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Protein

Synaptotagmin-14

Gene

SYT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-14
Alternative name(s):
Synaptotagmin XIV
Short name:
SytXIV
Gene namesi
Name:SYT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143469.16
HGNCiHGNC:23143 SYT14
MIMi610949 gene
neXtProtiNX_Q8NB59

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 47Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST23
Topological domaini48 – 555CytoplasmicSequence analysisAdd BLAST508

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation.
See also OMIM:614229
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066664439G → D in SCAR11; shows intracellular localization different from that of the wild-type protein; forms a reticular pattern in the cytoplasm; does not show submembranous distribution; is abnormally retained in the endoplasmic reticulum consistent to improper folding. 1 PublicationCorresponds to variant dbSNP:rs387907033Ensembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi255928
MalaCardsiSYT14
MIMi614229 phenotype
OpenTargetsiENSG00000143469
Orphaneti284271 Autosomal recessive cerebellar ataxia-psychomotor retardation syndrome
PharmGKBiPA134887689

Polymorphism and mutation databases

BioMutaiSYT14
DMDMi116242810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839781 – 555Synaptotagmin-14Add BLAST555

Proteomic databases

MaxQBiQ8NB59
PaxDbiQ8NB59
PeptideAtlasiQ8NB59
PRIDEiQ8NB59
ProteomicsDBi72737
72738 [Q8NB59-2]
72739 [Q8NB59-3]
72740 [Q8NB59-4]
72741 [Q8NB59-5]
72742 [Q8NB59-6]

PTM databases

iPTMnetiQ8NB59
PhosphoSitePlusiQ8NB59

Expressioni

Tissue specificityi

Highly expressed in fetal and adult brain tissue.1 Publication

Gene expression databases

BgeeiENSG00000143469 Expressed in 54 organ(s), highest expression level in corpus callosum
CleanExiHS_SYT14
ExpressionAtlasiQ8NB59 baseline and differential
GenevisibleiQ8NB59 HS

Organism-specific databases

HPAiHPA036963

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers (By similarity).By similarity

Protein-protein interaction databases

BioGridi129128, 1 interactor
STRINGi9606.ENSP00000389039

Structurei

3D structure databases

ProteinModelPortaliQ8NB59
SMRiQ8NB59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 378C2 1PROSITE-ProRule annotationAdd BLAST103
Domaini417 – 521C2 2PROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3J Eukaryota
ENOG41117JG LUCA
GeneTreeiENSGT00920000148994
HOVERGENiHBG062897
InParanoidiQ8NB59
KOiK19328
OMAiDSQMSMS
OrthoDBiEOG091G099X
PhylomeDBiQ8NB59
TreeFamiTF351132

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028696 SYT14
PANTHERiPTHR10024:SF209 PTHR10024:SF209, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NB59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF
60 70 80 90 100
CFENVGGFPD LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH
110 120 130 140 150
EALSRTHNSR LPLADSRQRN YAWETRQKYS PLSAEYDGYS SEASIDEGNC
160 170 180 190 200
IQRMRRTPPL DELQPPPYQD DSGSPHLSCT PSEIGDSKCE FSHCSNSPRC
210 220 230 240 250
SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM SAQGSSSQLP
260 270 280 290 300
KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV
310 320 330 340 350
HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV
360 370 380 390 400
HRMKKEKIVG EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS
410 420 430 440 450
CSESTSSCQS LEHGSVPEIL IGLLYNATTG RLSAEVIKGS HFKNLAANRP
460 470 480 490 500
PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT
510 520 530 540 550
LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE SKGQQVCRWH

ALLES
Length:555
Mass (Da):62,287
Last modified:October 17, 2006 - v2
Checksum:iA7E7359DC3DEF5B9
GO
Isoform 2 (identifier: Q8NB59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-457: PPNTYVKL → HPMDCSVV
     458-555: Missing.

Show »
Length:457
Mass (Da):50,923
Checksum:i6921572FE920B878
GO
Isoform 3 (identifier: Q8NB59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:517
Mass (Da):58,289
Checksum:i4211CBB56E0E73EC
GO
Isoform 4 (identifier: Q8NB59-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     299-303: QVHLV → AVTPK
     304-555: Missing.

Show »
Length:265
Mass (Da):29,654
Checksum:iFC80A0B09B5DE2BD
GO
Isoform 5 (identifier: Q8NB59-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-452: N → TFHPLLSDGLFCCLKHLIGGQVYIIRD

Show »
Length:581
Mass (Da):65,215
Checksum:i96CAD81E55551FB5
GO
Isoform 6 (identifier: Q8NB59-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-452: N → NGLFCCLKHLIGGQVYIIRD

Show »
Length:574
Mass (Da):64,418
Checksum:i0DA3491777CA1FF4
GO
Isoform 7 (identifier: Q8NB59-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MAIEGGERTCGVHELICIRK → MASASWRLKV...ASASQVTGTT
     452-452: N → NGLFCCLKHLIGGQVYIIRD

Note: No experimental confirmation available.
Show »
Length:619
Mass (Da):69,346
Checksum:iBD9AAB3F9D5F0AE4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTZ1A0A1B0GTZ1_HUMAN
Synaptotagmin-14
SYT14
864Annotation score:
A0A0A0MTK4A0A0A0MTK4_HUMAN
Synaptotagmin-14
SYT14
504Annotation score:
A0A1B0GTF1A0A1B0GTF1_HUMAN
Synaptotagmin-14
SYT14
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195S → N in CAE85112 (PubMed:15238157).Curated1
Sequence conflicti323V → A in CAE85113 (PubMed:15238157).Curated1
Sequence conflicti514K → E in BAC76809 (PubMed:12801916).Curated1
Sequence conflicti514K → E in BAC03682 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066663138G → E1 PublicationCorresponds to variant dbSNP:rs759296305Ensembl.1
Natural variantiVAR_066664439G → D in SCAR11; shows intracellular localization different from that of the wild-type protein; forms a reticular pattern in the cytoplasm; does not show submembranous distribution; is abnormally retained in the endoplasmic reticulum consistent to improper folding. 1 PublicationCorresponds to variant dbSNP:rs387907033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0116021 – 38Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_0461241 – 20MAIEG…ICIRK → MASASWRLKVEREPVEYMNL SVLEKIGYFSVARLEYSGTI LAHCNFRLLGSNDSSASASQ VTGTT in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_011603299 – 303QVHLV → AVTPK in isoform 4. 1 Publication5
Alternative sequenceiVSP_011604304 – 555Missing in isoform 4. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_011605450 – 457PPNTYVKL → HPMDCSVV in isoform 2. 1 Publication8
Alternative sequenceiVSP_011607452N → TFHPLLSDGLFCCLKHLIGG QVYIIRD in isoform 5. 1 Publication1
Alternative sequenceiVSP_011608452N → NGLFCCLKHLIGGQVYIIRD in isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_011606458 – 555Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102948 mRNA Translation: BAC76809.1
AJ617623 mRNA Translation: CAE85109.1
AJ617624 mRNA Translation: CAE85110.1
AJ617625 mRNA Translation: CAE85111.1
AJ617626 mRNA Translation: CAE85112.1
AJ617627 mRNA Translation: CAE85113.1
AK091517 mRNA Translation: BAC03682.1
AL513263, AL022397, AL022399 Genomic DNA Translation: CAI17884.1
AL022397, AL022399, AL513263 Genomic DNA Translation: CAI17887.1
AL022397, AL513263, AL022399 Genomic DNA Translation: CAI17888.1
AL022397, AL513263 Genomic DNA Translation: CAI17889.1
AL022399, AL513263, AL022397 Genomic DNA Translation: CAI22770.1
AL513263, AL022399, AL022397 Genomic DNA Translation: CAI17885.1
AL513263, AL022397 Genomic DNA Translation: CAI17886.1
AL022399, AL022397, AL513263 Genomic DNA Translation: CAI22771.1
BC144157 mRNA No translation available.
CCDSiCCDS31014.1 [Q8NB59-1]
CCDS53469.1 [Q8NB59-7]
CCDS53470.1 [Q8NB59-6]
CCDS58058.1 [Q8NB59-3]
RefSeqiNP_001139734.1, NM_001146262.2 [Q8NB59-6]
NP_001242935.1, NM_001256006.1 [Q8NB59-3]
NP_694994.2, NM_153262.3 [Q8NB59-1]
UniGeneiHs.658866

Genome annotation databases

EnsembliENST00000367015; ENSP00000355982; ENSG00000143469 [Q8NB59-3]
ENST00000367019; ENSP00000355986; ENSG00000143469 [Q8NB59-6]
ENST00000399639; ENSP00000445837; ENSG00000143469 [Q8NB59-4]
ENST00000472886; ENSP00000418901; ENSG00000143469 [Q8NB59-1]
ENST00000537238; ENSP00000437423; ENSG00000143469 [Q8NB59-3]
ENST00000629778; ENSP00000486230; ENSG00000143469 [Q8NB59-7]
GeneIDi255928
KEGGihsa:255928
UCSCiuc001hht.6 human [Q8NB59-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB102948 mRNA Translation: BAC76809.1
AJ617623 mRNA Translation: CAE85109.1
AJ617624 mRNA Translation: CAE85110.1
AJ617625 mRNA Translation: CAE85111.1
AJ617626 mRNA Translation: CAE85112.1
AJ617627 mRNA Translation: CAE85113.1
AK091517 mRNA Translation: BAC03682.1
AL513263, AL022397, AL022399 Genomic DNA Translation: CAI17884.1
AL022397, AL022399, AL513263 Genomic DNA Translation: CAI17887.1
AL022397, AL513263, AL022399 Genomic DNA Translation: CAI17888.1
AL022397, AL513263 Genomic DNA Translation: CAI17889.1
AL022399, AL513263, AL022397 Genomic DNA Translation: CAI22770.1
AL513263, AL022399, AL022397 Genomic DNA Translation: CAI17885.1
AL513263, AL022397 Genomic DNA Translation: CAI17886.1
AL022399, AL022397, AL513263 Genomic DNA Translation: CAI22771.1
BC144157 mRNA No translation available.
CCDSiCCDS31014.1 [Q8NB59-1]
CCDS53469.1 [Q8NB59-7]
CCDS53470.1 [Q8NB59-6]
CCDS58058.1 [Q8NB59-3]
RefSeqiNP_001139734.1, NM_001146262.2 [Q8NB59-6]
NP_001242935.1, NM_001256006.1 [Q8NB59-3]
NP_694994.2, NM_153262.3 [Q8NB59-1]
UniGeneiHs.658866

3D structure databases

ProteinModelPortaliQ8NB59
SMRiQ8NB59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129128, 1 interactor
STRINGi9606.ENSP00000389039

PTM databases

iPTMnetiQ8NB59
PhosphoSitePlusiQ8NB59

Polymorphism and mutation databases

BioMutaiSYT14
DMDMi116242810

Proteomic databases

MaxQBiQ8NB59
PaxDbiQ8NB59
PeptideAtlasiQ8NB59
PRIDEiQ8NB59
ProteomicsDBi72737
72738 [Q8NB59-2]
72739 [Q8NB59-3]
72740 [Q8NB59-4]
72741 [Q8NB59-5]
72742 [Q8NB59-6]

Protocols and materials databases

DNASUi255928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367015; ENSP00000355982; ENSG00000143469 [Q8NB59-3]
ENST00000367019; ENSP00000355986; ENSG00000143469 [Q8NB59-6]
ENST00000399639; ENSP00000445837; ENSG00000143469 [Q8NB59-4]
ENST00000472886; ENSP00000418901; ENSG00000143469 [Q8NB59-1]
ENST00000537238; ENSP00000437423; ENSG00000143469 [Q8NB59-3]
ENST00000629778; ENSP00000486230; ENSG00000143469 [Q8NB59-7]
GeneIDi255928
KEGGihsa:255928
UCSCiuc001hht.6 human [Q8NB59-1]

Organism-specific databases

CTDi255928
DisGeNETi255928
EuPathDBiHostDB:ENSG00000143469.16
GeneCardsiSYT14
HGNCiHGNC:23143 SYT14
HPAiHPA036963
MalaCardsiSYT14
MIMi610949 gene
614229 phenotype
neXtProtiNX_Q8NB59
OpenTargetsiENSG00000143469
Orphaneti284271 Autosomal recessive cerebellar ataxia-psychomotor retardation syndrome
PharmGKBiPA134887689
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT3J Eukaryota
ENOG41117JG LUCA
GeneTreeiENSGT00920000148994
HOVERGENiHBG062897
InParanoidiQ8NB59
KOiK19328
OMAiDSQMSMS
OrthoDBiEOG091G099X
PhylomeDBiQ8NB59
TreeFamiTF351132

Miscellaneous databases

ChiTaRSiSYT14 human
GeneWikiiSYT14
GenomeRNAii255928
PROiPR:Q8NB59
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143469 Expressed in 54 organ(s), highest expression level in corpus callosum
CleanExiHS_SYT14
ExpressionAtlasiQ8NB59 baseline and differential
GenevisibleiQ8NB59 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028696 SYT14
PANTHERiPTHR10024:SF209 PTHR10024:SF209, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYT14_HUMAN
AccessioniPrimary (citable) accession number: Q8NB59
Secondary accession number(s): B1AJU0
, B1AJU1, F5H426, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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