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UniProtKB - Q8NB15 (ZN511_HUMAN)
Protein
Zinc finger protein 511
Gene
ZNF511
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 105 | C2H2-type 1Add BLAST | 26 | |
Zinc fingeri | 107 – 130 | C2H2-type 2Add BLAST | 24 | |
Zinc fingeri | 144 – 169 | C2H2-type 3Add BLAST | 26 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NB15 |
SignaLinki | Q8NB15 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 511Curated |
Gene namesi | Name:ZNF511Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28445, ZNF511 |
neXtProti | NX_Q8NB15 |
VEuPathDBi | HostDB:ENSG00000198546 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198546 |
PharmGKBi | PA134940031 |
Miscellaneous databases
Pharosi | Q8NB15, Tdark |
Genetic variation databases
BioMutai | ZNF511 |
DMDMi | 74760090 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047629 | 1 – 252 | Zinc finger protein 511Add BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 240 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
EPDi | Q8NB15 |
jPOSTi | Q8NB15 |
MassIVEi | Q8NB15 |
MaxQBi | Q8NB15 |
PaxDbi | Q8NB15 |
PeptideAtlasi | Q8NB15 |
PRIDEi | Q8NB15 |
ProteomicsDBi | 72716 [Q8NB15-1] 72717 [Q8NB15-2] |
PTM databases
iPTMneti | Q8NB15 |
PhosphoSitePlusi | Q8NB15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198546, Expressed in skeletal muscle tissue and 217 other tissues |
Genevisiblei | Q8NB15, HS |
Organism-specific databases
HPAi | ENSG00000198546, Low tissue specificity |
Interactioni
Binary interactionsi
Q8NB15
Protein-protein interaction databases
BioGRIDi | 125611, 40 interactors |
IntActi | Q8NB15, 26 interactors |
STRINGi | 9606.ENSP00000355251 |
Miscellaneous databases
RNActi | Q8NB15, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8NB15 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 177 – 221 | DisorderedSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 105 | C2H2-type 1Add BLAST | 26 | |
Zinc fingeri | 107 – 130 | C2H2-type 2Add BLAST | 24 | |
Zinc fingeri | 144 – 169 | C2H2-type 3Add BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4173, Eukaryota |
GeneTreei | ENSGT00390000011381 |
HOGENOMi | CLU_092647_0_0_1 |
InParanoidi | Q8NB15 |
OMAi | CHISGCR |
OrthoDBi | 1360267at2759 |
PhylomeDBi | Q8NB15 |
TreeFami | TF323277 |
Family and domain databases
InterProi | View protein in InterPro IPR039258, ZNF511 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21354, PTHR21354, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 2 (identifier: Q8NB15-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQLPPALCAR LAAGPGAAEP LPVERDPAAG AAPFRFVARP VRFPREHQFF
60 70 80 90 100
EDGDVQRHLY LQDVIMQVAD VPEKPRVPAF ACQVAGCCQV FDALDDYEHH
110 120 130 140 150
YHTLHGNVCS FCKRAFPSGH LLDAHILEWH DSLFQILSER QDMYQCLVEG
160 170 180 190 200
CTEKFKTSRD RKDHMVRMHL YPADFRFDKP KKSRSPASAE APGDSGERSE
210 220 230 240 250
GEAMEICSEP VAASPAPAGE RRIYRHRIPS TICFGQGAAR GFKSNKKKTK
QC
Sequence cautioni
The sequence AAH15139 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059997 | 228 – 252 | IPSTI…KTKQC → SVSELFLKPVLNMCSVLRIL GCTWAAALLILNSER in isoform 1. Add BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091711 mRNA Translation: BAC03729.1 AK292380 mRNA Translation: BAF85069.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61333.1 BC015139 mRNA Translation: AAH15139.1 Different initiation. BC019897 mRNA Translation: AAH19897.1 |
CCDSi | CCDS7677.1 [Q8NB15-2] |
RefSeqi | NP_665805.2, NM_145806.3 [Q8NB15-2] |
Genome annotation databases
Ensembli | ENST00000359035.4; ENSP00000351929.3; ENSG00000198546.15 [Q8NB15-1] ENST00000361518.10; ENSP00000355251.5; ENSG00000198546.15 |
GeneIDi | 118472 |
KEGGi | hsa:118472 |
MANE-Selecti | ENST00000361518.10; ENSP00000355251.5; NM_145806.4; NP_665805.2 |
UCSCi | uc001lmj.2, human [Q8NB15-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091711 mRNA Translation: BAC03729.1 AK292380 mRNA Translation: BAF85069.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61333.1 BC015139 mRNA Translation: AAH15139.1 Different initiation. BC019897 mRNA Translation: AAH19897.1 |
CCDSi | CCDS7677.1 [Q8NB15-2] |
RefSeqi | NP_665805.2, NM_145806.3 [Q8NB15-2] |
3D structure databases
AlphaFoldDBi | Q8NB15 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 125611, 40 interactors |
IntActi | Q8NB15, 26 interactors |
STRINGi | 9606.ENSP00000355251 |
PTM databases
iPTMneti | Q8NB15 |
PhosphoSitePlusi | Q8NB15 |
Genetic variation databases
BioMutai | ZNF511 |
DMDMi | 74760090 |
Proteomic databases
EPDi | Q8NB15 |
jPOSTi | Q8NB15 |
MassIVEi | Q8NB15 |
MaxQBi | Q8NB15 |
PaxDbi | Q8NB15 |
PeptideAtlasi | Q8NB15 |
PRIDEi | Q8NB15 |
ProteomicsDBi | 72716 [Q8NB15-1] 72717 [Q8NB15-2] |
Protocols and materials databases
Antibodypediai | 32647, 64 antibodies from 16 providers |
DNASUi | 118472 |
Genome annotation databases
Ensembli | ENST00000359035.4; ENSP00000351929.3; ENSG00000198546.15 [Q8NB15-1] ENST00000361518.10; ENSP00000355251.5; ENSG00000198546.15 |
GeneIDi | 118472 |
KEGGi | hsa:118472 |
MANE-Selecti | ENST00000361518.10; ENSP00000355251.5; NM_145806.4; NP_665805.2 |
UCSCi | uc001lmj.2, human [Q8NB15-2] |
Organism-specific databases
CTDi | 118472 |
GeneCardsi | ZNF511 |
HGNCi | HGNC:28445, ZNF511 |
HPAi | ENSG00000198546, Low tissue specificity |
neXtProti | NX_Q8NB15 |
OpenTargetsi | ENSG00000198546 |
PharmGKBi | PA134940031 |
VEuPathDBi | HostDB:ENSG00000198546 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4173, Eukaryota |
GeneTreei | ENSGT00390000011381 |
HOGENOMi | CLU_092647_0_0_1 |
InParanoidi | Q8NB15 |
OMAi | CHISGCR |
OrthoDBi | 1360267at2759 |
PhylomeDBi | Q8NB15 |
TreeFami | TF323277 |
Enzyme and pathway databases
PathwayCommonsi | Q8NB15 |
SignaLinki | Q8NB15 |
Miscellaneous databases
BioGRID-ORCSi | 118472, 108 hits in 1084 CRISPR screens |
ChiTaRSi | ZNF511, human |
GenomeRNAii | 118472 |
Pharosi | Q8NB15, Tdark |
PROi | PR:Q8NB15 |
RNActi | Q8NB15, protein |
Gene expression databases
Bgeei | ENSG00000198546, Expressed in skeletal muscle tissue and 217 other tissues |
Genevisiblei | Q8NB15, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039258, ZNF511 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21354, PTHR21354, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN511_HUMAN | |
Accessioni | Q8NB15Primary (citable) accession number: Q8NB15 Secondary accession number(s): A8K8L5, Q8WUP1, Q96BV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | January 16, 2019 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families