UniProtKB - Q8NBB4 (ZSCA1_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 1
Gene
ZSCAN1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NBB4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 1 |
Gene namesi | Name:ZSCAN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152467.9 |
HGNCi | HGNC:23712, ZSCAN1 |
neXtProti | NX_Q8NBB4 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 284312 |
PharmGKBi | PA143485394 |
Miscellaneous databases
Pharosi | Q8NBB4, Tbio |
Polymorphism and mutation databases
BioMutai | ZSCAN1 |
DMDMi | 296453061 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047748 | 1 – 408 | Zinc finger and SCAN domain-containing protein 1Add BLAST | 408 |
Proteomic databases
jPOSTi | Q8NBB4 |
MassIVEi | Q8NBB4 |
PaxDbi | Q8NBB4 |
PRIDEi | Q8NBB4 |
ProteomicsDBi | 72755 [Q8NBB4-1] 72756 [Q8NBB4-2] |
PTM databases
iPTMneti | Q8NBB4 |
PhosphoSitePlusi | Q8NBB4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152467, Expressed in adenohypophysis and 95 other tissues |
ExpressionAtlasi | Q8NBB4, baseline and differential |
Genevisiblei | Q8NBB4, HS |
Organism-specific databases
HPAi | ENSG00000152467, Tissue enhanced (brain, epididymis, pituitary gland) |
Interactioni
Binary interactionsi
Hide detailsQ8NBB4
With | #Exp. | IntAct |
---|---|---|
GOPC [Q9HD26] | 3 | EBI-5292994,EBI-349832 |
PPL [O60437] | 3 | EBI-5292994,EBI-368321 |
Isoform 2 [Q8NBB4-2]
With | #Exp. | IntAct |
---|---|---|
NFYC - isoform 1 [Q13952-2] | 3 | EBI-12021938,EBI-11956831 |
PPL [O60437] | 3 | EBI-12021938,EBI-368321 |
ZSCAN22 [P10073] | 3 | EBI-12021938,EBI-10178224 |
Protein-protein interaction databases
BioGRIDi | 129825, 52 interactors |
IntActi | Q8NBB4, 18 interactors |
STRINGi | 9606.ENSP00000282326 |
Miscellaneous databases
RNActi | Q8NBB4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 120 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164008 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8NBB4 |
OMAi | HTVHGHM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NBB4 |
TreeFami | TF336839 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NBB4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS
60 70 80 90 100
GPHLALGQLW TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS
110 120 130 140 150
QGPRSCREAA SLVEDLTQMC QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ
160 170 180 190 200
KEPSQASELI LDAVAAAPAL PEESEWLETT QLQQSLHTRA EAEAPRAPGL
210 220 230 240 250
LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG PSAQRISPRR
260 270 280 290 300
RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
310 320 330 340 350
FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK
360 370 380 390 400
APRSKGPRES VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK
LHTAHGHM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGR0 | A0A0C4DGR0_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN1 | 178 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 132 | E → G in BAC03582 (PubMed:14702039).Curated | 1 | ||
Isoform 2 (identifier: Q8NBB4-2) | |||||
Sequence conflicti | 130 | R → P in AAQ16582 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011953 | 124 – 178 | VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2. 2 PublicationsAdd BLAST | 55 | |
Alternative sequenceiVSP_011954 | 179 – 408 | Missing in isoform 2. 2 PublicationsAdd BLAST | 230 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY280370 mRNA Translation: AAQ16582.1 AK091098 mRNA Translation: BAC03582.1 AC008751 Genomic DNA No translation available. AC008969 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72550.1 BC048099 mRNA Translation: AAH48099.1 BC107729 mRNA Translation: AAI07730.1 |
CCDSi | CCDS12969.1 [Q8NBB4-1] |
RefSeqi | NP_872378.3, NM_182572.3 [Q8NBB4-1] |
Genome annotation databases
Ensembli | ENST00000282326; ENSP00000282326; ENSG00000152467 [Q8NBB4-1] |
GeneIDi | 284312 |
KEGGi | hsa:284312 |
UCSCi | uc002qra.2, human [Q8NBB4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY280370 mRNA Translation: AAQ16582.1 AK091098 mRNA Translation: BAC03582.1 AC008751 Genomic DNA No translation available. AC008969 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72550.1 BC048099 mRNA Translation: AAH48099.1 BC107729 mRNA Translation: AAI07730.1 |
CCDSi | CCDS12969.1 [Q8NBB4-1] |
RefSeqi | NP_872378.3, NM_182572.3 [Q8NBB4-1] |
3D structure databases
SMRi | Q8NBB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129825, 52 interactors |
IntActi | Q8NBB4, 18 interactors |
STRINGi | 9606.ENSP00000282326 |
PTM databases
iPTMneti | Q8NBB4 |
PhosphoSitePlusi | Q8NBB4 |
Polymorphism and mutation databases
BioMutai | ZSCAN1 |
DMDMi | 296453061 |
Proteomic databases
jPOSTi | Q8NBB4 |
MassIVEi | Q8NBB4 |
PaxDbi | Q8NBB4 |
PRIDEi | Q8NBB4 |
ProteomicsDBi | 72755 [Q8NBB4-1] 72756 [Q8NBB4-2] |
Protocols and materials databases
ABCDi | Q8NBB4, 4 sequenced antibodies |
Antibodypediai | 1802, 106 antibodies |
Genome annotation databases
Ensembli | ENST00000282326; ENSP00000282326; ENSG00000152467 [Q8NBB4-1] |
GeneIDi | 284312 |
KEGGi | hsa:284312 |
UCSCi | uc002qra.2, human [Q8NBB4-1] |
Organism-specific databases
CTDi | 284312 |
DisGeNETi | 284312 |
EuPathDBi | HostDB:ENSG00000152467.9 |
GeneCardsi | ZSCAN1 |
HGNCi | HGNC:23712, ZSCAN1 |
HPAi | ENSG00000152467, Tissue enhanced (brain, epididymis, pituitary gland) |
neXtProti | NX_Q8NBB4 |
PharmGKBi | PA143485394 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164008 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q8NBB4 |
OMAi | HTVHGHM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NBB4 |
TreeFami | TF336839 |
Enzyme and pathway databases
PathwayCommonsi | Q8NBB4 |
Miscellaneous databases
BioGRID-ORCSi | 284312, 7 hits in 868 CRISPR screens |
GenomeRNAii | 284312 |
Pharosi | Q8NBB4, Tbio |
PROi | PR:Q8NBB4 |
RNActi | Q8NBB4, protein |
Gene expression databases
Bgeei | ENSG00000152467, Expressed in adenohypophysis and 95 other tissues |
ExpressionAtlasi | Q8NBB4, baseline and differential |
Genevisiblei | Q8NBB4, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSCA1_HUMAN | |
Accessioni | Q8NBB4Primary (citable) accession number: Q8NBB4 Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM