UniProtKB - Q8NB16 (MLKL_HUMAN)
Mixed lineage kinase domain-like protein
MLKL
Functioni
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).
Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).
Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671).
In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity).
Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
By similarity5 PublicationsMiscellaneous
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 86 | Target of necrosulfonamide inhibitor1 Publication | 1 | |
Binding sitei | 230 | ATPCurated | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 209 – 217 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- identical protein binding Source: IntAct
- JUN kinase kinase kinase activity Source: GO_Central
- protein-containing complex binding Source: UniProtKB
- protein kinase activity Source: GO_Central
- protein kinase binding Source: Ensembl
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
- defense response to virus Source: UniProtKB
- execution phase of necroptosis Source: UniProtKB
- necroptotic process Source: UniProtKB
- necroptotic signaling pathway Source: UniProtKB
- protein homotrimerization Source: UniProtKB
Keywordsi
Biological process | Necrosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8NB16 |
Reactomei | R-HSA-3295583, TRP channels R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-9686347, Microbial modulation of RIPK1-mediated regulated necrosis |
SignaLinki | Q8NB16 |
SIGNORi | Q8NB16 |
Protein family/group databases
TCDBi | 1.A.105.1.1, the mixed lineage kinase domain-like (mlkl) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mixed lineage kinase domain-like proteinCuratedShort name: hMLKL1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26617, MLKL |
MIMi | 615153, gene |
neXtProti | NX_Q8NB16 |
VEuPathDBi | HostDB:ENSG00000168404 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity).By similarity1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: HPA
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 58 | L → G: Does not affect formation of homotrimers, while translocation to the plasma membrane on necroptosis induction is impaired; when associated with G-76. 1 Publication | 1 | |
Mutagenesisi | 76 | I → G: Does not affect formation of homotrimers, while translocation to the plasma membrane on necroptosis induction is impaired; when associated with G-58. 1 Publication | 1 | |
Mutagenesisi | 86 | C → S: Abolishes binding to necrosulfonamide inhibitor. 1 Publication | 1 | |
Mutagenesisi | 162 | L → G: Impairs formation of homotrimers and translocation to the plasma membrane on necroptosis induction; when associated with G-165. 1 Publication | 1 | |
Mutagenesisi | 165 | L → G: Impairs formation of homotrimers and translocation to the plasma membrane on necroptosis induction; when associated with G-162. 1 Publication | 1 | |
Mutagenesisi | 230 | K → M: Abolishes ATP-binding. 1 Publication | 1 | |
Mutagenesisi | 331 | K → N: Impairs ATP-binding. 1 Publication | 1 | |
Mutagenesisi | 351 | E → K: Binds ATP with an enhanced affinity. 1 Publication | 1 | |
Mutagenesisi | 357 – 358 | TS → ED: Mimics phosphorylation state; acts as a dominant-negative mutant that impairs necroptosis. | 2 | |
Mutagenesisi | 357 | T → A: No effect. Abolishes ability to mediate necroptosis; when associated with A-358. 1 Publication | 1 | |
Mutagenesisi | 358 | S → A: No effect. Abolishes ability to mediate necroptosis; when associated with A-357. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 197259 |
OpenTargetsi | ENSG00000168404 |
PharmGKBi | PA142671349 |
Miscellaneous databases
Pharosi | Q8NB16, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1938217 |
GuidetoPHARMACOLOGYi | 2106 |
Genetic variation databases
BioMutai | MLKL |
DMDMi | 74762545 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248239 | 1 – 471 | Mixed lineage kinase domain-like proteinAdd BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 357 | Phosphothreonine; by RIPK31 Publication | 1 | |
Modified residuei | 358 | Phosphoserine; by RIPK32 Publications | 1 | |
Modified residuei | 360 | Phosphoserine; by RIPK3By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-895 CPTAC-896 |
EPDi | Q8NB16 |
jPOSTi | Q8NB16 |
MassIVEi | Q8NB16 |
MaxQBi | Q8NB16 |
PaxDbi | Q8NB16 |
PeptideAtlasi | Q8NB16 |
PRIDEi | Q8NB16 |
ProteomicsDBi | 72718 [Q8NB16-1] 72719 [Q8NB16-2] |
PTM databases
GlyGeni | Q8NB16, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q8NB16 |
PhosphoSitePlusi | Q8NB16 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168404, Expressed in granulocyte and 201 other tissues |
ExpressionAtlasi | Q8NB16, baseline and differential |
Genevisiblei | Q8NB16, HS |
Organism-specific databases
HPAi | ENSG00000168404, Low tissue specificity |
Interactioni
Subunit structurei
Homooligomer (PubMed:29883610). Homotrimer; forms homotrimers on necroptosis induction (PubMed:24316671). Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3 (PubMed:22265414). Within this complex, may play a role in the proper targeting of RIPK1-RIPK3 to its downstream effector PGAM5 (PubMed:22265414).
Interacts with RIPK3; the interaction is direct and promotes its phosphorylation and subsequent activation (PubMed:22265413, PubMed:22421439, PubMed:29883609).
6 PublicationsBinary interactionsi
Q8NB16
With | #Exp. | IntAct |
---|---|---|
RIPK3 [Q9Y572] | 10 | EBI-1055040,EBI-298250 |
MLKL - isoform 1 [Q8NB16-1]
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-16084674,EBI-16084674 |
Isoform 2 [Q8NB16-2]
With | #Exp. | IntAct |
---|---|---|
PSMB1 [P20618] | 3 | EBI-19046912,EBI-372273 |
S100A10 [P60903] | 3 | EBI-19046912,EBI-717048 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 128244, 32 interactors |
DIPi | DIP-41782N |
IntActi | Q8NB16, 21 interactors |
MINTi | Q8NB16 |
STRINGi | 9606.ENSP00000308351 |
Chemistry databases
BindingDBi | Q8NB16 |
Miscellaneous databases
RNActi | Q8NB16, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q8NB16 |
BMRBi | Q8NB16 |
SMRi | Q8NB16 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 194 – 469 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 276 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 149 | N-terminal bundle and brace (NBB); mediates INSP6 binding1 PublicationAdd BLAST | 149 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 55 – 84 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 139 – 180 | Sequence analysisAdd BLAST | 42 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00390000016453 |
HOGENOMi | CLU_044216_0_0_1 |
InParanoidi | Q8NB16 |
OMAi | ESKVDWM |
OrthoDBi | 1388260at2759 |
PhylomeDBi | Q8NB16 |
TreeFami | TF328453 |
Family and domain databases
Gene3Di | 1.20.930.20, 1 hit |
InterProi | View protein in InterPro IPR036537, Adaptor_Cbl_N_dom_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK
60 70 80 90 100
RSVPSEKLTT AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD
110 120 130 140 150
VNRKLSDVWK ELSLLLQVEQ RMPVSPISQG ASWAQEDQQD ADEDRRAFQM
160 170 180 190 200
LRRDNEKIEA SLRRLEINMK EIKETLRQYL PPKCMQEIPQ EQIKEIKKEQ
210 220 230 240 250
LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI AIVRQTFNKE
260 270 280 290 300
IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD
310 320 330 340 350
LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF
360 370 380 390 400
ELRKTQTSMS LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI
410 420 430 440 450
VLWEIATGDI PFQGCNSEKI RKLVAVKRQQ EPLGEDCPSE LREIIDECRA
460 470
HDPSVRPSVD EILKKLSTFS K
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L2T9 | I3L2T9_HUMAN | Mixed lineage kinase domain-like pr... | MLKL | 211 | Annotation score: | ||
I3L4Z5 | I3L4Z5_HUMAN | Mixed lineage kinase domain-like pr... | MLKL | 62 | Annotation score: | ||
I3L4A6 | I3L4A6_HUMAN | Mixed lineage kinase domain-like pr... | MLKL | 175 | Annotation score: | ||
I3L2U3 | I3L2U3_HUMAN | Mixed lineage kinase domain-like pr... | MLKL | 102 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041350 | 52 | S → T1 PublicationCorresponds to variant dbSNP:rs34251827Ensembl. | 1 | |
Natural variantiVAR_041351 | 100 | D → E1 PublicationCorresponds to variant dbSNP:rs33987771EnsemblClinVar. | 1 | |
Natural variantiVAR_041352 | 132 | S → P1 PublicationCorresponds to variant dbSNP:rs35589326EnsemblClinVar. | 1 | |
Natural variantiVAR_041353 | 146 | R → Q1 PublicationCorresponds to variant dbSNP:rs34515646EnsemblClinVar. | 1 | |
Natural variantiVAR_041354 | 169 | M → L1 PublicationCorresponds to variant dbSNP:rs55929310Ensembl. | 1 | |
Natural variantiVAR_041355 | 291 | L → P in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1313508921Ensembl. | 1 | |
Natural variantiVAR_041356 | 364 | T → M1 PublicationCorresponds to variant dbSNP:rs34389205Ensembl. | 1 | |
Natural variantiVAR_041357 | 398 | F → I in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041358 | 421 | R → H1 PublicationCorresponds to variant dbSNP:rs55987292Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052133 | 179 – 205 | YLPPK…LSGSP → SLESSSGKSPLEISRFKVKN VKTGSAS in isoform 2. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_052134 | 206 – 413 | Missing in isoform 2. 1 PublicationAdd BLAST | 208 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091708 mRNA Translation: BAC03728.1 AC109599 Genomic DNA No translation available. BC028141 mRNA Translation: AAH28141.1 |
CCDSi | CCDS32487.1 [Q8NB16-1] CCDS45528.1 [Q8NB16-2] |
RefSeqi | NP_001135969.1, NM_001142497.2 [Q8NB16-2] NP_689862.1, NM_152649.3 [Q8NB16-1] XP_005255891.1, XM_005255834.3 [Q8NB16-1] |
Genome annotation databases
Ensembli | ENST00000306247.11; ENSP00000303118.7; ENSG00000168404.13 [Q8NB16-2] ENST00000308807.12; ENSP00000308351.7; ENSG00000168404.13 |
GeneIDi | 197259 |
KEGGi | hsa:197259 |
MANE-Selecti | ENST00000308807.12; ENSP00000308351.7; NM_152649.4; NP_689862.1 |
UCSCi | uc002fdb.3, human [Q8NB16-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091708 mRNA Translation: BAC03728.1 AC109599 Genomic DNA No translation available. BC028141 mRNA Translation: AAH28141.1 |
CCDSi | CCDS32487.1 [Q8NB16-1] CCDS45528.1 [Q8NB16-2] |
RefSeqi | NP_001135969.1, NM_001142497.2 [Q8NB16-2] NP_689862.1, NM_152649.3 [Q8NB16-1] XP_005255891.1, XM_005255834.3 [Q8NB16-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MSV | NMR | - | A | 1-154 | [»] | |
4M67 | X-ray | 1.90 | A | 179-471 | [»] | |
4MWI | X-ray | 1.70 | A | 183-471 | [»] | |
5KNJ | X-ray | 2.88 | A/B | 191-471 | [»] | |
5KO1 | X-ray | 2.16 | A | 191-471 | [»] | |
6BWK | X-ray | 2.79 | A | 190-471 | [»] | |
6D74 | NMR | - | A | 1-156 | [»] | |
6LK5 | X-ray | 2.50 | A | 1-471 | [»] | |
6LK6 | X-ray | 2.41 | A | 179-471 | [»] | |
6O5Z | X-ray | 2.29 | A/B | 190-471 | [»] | |
6UX8 | X-ray | 2.50 | A | 5-154 | [»] | |
6ZLE | NMR | - | A | 2-154 | [»] | |
6ZPR | NMR | - | A | 2-154 | [»] | |
6ZVO | X-ray | 1.37 | A/B/C | 2-150 | [»] | |
6ZZ1 | X-ray | 1.64 | A/B | 2-150 | [»] | |
7JW7 | X-ray | 2.63 | A | 190-471 | [»] | |
7JXU | X-ray | 2.44 | A/B | 190-471 | [»] | |
7MON | X-ray | 2.23 | A | 190-471 | [»] | |
7NM2 | NMR | - | A | 2-154 | [»] | |
7NM4 | NMR | - | A | 2-154 | [»] | |
7NM5 | NMR | - | A | 2-154 | [»] | |
AlphaFoldDBi | Q8NB16 | |||||
BMRBi | Q8NB16 | |||||
SMRi | Q8NB16 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128244, 32 interactors |
DIPi | DIP-41782N |
IntActi | Q8NB16, 21 interactors |
MINTi | Q8NB16 |
STRINGi | 9606.ENSP00000308351 |
Chemistry databases
BindingDBi | Q8NB16 |
ChEMBLi | CHEMBL1938217 |
GuidetoPHARMACOLOGYi | 2106 |
Protein family/group databases
TCDBi | 1.A.105.1.1, the mixed lineage kinase domain-like (mlkl) family |
PTM databases
GlyGeni | Q8NB16, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q8NB16 |
PhosphoSitePlusi | Q8NB16 |
Genetic variation databases
BioMutai | MLKL |
DMDMi | 74762545 |
Proteomic databases
CPTACi | CPTAC-895 CPTAC-896 |
EPDi | Q8NB16 |
jPOSTi | Q8NB16 |
MassIVEi | Q8NB16 |
MaxQBi | Q8NB16 |
PaxDbi | Q8NB16 |
PeptideAtlasi | Q8NB16 |
PRIDEi | Q8NB16 |
ProteomicsDBi | 72718 [Q8NB16-1] 72719 [Q8NB16-2] |
Protocols and materials databases
Antibodypediai | 2097, 353 antibodies from 38 providers |
DNASUi | 197259 |
Genome annotation databases
Ensembli | ENST00000306247.11; ENSP00000303118.7; ENSG00000168404.13 [Q8NB16-2] ENST00000308807.12; ENSP00000308351.7; ENSG00000168404.13 |
GeneIDi | 197259 |
KEGGi | hsa:197259 |
MANE-Selecti | ENST00000308807.12; ENSP00000308351.7; NM_152649.4; NP_689862.1 |
UCSCi | uc002fdb.3, human [Q8NB16-1] |
Organism-specific databases
CTDi | 197259 |
DisGeNETi | 197259 |
GeneCardsi | MLKL |
HGNCi | HGNC:26617, MLKL |
HPAi | ENSG00000168404, Low tissue specificity |
MIMi | 615153, gene |
neXtProti | NX_Q8NB16 |
OpenTargetsi | ENSG00000168404 |
PharmGKBi | PA142671349 |
VEuPathDBi | HostDB:ENSG00000168404 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00390000016453 |
HOGENOMi | CLU_044216_0_0_1 |
InParanoidi | Q8NB16 |
OMAi | ESKVDWM |
OrthoDBi | 1388260at2759 |
PhylomeDBi | Q8NB16 |
TreeFami | TF328453 |
Enzyme and pathway databases
PathwayCommonsi | Q8NB16 |
Reactomei | R-HSA-3295583, TRP channels R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-9686347, Microbial modulation of RIPK1-mediated regulated necrosis |
SignaLinki | Q8NB16 |
SIGNORi | Q8NB16 |
Miscellaneous databases
BioGRID-ORCSi | 197259, 15 hits in 1114 CRISPR screens |
ChiTaRSi | MLKL, human |
GenomeRNAii | 197259 |
Pharosi | Q8NB16, Tchem |
PROi | PR:Q8NB16 |
RNActi | Q8NB16, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168404, Expressed in granulocyte and 201 other tissues |
ExpressionAtlasi | Q8NB16, baseline and differential |
Genevisiblei | Q8NB16, HS |
Family and domain databases
Gene3Di | 1.20.930.20, 1 hit |
InterProi | View protein in InterPro IPR036537, Adaptor_Cbl_N_dom_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MLKL_HUMAN | |
Accessioni | Q8NB16Primary (citable) accession number: Q8NB16 Secondary accession number(s): A6NCE4, Q8N6V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families