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Protein

Zinc finger and BTB domain-containing protein 8B

Gene

ZBTB8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 363C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 392C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8B
Gene namesi
Name:ZBTB8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000273274.1
HGNCiHGNC:37057 ZBTB8B
neXtProtiNX_Q8NAP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000254553
PharmGKBiPA164727627

Polymorphism and mutation databases

BioMutaiZBTB8B
DMDMi308153528

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477211 – 495Zinc finger and BTB domain-containing protein 8BAdd BLAST495

Proteomic databases

EPDiQ8NAP8
PaxDbiQ8NAP8
PeptideAtlasiQ8NAP8
PRIDEiQ8NAP8
ProteomicsDBi72689
72690 [Q8NAP8-2]

PTM databases

iPTMnetiQ8NAP8
PhosphoSitePlusiQ8NAP8

Expressioni

Gene expression databases

BgeeiENSG00000273274
CleanExiHS_ZBTB8
GenevisibleiQ8NAP8 HS

Organism-specific databases

HPAiHPA055553

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi608552, 7 interactors
IntActiQ8NAP8, 14 interactors
STRINGi9606.ENSP00000400836

Structurei

3D structure databases

ProteinModelPortaliQ8NAP8
SMRiQ8NAP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 153Poly-AlaAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri341 – 363C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 392C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000124661
InParanoidiQ8NAP8
KOiK10495
OMAiQMNDVVN
OrthoDBiEOG091G05WK
PhylomeDBiQ8NAP8
TreeFamiTF330979

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NAP8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR
60 70 80 90 100
ALLIHYIQDS GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS
110 120 130 140 150
AASYLQMNDV VNFCKTYIRS SLDICRKMEK EAAVAAAVAA AAAAAAAAAA
160 170 180 190 200
AAAHQVDSES PSSGREGTSC GTKSLVSSPA EGEKSVECLR ESPCGDCGDC
210 220 230 240 250
HPLELVVRDS LGGGSADSNL STPPKRIEPK VEFDADEVEV DVGEQLQQYA
260 270 280 290 300
APLNLAHVEE ALPSGQAVDL AYSNYHVKQF LEALLRNSAA PSKDDADHHF
310 320 330 340 350
SRSLEGRPEG AGVAMSSMMD VQADWYGEDS GDVLVVPIKL HKCPFCPYTA
360 370 380 390 400
KQKGILKRHI RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSNRPIIC
410 420 430 440 450
KGCRRTFTSH LSQGLRRFGL CDSCTCVTDT PDDDDDLMPI NLSLVEASSE
460 470 480 490
SQEKSDTDND WPIYVESGEE NDPAGDDSDD KPQIQPNLSD RETLT
Length:495
Mass (Da):54,175
Last modified:October 5, 2010 - v2
Checksum:iB5139F634D10C8C9
GO
Isoform 2 (identifier: Q8NAP8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-495: GEENDPAGDDSDDKPQIQPNLSDRETLT → EIGSHYVAQASLELLALSQPPASASQSAGITDGVSLCCPGRSTVA

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:512
Mass (Da):55,562
Checksum:iBB970D200B60CC9F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035602181E → K in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039858468 – 495GEEND…RETLT → EIGSHYVAQASLELLALSQP PASASQSAGITDGVSLCCPG RSTVA in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092326 mRNA Translation: BAC03863.1
AL033529 Genomic DNA No translation available.
AL356986 Genomic DNA No translation available.
DQ500954 mRNA Translation: ABF68616.1
AL442095 mRNA Translation: CAH10660.1
CCDSiCCDS44104.1 [Q8NAP8-1]
RefSeqiNP_001139192.1, NM_001145720.1 [Q8NAP8-1]
UniGeneiHs.647658

Genome annotation databases

EnsembliENST00000609129; ENSP00000476499; ENSG00000273274 [Q8NAP8-1]
GeneIDi728116
KEGGihsa:728116
UCSCiuc001bvl.5 human [Q8NAP8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT8B_HUMAN
AccessioniPrimary (citable) accession number: Q8NAP8
Secondary accession number(s): Q15DG5, Q5VXR5, Q69YT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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