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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

Gene

ANKRD52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
Short name:
PP6-ARS-C
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C
Alternative name(s):
Ankyrin repeat domain-containing protein 52
Gene namesi
Name:ANKRD52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139645.9
HGNCiHGNC:26614 ANKRD52
neXtProtiNX_Q8NB46

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139645
PharmGKBiPA143485302

Polymorphism and mutation databases

BioMutaiANKRD52
DMDMi296439443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445871 – 1076Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit CAdd BLAST1076

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1075PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NB46
MaxQBiQ8NB46
PaxDbiQ8NB46
PeptideAtlasiQ8NB46
PRIDEiQ8NB46
ProteomicsDBi72730

PTM databases

iPTMnetiQ8NB46
PhosphoSitePlusiQ8NB46

Expressioni

Gene expression databases

BgeeiENSG00000139645 Expressed in 150 organ(s), highest expression level in left adrenal gland
CleanExiHS_ANKRD52
GenevisibleiQ8NB46 HS

Organism-specific databases

HPAiHPA043815

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP6R1Q9UPN74EBI-1996119,EBI-359745

Protein-protein interaction databases

BioGridi129540, 44 interactors
IntActiQ8NB46, 19 interactors
MINTiQ8NB46
STRINGi9606.ENSP00000267116

Structurei

3D structure databases

ProteinModelPortaliQ8NB46
SMRiQ8NB46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati422 – 451ANK 13Add BLAST30
Repeati455 – 484ANK 14Add BLAST30
Repeati488 – 545ANK 15Add BLAST58
Repeati549 – 579ANK 16Add BLAST31
Repeati584 – 613ANK 17Add BLAST30
Repeati617 – 646ANK 18Add BLAST30
Repeati651 – 680ANK 19Add BLAST30
Repeati687 – 716ANK 20Add BLAST30
Repeati720 – 749ANK 21Add BLAST30
Repeati753 – 782ANK 22Add BLAST30
Repeati790 – 819ANK 23Add BLAST30
Repeati822 – 852ANK 24Add BLAST31
Repeati857 – 886ANK 25Add BLAST30
Repeati890 – 920ANK 26Add BLAST31
Repeati924 – 953ANK 27Add BLAST30
Repeati960 – 989ANK 28Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000033959
HOVERGENiHBG067697
InParanoidiQ8NB46
KOiK15504
OMAiHEDCLEV
OrthoDBiEOG091G02S4
PhylomeDBiQ8NB46
TreeFamiTF312824

Family and domain databases

CDDicd00204 ANK, 8 hits
Gene3Di1.25.40.20, 9 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 28 hits
SUPFAMiSSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits

Sequencei

Sequence statusi: Complete.

Q8NB46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY
60 70 80 90 100
VGDVPILQLL LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV
110 120 130 140 150
NARDKLWQTP LHVAAANRAT KCAEALAPLL SSLNVADRSG RSALHHAVHS
160 170 180 190 200
GHLETVNLLL NKGASLNVCD KKERQPLHWA AFLGHLEVLK LLVARGADLG
210 220 230 240 250
CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN TALHIACYLG
260 270 280 290 300
QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
310 320 330 340 350
YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG
360 370 380 390 400
HELLISTLMT NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI
410 420 430 440 450
VSSLSNEHVL SAGFDINTPD NLGRTCLHAA ASGGNVECLN LLLSSGADLR
460 470 480 490 500
RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA GVNEADCKGC SPLHYAAASD
510 520 530 540 550
TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG ADPSLRDRQG
560 570 580 590 600
YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA
610 620 630 640 650
LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK
660 670 680 690 700
RKWTPLHAAA ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH
710 720 730 740 750
VDCVHLLLEK GSTADAADLR GRTALHRGAV TGCEDCLAAL LDHDAFVLCR
760 770 780 790 800
DFKGRTPIHL ASACGHTAVL RTLLQAALST DPLDAGVDYS GYSPMHWASY
810 820 830 840 850
TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE MLLGALGAKI
860 870 880 890 900
VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
910 920 930 940 950
NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD
960 970 980 990 1000
LGLINATNSA LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA
1010 1020 1030 1040 1050
CAPNKDVADC LALILSTMKP FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG
1060 1070
ALPHGASCPY SQERPGAIGL DGCYSE
Length:1,076
Mass (Da):115,077
Last modified:May 18, 2010 - v3
Checksum:i8CEE6E151956EAFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti686A → V in AK091555 (PubMed:14702039).Curated1
Sequence conflicti856A → T in AK091555 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190990 mRNA Translation: BAG16262.1
AC073896 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96919.1
AK091555 mRNA No translation available.
CCDSiCCDS44920.1
RefSeqiNP_775866.2, NM_173595.3
UniGeneiHs.524506

Genome annotation databases

EnsembliENST00000267116; ENSP00000267116; ENSG00000139645
GeneIDi283373
KEGGihsa:283373
UCSCiuc001skm.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190990 mRNA Translation: BAG16262.1
AC073896 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96919.1
AK091555 mRNA No translation available.
CCDSiCCDS44920.1
RefSeqiNP_775866.2, NM_173595.3
UniGeneiHs.524506

3D structure databases

ProteinModelPortaliQ8NB46
SMRiQ8NB46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129540, 44 interactors
IntActiQ8NB46, 19 interactors
MINTiQ8NB46
STRINGi9606.ENSP00000267116

PTM databases

iPTMnetiQ8NB46
PhosphoSitePlusiQ8NB46

Polymorphism and mutation databases

BioMutaiANKRD52
DMDMi296439443

Proteomic databases

EPDiQ8NB46
MaxQBiQ8NB46
PaxDbiQ8NB46
PeptideAtlasiQ8NB46
PRIDEiQ8NB46
ProteomicsDBi72730

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267116; ENSP00000267116; ENSG00000139645
GeneIDi283373
KEGGihsa:283373
UCSCiuc001skm.5 human

Organism-specific databases

CTDi283373
EuPathDBiHostDB:ENSG00000139645.9
GeneCardsiANKRD52
H-InvDBiHIX0010731
HGNCiHGNC:26614 ANKRD52
HPAiHPA043815
neXtProtiNX_Q8NB46
OpenTargetsiENSG00000139645
PharmGKBiPA143485302
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00840000129677
HOGENOMiHOG000033959
HOVERGENiHBG067697
InParanoidiQ8NB46
KOiK15504
OMAiHEDCLEV
OrthoDBiEOG091G02S4
PhylomeDBiQ8NB46
TreeFamiTF312824

Miscellaneous databases

ChiTaRSiANKRD52 human
GenomeRNAii283373
PROiPR:Q8NB46

Gene expression databases

BgeeiENSG00000139645 Expressed in 150 organ(s), highest expression level in left adrenal gland
CleanExiHS_ANKRD52
GenevisibleiQ8NB46 HS

Family and domain databases

CDDicd00204 ANK, 8 hits
Gene3Di1.25.40.20, 9 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 9 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 28 hits
SUPFAMiSSF48403 SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 21 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR52_HUMAN
AccessioniPrimary (citable) accession number: Q8NB46
Secondary accession number(s): A6NE79, B1Q2K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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