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Entry version 133 (29 Sep 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Xyloside xylosyltransferase 1

Gene

XXYLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose (PubMed:22117070, PubMed:8982869).

Known targets include Notch proteins and coagulation factors, such as F9 (PubMed:22117070, PubMed:8982869).

2 Publications

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Has the highest in vitro activity with 20 mM Mn2+, a concentration entirely out of the physiological range. Can also utilize Mg2+, suggesting this may be the physiological cofactor.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.28 mM for UDP-alpha-D-xylose1 Publication

pH dependencei

Optimum pH is 7.2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi226ManganeseBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei227UDP-alpha-D-xylose; via amide nitrogenBy similarity1
Metal bindingi228ManganeseBy similarity1
Binding sitei290UDP-alpha-D-xyloseBy similarity1
Binding sitei328UDP-alpha-D-xylose; via carbonyl oxygenBy similarity1
Binding sitei331Substrate glycopeptideBy similarity1
Binding sitei331UDP-alpha-D-xyloseBy similarity1
Binding sitei360Substrate glycopeptideBy similarity1
Metal bindingi383ManganeseBy similarity1
Binding sitei385Substrate glycopeptideBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NBI6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NBI6

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT8, Glycosyltransferase Family 8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Xyloside xylosyltransferase 11 Publication (EC:2.4.2.622 Publications)
Alternative name(s):
UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XXYLT1
Synonyms:C3orf21
ORF Names:PSEC0251
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26639, XXYLT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614552, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBI6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173950

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23Cytoplasmic1 PublicationAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini45 – 393Lumenal1 PublicationAdd BLAST349

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
152002

Open Targets

More...
OpenTargetsi
ENSG00000173950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925222

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBI6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XXYLT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002344271 – 393Xyloside xylosyltransferase 1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi350 ↔ 375By similarity
Disulfide bondi357 ↔ 386By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NBI6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NBI6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBI6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBI6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBI6

PeptideAtlas

More...
PeptideAtlasi
Q8NBI6

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBI6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72773 [Q8NBI6-1]
72774 [Q8NBI6-2]
72775 [Q8NBI6-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8NBI6, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173950, Expressed in cortical plate and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBI6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBI6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173950, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:22117070). Dimer formation may be essential for the retention in endoplasmic reticulum (Probable).

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127415, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBI6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309640

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NBI6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBI6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 106UDP-alpha-D-xylose bindingBy similarity3
Regioni263 – 266Interaction with target proteinsBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3765, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_048175_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBI6

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYTIYDV

Database of Orthologous Groups

More...
OrthoDBi
830935at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBI6

TreeFam database of animal gene trees

More...
TreeFami
TF323210

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002495, Glyco_trans_8
IPR029044, Nucleotide-diphossugar_trans
IPR042465, XXLT1

The PANTHER Classification System

More...
PANTHERi
PTHR46612, PTHR46612, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01501, Glyco_transf_8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLRGGLPC ARAMARLGAV RSHYCALLLA AALAVCAFYY LGSGRETFSS
60 70 80 90 100
ATKRLKEARA GAPAAPSPPA LELARGSVAP APGAKAKSLE GGGAGPVDYH
110 120 130 140 150
LLMMFTKAEH NAALQAKARV ALRSLLRLAK FEAHEVLNLH FVSEEASREV
160 170 180 190 200
AKGLLRELLP PAAGFKCKVI FHDVAVLTDK LFPIVEAMQK HFSAGLGTYY
210 220 230 240 250
SDSIFFLSVA MHQIMPKEIL QIIQLDLDLK FKTNIRELFE EFDSFLPGAI
260 270 280 290 300
IGIAREMQPV YRHTFWQFRH ENPQTRVGGP PPEGLPGFNS GVMLLNLEAM
310 320 330 340 350
RQSPLYSRLL EPAQVQQLAD KYHFRGHLGD QDFFTMIGME HPKLFHVLDC
360 370 380 390
TWNRQLCTWW RDHGYSDVFE AYFRCEGHVK IYHGNCNTPI PED
Length:393
Mass (Da):43,807
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C788AFDF933A23D
GO
Isoform 2 (identifier: Q8NBI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-217: IFFLSVAMHQIMPK → MWPPRCKDPGRQSA

Show »
Length:190
Mass (Da):22,304
Checksum:i8E76B9CC7AFB4FD5
GO
Isoform 3 (identifier: Q8NBI6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-206: Missing.
     207-262: LSVAMHQIMP...IAREMQPVYR → MNGMSVLMKE...WSWTSQPLEL

Show »
Length:187
Mass (Da):21,817
Checksum:i9A49152D460573D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2F4H7C2F4_HUMAN
Xyloside xylosyltransferase 1
XXYLT1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9D0A0A140T9D0_HUMAN
Xyloside xylosyltransferase 1
XXYLT1
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEN6F8WEN6_HUMAN
Xyloside xylosyltransferase 1
XXYLT1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19036 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0183151 – 203Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_018317204 – 217IFFLS…QIMPK → MWPPRCKDPGRQSA in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_018316204 – 206Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_018318207 – 262LSVAM…QPVYR → MNGMSVLMKETLKSSVTPSP YEETGERQPSVNWAVSPHQT QNQWARWSWTSQPLEL in isoform 3. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057046 mRNA Translation: BAB71355.1
AK092474 mRNA Translation: BAC03899.1
AK075551 mRNA Translation: BAC11694.1
CH471052 Genomic DNA Translation: EAW78028.1
CH471052 Genomic DNA Translation: EAW78029.1
BC019036 mRNA Translation: AAH19036.1 Different initiation.
BC039067 mRNA Translation: AAH39067.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43188.1 [Q8NBI6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_689744.3, NM_152531.4 [Q8NBI6-1]
XP_016861239.1, XM_017005750.1 [Q8NBI6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310380; ENSP00000309640; ENSG00000173950 [Q8NBI6-1]
ENST00000356740; ENSP00000349179; ENSG00000173950 [Q8NBI6-3]
ENST00000437101; ENSP00000409865; ENSG00000173950 [Q8NBI6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
152002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:152002

UCSC genome browser

More...
UCSCi
uc003fuk.4, human [Q8NBI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057046 mRNA Translation: BAB71355.1
AK092474 mRNA Translation: BAC03899.1
AK075551 mRNA Translation: BAC11694.1
CH471052 Genomic DNA Translation: EAW78028.1
CH471052 Genomic DNA Translation: EAW78029.1
BC019036 mRNA Translation: AAH19036.1 Different initiation.
BC039067 mRNA Translation: AAH39067.2
CCDSiCCDS43188.1 [Q8NBI6-1]
RefSeqiNP_689744.3, NM_152531.4 [Q8NBI6-1]
XP_016861239.1, XM_017005750.1 [Q8NBI6-2]

3D structure databases

SMRiQ8NBI6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127415, 33 interactors
IntActiQ8NBI6, 8 interactors
STRINGi9606.ENSP00000309640

Protein family/group databases

CAZyiGT8, Glycosyltransferase Family 8

PTM databases

GlyGeniQ8NBI6, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8NBI6
PhosphoSitePlusiQ8NBI6

Genetic variation databases

BioMutaiXXYLT1
DMDMi74751171

Proteomic databases

EPDiQ8NBI6
jPOSTiQ8NBI6
MassIVEiQ8NBI6
MaxQBiQ8NBI6
PaxDbiQ8NBI6
PeptideAtlasiQ8NBI6
PRIDEiQ8NBI6
ProteomicsDBi72773 [Q8NBI6-1]
72774 [Q8NBI6-2]
72775 [Q8NBI6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
53804, 49 antibodies

The DNASU plasmid repository

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DNASUi
152002

Genome annotation databases

EnsembliENST00000310380; ENSP00000309640; ENSG00000173950 [Q8NBI6-1]
ENST00000356740; ENSP00000349179; ENSG00000173950 [Q8NBI6-3]
ENST00000437101; ENSP00000409865; ENSG00000173950 [Q8NBI6-2]
GeneIDi152002
KEGGihsa:152002
UCSCiuc003fuk.4, human [Q8NBI6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152002
DisGeNETi152002

GeneCards: human genes, protein and diseases

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GeneCardsi
XXYLT1
HGNCiHGNC:26639, XXYLT1
HPAiENSG00000173950, Low tissue specificity
MIMi614552, gene
neXtProtiNX_Q8NBI6
OpenTargetsiENSG00000173950
PharmGKBiPA134925222
VEuPathDBiHostDB:ENSG00000173950

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3765, Eukaryota
GeneTreeiENSGT00940000158154
HOGENOMiCLU_048175_0_0_1
InParanoidiQ8NBI6
OMAiIYTIYDV
OrthoDBi830935at2759
PhylomeDBiQ8NBI6
TreeFamiTF323210

Enzyme and pathway databases

PathwayCommonsiQ8NBI6
SIGNORiQ8NBI6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
152002, 12 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
XXYLT1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
152002
PharosiQ8NBI6, Tbio

Protein Ontology

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PROi
PR:Q8NBI6
RNActiQ8NBI6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173950, Expressed in cortical plate and 149 other tissues
ExpressionAtlasiQ8NBI6, baseline and differential
GenevisibleiQ8NBI6, HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495, Glyco_trans_8
IPR029044, Nucleotide-diphossugar_trans
IPR042465, XXLT1
PANTHERiPTHR46612, PTHR46612, 1 hit
PfamiView protein in Pfam
PF01501, Glyco_transf_8, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXXLT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBI6
Secondary accession number(s): D3DNW5
, Q8NAL3, Q8WV03, Q96ME0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2002
Last modified: September 29, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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