FNDC5

Functionⁱ

Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.1 Publication

Caution

It is uncertain whether Met-1 or Met-76 is the initiator. Transcript evidence available at present time points at Met-76. In this short version of the protein, the signal peptide cannot be predicted and the irisin peptide is severely truncated. The first initiation codon corresponds to a non-AUG site, an N-terminal ATA codon. This initiation codon has been annotated as it is in good Kozak context and it is conserved in other primates, including gibbon, chimpanzee and gorilla. Although the existence of such a form has not been demonstrated in human, western blot analysis following endurance exercise shows the presence of an irisin peptide of similar size in human and mouse plasma (PubMed:22237023), suggesting the existence of full-length irisin in human, at least in some tissues. However, expression from Met-1 may be less efficient than that from Met-76 (PubMed:24040023).2 Publications

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of brown fat cell differentiation Source: UniProtKB
response to muscle activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibronectin type III domain-containing protein 5 Alternative name(s): Fibronectin type III repeat-containing protein 2 Cleaved into the following chain: Irisin
Gene namesⁱ	Name:FNDC5 Synonyms:FRCP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160097.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20240 FNDC5
MIMⁱ	611906 gene
neXtProtⁱ	NX_Q8NAU1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	32 – 152	ExtracellularSequence analysisAdd BLAST	121
Transmembraneⁱ	153 – 173	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	174 – 212	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Peroxisome, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	252995
Open Targets More...OpenTargetsⁱ	ENSG00000160097
PharmGKBⁱ	PA134924607

Polymorphism and mutation databases

DMDMⁱ	403314395

DMDMⁱ

403314395

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 31	Sequence analysisAdd BLAST	31
ChainⁱPRO_0000328971	32 – 212	Fibronectin type III domain-containing protein 5Add BLAST	181
ChainⁱPRO_0000415857	32 – 143	IrisinAdd BLAST	112

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	39	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	84	N-linked (GlcNAc...) asparagineSequence analysis		1

Post-translational modificationⁱ

The extracellular domain is cleaved and released from the cell membrane.

N-Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q8NAU1
PeptideAtlas More...PeptideAtlasⁱ	Q8NAU1
PRIDEⁱ	Q8NAU1
ProteomicsDBⁱ	72700 72701 [Q8NAU1-2] 72702 [Q8NAU1-3] 72703 [Q8NAU1-4]

PTM databases

iPTMnetⁱ	Q8NAU1
PhosphoSitePlusⁱ	Q8NAU1

Expressionⁱ

Tissue specificityⁱ

Inductionⁱ

Has been shown to be up-regulated some twofold by muscular exercise at the mRNA and protein level; this effect has been suggested to be mediated by PPARGC1A (PubMed:22237023). However, up-regulation upon exercise could not be reproduced, at least not at the mRNA level (PubMed:24040023).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000160097 Expressed in 155 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_FNDC5
ExpressionAtlasⁱ	Q8NAU1 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051290

HPAⁱ

HPA051290

Interactionⁱ

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128948, 11 interactors
STRINGⁱ	9606.ENSP00000362570

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	38 – 44	Combined sources	7
Beta strandⁱ	50 – 55	Combined sources	6
Turnⁱ	59 – 61	Combined sources	3
Beta strandⁱ	62 – 73	Combined sources	12
Beta strandⁱ	77 – 84	Combined sources	8
Beta strandⁱ	89 – 92	Combined sources	4
Beta strandⁱ	100 – 111	Combined sources	12
Beta strandⁱ	120 – 123	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8NAU1
SMRⁱ	Q8NAU1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 127	Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST		92

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	210 – 212	Microbody targeting signalSequence analysis		3

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IESX Eukaryota ENOG410YC2F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004923
HOGENOMⁱ	HOG000082536
HOVERGENⁱ	HBG067308
InParanoidⁱ	Q8NAU1
TreeFamⁱ	TF325415

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8NAU1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPGSPSAWP PRARAALRLW LGCVCFALVQ ADSPSAPVNV TVRHLKANSA 
        60         70         80         90        100
VVSWDVLEDE VVIGFAISQQ KKDVRMLRFI QEVNTTTRSC ALWDLEEDTE 
       110        120        130        140        150
YIVHVQAISI QGQSPASEPV LFKTPREAEK MASKNKDEVT MKEMGRNQQL 
       160        170        180        190        200
RTGEVLIIVV VLFMWAGVIA LFCRQYDIIK DNEPNNNKEK TKSASETSTP 
       210 
EHQGGGLLRS KI

Length:212

Mass (Da):23,659

Last modified:September 5, 2012 - v3

Checksum:ⁱC4A066452A05A134

GO

Isoform 2 (identifier: Q8NAU1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
180-181: KD → EA
182-212: Missing.

« Hide

        10         20         30         40         50
MHPGSPSAWP PRARAALRLW LGCVCFALVQ ADSPSAPVNV TVRHLKANSA 
        60         70         80         90        100
VVSWDVLEDE VVIGFAISQQ KKDVRMLRFI QEVNTTTRSC ALWDLEEDTE 
       110        120        130        140        150
YIVHVQAISI QGQSPASEPV LFKTPREAEK MASKNKDEVT MKEMGRNQQL 
       160        170        180 
RTGEVLIIVV VLFMWAGVIA LFCRQYDIIE A

Note: No experimental confirmation available.

Show »

Length:181

Mass (Da):20,281

Checksum:ⁱ36BEE521AFABE5A6

GO

Isoform 3 (identifier: Q8NAU1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-75: Missing.
212-212: I → VRARPGPGWATLCLMLW

« Hide

        10         20         30         40         50
MLRFIQEVNT TTRSCALWDL EEDTEYIVHV QAISIQGQSP ASEPVLFKTP 
        60         70         80         90        100
REAEKMASKN KDEVTMKEMG RNQQLRTGEV LIIVVVLFMW AGVIALFCRQ 
       110        120        130        140        150
YDIIKDNEPN NNKEKTKSAS ETSTPEHQGG GLLRSKVRAR PGPGWATLCL 

MLW

Note: No experimental confirmation available.

Show »

Length:153

Mass (Da):17,323

Checksum:ⁱ4DA2ABEAC5B4D934

GO

Isoform 4 (identifier: Q8NAU1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-75: Missing.

« Hide

        10         20         30         40         50
MLRFIQEVNT TTRSCALWDL EEDTEYIVHV QAISIQGQSP ASEPVLFKTP 
        60         70         80         90        100
REAEKMASKN KDEVTMKEMG RNQQLRTGEV LIIVVVLFMW AGVIALFCRQ 
       110        120        130 
YDIIKDNEPN NNKEKTKSAS ETSTPEHQGG GLLRSKI

Note: No experimental confirmation available.

Show »

Length:137

Mass (Da):15,527

Checksum:ⁱ1045BF9CE29A41E4

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MRR6	A0A0A0MRR6_HUMAN		Fibronectin type III domain-contain... Fibronectin type III domain-containing protein 5	FNDC5	212	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032860	1 – 75	Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	75
Alternative sequenceⁱVSP_032861	180 – 181	KD → EA in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_032862	182 – 212	Missing in isoform 2. 1 PublicationAdd BLAST	31
Alternative sequenceⁱVSP_032863	212	I → VRARPGPGWATLCLMLW in isoform 3. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092102 mRNA Translation: BAC03806.1 AC114493 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07499.1 CH471059 Genomic DNA Translation: EAX07502.1 CH471059 Genomic DNA Translation: EAX07500.1 BC062297 mRNA Translation: AAH62297.1 BX537781 mRNA Translation: CAD97840.1 BF221649 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS369.2 [Q8NAU1-1] CCDS65483.1 [Q8NAU1-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165411.2, NM_001171940.1 [Q8NAU1-2] NP_001165412.1, NM_001171941.2 [Q8NAU1-3] NP_715637.2, NM_153756.2 [Q8NAU1-1]
UniGeneⁱ	Hs.524234

Genome annotation databases

Ensemblⁱ	ENST00000496770; ENSP00000476320; ENSG00000160097 [Q8NAU1-3] ENST00000640867; ENSP00000491708; ENSG00000160097 [Q8NAU1-1]
GeneIDⁱ	252995
KEGGⁱ	hsa:252995
UCSC genome browser More...UCSCⁱ	uc001bwg.5 human [Q8NAU1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NAU1	FNDC5 isoform 2		PANTR		212	UniRef100_Q8NAU1
FNDC5 isoform 3		PONAB		212
Q8NAU1-3	Fibronectin type III domain containing 5		PANTR		228	UniRef100_K7B1J6
FNDC5 isoform 2		PONAB		153
Uncharacterized protein		PANPA		153
FNDC5 isoform 6		PANTR		153
Q8NAU1-4	Uncharacterized protein		PAPAN		212	UniRef100_A0A2I3N0R5
Uncharacterized protein		Cebus capucinus imitator		212
Uncharacterized protein		CERAT		212
Uncharacterized protein		RHIRO		212
Uncharacterized protein		AOTNA		212
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8NAU1	FNDC5 isoform 2		PANTR		212	UniRef90_Q8NAU1
FNDC5 isoform 3		PONAB		212
Uncharacterized protein		NOMLE		212
Fibronectin type III domain-containing protein 5		HUMAN		212
Fibronectin type III domain containing 5		GORGO		212
+3
Q8NAU1-3	Fibronectin type III domain containing 5		PANTR		228	UniRef90_K7B1J6
FNDC5 isoform 2		PONAB		153
Uncharacterized protein		PANPA		153
Uncharacterized protein		AOTNA		228
UPI000840731B		CALJA		280
+7
Q8NAU1-4	Fibronectin type III domain containing 5		CANLF		216	UniRef90_F1PLK7
Fibronectin type III domain containing 5		CALJA		254
Uncharacterized protein		PIG		250
Uncharacterized protein		FELCA		250
Fibronectin type III domain containing 5		SAIBB		219
+52

Protein	Similar proteins		Species	Score	Length	Source
Q8NAU1	Fibronectin type III domain-containing protein 5		MOUSE		209	UniRef50_Q8K4Z2
Fibronectin type III domain-containing protein 5		RAT		209
Uncharacterized protein		PROCO		252
Uncharacterized protein		AOTNA		227
Fibronectin type III domain containing 5		PANTR		228
+160
Q8NAU1-2	Uncharacterized protein		BAMTH		190	UniRef50_Q8NAU1-2
FNDC5 (Fragment)		blackstripe livebearer		185
Fibronectin type III domain containing 5a (Fragment)		Nothobranchius korthausae		170
fibronectin type III domain-containing protein 5		ERIEU		137
fibronectin type III domain-containing protein 5 isoform X1		DIPOR		176
+63

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092102 mRNA Translation: BAC03806.1 AC114493 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07499.1 CH471059 Genomic DNA Translation: EAX07502.1 CH471059 Genomic DNA Translation: EAX07500.1 BC062297 mRNA Translation: AAH62297.1 BX537781 mRNA Translation: CAD97840.1 BF221649 mRNA No translation available.
CCDSⁱ	CCDS369.2 [Q8NAU1-1] CCDS65483.1 [Q8NAU1-3]
RefSeqⁱ	NP_001165411.2, NM_001171940.1 [Q8NAU1-2] NP_001165412.1, NM_001171941.2 [Q8NAU1-3] NP_715637.2, NM_153756.2 [Q8NAU1-1]
UniGeneⁱ	Hs.524234

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4LSD	X-ray	2.28	A/B/C/D/E/F/G/H	33-130	[»]
ProteinModelPortalⁱ	Q8NAU1
SMRⁱ	Q8NAU1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128948, 11 interactors
STRINGⁱ	9606.ENSP00000362570

PTM databases

iPTMnetⁱ	Q8NAU1
PhosphoSitePlusⁱ	Q8NAU1

Polymorphism and mutation databases

DMDMⁱ	403314395

DMDMⁱ

403314395

Proteomic databases

PaxDbⁱ	Q8NAU1
PeptideAtlasⁱ	Q8NAU1
PRIDEⁱ	Q8NAU1
ProteomicsDBⁱ	72700 72701 [Q8NAU1-2] 72702 [Q8NAU1-3] 72703 [Q8NAU1-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	252995
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000496770; ENSP00000476320; ENSG00000160097 [Q8NAU1-3] ENST00000640867; ENSP00000491708; ENSG00000160097 [Q8NAU1-1]
GeneIDⁱ	252995
KEGGⁱ	hsa:252995
UCSCⁱ	uc001bwg.5 human [Q8NAU1-1]

Organism-specific databases

CTDⁱ	252995
DisGeNETⁱ	252995
EuPathDBⁱ	HostDB:ENSG00000160097.15
GeneCardsⁱ	FNDC5
HGNCⁱ	HGNC:20240 FNDC5
HPAⁱ	HPA051290
MIMⁱ	611906 gene
neXtProtⁱ	NX_Q8NAU1
OpenTargetsⁱ	ENSG00000160097
PharmGKBⁱ	PA134924607
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IESX Eukaryota ENOG410YC2F LUCA
GeneTreeⁱ	ENSGT00390000004923
HOGENOMⁱ	HOG000082536
HOVERGENⁱ	HBG067308
InParanoidⁱ	Q8NAU1
TreeFamⁱ	TF325415

Miscellaneous databases

ChiTaRSⁱ	FNDC5 human
GenomeRNAiⁱ	252995
Protein Ontology More...PROⁱ	PR:Q8NAU1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160097 Expressed in 155 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_FNDC5
ExpressionAtlasⁱ	Q8NAU1 baseline and differential

Family and domain databases

CDDⁱ	cd00063 FN3, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF00041 fn3, 1 hit
SMARTⁱ	View protein in SMART SM00060 FN3, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FNDC5_HUMAN
Accessionⁱ	Q8NAU1Primary (citable) accession number: Q8NAU1 Secondary accession number(s): A6NMC9 , D3DPQ6, Q6P6D9, Q7Z676
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	September 5, 2012
	Last modified:	September 12, 2018
	This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8NAU1 (FNDC5_HUMAN)

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Fibronectin type III domain-containing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Peroxisome

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Peroxisome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ