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Protein

Zinc finger protein GLIS1

Gene

GLIS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gene namesi
Name:GLIS1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174332.5
HGNCiHGNC:29525 GLIS1
MIMi610378 gene
neXtProtiNX_Q8NBF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi148979
OpenTargetsiENSG00000174332
PharmGKBiPA134948186

Polymorphism and mutation databases

BioMutaiGLIS1
DMDMi209572624

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472091 – 620Zinc finger protein GLIS1Add BLAST620

Proteomic databases

MaxQBiQ8NBF1
PaxDbiQ8NBF1
PeptideAtlasiQ8NBF1
PRIDEiQ8NBF1
ProteomicsDBi72760

PTM databases

iPTMnetiQ8NBF1
PhosphoSitePlusiQ8NBF1

Expressioni

Gene expression databases

BgeeiENSG00000174332
CleanExiHS_GLIS1
ExpressionAtlasiQ8NBF1 baseline and differential
GenevisibleiQ8NBF1 HS

Organism-specific databases

HPAiHPA001409

Interactioni

Protein-protein interaction databases

IntActiQ8NBF1, 2 interactors
STRINGi9606.ENSP00000309653

Structurei

3D structure databases

ProteinModelPortaliQ8NBF1
SMRiQ8NBF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi340 – 356Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi456 – 511Pro-richAdd BLAST56

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000231136
HOVERGENiHBG051736
InParanoidiQ8NBF1
KOiK09232
PhylomeDBiQ8NBF1
TreeFamiTF350216

Family and domain databases

InterProiView protein in InterPro
IPR030430 GLIS1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF93 PTHR19818:SF93, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q8NBF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG
60 70 80 90 100
LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC
110 120 130 140 150
VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA
160 170 180 190 200
DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV
210 220 230 240 250
DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL
260 270 280 290 300
IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ
310 320 330 340 350
KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE
360 370 380 390 400
QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP
410 420 430 440 450
GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST
460 470 480 490 500
RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF
510 520 530 540 550
QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF
560 570 580 590 600
NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF
610 620
FPNGAFDHCL GHIPSIYTDT
Length:620
Mass (Da):65,976
Last modified:October 14, 2008 - v2
Checksum:iA07F61B35CF12EB7
GO

Sequence cautioni

The sequence BAC04178 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221I → T in BAC03494 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047031110T → A1 PublicationCorresponds to variant dbSNP:rs4307514Ensembl.1
Natural variantiVAR_033544157F → L. Corresponds to variant dbSNP:rs34961060Ensembl.1
Natural variantiVAR_047032187A → G1 PublicationCorresponds to variant dbSNP:rs35227000Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA Translation: BAC03494.1
AK093474 mRNA Translation: BAC04178.1 Different initiation.
AC105280 Genomic DNA No translation available.
AL591720 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06734.1
BC101799 mRNA Translation: AAI01800.1
BC104911 mRNA Translation: AAI04912.1
CCDSiCCDS582.1
RefSeqiNP_671726.2, NM_147193.2
UniGeneiHs.306691

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332
GeneIDi148979
KEGGihsa:148979
UCSCiuc001cvr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGLIS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBF1
Secondary accession number(s): Q2M3G9, Q8N9V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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