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UniProtKB - Q8NBI5 (S43A3_HUMAN)

Entry version 131 (10 Feb 2021)
Sequence version 2 (02 Oct 2007)
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Protein

Solute carrier family 43 member 3

Gene

SLC43A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transporter.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NBI5

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.1.44.3, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 43 member 3
Alternative name(s):
Protein FOAP-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC43A3
ORF Names:PSEC0252
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17466, SLC43A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618034, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NBI5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134802.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Transmembranei396 – 418HelicalSequence analysisAdd BLAST23
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		29015

Open Targets

More...OpenTargetsi		ENSG00000134802

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134924689

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NBI5, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00993, Azathioprine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC43A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		158706361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003050361 – 491Solute carrier family 43 member 3Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei253PhosphoserineCombined sources1
Modified residuei258PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8NBI5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NBI5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NBI5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8NBI5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NBI5

PeptideAtlas

More...PeptideAtlasi		Q8NBI5

PRoteomics IDEntifications database

More...PRIDEi		Q8NBI5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17547
72772 [Q8NBI5-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NBI5, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NBI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NBI5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8NBI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in macrophages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134802, Expressed in right lobe of liver and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NBI5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NBI5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134802, Tissue enhanced (liver, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118823, 18 interactors

Protein interaction database and analysis system

More...IntActi		Q8NBI5, 13 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000434515

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NBI5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC43A transporter (TC 2.A.1.44) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRYG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157622

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035676_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NBI5

Identification of Orthologs from Complete Genome Data

More...OMAi		VCYEQEL

Database of Orthologous Groups

More...OrthoDBi		639867at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NBI5

TreeFam database of animal gene trees

More...TreeFami		TF328358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
IPR027197, SLC43A3

The PANTHER Classification System

More...PANTHERi		PTHR20765, PTHR20765, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD 
        60         70         80         90        100
AGPIGNATGQ ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA 
       110        120        130        140        150
RLIAIFFYTT ATLIIAFTSA GSAVLLFLAM PMLTIGGILF LITNLQIGNL 
       160        170        180        190        200
FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY EKGISLRASF IFISVCSTWH 
       210        220        230        240        250
VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE HENRELQSKE 
       260        270        280        290        300
FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL 
       310        320        330        340        350
NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA 
       360        370        380        390        400
RKTGSSTLAV ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI 
       410        420        430        440        450
SRSFLYGSNA AFLTLAFPSE HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS 
       460        470        480        490 
LQNDPFYVNV MFMLAILLTF FHPFLVYREC RTWKESPSAI A
Length:491
Mass (Da):54,529
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6BC8E48F38B1D8C
GO
Isoform 2 (identifier: Q8NBI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: A → AGRLGCMGDLFSTP

Show »
Length:504
Mass (Da):55,864
Checksum:i93D0EBFC39DAC502
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YD64H0YD64_HUMAN
Solute carrier family 43 member 3
SLC43A3
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS74E9PS74_HUMAN
Solute carrier family 43 member 3
SLC43A3
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR64E9PR64_HUMAN
Solute carrier family 43 member 3
SLC43A3
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR94E9PR94_HUMAN
Solute carrier family 43 member 3
SLC43A3
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSH9E9PSH9_HUMAN
Solute carrier family 43 member 3
SLC43A3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJL3E9PJL3_HUMAN
Solute carrier family 43 member 3
SLC43A3
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJT6E9PJT6_HUMAN
Solute carrier family 43 member 3
SLC43A3
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKW3E9PKW3_HUMAN
Solute carrier family 43 member 3
SLC43A3
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLF2E9PLF2_HUMAN
Solute carrier family 43 member 3
SLC43A3
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLP1E9PLP1_HUMAN
Solute carrier family 43 member 3
SLC43A3
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172V → A in BAG60330 (PubMed:14702039).Curated1
Sequence conflicti459N → D in BAC11695 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03515653P → L. Corresponds to variant dbSNP:rs34799622Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05562061A → AGRLGCMGDLFSTP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB028927 mRNA Translation: BAB82466.1
AK298028 mRNA Translation: BAG60330.1
CR457391 mRNA Translation: CAG33672.1
AK075552 mRNA Translation: BAC11695.1
AL157431 mRNA Translation: CAB75655.1
AP000781 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73741.1
BC003163 mRNA Translation: AAH03163.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS60784.1 [Q8NBI5-2]
CCDS7956.1 [Q8NBI5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T46915

NCBI Reference Sequences

More...RefSeqi		NP_001265130.1, NM_001278201.1 [Q8NBI5-1]
NP_001265135.1, NM_001278206.1 [Q8NBI5-2]
NP_054815.2, NM_014096.3 [Q8NBI5-1]
NP_060081.1, NM_017611.2 [Q8NBI5-1]
NP_955361.1, NM_199329.2 [Q8NBI5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000352187; ENSP00000337561; ENSG00000134802 [Q8NBI5-1]
ENST00000395123; ENSP00000378555; ENSG00000134802 [Q8NBI5-1]
ENST00000395124; ENSP00000378556; ENSG00000134802 [Q8NBI5-1]
ENST00000529554; ENSP00000436254; ENSG00000134802 [Q8NBI5-1]
ENST00000533524; ENSP00000434515; ENSG00000134802 [Q8NBI5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29015

UCSC genome browser

More...UCSCi		uc001nkg.5, human [Q8NBI5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028927 mRNA Translation: BAB82466.1
AK298028 mRNA Translation: BAG60330.1
CR457391 mRNA Translation: CAG33672.1
AK075552 mRNA Translation: BAC11695.1
AL157431 mRNA Translation: CAB75655.1
AP000781 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73741.1
BC003163 mRNA Translation: AAH03163.1
CCDSiCCDS60784.1 [Q8NBI5-2]
CCDS7956.1 [Q8NBI5-1]
PIRiT46915
RefSeqiNP_001265130.1, NM_001278201.1 [Q8NBI5-1]
NP_001265135.1, NM_001278206.1 [Q8NBI5-2]
NP_054815.2, NM_014096.3 [Q8NBI5-1]
NP_060081.1, NM_017611.2 [Q8NBI5-1]
NP_955361.1, NM_199329.2 [Q8NBI5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118823, 18 interactors
IntActiQ8NBI5, 13 interactors
STRINGi9606.ENSP00000434515

Chemistry databases

DrugBankiDB00993, Azathioprine

Protein family/group databases

TCDBi2.A.1.44.3, the major facilitator superfamily (mfs)

PTM databases

GlyGeniQ8NBI5, 3 sites
iPTMnetiQ8NBI5
PhosphoSitePlusiQ8NBI5
SwissPalmiQ8NBI5

Genetic variation databases

BioMutaiSLC43A3
DMDMi158706361

Proteomic databases

EPDiQ8NBI5
jPOSTiQ8NBI5
MassIVEiQ8NBI5
MaxQBiQ8NBI5
PaxDbiQ8NBI5
PeptideAtlasiQ8NBI5
PRIDEiQ8NBI5
ProteomicsDBi17547
72772 [Q8NBI5-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14150, 70 antibodies

The DNASU plasmid repository

More...DNASUi		29015

Genome annotation databases

EnsembliENST00000352187; ENSP00000337561; ENSG00000134802 [Q8NBI5-1]
ENST00000395123; ENSP00000378555; ENSG00000134802 [Q8NBI5-1]
ENST00000395124; ENSP00000378556; ENSG00000134802 [Q8NBI5-1]
ENST00000529554; ENSP00000436254; ENSG00000134802 [Q8NBI5-1]
ENST00000533524; ENSP00000434515; ENSG00000134802 [Q8NBI5-2]
GeneIDi29015
KEGGihsa:29015
UCSCiuc001nkg.5, human [Q8NBI5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29015
DisGeNETi29015

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC43A3
HGNCiHGNC:17466, SLC43A3
HPAiENSG00000134802, Tissue enhanced (liver, thyroid gland)
MIMi618034, gene
neXtProtiNX_Q8NBI5
OpenTargetsiENSG00000134802
PharmGKBiPA134924689
VEuPathDBiHostDB:ENSG00000134802.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRYG, Eukaryota
GeneTreeiENSGT00940000157622
HOGENOMiCLU_035676_1_1_1
InParanoidiQ8NBI5
OMAiVCYEQEL
OrthoDBi639867at2759
PhylomeDBiQ8NBI5
TreeFamiTF328358

Enzyme and pathway databases

PathwayCommonsiQ8NBI5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29015, 10 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC43A3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29015
PharosiQ8NBI5, Tdark

Protein Ontology

More...PROi		PR:Q8NBI5
RNActiQ8NBI5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134802, Expressed in right lobe of liver and 215 other tissues
ExpressionAtlasiQ8NBI5, baseline and differential
GenevisibleiQ8NBI5, HS

Family and domain databases

InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
IPR027197, SLC43A3
PANTHERiPTHR20765, PTHR20765, 1 hit
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS43A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBI5
Secondary accession number(s): B4DNR8, E7EQD2, Q9NSS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: February 10, 2021
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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