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Protein

Zinc finger and SCAN domain-containing protein 1

Gene

ZSCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 1
Gene namesi
Name:ZSCAN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000152467.9
HGNCiHGNC:23712 ZSCAN1
neXtProtiNX_Q8NBB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi284312
PharmGKBiPA143485394

Polymorphism and mutation databases

BioMutaiZSCAN1
DMDMi296453061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477481 – 408Zinc finger and SCAN domain-containing protein 1Add BLAST408

Proteomic databases

PaxDbiQ8NBB4
PRIDEiQ8NBB4
ProteomicsDBi72755
72756 [Q8NBB4-2]

PTM databases

iPTMnetiQ8NBB4
PhosphoSitePlusiQ8NBB4

Expressioni

Gene expression databases

BgeeiENSG00000152467
CleanExiHS_ZSCAN1
ExpressionAtlasiQ8NBB4 baseline and differential
GenevisibleiQ8NBB4 HS

Organism-specific databases

HPAiHPA007938

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi129825, 50 interactors
IntActiQ8NBB4, 5 interactors
STRINGi9606.ENSP00000282326

Structurei

3D structure databases

ProteinModelPortaliQ8NBB4
SMRiQ8NBB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 120SCAN boxPROSITE-ProRule annotationAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000170824
InParanoidiQ8NBB4
KOiK09230
OMAiQKTHREE
OrthoDBiEOG091G08DK
PhylomeDBiQ8NBB4
TreeFamiTF336839

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS
60 70 80 90 100
GPHLALGQLW TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS
110 120 130 140 150
QGPRSCREAA SLVEDLTQMC QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ
160 170 180 190 200
KEPSQASELI LDAVAAAPAL PEESEWLETT QLQQSLHTRA EAEAPRAPGL
210 220 230 240 250
LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG PSAQRISPRR
260 270 280 290 300
RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
310 320 330 340 350
FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK
360 370 380 390 400
APRSKGPRES VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK

LHTAHGHM
Length:408
Mass (Da):45,286
Last modified:May 18, 2010 - v2
Checksum:i95AB02559C6CA217
GO
Isoform 2 (identifier: Q8NBB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: VLVSLDSVEP...ALPEESEWLE → GERRRLRAPG...RGCVFNYFYI
     179-408: Missing.

Show »
Length:178
Mass (Da):20,139
Checksum:i6B574D047929CE94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132E → G in BAC03582 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q8NBB4-2)
Sequence conflicti130R → P in AAQ16582 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011953124 – 178VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_011954179 – 408Missing in isoform 2. 2 PublicationsAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280370 mRNA Translation: AAQ16582.1
AK091098 mRNA Translation: BAC03582.1
AC008751 Genomic DNA No translation available.
AC008969 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72550.1
BC048099 mRNA Translation: AAH48099.1
BC107729 mRNA Translation: AAI07730.1
CCDSiCCDS12969.1 [Q8NBB4-1]
RefSeqiNP_872378.3, NM_182572.3 [Q8NBB4-1]
UniGeneiHs.643437

Genome annotation databases

EnsembliENST00000282326; ENSP00000282326; ENSG00000152467 [Q8NBB4-1]
GeneIDi284312
KEGGihsa:284312
UCSCiuc002qra.2 human [Q8NBB4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZSCA1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBB4
Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

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