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Entry version 131 (12 Aug 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Zinc finger protein GLIS1

Gene

GLIS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NBF1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLIS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174332.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29525, GLIS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610378, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

The combined transgenic expression of the OSK transcription factors POU5F1/OCT4, SOX2 and KLF4, reprograms differentiated cells into induced pluripotent stem cells/iSPCs. iPSCs exhibit the morphology and properties of embryonic stem/ES cells. The coexpression of GLIS1 can increase the efficiency of OSK-induced pluripotent stem cells/iPSCs production.2 Publications

Organism-specific databases

DisGeNET

More...
DisGeNETi
148979

Open Targets

More...
OpenTargetsi
ENSG00000174332

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134948186

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NBF1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLIS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572624

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472091 – 620Zinc finger protein GLIS1Add BLAST620

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NBF1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NBF1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NBF1

PeptideAtlas

More...
PeptideAtlasi
Q8NBF1

PRoteomics IDEntifications database

More...
PRIDEi
Q8NBF1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72760

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NBF1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NBF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174332, Expressed in prostate gland and 99 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NBF1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NBF1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174332, Tissue enhanced (prostate, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KLF4 (PubMed:21654807).

Interacts with POU5F1 and/or POU5F1B (PubMed:21654807).

Interacts with SOX2 (PubMed:21654807).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
127182, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NBF1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309653

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NBF1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NBF1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi340 – 356Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi456 – 511Pro-richAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014147_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NBF1

KEGG Orthology (KO)

More...
KOi
K09232

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NBF1

TreeFam database of animal gene trees

More...
TreeFami
TF350216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043359, GLI-like
IPR030430, GLIS1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR45718, PTHR45718, 1 hit
PTHR45718:SF3, PTHR45718:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NBF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG
60 70 80 90 100
LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC
110 120 130 140 150
VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA
160 170 180 190 200
DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV
210 220 230 240 250
DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL
260 270 280 290 300
IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ
310 320 330 340 350
KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE
360 370 380 390 400
QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP
410 420 430 440 450
GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST
460 470 480 490 500
RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF
510 520 530 540 550
QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF
560 570 580 590 600
NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF
610 620
FPNGAFDHCL GHIPSIYTDT
Length:620
Mass (Da):65,976
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA07F61B35CF12EB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEX9A0A0D9SEX9_HUMAN
Zinc finger protein GLIS1
GLIS1
795Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04178 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221I → T in BAC03494 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047031110T → A1 PublicationCorresponds to variant dbSNP:rs4307514Ensembl.1
Natural variantiVAR_033544157F → L. Corresponds to variant dbSNP:rs34961060Ensembl.1
Natural variantiVAR_047032187A → G1 PublicationCorresponds to variant dbSNP:rs35227000Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK090634 mRNA Translation: BAC03494.1
AK093474 mRNA Translation: BAC04178.1 Different initiation.
AC105280 Genomic DNA No translation available.
AL591720 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06734.1
BC101799 mRNA Translation: AAI01800.1
BC104911 mRNA Translation: AAI04912.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS582.1

NCBI Reference Sequences

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RefSeqi
NP_671726.2, NM_147193.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312233; ENSP00000309653; ENSG00000174332

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148979

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148979

UCSC genome browser

More...
UCSCi
uc001cvr.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA Translation: BAC03494.1
AK093474 mRNA Translation: BAC04178.1 Different initiation.
AC105280 Genomic DNA No translation available.
AL591720 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06734.1
BC101799 mRNA Translation: AAI01800.1
BC104911 mRNA Translation: AAI04912.1
CCDSiCCDS582.1
RefSeqiNP_671726.2, NM_147193.2

3D structure databases

SMRiQ8NBF1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127182, 13 interactors
IntActiQ8NBF1, 2 interactors
STRINGi9606.ENSP00000309653

PTM databases

iPTMnetiQ8NBF1
PhosphoSitePlusiQ8NBF1

Polymorphism and mutation databases

BioMutaiGLIS1
DMDMi209572624

Proteomic databases

MassIVEiQ8NBF1
MaxQBiQ8NBF1
PaxDbiQ8NBF1
PeptideAtlasiQ8NBF1
PRIDEiQ8NBF1
ProteomicsDBi72760

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
748, 119 antibodies

The DNASU plasmid repository

More...
DNASUi
148979

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332
GeneIDi148979
KEGGihsa:148979
UCSCiuc001cvr.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148979
DisGeNETi148979
EuPathDBiHostDB:ENSG00000174332.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GLIS1
HGNCiHGNC:29525, GLIS1
HPAiENSG00000174332, Tissue enhanced (prostate, seminal vesicle)
MIMi610378, gene
neXtProtiNX_Q8NBF1
OpenTargetsiENSG00000174332
PharmGKBiPA134948186

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159218
HOGENOMiCLU_014147_2_1_1
InParanoidiQ8NBF1
KOiK09232
PhylomeDBiQ8NBF1
TreeFamiTF350216

Enzyme and pathway databases

PathwayCommonsiQ8NBF1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
148979, 10 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GLIS1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GLIS1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
148979
PharosiQ8NBF1, Tbio

Protein Ontology

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PROi
PR:Q8NBF1
RNActiQ8NBF1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174332, Expressed in prostate gland and 99 other tissues
ExpressionAtlasiQ8NBF1, baseline and differential
GenevisibleiQ8NBF1, HS

Family and domain databases

InterProiView protein in InterPro
IPR043359, GLI-like
IPR030430, GLIS1
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR45718, PTHR45718, 1 hit
PTHR45718:SF3, PTHR45718:SF3, 1 hit
PfamiView protein in Pfam
PF00096, zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLIS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBF1
Secondary accession number(s): Q2M3G9, Q8N9V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 14, 2008
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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