ZBTB8B

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	341 – 363	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	369 – 392	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 8B
Gene namesⁱ	Name:ZBTB8B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000273274.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37057 ZBTB8B
neXtProtⁱ	NX_Q8NAP8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000254553
PharmGKBⁱ	PA164727627

Polymorphism and mutation databases

BioMutaⁱ	ZBTB8B
DMDMⁱ	308153528

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047721	1 – 495	Zinc finger and BTB domain-containing protein 8BAdd BLAST		495

Proteomic databases

EPDⁱ	Q8NAP8
PaxDbⁱ	Q8NAP8
PeptideAtlas More...PeptideAtlasⁱ	Q8NAP8
PRIDEⁱ	Q8NAP8
ProteomicsDBⁱ	72689 72690 [Q8NAP8-2]

PTM databases

iPTMnetⁱ	Q8NAP8
PhosphoSitePlusⁱ	Q8NAP8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000273274
CleanExⁱ	HS_ZBTB8
Genevisibleⁱ	Q8NAP8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055553

HPAⁱ

HPA055553

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDC7	O00311	4	EBI-17494306,EBI-374980
LMO1	P25800	4	EBI-17494306,EBI-8639312
LMO3	Q8TAP4-4	4	EBI-17494306,EBI-11742507
SPATC1L	Q9H0A9-2	4	EBI-17494306,EBI-11995806

Show more details

Protein-protein interaction databases

BioGridⁱ	608552, 7 interactors
IntActⁱ	Q8NAP8, 14 interactors
STRINGⁱ	9606.ENSP00000400836

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NAP8
SMRⁱ	Q8NAP8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	BTBPROSITE-ProRule annotationAdd BLAST		69

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	132 – 153	Poly-AlaAdd BLAST		22

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	341 – 363	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	369 – 392	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000124661
InParanoidⁱ	Q8NAP8
KEGG Orthology (KO) More...KOⁱ	K10495
OMAⁱ	QMNDVVN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05WK
PhylomeDBⁱ	Q8NAP8
TreeFamⁱ	TF330979

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8NAP8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR 
        60         70         80         90        100
ALLIHYIQDS GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS 
       110        120        130        140        150
AASYLQMNDV VNFCKTYIRS SLDICRKMEK EAAVAAAVAA AAAAAAAAAA 
       160        170        180        190        200
AAAHQVDSES PSSGREGTSC GTKSLVSSPA EGEKSVECLR ESPCGDCGDC 
       210        220        230        240        250
HPLELVVRDS LGGGSADSNL STPPKRIEPK VEFDADEVEV DVGEQLQQYA 
       260        270        280        290        300
APLNLAHVEE ALPSGQAVDL AYSNYHVKQF LEALLRNSAA PSKDDADHHF 
       310        320        330        340        350
SRSLEGRPEG AGVAMSSMMD VQADWYGEDS GDVLVVPIKL HKCPFCPYTA 
       360        370        380        390        400
KQKGILKRHI RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSNRPIIC 
       410        420        430        440        450
KGCRRTFTSH LSQGLRRFGL CDSCTCVTDT PDDDDDLMPI NLSLVEASSE 
       460        470        480        490 
SQEKSDTDND WPIYVESGEE NDPAGDDSDD KPQIQPNLSD RETLT

Length:495

Mass (Da):54,175

Last modified:October 5, 2010 - v2

Checksum:ⁱB5139F634D10C8C9

GO

Isoform 2 (identifier: Q8NAP8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
468-495: GEENDPAGDDSDDKPQIQPNLSDRETLT → EIGSHYVAQASLELLALSQPPASASQSAGITDGVSLCCPGRSTVA

« Hide

        10         20         30         40         50
MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR 
        60         70         80         90        100
ALLIHYIQDS GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS 
       110        120        130        140        150
AASYLQMNDV VNFCKTYIRS SLDICRKMEK EAAVAAAVAA AAAAAAAAAA 
       160        170        180        190        200
AAAHQVDSES PSSGREGTSC GTKSLVSSPA EGEKSVECLR ESPCGDCGDC 
       210        220        230        240        250
HPLELVVRDS LGGGSADSNL STPPKRIEPK VEFDADEVEV DVGEQLQQYA 
       260        270        280        290        300
APLNLAHVEE ALPSGQAVDL AYSNYHVKQF LEALLRNSAA PSKDDADHHF 
       310        320        330        340        350
SRSLEGRPEG AGVAMSSMMD VQADWYGEDS GDVLVVPIKL HKCPFCPYTA 
       360        370        380        390        400
KQKGILKRHI RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSNRPIIC 
       410        420        430        440        450
KGCRRTFTSH LSQGLRRFGL CDSCTCVTDT PDDDDDLMPI NLSLVEASSE 
       460        470        480        490        500
SQEKSDTDND WPIYVESEIG SHYVAQASLE LLALSQPPAS ASQSAGITDG 
       510 
VSLCCPGRST VA

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:512

Mass (Da):55,562

Checksum:ⁱBB970D200B60CC9F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035602	181	E → K in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039858	468 – 495	GEEND…RETLT → EIGSHYVAQASLELLALSQP PASASQSAGITDGVSLCCPG RSTVA in isoform 2. 2 PublicationsAdd BLAST		28

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092326 mRNA Translation: BAC03863.1 AL033529 Genomic DNA No translation available. AL356986 Genomic DNA No translation available. DQ500954 mRNA Translation: ABF68616.1 AL442095 mRNA Translation: CAH10660.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44104.1 [Q8NAP8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001139192.1, NM_001145720.1 [Q8NAP8-1]
UniGeneⁱ	Hs.647658

Genome annotation databases

Ensemblⁱ	ENST00000609129; ENSP00000476499; ENSG00000273274 [Q8NAP8-1]
GeneIDⁱ	728116
KEGGⁱ	hsa:728116
UCSC genome browser More...UCSCⁱ	uc001bvl.5 human [Q8NAP8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8NAP8	UPI000B51422C		AOTNA		510
UPI00045D8643		Orycteropus afer afer		497
UPI00038C4982		ICTTR		496
Uncharacterized protein (Fragment)		LOXAF		496
Uncharacterized protein		Cebus capucinus imitator		495
+37
Q8NAP8-2	Uncharacterized protein		MACMU		512
Uncharacterized protein		MACFA		512

Protein	Similar proteins		Species	Score	Length
Q8NAP8	UPI000B51422C		AOTNA		510
UPI00045D8643		Orycteropus afer afer		497
Uncharacterized protein (Fragment)		LOXAF		496
UPI00038C4982		ICTTR		496
UPI0005BC99D2		PTEVA		495
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK092326 mRNA Translation: BAC03863.1 AL033529 Genomic DNA No translation available. AL356986 Genomic DNA No translation available. DQ500954 mRNA Translation: ABF68616.1 AL442095 mRNA Translation: CAH10660.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44104.1 [Q8NAP8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001139192.1, NM_001145720.1 [Q8NAP8-1]
UniGeneⁱ	Hs.647658

3D structure databases

ProteinModelPortalⁱ	Q8NAP8
SMRⁱ	Q8NAP8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	608552, 7 interactors
IntActⁱ	Q8NAP8, 14 interactors
STRINGⁱ	9606.ENSP00000400836

PTM databases

iPTMnetⁱ	Q8NAP8
PhosphoSitePlusⁱ	Q8NAP8

Polymorphism and mutation databases

BioMutaⁱ	ZBTB8B
DMDMⁱ	308153528

Proteomic databases

EPDⁱ	Q8NAP8
PaxDbⁱ	Q8NAP8
PeptideAtlas More...PeptideAtlasⁱ	Q8NAP8
PRIDEⁱ	Q8NAP8
ProteomicsDBⁱ	72689 72690 [Q8NAP8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000609129; ENSP00000476499; ENSG00000273274 [Q8NAP8-1]
GeneIDⁱ	728116
KEGGⁱ	hsa:728116
UCSC genome browser More...UCSCⁱ	uc001bvl.5 human [Q8NAP8-1]

Organism-specific databases

CTDⁱ	728116
EuPathDBⁱ	HostDB:ENSG00000273274.1
GeneCardsⁱ	ZBTB8B
H-InvDBⁱ	HIX0017517
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37057 ZBTB8B
Human Protein Atlas More...HPAⁱ	HPA055553
neXtProtⁱ	NX_Q8NAP8
Open Targets More...OpenTargetsⁱ	ENSG00000254553
PharmGKBⁱ	PA164727627
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000124661
InParanoidⁱ	Q8NAP8
KEGG Orthology (KO) More...KOⁱ	K10495
OMAⁱ	QMNDVVN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05WK
PhylomeDBⁱ	Q8NAP8
TreeFamⁱ	TF330979

Miscellaneous databases

ChiTaRSⁱ	ZBTB8B human
GenomeRNAiⁱ	728116
Protein Ontology More...PROⁱ	PR:Q8NAP8

Gene expression databases

Bgeeⁱ	ENSG00000273274
CleanExⁱ	HS_ZBTB8
Genevisibleⁱ	Q8NAP8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT8B_HUMAN
Accessionⁱ	Q8NAP8Primary (citable) accession number: Q8NAP8 Secondary accession number(s): Q15DG5, Q5VXR5, Q69YT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	October 5, 2010
	Last modified:	July 18, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q8NAP8 (ZBT8B_HUMAN)

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Zinc finger and BTB domain-containing protein 8B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ