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UniProtKB - Q8NAP8 (ZBT8B_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 8B
Gene
ZBTB8B
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 341 – 363 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 392 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NAP8 |
SignaLinki | Q8NAP8 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 8B |
Gene namesi | Name:ZBTB8B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37057, ZBTB8B |
neXtProti | NX_Q8NAP8 |
VEuPathDBi | HostDB:ENSG00000273274 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 728116 |
OpenTargetsi | ENSG00000254553 |
PharmGKBi | PA164727627 |
Miscellaneous databases
Pharosi | Q8NAP8, Tdark |
Genetic variation databases
BioMutai | ZBTB8B |
DMDMi | 308153528 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047721 | 1 – 495 | Zinc finger and BTB domain-containing protein 8BAdd BLAST | 495 |
Proteomic databases
MassIVEi | Q8NAP8 |
PaxDbi | Q8NAP8 |
PeptideAtlasi | Q8NAP8 |
PRIDEi | Q8NAP8 |
ProteomicsDBi | 72689 [Q8NAP8-1] 72690 [Q8NAP8-2] |
PTM databases
iPTMneti | Q8NAP8 |
PhosphoSitePlusi | Q8NAP8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000273274, Expressed in cortical plate and 31 other tissues |
Genevisiblei | Q8NAP8, HS |
Organism-specific databases
HPAi | ENSG00000273274, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Q8NAP8
Protein-protein interaction databases
BioGRIDi | 608552, 16 interactors |
IntActi | Q8NAP8, 9 interactors |
STRINGi | 9606.ENSP00000476499 |
Miscellaneous databases
RNActi | Q8NAP8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 92 | BTBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 178 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 446 – 495 | DisorderedSequence analysisAdd BLAST | 50 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 341 – 363 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 392 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154994 |
HOGENOMi | CLU_022356_0_1_1 |
InParanoidi | Q8NAP8 |
OMAi | HRSIWPM |
OrthoDBi | 755439at2759 |
PhylomeDBi | Q8NAP8 |
TreeFami | TF330979 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8NAP8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR
60 70 80 90 100
ALLIHYIQDS GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS
110 120 130 140 150
AASYLQMNDV VNFCKTYIRS SLDICRKMEK EAAVAAAVAA AAAAAAAAAA
160 170 180 190 200
AAAHQVDSES PSSGREGTSC GTKSLVSSPA EGEKSVECLR ESPCGDCGDC
210 220 230 240 250
HPLELVVRDS LGGGSADSNL STPPKRIEPK VEFDADEVEV DVGEQLQQYA
260 270 280 290 300
APLNLAHVEE ALPSGQAVDL AYSNYHVKQF LEALLRNSAA PSKDDADHHF
310 320 330 340 350
SRSLEGRPEG AGVAMSSMMD VQADWYGEDS GDVLVVPIKL HKCPFCPYTA
360 370 380 390 400
KQKGILKRHI RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSNRPIIC
410 420 430 440 450
KGCRRTFTSH LSQGLRRFGL CDSCTCVTDT PDDDDDLMPI NLSLVEASSE
460 470 480 490
SQEKSDTDND WPIYVESGEE NDPAGDDSDD KPQIQPNLSD RETLT
Isoform 2 (identifier: Q8NAP8-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
468-495: GEENDPAGDDSDDKPQIQPNLSDRETLT → EIGSHYVAQASLELLALSQPPASASQSAGITDGVSLCCPGRSTVA
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035602 | 181 | E → K in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039858 | 468 – 495 | GEEND…RETLT → EIGSHYVAQASLELLALSQP PASASQSAGITDGVSLCCPG RSTVA in isoform 2. 2 PublicationsAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092326 mRNA Translation: BAC03863.1 AL033529 Genomic DNA No translation available. AL356986 Genomic DNA No translation available. DQ500954 mRNA Translation: ABF68616.1 AL442095 mRNA Translation: CAH10660.1 |
CCDSi | CCDS44104.1 [Q8NAP8-1] |
RefSeqi | NP_001139192.1, NM_001145720.1 [Q8NAP8-1] |
Genome annotation databases
Ensembli | ENST00000609129; ENSP00000476499; ENSG00000273274 |
GeneIDi | 728116 |
KEGGi | hsa:728116 |
MANE-Selecti | ENST00000609129.2; ENSP00000476499.1; NM_001145720.2; NP_001139192.1 |
UCSCi | uc001bvl.5, human [Q8NAP8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092326 mRNA Translation: BAC03863.1 AL033529 Genomic DNA No translation available. AL356986 Genomic DNA No translation available. DQ500954 mRNA Translation: ABF68616.1 AL442095 mRNA Translation: CAH10660.1 |
CCDSi | CCDS44104.1 [Q8NAP8-1] |
RefSeqi | NP_001139192.1, NM_001145720.1 [Q8NAP8-1] |
3D structure databases
SMRi | Q8NAP8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 608552, 16 interactors |
IntActi | Q8NAP8, 9 interactors |
STRINGi | 9606.ENSP00000476499 |
PTM databases
iPTMneti | Q8NAP8 |
PhosphoSitePlusi | Q8NAP8 |
Genetic variation databases
BioMutai | ZBTB8B |
DMDMi | 308153528 |
Proteomic databases
MassIVEi | Q8NAP8 |
PaxDbi | Q8NAP8 |
PeptideAtlasi | Q8NAP8 |
PRIDEi | Q8NAP8 |
ProteomicsDBi | 72689 [Q8NAP8-1] 72690 [Q8NAP8-2] |
Protocols and materials databases
Antibodypediai | 71786, 91 antibodies from 17 providers |
DNASUi | 728116 |
Genome annotation databases
Ensembli | ENST00000609129; ENSP00000476499; ENSG00000273274 |
GeneIDi | 728116 |
KEGGi | hsa:728116 |
MANE-Selecti | ENST00000609129.2; ENSP00000476499.1; NM_001145720.2; NP_001139192.1 |
UCSCi | uc001bvl.5, human [Q8NAP8-1] |
Organism-specific databases
CTDi | 728116 |
DisGeNETi | 728116 |
GeneCardsi | ZBTB8B |
HGNCi | HGNC:37057, ZBTB8B |
HPAi | ENSG00000273274, Tissue enhanced (brain) |
neXtProti | NX_Q8NAP8 |
OpenTargetsi | ENSG00000254553 |
PharmGKBi | PA164727627 |
VEuPathDBi | HostDB:ENSG00000273274 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154994 |
HOGENOMi | CLU_022356_0_1_1 |
InParanoidi | Q8NAP8 |
OMAi | HRSIWPM |
OrthoDBi | 755439at2759 |
PhylomeDBi | Q8NAP8 |
TreeFami | TF330979 |
Enzyme and pathway databases
PathwayCommonsi | Q8NAP8 |
SignaLinki | Q8NAP8 |
Miscellaneous databases
BioGRID-ORCSi | 728116, 5 hits in 1038 CRISPR screens |
ChiTaRSi | ZBTB8B, human |
GenomeRNAii | 728116 |
Pharosi | Q8NAP8, Tdark |
PROi | PR:Q8NAP8 |
RNActi | Q8NAP8, protein |
Gene expression databases
Bgeei | ENSG00000273274, Expressed in cortical plate and 31 other tissues |
Genevisiblei | Q8NAP8, HS |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT8B_HUMAN | |
Accessioni | Q8NAP8Primary (citable) accession number: Q8NAP8 Secondary accession number(s): Q15DG5, Q5VXR5, Q69YT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports