UniProtKB - Q8NAP3 (ZBT38_HUMAN)

BLAST

>sp|Q8NAP3|ZBT38_HUMAN Zinc finger and BTB domain-containing protein 38 OS=Homo sapiens OX=9606 GN=ZBTB38 PE=1 SV=2
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKN
IFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLE
DLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMF
SPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREH
DGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQP
AAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAH
MQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGG
SFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHAN
VHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHA
IDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAP
GTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEAL
KMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHS
SQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKT
TSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQIT
VKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMS
EVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDC
AVGKAPQDKPFEEEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQ
SPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNET
LKIHERIHTGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAAL
GMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL

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History
Entry version 143 (07 Nov 2018)
Sequence version 2 (05 Jul 2005)
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Protein

Zinc finger and BTB domain-containing protein 38

Gene

ZBTB38

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	342 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	371 – 395	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	460 – 482	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	488 – 510	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	516 – 539	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1010 – 1032	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1038 – 1060	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1066 – 1088	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1094 – 1116	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1125 – 1147	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
methyl-CpG binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16354688
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16354688

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24726359
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 16354688
- 24726359
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of DNA replication
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24726359
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 38
Gene namesⁱ	Name:ZBTB38Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177311.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26636 ZBTB38
MIMⁱ	612218 gene
neXtProtⁱ	NX_Q8NAP3

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	253461
MIMⁱ	612221 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000177311
PharmGKBⁱ	PA142670542

Polymorphism and mutation databases

BioMutaⁱ	ZBTB38
DMDMⁱ	68566212

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047742	1 – 1195	Zinc finger and BTB domain-containing protein 38Add BLAST		1195

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	43	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	130	PhosphoserineCombined sources	1
Cross-linkⁱ	145	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	148	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	151	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	309	PhosphoserineCombined sources	1
Cross-linkⁱ	550	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	557	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	754	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	758	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	763	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	804	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	814	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	821	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	842	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	850	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	857	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	923	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	964	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	969	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	977	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	981	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	991	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1017	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1026	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1109	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1132	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1135	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1150	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	1183	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Ubiquitinated by RBBP6; leading to its degradation by the proteasome.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8NAP3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NAP3
PaxDbⁱ	Q8NAP3
PeptideAtlas More...PeptideAtlasⁱ	Q8NAP3
PRIDEⁱ	Q8NAP3
ProteomicsDBⁱ	72688

PTM databases

iPTMnetⁱ	Q8NAP3
PhosphoSitePlusⁱ	Q8NAP3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000177311 Expressed in 241 organ(s), highest expression level in intestine
CleanExⁱ	HS_ZBTB38
ExpressionAtlasⁱ	Q8NAP3 baseline and differential
Genevisibleⁱ	Q8NAP3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014865 HPA059378

HPAⁱ

HPA014865
HPA059378

Interactionⁱ

Subunit structureⁱ

Interacts with CBFA2T3. Interacts with ZBTB4. Interacts with RBBP6.3 Publications

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16354688

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128969, 47 interactors
IntActⁱ	Q8NAP3, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q8NAP3
STRINGⁱ	9606.ENSP00000406955

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NAP3
SMRⁱ	Q8NAP3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 100	BTBPROSITE-ProRule annotationAdd BLAST		68

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	300 – 523	Interaction with CBFA2T31 PublicationAdd BLAST		224

Domainⁱ

The BTB domain is not required for activation of transcription or self-association.By similarity

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	342 – 364	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	371 – 395	C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	460 – 482	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	488 – 510	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	516 – 539	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	1010 – 1032	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1038 – 1060	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1066 – 1088	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1094 – 1116	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	1125 – 1147	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125416
HOVERGENⁱ	HBG084299
InParanoidⁱ	Q8NAP3
KEGG Orthology (KO) More...KOⁱ	K10510
OMAⁱ	KMRKVNW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00XR
PhylomeDBⁱ	Q8NAP3
TreeFamⁱ	TF333100

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show all Align All

Q8NAP3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV 
        60         70         80         90        100
LAASSLYFKN IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR 
       110        120        130        140        150
QETVTDLAAA GKKLGISFLE DLTDRNFSNS PGPYVFCITE KGVVKEEKNE 
       160        170        180        190        200
KRHEEPAITN GPRITNAFSI IETENSNNMF SPLDLRASFK KVSDSMRTAS 
       210        220        230        240        250
LCLERTDVCH EAEPVRTLAE HSYAVSSVAE AYRSQPVREH DGSSPGNTGK 
       260        270        280        290        300
ENCEALAAKP KTCRKPKTFS IPQDSDSATE NIPPPPVSNL EVNQERSPQP 
       310        320        330        340        350
AAVLTRSKSP NNEGDVHFSR EDENQSSDVP GPPAAEVPPL VYNCSCCSKA 
       360        370        380        390        400
FDSSTLLSAH MQLHKPTQEP LVCKYCNKQF TTLNRLDRHE QICMRSSHMP 
       410        420        430        440        450
IPGGNQRFLE NYPTIGQNGG SFTGPEPLLS ENRIGEFSST GSTLPDTDHM 
       460        470        480        490        500
VKFVNGQMLY SCVVCKRSYV TLSSLRRHAN VHSWRRTYPC HYCNKVFALA 
       510        520        530        540        550
EYRTRHEIWH TGERRYQCIF CLETFMTYYI LKNHQKSFHA IDHRLSISKK 
       560        570        580        590        600
TANGGLKPSV YPYKLYRLLP MKCKRAPYKS YRNSSYENAR ENSQMNESAP 
       610        620        630        640        650
GTYVVQNPHS SELPTLNFQD TVNTLTNSPA IPLETSACQD IPTSANVQNA 
       660        670        680        690        700
EGTKWGEEAL KMDLDNNFYS TEVSVSSTEN AVSSDLRAGD VPVLSLSNSS 
       710        720        730        740        750
ENAASVISYS GSAPSVIVHS SQFSSVIMHS NAIAAMTSSN HRAFSDPAVS 
       760        770        780        790        800
QSLKDDSKPE PDKVGRFASR PKSIKEKKKT TSHTRGEIPE ESNYVADPGG 
       810        820        830        840        850
SLSKTTNIAE ETSKIETYIA KPALPGTSTN SNVAPLCQIT VKIGNEAIVK 
       860        870        880        890        900
RHILGSKLFY KRGRRPKYQM QEEPLPQGND PEPSGDSPLG LCQSECMEMS 
       910        920        930        940        950
EVFDDASDQD STDKPWRPYY NYKPKKKSRQ LKKMRKVNWR KEHGNRSPSH 
       960        970        980        990       1000
KCKYPAELDC AVGKAPQDKP FEEEETKEMP KLQCELCDGD KAVGAGNQGR 
      1010       1020       1030       1040       1050
PHRHLTSRPY ACELCAKQFQ SPSTLKMHMR CHTGEKPYQC KTCGRCFSVQ 
      1060       1070       1080       1090       1100
GNLQKHERIH LGLKEFVCQY CNKAFTLNET LKIHERIHTG EKRYHCQFCF 
      1110       1120       1130       1140       1150
QRFLYLSTKR NHEQRHIREH NGKGYACFQC PKICKTAAAL GMHQKKHLFK 
      1160       1170       1180       1190 
SPSQQEKIGD VCHENSNPLE NQHFIGSEDN DQKDNIQTGV ENVVL

Length:1,195

Mass (Da):134,257

Last modified:July 5, 2005 - v2

Checksum:ⁱA44561D86ACCC2D8

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	D6RBC4	D6RBC4_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	771	Annotation score:
	A0A1B0GV48	A0A1B0GV48_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	725	Annotation score:
	D6R9I1	D6R9I1_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	210	Annotation score:
	D6RHD1	D6RHD1_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	118	Annotation score:
	D6RE69	D6RE69_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	150	Annotation score:
	D6RGK1	D6RGK1_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	108	Annotation score:
	D6RJE1	D6RJE1_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	146	Annotation score:
	D6R9U6	D6R9U6_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	111	Annotation score:
	D6RC86	D6RC86_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	94	Annotation score:
	D6RAC4	D6RAC4_HUMAN	Zinc finger and BTB domain-containi... Zinc finger and BTB domain-containing protein 38	ZBTB38	69	Annotation score:
There is more potential isoformShow all

Sequence cautionⁱ

The sequence BAC03868 differs from that shown. Reason: Frameshift at position 147.Curated

Polymorphismⁱ

Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIMⁱ:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052917	319	S → A. Corresponds to variant dbSNP:rs16851435Ensembl.	1
Natural variantⁱVAR_052918	615	T → M. Corresponds to variant dbSNP:rs17787670Ensembl.	1
Natural variantⁱVAR_052919	809	A → T. Corresponds to variant dbSNP:rs3732867Ensembl.	1
Natural variantⁱVAR_079610	1067	V → I Found in patients with pathologic myopia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202147729Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC010184 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79004.1 CH471052 Genomic DNA Translation: EAW79005.1 AK092355 mRNA Translation: BAC03868.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43157.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073881.2, NM_001080412.2 XP_005247314.1, XM_005247257.1 XP_005247315.1, XM_005247258.1 XP_005247318.1, XM_005247261.3 XP_011510913.1, XM_011512611.1 XP_016861541.1, XM_017006052.1 XP_016861542.1, XM_017006053.1 XP_016861543.1, XM_017006054.1 XP_016861544.1, XM_017006055.1 XP_016861545.1, XM_017006056.1 XP_016861546.1, XM_017006057.1 XP_016861547.1, XM_017006058.1 XP_016861548.1, XM_017006059.1 XP_016861549.1, XM_017006060.1 XP_016861550.1, XM_017006061.1
UniGeneⁱ	Hs.518301

Genome annotation databases

Ensemblⁱ	ENST00000321464; ENSP00000372635; ENSG00000177311 ENST00000441582; ENSP00000406955; ENSG00000177311 ENST00000514251; ENSP00000426387; ENSG00000177311 ENST00000637056; ENSP00000490041; ENSG00000177311
GeneIDⁱ	253461
KEGGⁱ	hsa:253461
UCSC genome browser More...UCSCⁱ	uc062olr.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8NAP3	cDNA FLJ36882 fis, clone BLADE2000340, highly similar to Zinc finger and BTB domain-containing protein 38		HUMAN		601	UniRef100_Q8NAP3
ZBTB38 isoform 9 (Fragment)		PANTR		150
Zinc finger and BTB domain-containing protein 38 (Fragment)		HUMAN		725
Zinc finger and BTB domain-containing protein 38 (Fragment)		HUMAN		150
cDNA: FLJ22332 fis, clone HRC05753		HUMAN		326
+4

Protein	Similar proteins		Species	Score	Length	Source
Q8NAP3	cDNA FLJ36882 fis, clone BLADE2000340, highly similar to Zinc finger and BTB domain-containing protein 38		HUMAN		601	UniRef90_Q8NAP3
ZBTB38 isoform 9 (Fragment)		PANTR		150
Uncharacterized protein		PAPAN		1246
Zinc finger and BTB domain containing 38		OTOGA		1196
Uncharacterized protein		CHLSB		1196
+101

Protein	Similar proteins		Species	Score	Length	Source
Q8NAP3	Zinc finger and BTB domain-containing protein 38		RAT		1203	UniRef50_Q8NAP3
cDNA FLJ36882 fis, clone BLADE2000340, highly similar to Zinc finger and BTB domain-containing protein 38		HUMAN		601
ZBTB38 isoform 9 (Fragment)		PANTR		150
Uncharacterized protein		PAPAN		1246
Zinc finger and BTB domain containing 38		OTOGA		1196
+307

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC010184 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79004.1 CH471052 Genomic DNA Translation: EAW79005.1 AK092355 mRNA Translation: BAC03868.1 Frameshift.
CCDSⁱ	CCDS43157.1
RefSeqⁱ	NP_001073881.2, NM_001080412.2 XP_005247314.1, XM_005247257.1 XP_005247315.1, XM_005247258.1 XP_005247318.1, XM_005247261.3 XP_011510913.1, XM_011512611.1 XP_016861541.1, XM_017006052.1 XP_016861542.1, XM_017006053.1 XP_016861543.1, XM_017006054.1 XP_016861544.1, XM_017006055.1 XP_016861545.1, XM_017006056.1 XP_016861546.1, XM_017006057.1 XP_016861547.1, XM_017006058.1 XP_016861548.1, XM_017006059.1 XP_016861549.1, XM_017006060.1 XP_016861550.1, XM_017006061.1
UniGeneⁱ	Hs.518301

3D structure databases

ProteinModelPortalⁱ	Q8NAP3
SMRⁱ	Q8NAP3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128969, 47 interactors
IntActⁱ	Q8NAP3, 11 interactors
MINTⁱ	Q8NAP3
STRINGⁱ	9606.ENSP00000406955

PTM databases

iPTMnetⁱ	Q8NAP3
PhosphoSitePlusⁱ	Q8NAP3

Polymorphism and mutation databases

BioMutaⁱ	ZBTB38
DMDMⁱ	68566212

Proteomic databases

EPDⁱ	Q8NAP3
MaxQBⁱ	Q8NAP3
PaxDbⁱ	Q8NAP3
PeptideAtlasⁱ	Q8NAP3
PRIDEⁱ	Q8NAP3
ProteomicsDBⁱ	72688

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000321464; ENSP00000372635; ENSG00000177311 ENST00000441582; ENSP00000406955; ENSG00000177311 ENST00000514251; ENSP00000426387; ENSG00000177311 ENST00000637056; ENSP00000490041; ENSG00000177311
GeneIDⁱ	253461
KEGGⁱ	hsa:253461
UCSCⁱ	uc062olr.1 human

Organism-specific databases

CTDⁱ	253461
DisGeNETⁱ	253461
EuPathDBⁱ	HostDB:ENSG00000177311.10
GeneCardsⁱ	ZBTB38
H-InvDBⁱ	HIX0003727
HGNCⁱ	HGNC:26636 ZBTB38
HPAⁱ	HPA014865 HPA059378
MIMⁱ	612218 gene 612221 phenotype
neXtProtⁱ	NX_Q8NAP3
OpenTargetsⁱ	ENSG00000177311
PharmGKBⁱ	PA142670542
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00810000125416
HOVERGENⁱ	HBG084299
InParanoidⁱ	Q8NAP3
KOⁱ	K10510
OMAⁱ	KMRKVNW
OrthoDBⁱ	EOG091G00XR
PhylomeDBⁱ	Q8NAP3
TreeFamⁱ	TF333100

Miscellaneous databases

ChiTaRSⁱ	ZBTB38 human
GenomeRNAiⁱ	253461
Protein Ontology More...PROⁱ	PR:Q8NAP3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177311 Expressed in 241 organ(s), highest expression level in intestine
CleanExⁱ	HS_ZBTB38
ExpressionAtlasⁱ	Q8NAP3 baseline and differential
Genevisibleⁱ	Q8NAP3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 10 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 9 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT38_HUMAN
Accessionⁱ	Q8NAP3Primary (citable) accession number: Q8NAP3 Secondary accession number(s): D3DNF6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	July 5, 2005
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q8NAP3 (ZBT38_HUMAN)

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Zinc finger and BTB domain-containing protein 38

ZBTB38

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ