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Protein

Ubiquitin carboxyl-terminal hydrolase 38

Gene

USP38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei454NucleophilePROSITE-ProRule annotation1
Active sitei857Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: FlyBase

GO - Biological processi

  • protein deubiquitination Source: FlyBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC19.056

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 38 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 38
HP43.8KD
Ubiquitin thioesterase 38
Ubiquitin-specific-processing protease 38
Gene namesi
Name:USP38
Synonyms:KIAA1891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000170185.9
HGNCiHGNC:20067 USP38
neXtProtiNX_Q8NB14

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170185
PharmGKBiPA134880611

Polymorphism and mutation databases

BioMutaiUSP38

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806681 – 1042Ubiquitin carboxyl-terminal hydrolase 38Add BLAST1042

Proteomic databases

EPDiQ8NB14
MaxQBiQ8NB14
PaxDbiQ8NB14
PeptideAtlasiQ8NB14
PRIDEiQ8NB14
ProteomicsDBi72715

PTM databases

iPTMnetiQ8NB14
PhosphoSitePlusiQ8NB14

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle. Expressed in adrenal gland.2 Publications

Gene expression databases

BgeeiENSG00000170185
CleanExiHS_USP38
ExpressionAtlasiQ8NB14 baseline and differential
GenevisibleiQ8NB14 HS

Organism-specific databases

HPAiHPA036990
HPA047948

Interactioni

Protein-protein interaction databases

BioGridi124165, 11 interactors
IntActiQ8NB14, 7 interactors
MINTiQ8NB14
STRINGi9606.ENSP00000303434

Structurei

Secondary structure

11042
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 9Combined sources8
Helixi15 – 28Combined sources14
Helixi35 – 51Combined sources17
Helixi55 – 71Combined sources17
Helixi73 – 79Combined sources7
Helixi82 – 91Combined sources10
Helixi101 – 114Combined sources14
Helixi120 – 136Combined sources17
Helixi141 – 153Combined sources13
Helixi155 – 157Combined sources3
Helixi162 – 175Combined sources14
Helixi185 – 208Combined sources24
Helixi210 – 212Combined sources3
Helixi213 – 224Combined sources12
Helixi235 – 240Combined sources6
Helixi246 – 258Combined sources13
Helixi264 – 276Combined sources13
Helixi277 – 279Combined sources3
Helixi286 – 299Combined sources14
Helixi303 – 319Combined sources17
Helixi320 – 322Combined sources3
Turni324 – 326Combined sources3
Helixi327 – 340Combined sources14
Helixi346 – 351Combined sources6
Helixi352 – 354Combined sources3
Helixi355 – 362Combined sources8
Helixi368 – 387Combined sources20
Helixi392 – 402Combined sources11
Helixi410 – 416Combined sources7

3D structure databases

ProteinModelPortaliQ8NB14
SMRiQ8NB14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini445 – 949USPAdd BLAST505

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1864 Eukaryota
ENOG410XQ81 LUCA
GeneTreeiENSGT00890000139367
HOGENOMiHOG000007432
HOVERGENiHBG060424
InParanoidiQ8NB14
KOiK11854
OMAiHYYSYAR
OrthoDBiEOG091G04E6
PhylomeDBiQ8NB14
TreeFamiTF324529

Family and domain databases

CDDicd02664 Peptidase_C19H, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR033840 USP38
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 4 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB14-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL
60 70 80 90 100
EGQDPFQRQV GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD
110 120 130 140 150
VAILDYIHNG LKLIMSCPSV LDLFSLLQVE VLRMVCERPE PQLCARLSDL
160 170 180 190 200
LTDFVQCIPK GKLSITFCQQ LVRTIGHFQC VSTQERELRE YVSQVTKVSN
210 220 230 240 250
LLQNIWKAEP ATLLPSLQEV FASISSTDAS FEPSVALASL VQHIPLQMIT
260 270 280 290 300
VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV
310 320 330 340 350
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHL
360 370 380 390 400
IVPHVVNLVH SFKNDGLPSS TAFLVQLTEL IHCMMYHYSG FPDLYEPILE
410 420 430 440 450
AIKDFPKPSE EKIKLILNQS AWTSQSNSLA SCLSRLSGKS ETGKTGLINL
460 470 480 490 500
GNTCYMNSVI QALFMATDFR RQVLSLNLNG CNSLMKKLQH LFAFLAHTQR
510 520 530 540 550
EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE KILKVQASHK
560 570 580 590 600
PSEILECSET SLQEVASKAA VLTETPRTSD GEKTLIEKMF GGKLRTHIRC
610 620 630 640 650
LNCRSTSQKV EAFTDLSLAF CPSSSLENMS VQDPASSPSI QDGGLMQASV
660 670 680 690 700
PGPSEEPVVY NPTTAAFICD SLVNEKTIGS PPNEFYCSEN TSVPNESNKI
710 720 730 740 750
LVNKDVPQKP GGETTPSVTD LLNYFLAPEI LTGDNQYYCE NCASLQNAEK
760 770 780 790 800
TMQITEEPEY LILTLLRFSY DQKYHVRRKI LDNVSLPLVL ELPVKRITSF
810 820 830 840 850
SSLSESWSVD VDFTDLSENL AKKLKPSGTD EASCTKLVPY LLSSVVVHSG
860 870 880 890 900
ISSESGHYYS YARNITSTDS SYQMYHQSEA LALASSQSHL LGRDSPSAVF
910 920 930 940 950
EQDLENKEMS KEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQH
960 970 980 990 1000
STNGLSGNNP TSGLWINGDP PLQKELMDAI TKDNKLYLQE QELNARARAL
1010 1020 1030 1040
QAASASCSFR PNGFDDNDPP GSCGPTGGGG GGGFNTVGRL VF
Length:1,042
Mass (Da):116,546
Last modified:October 10, 2003 - v2
Checksum:iD888D4F44C6E7251
GO
Isoform 2 (identifier: Q8NB14-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     990-1042: EQELNARARALQAASASCSFRPNGFDDNDPPGSCGPTGGGGGGGFNTVGRLVF → VSWKYKLYLLKILNN

Note: No experimental confirmation available.
Show »
Length:1,004
Mass (Da):113,157
Checksum:i89960B24E70287A4
GO

Sequence cautioni

The sequence AAK26248 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71627 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03730 differs from that shown. The absence of the residues from Tyr-840 to Ser-871 is not the result of an alternative splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti646M → V in BAC03730 (PubMed:14702039).Curated1
Sequence conflicti919S → G in BAB71627 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054486990 – 1042EQELN…GRLVF → VSWKYKLYLLKILNN in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057992 mRNA Translation: BAB71627.1 Different initiation.
AK091712 mRNA Translation: BAC03730.1 Sequence problems.
AK126943 mRNA Translation: BAG54405.1
AL833976 mRNA Translation: CAD38820.1
AC099549 Genomic DNA No translation available.
AC116175 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05075.1
CH471056 Genomic DNA Translation: EAX05076.1
BC039115 mRNA Translation: AAH39115.1
BC068975 mRNA Translation: AAH68975.1
AB067478 mRNA Translation: BAB67784.1
AF211481 mRNA Translation: AAK26248.1 Different initiation.
CCDSiCCDS3758.1 [Q8NB14-1]
CCDS77964.1 [Q8NB14-2]
RefSeqiNP_001277254.1, NM_001290325.1 [Q8NB14-2]
NP_001277255.1, NM_001290326.1
NP_115946.2, NM_032557.6 [Q8NB14-1]
UniGeneiHs.480848

Genome annotation databases

EnsembliENST00000307017; ENSP00000303434; ENSG00000170185 [Q8NB14-1]
ENST00000510377; ENSP00000427647; ENSG00000170185 [Q8NB14-2]
GeneIDi84640
KEGGihsa:84640
UCSCiuc003ija.5 human [Q8NB14-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUBP38_HUMAN
AccessioniPrimary (citable) accession number: Q8NB14
Secondary accession number(s): B3KX93
, Q3ZCV1, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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