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Entry version 153 (08 May 2019)
Sequence version 3 (05 Apr 2011)
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Protein

Zinc finger protein 62 homolog

Gene

ZFP62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in differentiating skeletal muscle.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri225 – 247C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 834C2H2-type 22PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri840 – 862C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 62 homolog
Short name:
Zfp-62
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFP62
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23241 ZFP62

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610281 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NB50

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000196670

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134969387

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFP62

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478553

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473051 – 900Zinc finger protein 62 homologAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki587Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki748Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki882Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NB50

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NB50

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NB50

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NB50

PeptideAtlas

More...
PeptideAtlasi
Q8NB50

PRoteomics IDEntifications database

More...
PRIDEi
Q8NB50

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72735
72736 [Q8NB50-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NB50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NB50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196670 Expressed in 202 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NB50 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NB50 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048629

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
569091, 22 interactors

Protein interaction database and analysis system

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IntActi
Q8NB50, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000423820

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NB50

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 247C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 834C2H2-type 22PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri840 – 862C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162750

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NB50

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSRTCPR

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NB50

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 22 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 26 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 25 hits
PS50157 ZINC_FINGER_C2H2_2, 26 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NB50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHLKTSTED EEPTEEYENV GNAASKWPKV EDPMPESKVG DTCVWDSKVE
60 70 80 90 100
NQQKKPVENR MKEDKSSIRE AISKAKSTAN IKTEQEGEAS EKSLHLSPQH
110 120 130 140 150
ITHQTMPIGQ RGSEQGKRVE NINGTSYPSL QQKTNAVKKL HKCDECGKSF
160 170 180 190 200
KYNSRLVQHK IMHTGEKRYE CDDCGGTFRS SSSLRVHKRI HTGEKPYKCE
210 220 230 240 250
ECGKAYMSYS SLINHKSTHS GEKNCKCDEC GKSFNYSSVL DQHKRIHTGE
260 270 280 290 300
KPYECGECGK AFRNSSGLRV HKRIHTGEKP YECDICGKTF SNSSGLRVHK
310 320 330 340 350
RIHTGEKPYE CDECGKAFIT CRTLLNHKSI HFGDKPYKCD ECEKSFNYSS
360 370 380 390 400
LLIQHKVIHT GEKPYECDEC GKAFRNSSGL IVHKRIHTGE KPYKCDVCGK
410 420 430 440 450
AFSYSSGLAV HKSIHPGKKA HECKECGKSF SYNSLLLQHR TIHTGERPYV
460 470 480 490 500
CDVCGKTFRN NAGLKVHRRL HTGEKPYKCD VCGKAYISRS SLKNHKGIHL
510 520 530 540 550
GEKPYKCSYC EKSFNYSSAL EQHKRIHTRE KPFGCDECGK AFRNNSGLKV
560 570 580 590 600
HKRIHTGERP YKCEECGKAY ISLSSLINHK SVHPGEKPFK CDECEKAFIT
610 620 630 640 650
YRTLTNHKKV HLGEKPYKCD VCEKSFNYTS LLSQHRRVHT REKPYECDRC
660 670 680 690 700
EKVFRNNSSL KVHKRIHTGE RPYECDVCGK AYISHSSLIN HKSTHPGRTP
710 720 730 740 750
HTCDECGKAF FSSRTLISHK RVHLGEKPFK CVECGKSFSY SSLLSQHKRI
760 770 780 790 800
HTGEKPYVCD RCGKAFRNSS GLTVHKRIHT GEKPYECDEC GKAYISHSSL
810 820 830 840 850
INHKSVHQGK QPYNCECGKS FNYRSVLDQH KRIHTGKKPY RCNECGKAFN
860 870 880 890 900
IRSNLTKHKR THTGEESLNV IYVGSYSGTS QKRTYEGGNA LDGGRMRMPL
Length:900
Mass (Da):102,511
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C1D915D03FBBE67
GO
Isoform 2 (identifier: Q8NB50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-534: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):80,231
Checksum:iB482C854BD712B8E
GO
Isoform 3 (identifier: Q8NB50-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:867
Mass (Da):98,780
Checksum:iE8BB0BD0D5E2AB87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9C0D6R9C0_HUMAN
Zinc finger protein 62 homolog
ZFP62
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBG3D6RBG3_HUMAN
Zinc finger protein 62 homolog
ZFP62
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCF6D6RCF6_HUMAN
Zinc finger protein 62 homolog
ZFP62
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI40762 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03691 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58558 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.Curated
The sequence CAI46133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti321C → R in BAC03691 (PubMed:14702039).Curated1
Sequence conflicti690N → I in BAG64495 (PubMed:14702039).Curated1
Sequence conflicti800L → F in BAG58558 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06488134M → I1 PublicationCorresponds to variant dbSNP:rs705441Ensembl.1
Natural variantiVAR_064882698R → K3 PublicationsCorresponds to variant dbSNP:rs168726Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452571 – 33Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_010136339 – 534Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091550 mRNA Translation: BAC03691.1 Different initiation.
AK295714 mRNA Translation: BAG58558.1 Sequence problems.
AK303450 mRNA Translation: BAG64495.1
DA323041 mRNA No translation available.
AC022413 Genomic DNA No translation available.
AL832408 Transcribed RNA Translation: CAI46133.1 Different initiation.
BC140761 mRNA Translation: AAI40762.1 Different initiation.
BC171780 mRNA Translation: AAI71780.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47357.2 [Q8NB50-3]
CCDS54955.1 [Q8NB50-1]

NCBI Reference Sequences

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RefSeqi
NP_001166109.1, NM_001172638.1 [Q8NB50-1]
NP_689496.4, NM_152283.4 [Q8NB50-3]
XP_016865199.1, XM_017009710.1
XP_016865200.1, XM_017009711.1 [Q8NB50-3]
XP_016865201.1, XM_017009712.1
XP_016865202.1, XM_017009713.1 [Q8NB50-3]
XP_016865203.1, XM_017009714.1 [Q8NB50-3]
XP_016865204.1, XM_017009715.1 [Q8NB50-3]
XP_016865206.1, XM_017009717.1 [Q8NB50-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000502412; ENSP00000423820; ENSG00000196670 [Q8NB50-1]
ENST00000512132; ENSP00000426193; ENSG00000196670 [Q8NB50-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
643836

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:643836

UCSC genome browser

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UCSCi
uc011dhe.3 human [Q8NB50-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091550 mRNA Translation: BAC03691.1 Different initiation.
AK295714 mRNA Translation: BAG58558.1 Sequence problems.
AK303450 mRNA Translation: BAG64495.1
DA323041 mRNA No translation available.
AC022413 Genomic DNA No translation available.
AL832408 Transcribed RNA Translation: CAI46133.1 Different initiation.
BC140761 mRNA Translation: AAI40762.1 Different initiation.
BC171780 mRNA Translation: AAI71780.1
CCDSiCCDS47357.2 [Q8NB50-3]
CCDS54955.1 [Q8NB50-1]
RefSeqiNP_001166109.1, NM_001172638.1 [Q8NB50-1]
NP_689496.4, NM_152283.4 [Q8NB50-3]
XP_016865199.1, XM_017009710.1
XP_016865200.1, XM_017009711.1 [Q8NB50-3]
XP_016865201.1, XM_017009712.1
XP_016865202.1, XM_017009713.1 [Q8NB50-3]
XP_016865203.1, XM_017009714.1 [Q8NB50-3]
XP_016865204.1, XM_017009715.1 [Q8NB50-3]
XP_016865206.1, XM_017009717.1 [Q8NB50-1]

3D structure databases

SMRiQ8NB50
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569091, 22 interactors
IntActiQ8NB50, 1 interactor
STRINGi9606.ENSP00000423820

PTM databases

iPTMnetiQ8NB50
PhosphoSitePlusiQ8NB50

Polymorphism and mutation databases

BioMutaiZFP62
DMDMi327478553

Proteomic databases

EPDiQ8NB50
jPOSTiQ8NB50
MaxQBiQ8NB50
PaxDbiQ8NB50
PeptideAtlasiQ8NB50
PRIDEiQ8NB50
ProteomicsDBi72735
72736 [Q8NB50-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502412; ENSP00000423820; ENSG00000196670 [Q8NB50-1]
ENST00000512132; ENSP00000426193; ENSG00000196670 [Q8NB50-3]
GeneIDi643836
KEGGihsa:643836
UCSCiuc011dhe.3 human [Q8NB50-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
643836

GeneCards: human genes, protein and diseases

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GeneCardsi
ZFP62
HGNCiHGNC:23241 ZFP62
HPAiHPA048629
MIMi610281 gene
neXtProtiNX_Q8NB50
OpenTargetsiENSG00000196670
PharmGKBiPA134969387

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162750
InParanoidiQ8NB50
OMAiNSRTCPR
OrthoDBi1318335at2759
PhylomeDBiQ8NB50
TreeFamiTF343410

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
643836

Protein Ontology

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PROi
PR:Q8NB50

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196670 Expressed in 202 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ8NB50 baseline and differential
GenevisibleiQ8NB50 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 22 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 26 hits
SUPFAMiSSF57667 SSF57667, 16 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 25 hits
PS50157 ZINC_FINGER_C2H2_2, 26 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFP62_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NB50
Secondary accession number(s): B4DIP6
, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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