UniProtKB - Q8NBI5 (S43A3_HUMAN)
Protein
Solute carrier family 43 member 3
Gene
SLC43A3
Organism
Homo sapiens (Human)
Status
Functioni
Putative transporter.By similarity
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q8NBI5 |
Protein family/group databases
TCDBi | 2.A.1.44.3, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 43 member 3Alternative name(s): Protein FOAP-13 |
Gene namesi | Name:SLC43A3 ORF Names:PSEC0252 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17466, SLC43A3 |
MIMi | 618034, gene |
neXtProti | NX_Q8NBI5 |
VEuPathDBi | HostDB:ENSG00000134802.17 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 72 – 92 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 102 – 122 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 279 – 299 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 319 – 339 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 396 – 418 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 427 – 447 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 29015 |
OpenTargetsi | ENSG00000134802 |
PharmGKBi | PA134924689 |
Miscellaneous databases
Pharosi | Q8NBI5, Tdark |
Chemistry databases
DrugBanki | DB00993, Azathioprine |
Genetic variation databases
BioMutai | SLC43A3 |
DMDMi | 158706361 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305036 | 1 – 491 | Solute carrier family 43 member 3Add BLAST | 491 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 253 | PhosphoserineCombined sources | 1 | |
Modified residuei | 258 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8NBI5 |
jPOSTi | Q8NBI5 |
MassIVEi | Q8NBI5 |
MaxQBi | Q8NBI5 |
PaxDbi | Q8NBI5 |
PeptideAtlasi | Q8NBI5 |
PRIDEi | Q8NBI5 |
ProteomicsDBi | 17547 72772 [Q8NBI5-1] |
PTM databases
GlyGeni | Q8NBI5, 3 sites |
iPTMneti | Q8NBI5 |
PhosphoSitePlusi | Q8NBI5 |
SwissPalmi | Q8NBI5 |
Expressioni
Tissue specificityi
Highly expressed in macrophages.1 Publication
Gene expression databases
Bgeei | ENSG00000134802, Expressed in right lobe of liver and 215 other tissues |
ExpressionAtlasi | Q8NBI5, baseline and differential |
Genevisiblei | Q8NBI5, HS |
Organism-specific databases
HPAi | ENSG00000134802, Tissue enhanced (liver, thyroid gland) |
Interactioni
Binary interactionsi
Q8NBI5
With | #Exp. | IntAct |
---|---|---|
VCP [P55072] | 3 | EBI-2855542,EBI-355164 |
Protein-protein interaction databases
BioGRIDi | 118823, 18 interactors |
IntActi | Q8NBI5, 13 interactors |
STRINGi | 9606.ENSP00000434515 |
Miscellaneous databases
RNActi | Q8NBI5, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRYG, Eukaryota |
GeneTreei | ENSGT00940000157622 |
HOGENOMi | CLU_035676_1_1_1 |
InParanoidi | Q8NBI5 |
OMAi | VCYEQEL |
OrthoDBi | 639867at2759 |
PhylomeDBi | Q8NBI5 |
TreeFami | TF328358 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf IPR027197, SLC43A3 |
PANTHERi | PTHR20765, PTHR20765, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NBI5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD
60 70 80 90 100
AGPIGNATGQ ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA
110 120 130 140 150
RLIAIFFYTT ATLIIAFTSA GSAVLLFLAM PMLTIGGILF LITNLQIGNL
160 170 180 190 200
FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY EKGISLRASF IFISVCSTWH
210 220 230 240 250
VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE HENRELQSKE
260 270 280 290 300
FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL
310 320 330 340 350
NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA
360 370 380 390 400
RKTGSSTLAV ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI
410 420 430 440 450
SRSFLYGSNA AFLTLAFPSE HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS
460 470 480 490
LQNDPFYVNV MFMLAILLTF FHPFLVYREC RTWKESPSAI A
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YD64 | H0YD64_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 137 | Annotation score: | ||
E9PS74 | E9PS74_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 331 | Annotation score: | ||
E9PR64 | E9PR64_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 169 | Annotation score: | ||
E9PR94 | E9PR94_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 126 | Annotation score: | ||
E9PSH9 | E9PSH9_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 119 | Annotation score: | ||
E9PJL3 | E9PJL3_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 109 | Annotation score: | ||
E9PJT6 | E9PJT6_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 78 | Annotation score: | ||
E9PKW3 | E9PKW3_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 133 | Annotation score: | ||
E9PLF2 | E9PLF2_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 107 | Annotation score: | ||
E9PLP1 | E9PLP1_HUMAN | Solute carrier family 43 member 3 | SLC43A3 | 82 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 | V → A in BAG60330 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 459 | N → D in BAC11695 (PubMed:16303743).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035156 | 53 | P → L. Corresponds to variant dbSNP:rs34799622Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055620 | 61 | A → AGRLGCMGDLFSTP in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028927 mRNA Translation: BAB82466.1 AK298028 mRNA Translation: BAG60330.1 CR457391 mRNA Translation: CAG33672.1 AK075552 mRNA Translation: BAC11695.1 AL157431 mRNA Translation: CAB75655.1 AP000781 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73741.1 BC003163 mRNA Translation: AAH03163.1 |
CCDSi | CCDS60784.1 [Q8NBI5-2] CCDS7956.1 [Q8NBI5-1] |
PIRi | T46915 |
RefSeqi | NP_001265130.1, NM_001278201.1 [Q8NBI5-1] NP_001265135.1, NM_001278206.1 [Q8NBI5-2] NP_054815.2, NM_014096.3 [Q8NBI5-1] NP_060081.1, NM_017611.2 [Q8NBI5-1] NP_955361.1, NM_199329.2 [Q8NBI5-1] |
Genome annotation databases
Ensembli | ENST00000352187; ENSP00000337561; ENSG00000134802 [Q8NBI5-1] ENST00000395123; ENSP00000378555; ENSG00000134802 [Q8NBI5-1] ENST00000395124; ENSP00000378556; ENSG00000134802 [Q8NBI5-1] ENST00000529554; ENSP00000436254; ENSG00000134802 [Q8NBI5-1] ENST00000533524; ENSP00000434515; ENSG00000134802 [Q8NBI5-2] |
GeneIDi | 29015 |
KEGGi | hsa:29015 |
UCSCi | uc001nkg.5, human [Q8NBI5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028927 mRNA Translation: BAB82466.1 AK298028 mRNA Translation: BAG60330.1 CR457391 mRNA Translation: CAG33672.1 AK075552 mRNA Translation: BAC11695.1 AL157431 mRNA Translation: CAB75655.1 AP000781 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW73741.1 BC003163 mRNA Translation: AAH03163.1 |
CCDSi | CCDS60784.1 [Q8NBI5-2] CCDS7956.1 [Q8NBI5-1] |
PIRi | T46915 |
RefSeqi | NP_001265130.1, NM_001278201.1 [Q8NBI5-1] NP_001265135.1, NM_001278206.1 [Q8NBI5-2] NP_054815.2, NM_014096.3 [Q8NBI5-1] NP_060081.1, NM_017611.2 [Q8NBI5-1] NP_955361.1, NM_199329.2 [Q8NBI5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 118823, 18 interactors |
IntActi | Q8NBI5, 13 interactors |
STRINGi | 9606.ENSP00000434515 |
Chemistry databases
DrugBanki | DB00993, Azathioprine |
Protein family/group databases
TCDBi | 2.A.1.44.3, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q8NBI5, 3 sites |
iPTMneti | Q8NBI5 |
PhosphoSitePlusi | Q8NBI5 |
SwissPalmi | Q8NBI5 |
Genetic variation databases
BioMutai | SLC43A3 |
DMDMi | 158706361 |
Proteomic databases
EPDi | Q8NBI5 |
jPOSTi | Q8NBI5 |
MassIVEi | Q8NBI5 |
MaxQBi | Q8NBI5 |
PaxDbi | Q8NBI5 |
PeptideAtlasi | Q8NBI5 |
PRIDEi | Q8NBI5 |
ProteomicsDBi | 17547 72772 [Q8NBI5-1] |
Protocols and materials databases
Antibodypediai | 14150, 70 antibodies |
DNASUi | 29015 |
Genome annotation databases
Ensembli | ENST00000352187; ENSP00000337561; ENSG00000134802 [Q8NBI5-1] ENST00000395123; ENSP00000378555; ENSG00000134802 [Q8NBI5-1] ENST00000395124; ENSP00000378556; ENSG00000134802 [Q8NBI5-1] ENST00000529554; ENSP00000436254; ENSG00000134802 [Q8NBI5-1] ENST00000533524; ENSP00000434515; ENSG00000134802 [Q8NBI5-2] |
GeneIDi | 29015 |
KEGGi | hsa:29015 |
UCSCi | uc001nkg.5, human [Q8NBI5-1] |
Organism-specific databases
CTDi | 29015 |
DisGeNETi | 29015 |
GeneCardsi | SLC43A3 |
HGNCi | HGNC:17466, SLC43A3 |
HPAi | ENSG00000134802, Tissue enhanced (liver, thyroid gland) |
MIMi | 618034, gene |
neXtProti | NX_Q8NBI5 |
OpenTargetsi | ENSG00000134802 |
PharmGKBi | PA134924689 |
VEuPathDBi | HostDB:ENSG00000134802.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRYG, Eukaryota |
GeneTreei | ENSGT00940000157622 |
HOGENOMi | CLU_035676_1_1_1 |
InParanoidi | Q8NBI5 |
OMAi | VCYEQEL |
OrthoDBi | 639867at2759 |
PhylomeDBi | Q8NBI5 |
TreeFami | TF328358 |
Enzyme and pathway databases
PathwayCommonsi | Q8NBI5 |
Miscellaneous databases
BioGRID-ORCSi | 29015, 10 hits in 877 CRISPR screens |
ChiTaRSi | SLC43A3, human |
GenomeRNAii | 29015 |
Pharosi | Q8NBI5, Tdark |
PROi | PR:Q8NBI5 |
RNActi | Q8NBI5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134802, Expressed in right lobe of liver and 215 other tissues |
ExpressionAtlasi | Q8NBI5, baseline and differential |
Genevisiblei | Q8NBI5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR036259, MFS_trans_sf IPR027197, SLC43A3 |
PANTHERi | PTHR20765, PTHR20765, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S43A3_HUMAN | |
Accessioni | Q8NBI5Primary (citable) accession number: Q8NBI5 Secondary accession number(s): B4DNR8, E7EQD2, Q9NSS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants