 206Missing in isoform 3. 1 Publication3
    Alternative sequenceiVSP_018318207 – 262LSVAM…QPVYR → MNGMSVLMKETLKSSVTPSP YEETGERQPSVNWAVSPHQT QNQWARWSWTSQPLEL in isoform 3. 1 PublicationAdd BLAST56

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK057046 mRNA Translation: BAB71355.1
    AK092474 mRNA Translation: BAC03899.1
    AK075551 mRNA Translation: BAC11694.1
    CH471052 Genomic DNA Translation: EAW78028.1
    CH471052 Genomic DNA Translation: EAW78029.1
    BC019036 mRNA Translation: AAH19036.1 Different initiation.
    BC039067 mRNA Translation: AAH39067.2

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS43188.1 [Q8NBI6-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_689744.3, NM_152531.4 [Q8NBI6-1]
    XP_016861239.1, XM_017005750.1 [Q8NBI6-2]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.478741
    Hs.744847

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000310380; ENSP00000309640; ENSG00000173950 [Q8NBI6-1]
    ENST00000356740; ENSP00000349179; ENSG00000173950 [Q8NBI6-3]
    ENST00000437101; ENSP00000409865; ENSG00000173950 [Q8NBI6-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    152002

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:152002

    UCSC genome browser

    More...
    UCSCi
    uc003fuk.4 human [Q8NBI6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK057046 mRNA Translation: BAB71355.1
    AK092474 mRNA Translation: BAC03899.1
    AK075551 mRNA Translation: BAC11694.1
    CH471052 Genomic DNA Translation: EAW78028.1
    CH471052 Genomic DNA Translation: EAW78029.1
    BC019036 mRNA Translation: AAH19036.1 Different initiation.
    BC039067 mRNA Translation: AAH39067.2
    CCDSiCCDS43188.1 [Q8NBI6-1]
    RefSeqiNP_689744.3, NM_152531.4 [Q8NBI6-1]
    XP_016861239.1, XM_017005750.1 [Q8NBI6-2]
    UniGeneiHs.478741
    Hs.744847

    3D structure databases

    ProteinModelPortaliQ8NBI6
    SMRiQ8NBI6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi127415, 28 interactors
    IntActiQ8NBI6, 1 interactor
    STRINGi9606.ENSP00000309640

    Protein family/group databases

    CAZyiGT8 Glycosyltransferase Family 8

    PTM databases

    iPTMnetiQ8NBI6
    PhosphoSitePlusiQ8NBI6

    Polymorphism and mutation databases

    BioMutaiXXYLT1
    DMDMi74751171

    Proteomic databases

    EPDiQ8NBI6
    MaxQBiQ8NBI6
    PaxDbiQ8NBI6
    PeptideAtlasiQ8NBI6
    PRIDEiQ8NBI6
    ProteomicsDBi72773
    72774 [Q8NBI6-2]
    72775 [Q8NBI6-3]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    152002
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000310380; ENSP00000309640; ENSG00000173950 [Q8NBI6-1]
    ENST00000356740; ENSP00000349179; ENSG00000173950 [Q8NBI6-3]
    ENST00000437101; ENSP00000409865; ENSG00000173950 [Q8NBI6-2]
    GeneIDi152002
    KEGGihsa:152002
    UCSCiuc003fuk.4 human [Q8NBI6-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    152002
    EuPathDBiHostDB:ENSG00000173950.15

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    XXYLT1

    H-Invitational Database, human transcriptome db

    More...
    H-InvDBi
    HIX0017512
    HGNCiHGNC:26639 XXYLT1
    MIMi614552 gene
    neXtProtiNX_Q8NBI6
    OpenTargetsiENSG00000173950
    PharmGKBiPA134925222

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3765 Eukaryota
    ENOG410XRNY LUCA
    GeneTreeiENSGT00940000158154
    HOGENOMiHOG000007690
    HOVERGENiHBG061240
    InParanoidiQ8NBI6
    OMAiLMMFTKV
    OrthoDBiEOG091G0GY6
    PhylomeDBiQ8NBI6
    TreeFamiTF323210

    Enzyme and pathway databases

    SIGNORiQ8NBI6

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    XXYLT1 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    152002

    Protein Ontology

    More...
    PROi
    PR:Q8NBI6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000173950 Expressed in 134 organ(s), highest expression level in oocyte
    CleanExiHS_C3orf21
    ExpressionAtlasiQ8NBI6 baseline and differential
    GenevisibleiQ8NBI6 HS

    Family and domain databases

    Gene3Di3.90.550.10, 1 hit
    InterProiView protein in InterPro
    IPR002495 Glyco_trans_8
    IPR029044 Nucleotide-diphossugar_trans
    PfamiView protein in Pfam
    PF01501 Glyco_transf_8, 1 hit
    SUPFAMiSSF53448 SSF53448, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXXLT1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBI6
    Secondary accession number(s): D3DNW5
    , Q8NAL3, Q8WV03, Q96ME0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2002
    Last modified: December 5, 2018
    This is version 116 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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