ZNF511

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	80 – 105	C2H2-type 1Add BLAST	26
Zinc fingerⁱ	107 – 130	C2H2-type 2Add BLAST	24
Zinc fingerⁱ	144 – 169	C2H2-type 3Add BLAST	26

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 511
Gene namesⁱ	Name:ZNF511
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198546.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28445 ZNF511
neXtProtⁱ	NX_Q8NB15

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198546
PharmGKBⁱ	PA134940031

Polymorphism and mutation databases

BioMutaⁱ	ZNF511
DMDMⁱ	74760090

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047629	1 – 262	Zinc finger protein 511Add BLAST		262

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 2 (identifier: Q8NB15-2)
Modified residueⁱ	240	Omega-N-methylarginineCombined sources		1

Keywords - PTMⁱ

Methylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NB15
PaxDbⁱ	Q8NB15
PeptideAtlas More...PeptideAtlasⁱ	Q8NB15
PRIDEⁱ	Q8NB15
ProteomicsDBⁱ	72716 72717 [Q8NB15-2]

PTM databases

iPTMnetⁱ	Q8NB15
PhosphoSitePlusⁱ	Q8NB15

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198546 Expressed in 202 organ(s), highest expression level in liver
CleanExⁱ	HS_ZNF511
Genevisibleⁱ	Q8NB15 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035360

HPAⁱ

HPA035360

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ISL1	P61371	3	EBI-10269136,EBI-3906896
TMCO6	Q96DC7	4	EBI-12179871,EBI-746174

Protein-protein interaction databases

BioGridⁱ	125611, 23 interactors
IntActⁱ	Q8NB15, 15 interactors
STRINGⁱ	9606.ENSP00000355251

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NB15
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	80 – 105	C2H2-type 1Add BLAST	26
Zinc fingerⁱ	107 – 130	C2H2-type 2Add BLAST	24
Zinc fingerⁱ	144 – 169	C2H2-type 3Add BLAST	26

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4173 Eukaryota ENOG4111TX5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011381
HOGENOMⁱ	HOG000013167
HOVERGENⁱ	HBG094183
InParanoidⁱ	Q8NB15
OMAⁱ	RGFKSNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JFZ
PhylomeDBⁱ	Q8NB15
TreeFamⁱ	TF323277

Family and domain databases

InterProⁱ	View protein in InterPro IPR039258 ZNF511 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR21354 PTHR21354, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8NB15-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLPPALCAR LAAGPGAAEP LPVERDPAAG AAPFRFVARP VRFPREHQFF 
        60         70         80         90        100
EDGDVQRHLY LQDVIMQVAD VPEKPRVPAF ACQVAGCCQV FDALDDYEHH 
       110        120        130        140        150
YHTLHGNVCS FCKRAFPSGH LLDAHILEWH DSLFQILSER QDMYQCLVEG 
       160        170        180        190        200
CTEKFKTSRD RKDHMVRMHL YPADFRFDKP KKSRSPASAE APGDSGERSE 
       210        220        230        240        250
GEAMEICSEP VAASPAPAGE RRIYRHRSVS ELFLKPVLNM CSVLRILGCT 
       260 
WAAALLILNS ER

Length:262

Mass (Da):29,428

Last modified:October 1, 2002 - v1

Checksum:ⁱCDBA5CD0F34EC26D

GO

Isoform 2 (identifier: Q8NB15-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
228-262: SVSELFLKPVLNMCSVLRILGCTWAAALLILNSER → IPSTICFGQGAARGFKSNKKKTKQC

« Hide

        10         20         30         40         50
MQLPPALCAR LAAGPGAAEP LPVERDPAAG AAPFRFVARP VRFPREHQFF 
        60         70         80         90        100
EDGDVQRHLY LQDVIMQVAD VPEKPRVPAF ACQVAGCCQV FDALDDYEHH 
       110        120        130        140        150
YHTLHGNVCS FCKRAFPSGH LLDAHILEWH DSLFQILSER QDMYQCLVEG 
       160        170        180        190        200
CTEKFKTSRD RKDHMVRMHL YPADFRFDKP KKSRSPASAE APGDSGERSE 
       210        220        230        240        250
GEAMEICSEP VAASPAPAGE RRIYRHRIPS TICFGQGAAR GFKSNKKKTK 

QC

Show »

Length:252

Mass (Da):28,265

Checksum:ⁱ06EB73C722D8BA33

GO

Sequence cautionⁱ

The sequence AAH15139 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016035	228 – 262	SVSEL…LNSER → IPSTICFGQGAARGFKSNKK KTKQC in isoform 2. 1 PublicationAdd BLAST		35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091711 mRNA Translation: BAC03729.1 AK292380 mRNA Translation: BAF85069.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61333.1 BC015139 mRNA Translation: AAH15139.1 Different initiation. BC019897 mRNA Translation: AAH19897.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7677.1 [Q8NB15-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_665805.2, NM_145806.3 [Q8NB15-2]
UniGeneⁱ	Hs.422113

Genome annotation databases

Ensemblⁱ	ENST00000359035; ENSP00000351929; ENSG00000198546 [Q8NB15-1] ENST00000361518; ENSP00000355251; ENSG00000198546 [Q8NB15-2]
GeneIDⁱ	118472
KEGGⁱ	hsa:118472
UCSC genome browser More...UCSCⁱ	uc001lmj.2 human [Q8NB15-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NB15	Uncharacterized protein		MACNE		286	UniRef90_Q8NB15
Uncharacterized protein		NOMLE		262
Uncharacterized protein		RHIBE		262
Uncharacterized protein		PAPAN		262
Uncharacterized protein		RHIRO		262
+10
Q8NB15-2	ZNF511 isoform 1		PANTR		262	UniRef90_Q8NB15-2
Uncharacterized protein		GORGO		262
Uncharacterized protein		PANPA		245
ZNF511-PRAP1 readthrough		MANLE		211
ZNF511-PRAP1 readthrough		COLAP		211
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8NB15	Uncharacterized protein		MACNE		286	UniRef50_Q8NB15
Uncharacterized protein		RHIRO		262
Uncharacterized protein		CERAT		262
Uncharacterized protein		PAPAN		262
Uncharacterized protein		RHIBE		262
+29
Q8NB15-2	ZNF511 isoform 1		PANTR		262	UniRef50_Q8NB15-2
Uncharacterized protein		GORGO		262
Uncharacterized protein		PANPA		245
ZNF511-PRAP1 readthrough		COLAP		211
ZNF511-PRAP1 readthrough		MANLE		211
+40

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091711 mRNA Translation: BAC03729.1 AK292380 mRNA Translation: BAF85069.1 AL360181 Genomic DNA No translation available. CH471211 Genomic DNA Translation: EAW61333.1 BC015139 mRNA Translation: AAH15139.1 Different initiation. BC019897 mRNA Translation: AAH19897.1
CCDSⁱ	CCDS7677.1 [Q8NB15-2]
RefSeqⁱ	NP_665805.2, NM_145806.3 [Q8NB15-2]
UniGeneⁱ	Hs.422113

3D structure databases

ProteinModelPortalⁱ	Q8NB15
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125611, 23 interactors
IntActⁱ	Q8NB15, 15 interactors
STRINGⁱ	9606.ENSP00000355251

PTM databases

iPTMnetⁱ	Q8NB15
PhosphoSitePlusⁱ	Q8NB15

Polymorphism and mutation databases

BioMutaⁱ	ZNF511
DMDMⁱ	74760090

Proteomic databases

MaxQBⁱ	Q8NB15
PaxDbⁱ	Q8NB15
PeptideAtlasⁱ	Q8NB15
PRIDEⁱ	Q8NB15
ProteomicsDBⁱ	72716 72717 [Q8NB15-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	118472
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359035; ENSP00000351929; ENSG00000198546 [Q8NB15-1] ENST00000361518; ENSP00000355251; ENSG00000198546 [Q8NB15-2]
GeneIDⁱ	118472
KEGGⁱ	hsa:118472
UCSCⁱ	uc001lmj.2 human [Q8NB15-1]

Organism-specific databases

CTDⁱ	118472
EuPathDBⁱ	HostDB:ENSG00000198546.14
GeneCardsⁱ	ZNF511
HGNCⁱ	HGNC:28445 ZNF511
HPAⁱ	HPA035360
neXtProtⁱ	NX_Q8NB15
OpenTargetsⁱ	ENSG00000198546
PharmGKBⁱ	PA134940031
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4173 Eukaryota ENOG4111TX5 LUCA
GeneTreeⁱ	ENSGT00390000011381
HOGENOMⁱ	HOG000013167
HOVERGENⁱ	HBG094183
InParanoidⁱ	Q8NB15
OMAⁱ	RGFKSNK
OrthoDBⁱ	EOG091G0JFZ
PhylomeDBⁱ	Q8NB15
TreeFamⁱ	TF323277

Miscellaneous databases

ChiTaRSⁱ	ZNF511 human
GenomeRNAiⁱ	118472
Protein Ontology More...PROⁱ	PR:Q8NB15

Gene expression databases

Bgeeⁱ	ENSG00000198546 Expressed in 202 organ(s), highest expression level in liver
CleanExⁱ	HS_ZNF511
Genevisibleⁱ	Q8NB15 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039258 ZNF511 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR21354 PTHR21354, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN511_HUMAN
Accessionⁱ	Q8NB15Primary (citable) accession number: Q8NB15 Secondary accession number(s): A8K8L5, Q8WUP1, Q96BV2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8NB15 (ZN511_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Zinc finger protein 511

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ