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Protein

Uncharacterized protein C8orf58

Gene

C8orf58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf58
Gene namesi
Name:C8orf58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000241852.9
HGNCiHGNC:32233 C8orf58
neXtProtiNX_Q8NAV2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000241852
PharmGKBiPA142672321

Polymorphism and mutation databases

BioMutaiC8orf58
DMDMi146286069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856401 – 365Uncharacterized protein C8orf58Add BLAST365

Proteomic databases

MaxQBiQ8NAV2
PaxDbiQ8NAV2
PeptideAtlasiQ8NAV2
PRIDEiQ8NAV2
ProteomicsDBi72708
72709 [Q8NAV2-2]

PTM databases

iPTMnetiQ8NAV2
PhosphoSitePlusiQ8NAV2

Expressioni

Gene expression databases

BgeeiENSG00000241852 Expressed in 141 organ(s), highest expression level in spleen
CleanExiHS_C8orf58
ExpressionAtlasiQ8NAV2 baseline and differential
GenevisibleiQ8NAV2 HS

Organism-specific databases

HPAiHPA024667
HPA028286

Interactioni

Protein-protein interaction databases

BioGridi139076, 1 interactor
IntActiQ8NAV2, 2 interactors
STRINGi9606.ENSP00000289989

Structurei

3D structure databases

ProteinModelPortaliQ8NAV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHCI Eukaryota
ENOG4111EH3 LUCA
GeneTreeiENSGT00390000000531
HOGENOMiHOG000111619
HOVERGENiHBG060441
InParanoidiQ8NAV2
OrthoDBiEOG091G0LGV
PhylomeDBiQ8NAV2
TreeFamiTF337357

Family and domain databases

InterProiView protein in InterPro
IPR027958 DUF4657
PfamiView protein in Pfam
PF15552 DUF4657, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NAV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGRRRAFAV DGRDGAGEGL ARGCIVPGVT STYRRIPDAA HGCSSWERGD
60 70 80 90 100
KFRGVGREAL FLKLASRDSG VEMAVGDSPL AALPGLSQDS LDFESSGSSE
110 120 130 140 150
PPAQVGRLLA SQKLGEVLER SRRLPTAPTS LSGQHRSLRL ASKPEREVPL
160 170 180 190 200
GAGQQESMEA DTDLEAGLEE EAVGGLGPGA WACLPGQGLR YLEHLCLVLE
210 220 230 240 250
QMARLQQLYL QLRIQRPPGD PGEEESTRAP LPSPLHTPGN RGQGPWELLS
260 270 280 290 300
QTEHTGAKAA SPPKVEVPSA NPPRLPETPV EPTYHLPSSQ GHKRDISHWD
310 320 330 340 350
KVKVLLNRIC RRSHHHPEPP APPDGSDPRI ESRDLPERPQ CRPHRKTFMP
360
SLVVKKQRAK NLSVG
Length:365
Mass (Da):39,661
Last modified:May 1, 2007 - v2
Checksum:i63E4AF521AC22A8C
GO
Isoform 2 (identifier: Q8NAV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-301: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):38,623
Checksum:i2EC5820E39EFAB04
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX44A0A087WX44_HUMAN
Uncharacterized protein C8orf58
C8orf58
300Annotation score:
A0A087WZ43A0A087WZ43_HUMAN
Uncharacterized protein C8orf58
C8orf58
328Annotation score:
E5RJ64E5RJ64_HUMAN
Uncharacterized protein C8orf58
C8orf58
148Annotation score:
H0YAZ5H0YAZ5_HUMAN
Uncharacterized protein C8orf58
C8orf58
175Annotation score:

Sequence cautioni

The sequence BAC03795 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311R → W in BAC03795 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024876294 – 301Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR608004 mRNA No translation available.
AK092034 mRNA Translation: BAC03795.1 Different initiation.
AK295405 mRNA Translation: BAG58356.1
CCDSiCCDS34862.1 [Q8NAV2-1]
CCDS56527.1 [Q8NAV2-2]
RefSeqiNP_001013864.1, NM_001013842.2 [Q8NAV2-1]
NP_775957.2, NM_173686.2 [Q8NAV2-2]
UniGeneiHs.743508

Genome annotation databases

EnsembliENST00000289989; ENSP00000289989; ENSG00000241852 [Q8NAV2-1]
ENST00000409586; ENSP00000386265; ENSG00000241852 [Q8NAV2-2]
GeneIDi541565
KEGGihsa:541565
UCSCiuc003xce.4 human [Q8NAV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR608004 mRNA No translation available.
AK092034 mRNA Translation: BAC03795.1 Different initiation.
AK295405 mRNA Translation: BAG58356.1
CCDSiCCDS34862.1 [Q8NAV2-1]
CCDS56527.1 [Q8NAV2-2]
RefSeqiNP_001013864.1, NM_001013842.2 [Q8NAV2-1]
NP_775957.2, NM_173686.2 [Q8NAV2-2]
UniGeneiHs.743508

3D structure databases

ProteinModelPortaliQ8NAV2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139076, 1 interactor
IntActiQ8NAV2, 2 interactors
STRINGi9606.ENSP00000289989

PTM databases

iPTMnetiQ8NAV2
PhosphoSitePlusiQ8NAV2

Polymorphism and mutation databases

BioMutaiC8orf58
DMDMi146286069

Proteomic databases

MaxQBiQ8NAV2
PaxDbiQ8NAV2
PeptideAtlasiQ8NAV2
PRIDEiQ8NAV2
ProteomicsDBi72708
72709 [Q8NAV2-2]

Protocols and materials databases

DNASUi541565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289989; ENSP00000289989; ENSG00000241852 [Q8NAV2-1]
ENST00000409586; ENSP00000386265; ENSG00000241852 [Q8NAV2-2]
GeneIDi541565
KEGGihsa:541565
UCSCiuc003xce.4 human [Q8NAV2-1]

Organism-specific databases

CTDi541565
EuPathDBiHostDB:ENSG00000241852.9
GeneCardsiC8orf58
HGNCiHGNC:32233 C8orf58
HPAiHPA024667
HPA028286
neXtProtiNX_Q8NAV2
OpenTargetsiENSG00000241852
PharmGKBiPA142672321
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHCI Eukaryota
ENOG4111EH3 LUCA
GeneTreeiENSGT00390000000531
HOGENOMiHOG000111619
HOVERGENiHBG060441
InParanoidiQ8NAV2
OrthoDBiEOG091G0LGV
PhylomeDBiQ8NAV2
TreeFamiTF337357

Miscellaneous databases

ChiTaRSiC8orf58 human
GenomeRNAii541565
PROiPR:Q8NAV2

Gene expression databases

BgeeiENSG00000241852 Expressed in 141 organ(s), highest expression level in spleen
CleanExiHS_C8orf58
ExpressionAtlasiQ8NAV2 baseline and differential
GenevisibleiQ8NAV2 HS

Family and domain databases

InterProiView protein in InterPro
IPR027958 DUF4657
PfamiView protein in Pfam
PF15552 DUF4657, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCH058_HUMAN
AccessioniPrimary (citable) accession number: Q8NAV2
Secondary accession number(s): B4DI44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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