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Entry version 136 (16 Oct 2019)
Sequence version 3 (14 Oct 2008)
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Protein

Protein FAM184A

Gene

FAM184A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM184A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM184A
Synonyms:C6orf60
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20991 FAM184A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NB25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
79632

Open Targets

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OpenTargetsi
ENSG00000111879

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719768

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NB25

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM184A

Domain mapping of disease mutations (DMDM)

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DMDMi
209572754

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895121 – 1140Protein FAM184AAdd BLAST1140

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NB25

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NB25

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NB25

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NB25

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NB25

PeptideAtlas

More...
PeptideAtlasi
Q8NB25

PRoteomics IDEntifications database

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PRIDEi
Q8NB25

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
30129
72720 [Q8NB25-1]
72721 [Q8NB25-2]
72722 [Q8NB25-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NB25

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NB25

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q8NB25

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000111879 Expressed in 169 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NB25 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NB25 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034571
HPA034572
HPA041955

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122762, 16 interactors

Protein interaction database and analysis system

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IntActi
Q8NB25, 16 interactors

Molecular INTeraction database

More...
MINTi
Q8NB25

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342604

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NB25

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili57 – 256Sequence analysisAdd BLAST200
Coiled coili296 – 800Sequence analysisAdd BLAST505
Coiled coili868 – 907Sequence analysisAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM184 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFYF Eukaryota
ENOG410ZNZK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090031

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NB25

Identification of Orthologs from Complete Genome Data

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OMAi
SLQEAHI

Database of Orthologous Groups

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OrthoDBi
170922at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NB25

TreeFam database of animal gene trees

More...
TreeFami
TF316006

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029605 FAM184
IPR029607 FAM184A
IPR039478 FAM184A/B_N

The PANTHER Classification System

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PANTHERi
PTHR18870 PTHR18870, 1 hit
PTHR18870:SF7 PTHR18870:SF7, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15665 FAM184, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NB25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ
60 70 80 90 100
LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE
110 120 130 140 150
ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR
160 170 180 190 200
IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE
210 220 230 240 250
LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG
260 270 280 290 300
KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
310 320 330 340 350
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG
360 370 380 390 400
EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI
410 420 430 440 450
KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK
460 470 480 490 500
RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN
510 520 530 540 550
AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ
560 570 580 590 600
EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
610 620 630 640 650
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS
660 670 680 690 700
KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL
710 720 730 740 750
KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA
760 770 780 790 800
HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME
810 820 830 840 850
QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME
860 870 880 890 900
LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
910 920 930 940 950
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI
960 970 980 990 1000
MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML
1010 1020 1030 1040 1050
TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK
1060 1070 1080 1090 1100
NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL
1110 1120 1130 1140
PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF
Note: No experimental confirmation available.
Length:1,140
Mass (Da):132,965
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6565FD0C349B37E1
GO
Isoform 2 (identifier: Q8NB25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     924-972: Missing.
     1012-1046: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):123,198
Checksum:iFE34CBA8D03122B3
GO
Isoform 3 (identifier: Q8NB25-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1116: SPA → RYQ
     1117-1140: Missing.

Show »
Length:1,116
Mass (Da):130,330
Checksum:i10F25BC6E913E5C9
GO
Isoform 4 (identifier: Q8NB25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     924-972: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):113,569
Checksum:i41A5C04C5F22A3CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY63H7BY63_HUMAN
Protein FAM184A
FAM184A
936Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBA5H0YBA5_HUMAN
Protein FAM184A
FAM184A
996Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X2A7A0A087X2A7_HUMAN
Protein FAM184A
FAM184A
1,098Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBC0H0YBC0_HUMAN
Protein FAM184A
FAM184A
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBE3H0YBE3_HUMAN
Protein FAM184A
FAM184A
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBZ6H0YBZ6_HUMAN
Protein FAM184A
FAM184A
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGZ2A0A0C4DGZ2_HUMAN
Protein FAM184A
FAM184A
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQ67E7EQ67_HUMAN
Protein FAM184A
FAM184A
529Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y672H0Y672_HUMAN
Protein FAM184A
FAM184A
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9DI78B9DI78_HUMAN
Protein FAM184A
FAM184A
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14769 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC03719 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti546N → D in CAD98058 (PubMed:17974005).Curated1
Sequence conflicti620Missing in BAC03719 (PubMed:14702039).Curated1
Sequence conflicti739Q → R in BAC03719 (PubMed:14702039).Curated1
Sequence conflicti795F → L in CAD98058 (PubMed:17974005).Curated1
Sequence conflicti882H → R in CAD98058 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054101174Q → H. Corresponds to variant dbSNP:rs34681930Ensembl.1
Natural variantiVAR_054102177V → G. Corresponds to variant dbSNP:rs34977570Ensembl.1
Natural variantiVAR_054103599D → N. Corresponds to variant dbSNP:rs17827619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0445201 – 120Missing in isoform 4. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_007446924 – 972Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0074471012 – 1046Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0391021114 – 1116SPA → RYQ in isoform 3. 1 Publication3
Alternative sequenceiVSP_0391031117 – 1140Missing in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX538186 mRNA Translation: CAD98058.1
AL132874 Genomic DNA No translation available.
AL137009 Genomic DNA No translation available.
AL365275 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48188.1
AK024004 mRNA Translation: BAB14769.1 Different initiation.
AK091682 mRNA Translation: BAC03719.1 Different initiation.
BC009055 mRNA Translation: AAH09055.2
AL136767 mRNA Translation: CAB66701.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43499.1 [Q8NB25-1]
CCDS43500.1 [Q8NB25-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001093881.1, NM_001100411.2 [Q8NB25-4]
NP_001275505.1, NM_001288576.1
NP_078857.5, NM_024581.5 [Q8NB25-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338891; ENSP00000342604; ENSG00000111879 [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879 [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879 [Q8NB25-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79632

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79632

UCSC genome browser

More...
UCSCi
uc003pyj.5 human [Q8NB25-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538186 mRNA Translation: CAD98058.1
AL132874 Genomic DNA No translation available.
AL137009 Genomic DNA No translation available.
AL365275 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48188.1
AK024004 mRNA Translation: BAB14769.1 Different initiation.
AK091682 mRNA Translation: BAC03719.1 Different initiation.
BC009055 mRNA Translation: AAH09055.2
AL136767 mRNA Translation: CAB66701.1
CCDSiCCDS43499.1 [Q8NB25-1]
CCDS43500.1 [Q8NB25-4]
RefSeqiNP_001093881.1, NM_001100411.2 [Q8NB25-4]
NP_001275505.1, NM_001288576.1
NP_078857.5, NM_024581.5 [Q8NB25-1]

3D structure databases

SMRiQ8NB25
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122762, 16 interactors
IntActiQ8NB25, 16 interactors
MINTiQ8NB25
STRINGi9606.ENSP00000342604

PTM databases

iPTMnetiQ8NB25
PhosphoSitePlusiQ8NB25
SwissPalmiQ8NB25

Polymorphism and mutation databases

BioMutaiFAM184A
DMDMi209572754

Proteomic databases

EPDiQ8NB25
jPOSTiQ8NB25
MassIVEiQ8NB25
MaxQBiQ8NB25
PaxDbiQ8NB25
PeptideAtlasiQ8NB25
PRIDEiQ8NB25
ProteomicsDBi30129
72720 [Q8NB25-1]
72721 [Q8NB25-2]
72722 [Q8NB25-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79632

Genome annotation databases

EnsembliENST00000338891; ENSP00000342604; ENSG00000111879 [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879 [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879 [Q8NB25-2]
GeneIDi79632
KEGGihsa:79632
UCSCiuc003pyj.5 human [Q8NB25-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79632
DisGeNETi79632

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM184A
HGNCiHGNC:20991 FAM184A
HPAiHPA034571
HPA034572
HPA041955
neXtProtiNX_Q8NB25
OpenTargetsiENSG00000111879
PharmGKBiPA164719768

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFYF Eukaryota
ENOG410ZNZK LUCA
GeneTreeiENSGT00530000063669
HOGENOMiHOG000090031
InParanoidiQ8NB25
OMAiSLQEAHI
OrthoDBi170922at2759
PhylomeDBiQ8NB25
TreeFamiTF316006

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM184A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79632
PharosiQ8NB25

Protein Ontology

More...
PROi
PR:Q8NB25

Gene expression databases

BgeeiENSG00000111879 Expressed in 169 organ(s), highest expression level in lung
ExpressionAtlasiQ8NB25 baseline and differential
GenevisibleiQ8NB25 HS

Family and domain databases

InterProiView protein in InterPro
IPR029605 FAM184
IPR029607 FAM184A
IPR039478 FAM184A/B_N
PANTHERiPTHR18870 PTHR18870, 1 hit
PTHR18870:SF7 PTHR18870:SF7, 1 hit
PfamiView protein in Pfam
PF15665 FAM184, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF184A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NB25
Secondary accession number(s): B9DI75
, F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 14, 2008
Last modified: October 16, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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