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Entry version 155 (12 Aug 2020)
Sequence version 3 (12 Jun 2007)
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Protein

Protein unc-13 homolog C

Gene

UNC13C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1236Calcium 1PROSITE-ProRule annotation1
Metal bindingi1236Calcium 2PROSITE-ProRule annotation1
Metal bindingi1242Calcium 1PROSITE-ProRule annotation1
Metal bindingi1288Calcium 1PROSITE-ProRule annotation1
Metal bindingi1288Calcium 2PROSITE-ProRule annotation1
Metal bindingi1290Calcium 1PROSITE-ProRule annotation1
Metal bindingi1290Calcium 2PROSITE-ProRule annotation1
Metal bindingi1307Calcium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1097 – 1147Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NB66

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-13 homolog C
Alternative name(s):
Munc13-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNC13C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137766.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23149, UNC13C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614568, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NB66

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
440279

Open Targets

More...
OpenTargetsi
ENSG00000137766

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870087

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NB66, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UNC13C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
148887448

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885781 – 2214Protein unc-13 homolog CAdd BLAST2214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineBy similarity1
Modified residuei448PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei788PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NB66

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NB66

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NB66

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NB66

PeptideAtlas

More...
PeptideAtlasi
Q8NB66

PRoteomics IDEntifications database

More...
PRIDEi
Q8NB66

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72744

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NB66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NB66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137766, Expressed in secondary oocyte and 141 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NB66, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NB66, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137766, Group enriched (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STX1A and/or STX1B1, VAMP2 and SNAP25.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8NB66, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000260323

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NB66, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NB66

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1203 – 1327C2 1PROSITE-ProRule annotationAdd BLAST125
Domaini1637 – 1780MHD1PROSITE-ProRule annotationAdd BLAST144
Domaini1886 – 2028MHD2PROSITE-ProRule annotationAdd BLAST143
Domaini2044 – 2169C2 2PROSITE-ProRule annotationAdd BLAST126

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili99 – 135Sequence analysisAdd BLAST37
Coiled coili971 – 995Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi156 – 159Poly-Ser4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domains are not involved in calcium-dependent phospholipid binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1097 – 1147Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1011, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155174

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001304_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NB66

KEGG Orthology (KO)

More...
KOi
K15293

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEVYELH

Database of Orthologous Groups

More...
OrthoDBi
117172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NB66

TreeFam database of animal gene trees

More...
TreeFami
TF312844

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B
IPR027087, Unc13C

The PANTHER Classification System

More...
PANTHERi
PTHR10480, PTHR10480, 1 hit
PTHR10480:SF2, PTHR10480:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 2 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360, C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 2 hits
SM01145, DUF1041, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 2 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8NB66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVANFFKSLI LPYIHKLCKG MFTKKLGNTN KNKEYRQQKK DQDFPTAGQT
60 70 80 90 100
KSPKFSYTFK STVKKIAKCS STHNLSTEED EASKEFSLSP TFSYRVAIAN
110 120 130 140 150
GLQKNAKVTN SDNEDLLQEL SSIESSYSES LNELRSSTEN QAQSTHTMPV
160 170 180 190 200
RRNRKSSSSL APSEGSSDGE RTLHGLKLGA LRKLRKWKKS QECVSSDSEL
210 220 230 240 250
STMKKSWGIR SKSLDRTVRN PKTNALEPGF SSSGCISQTH DVMEMIFKEL
260 270 280 290 300
QGISQIETEL SELRGHVNAL KHSIDEISSS VEVVQSEIEQ LRTGFVQSRR
310 320 330 340 350
ETRDIHDYIK HLGHMGSKAS LRFLNVTEER FEYVESVVYQ ILIDKMGFSD
360 370 380 390 400
APNAIKIEFA QRIGHQRDCP NAKPRPILVY FETPQQRDSV LKKSYKLKGT
410 420 430 440 450
GIGISTDILT HDIRERKEKG IPSSQTYESM AIKLSTPEPK IKKNNWQSPD
460 470 480 490 500
DSDEDLESDL NRNSYAVLSK SELLTKGSTS KPSSKSHSAR SKNKTANSSR
510 520 530 540 550
ISNKSDYDKI SSQLPESDIL EKQTTTHYAD ATPLWHSQSD FFTAKLSRSE
560 570 580 590 600
SDFSKLCQSY SEDFSENQFF TRTNGSSLLS SSDRELWQRK QEGTATLYDS
610 620 630 640 650
PKDQHLNGGV QGIQGQTETE NTETVDSGMS NGMVCASGDR SHYSDSQLSL
660 670 680 690 700
HEDLSPWKEW NQGADLGLDS STQEGFDYET NSLFDQQLDV YNKDLEYLGK
710 720 730 740 750
CHSDLQDDSE SYDLTQDDNS SPCPGLDNEP QGQWVGQYDS YQGANSNELY
760 770 780 790 800
QNQNQLSMMY RSQSELQSDD SEDAPPKSWH SRLSIDLSDK TFSFPKFGST
810 820 830 840 850
LQRAKSALEV VWNKSTQSLS GYEDSGSSLM GRFRTLSQST ANESSTTLDS
860 870 880 890 900
DVYTEPYYYK AEDEEDYTEP VADNETDYVE VMEQVLAKLE NRTSITETDE
910 920 930 940 950
QMQAYDHLSY ETPYETPQDE GYDGPADDMV SEEGLEPLNE TSAEMEIRED
960 970 980 990 1000
ENQNIPEQPV EITKPKRIRP SFKEAALRAY KKQMAELEEK ILAGDSSSVD
1010 1020 1030 1040 1050
EKARIVSGND LDASKFSALQ VCGGAGGGLY GIDSMPDLRR KKTLPIVRDV
1060 1070 1080 1090 1100
AMTLAARKSG LSLAMVIRTS LNNEELKMHV FKKTLQALIY PMSSTIPHNF
1110 1120 1130 1140 1150
EVWTATTPTY CYECEGLLWG IARQGMKCLE CGVKCHEKCQ DLLNADCLQR
1160 1170 1180 1190 1200
AAEKSSKHGA EDKTQTIITA MKERMKIREK NRPEVFEVIQ EMFQISKEDF
1210 1220 1230 1240 1250
VQFTKAAKQS VLDGTSKWSA KITITVVSAQ GLQAKDKTGS SDPYVTVQVG
1260 1270 1280 1290 1300
KNKRRTKTIF GNLNPVWDEK FYFECHNSTD RIKVRVWDED DDIKSRVKQH
1310 1320 1330 1340 1350
FKKESDDFLG QTIVEVRTLS GEMDVWYNLE KRTDKSAVSG AIRLKINVEI
1360 1370 1380 1390 1400
KGEEKVAPYH IQYTCLHENL FHYLTEVKSN GGVKIPEVKG DEAWKVFFDD
1410 1420 1430 1440 1450
ASQEIVDEFA MRYGIESIYQ AMTHFSCLSS KYMCPGVPAV MSTLLANINA
1460 1470 1480 1490 1500
FYAHTTVSTN IQVSASDRFA ATNFGREKFI KLLDQLHNSL RIDLSKYREN
1510 1520 1530 1540 1550
FPASNTERLQ DLKSTVDLLT SITFFRMKVL ELQSPPKASM VVKDCVRACL
1560 1570 1580 1590 1600
DSTYKYIFDN CHELYSQLTD PSKKQDIPRE DQGPTTKNLD FWPQLITLMV
1610 1620 1630 1640 1650
TIIDEDKTAY TPVLNQFPQE LNMGKISAEI MWTLFALDMK YALEEHENQR
1660 1670 1680 1690 1700
LCKSTDYMNL HFKVKWFYNE YVRELPAFKD AVPEYSLWFE PFVMQWLDEN
1710 1720 1730 1740 1750
EDVSMEFLHG ALGRDKKDGF QQTSEHALFS CSVVDVFAQL NQSFEIIKKL
1760 1770 1780 1790 1800
ECPNPEALSH LMRRFAKTIN KVLLQYAAIV SSDFSSHCDK ENVPCILMNN
1810 1820 1830 1840 1850
IQQLRVQLEK MFESMGGKEL DSEASTILKE LQVKLSGVLD ELSVTYGESF
1860 1870 1880 1890 1900
QVIIEECIKQ MSFELNQMRA NGNTTSNKNS AAMDAEIVLR SLMDFLDKTL
1910 1920 1930 1940 1950
SLSAKICEKT VLKRVLKELW KLVLNKIEKQ IVLPPLTDQT GPQMIFIAAK
1960 1970 1980 1990 2000
DLGQLSKLKE HMIREDARGL TPRQCAIMEV VLATIKQYFH AGGNGLKKNF
2010 2020 2030 2040 2050
LEKSPDLQSL RYALSLYTQT TDALIKKFID TQTSQSRSSK DAVGQISVHV
2060 2070 2080 2090 2100
DITATPGTGD HKVTVKVIAI NDLNWQTTAM FRPFVEVCIL GPNLGDKKRK
2110 2120 2130 2140 2150
QGTKTKSNTW SPKYNETFQF ILGKENRPGA YELHLSVKDY CFAREDRIIG
2160 2170 2180 2190 2200
MTVIQLQNIA EKGSYGAWYP LLKNISMDET GLTILRILSQ RTSDDVAKEF
2210
VRLKSETRST EESA
Length:2,214
Mass (Da):250,911
Last modified:June 12, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8287DAD9DF99B7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISZ1A0A3B3ISZ1_HUMAN
Protein unc-13 homolog C
UNC13C
2,212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL13H0YL13_HUMAN
Protein unc-13 homolog C
UNC13C
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGH4A0A0C4DGH4_HUMAN
HCG38864
UNC13C hCG_38864
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRP8H3BRP8_HUMAN
Protein unc-13 homolog C
UNC13C
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH40740 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB70836 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03675 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC03675 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2036S → C in AAH40740 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067540304D → E Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant dbSNP:rs149448818Ensembl.1
Natural variantiVAR_061873609G → S. Corresponds to variant dbSNP:rs12437941Ensembl.1
Natural variantiVAR_052468942S → L. Corresponds to variant dbSNP:rs17731958Ensembl.1
Natural variantiVAR_0675412196V → A Rare variant; may act as a phenotype modifier in EIEE13 patients carrying SCN8A mutations. 1 PublicationCorresponds to variant dbSNP:rs146433220Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010867 Genomic DNA No translation available.
AC022302 Genomic DNA No translation available.
AC034103 Genomic DNA No translation available.
AC068711 Genomic DNA No translation available.
AK054981 mRNA Translation: BAB70836.1 Different initiation.
AK091491 mRNA Translation: BAC03675.1 Different initiation.
AL834407 mRNA Translation: CAD39069.2
BC040740 mRNA Translation: AAH40740.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS45264.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074003.1, NM_001080534.2
XP_005254451.1, XM_005254394.4
XP_016877709.1, XM_017022220.1
XP_016877710.1, XM_017022221.1
XP_016877711.1, XM_017022222.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260323; ENSP00000260323; ENSG00000137766

Database of genes from NCBI RefSeq genomes

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GeneIDi
440279

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:440279

UCSC genome browser

More...
UCSCi
uc002acm.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010867 Genomic DNA No translation available.
AC022302 Genomic DNA No translation available.
AC034103 Genomic DNA No translation available.
AC068711 Genomic DNA No translation available.
AK054981 mRNA Translation: BAB70836.1 Different initiation.
AK091491 mRNA Translation: BAC03675.1 Different initiation.
AL834407 mRNA Translation: CAD39069.2
BC040740 mRNA Translation: AAH40740.1 Different initiation.
CCDSiCCDS45264.1
RefSeqiNP_001074003.1, NM_001080534.2
XP_005254451.1, XM_005254394.4
XP_016877709.1, XM_017022220.1
XP_016877710.1, XM_017022221.1
XP_016877711.1, XM_017022222.1

3D structure databases

SMRiQ8NB66
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8NB66, 3 interactors
STRINGi9606.ENSP00000260323

PTM databases

iPTMnetiQ8NB66
PhosphoSitePlusiQ8NB66

Polymorphism and mutation databases

BioMutaiUNC13C
DMDMi148887448

Proteomic databases

EPDiQ8NB66
jPOSTiQ8NB66
MassIVEiQ8NB66
PaxDbiQ8NB66
PeptideAtlasiQ8NB66
PRIDEiQ8NB66
ProteomicsDBi72744

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51911, 30 antibodies

Genome annotation databases

EnsembliENST00000260323; ENSP00000260323; ENSG00000137766
GeneIDi440279
KEGGihsa:440279
UCSCiuc002acm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440279
DisGeNETi440279
EuPathDBiHostDB:ENSG00000137766.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UNC13C
HGNCiHGNC:23149, UNC13C
HPAiENSG00000137766, Group enriched (brain, testis)
MIMi614568, gene
neXtProtiNX_Q8NB66
OpenTargetsiENSG00000137766
PharmGKBiPA134870087

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1011, Eukaryota
GeneTreeiENSGT00940000155174
HOGENOMiCLU_001304_0_0_1
InParanoidiQ8NB66
KOiK15293
OMAiPEVYELH
OrthoDBi117172at2759
PhylomeDBiQ8NB66
TreeFamiTF312844

Enzyme and pathway databases

PathwayCommonsiQ8NB66

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
440279, 3 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UNC13C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
440279
PharosiQ8NB66, Tdark

Protein Ontology

More...
PROi
PR:Q8NB66
RNActiQ8NB66, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137766, Expressed in secondary oocyte and 141 other tissues
ExpressionAtlasiQ8NB66, baseline and differential
GenevisibleiQ8NB66, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B
IPR027087, Unc13C
PANTHERiPTHR10480, PTHR10480, 1 hit
PTHR10480:SF2, PTHR10480:SF2, 1 hit
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 2 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit
PRINTSiPR00360, C2DOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 2 hits
SM01145, DUF1041, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN13C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NB66
Secondary accession number(s): Q0P613, Q8ND48, Q96NP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 12, 2007
Last modified: August 12, 2020
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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