UniProtKB - Q8NAP3 (ZBT38_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 38
Gene
ZBTB38
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).By similarity2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 342 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 395 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 460 – 482 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 539 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1010 – 1032 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1038 – 1060 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1066 – 1088 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1094 – 1116 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1125 – 1147 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- methyl-CpG binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of DNA replication Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NAP3 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 38 |
Gene namesi | Name:ZBTB38Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177311.10 |
HGNCi | HGNC:26636, ZBTB38 |
MIMi | 612218, gene |
neXtProti | NX_Q8NAP3 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 1 Publication
Note: Localizes to chromocenters.1 Publication
Extracellular region or secreted
- blood microparticle Source: UniProtKB
Nucleus
- nuclear chromatin Source: GO_Central
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 253461 |
MIMi | 612221, phenotype |
OpenTargetsi | ENSG00000177311 |
PharmGKBi | PA142670542 |
Miscellaneous databases
Pharosi | Q8NAP3, Tbio |
Polymorphism and mutation databases
BioMutai | ZBTB38 |
DMDMi | 68566212 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047742 | 1 – 1195 | Zinc finger and BTB domain-containing protein 38Add BLAST | 1195 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 43 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 130 | PhosphoserineCombined sources | 1 | |
Cross-linki | 145 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 148 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 151 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 259 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 309 | PhosphoserineCombined sources | 1 | |
Cross-linki | 550 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 557 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 754 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 758 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 763 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 804 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 814 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 821 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 842 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 850 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 857 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 923 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 964 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 969 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 977 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 981 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 991 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1017 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1026 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1109 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1132 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1135 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1150 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Ubiquitinated by RBBP6; leading to its degradation by the proteasome.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8NAP3 |
jPOSTi | Q8NAP3 |
MassIVEi | Q8NAP3 |
MaxQBi | Q8NAP3 |
PaxDbi | Q8NAP3 |
PeptideAtlasi | Q8NAP3 |
PRIDEi | Q8NAP3 |
ProteomicsDBi | 72688 |
PTM databases
iPTMneti | Q8NAP3 |
PhosphoSitePlusi | Q8NAP3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177311, Expressed in intestine and 250 other tissues |
ExpressionAtlasi | Q8NAP3, baseline and differential |
Genevisiblei | Q8NAP3, HS |
Organism-specific databases
HPAi | ENSG00000177311, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CBFA2T3.
Interacts with ZBTB4.
Interacts with RBBP6.
3 PublicationsGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 128969, 140 interactors |
IntActi | Q8NAP3, 29 interactors |
MINTi | Q8NAP3 |
STRINGi | 9606.ENSP00000426387 |
Miscellaneous databases
RNActi | Q8NAP3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | Q8NAP3 |
SMRi | Q8NAP3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 100 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 300 – 523 | Interaction with CBFA2T31 PublicationAdd BLAST | 224 |
Domaini
The BTB domain is not required for activation of transcription or self-association.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 342 – 364 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 371 – 395 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 460 – 482 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 539 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 1010 – 1032 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1038 – 1060 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1066 – 1088 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1094 – 1116 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 1125 – 1147 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161449 |
InParanoidi | Q8NAP3 |
OMAi | KEHENRS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NAP3 |
TreeFami | TF333100 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
Q8NAP3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV
60 70 80 90 100
LAASSLYFKN IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR
110 120 130 140 150
QETVTDLAAA GKKLGISFLE DLTDRNFSNS PGPYVFCITE KGVVKEEKNE
160 170 180 190 200
KRHEEPAITN GPRITNAFSI IETENSNNMF SPLDLRASFK KVSDSMRTAS
210 220 230 240 250
LCLERTDVCH EAEPVRTLAE HSYAVSSVAE AYRSQPVREH DGSSPGNTGK
260 270 280 290 300
ENCEALAAKP KTCRKPKTFS IPQDSDSATE NIPPPPVSNL EVNQERSPQP
310 320 330 340 350
AAVLTRSKSP NNEGDVHFSR EDENQSSDVP GPPAAEVPPL VYNCSCCSKA
360 370 380 390 400
FDSSTLLSAH MQLHKPTQEP LVCKYCNKQF TTLNRLDRHE QICMRSSHMP
410 420 430 440 450
IPGGNQRFLE NYPTIGQNGG SFTGPEPLLS ENRIGEFSST GSTLPDTDHM
460 470 480 490 500
VKFVNGQMLY SCVVCKRSYV TLSSLRRHAN VHSWRRTYPC HYCNKVFALA
510 520 530 540 550
EYRTRHEIWH TGERRYQCIF CLETFMTYYI LKNHQKSFHA IDHRLSISKK
560 570 580 590 600
TANGGLKPSV YPYKLYRLLP MKCKRAPYKS YRNSSYENAR ENSQMNESAP
610 620 630 640 650
GTYVVQNPHS SELPTLNFQD TVNTLTNSPA IPLETSACQD IPTSANVQNA
660 670 680 690 700
EGTKWGEEAL KMDLDNNFYS TEVSVSSTEN AVSSDLRAGD VPVLSLSNSS
710 720 730 740 750
ENAASVISYS GSAPSVIVHS SQFSSVIMHS NAIAAMTSSN HRAFSDPAVS
760 770 780 790 800
QSLKDDSKPE PDKVGRFASR PKSIKEKKKT TSHTRGEIPE ESNYVADPGG
810 820 830 840 850
SLSKTTNIAE ETSKIETYIA KPALPGTSTN SNVAPLCQIT VKIGNEAIVK
860 870 880 890 900
RHILGSKLFY KRGRRPKYQM QEEPLPQGND PEPSGDSPLG LCQSECMEMS
910 920 930 940 950
EVFDDASDQD STDKPWRPYY NYKPKKKSRQ LKKMRKVNWR KEHGNRSPSH
960 970 980 990 1000
KCKYPAELDC AVGKAPQDKP FEEEETKEMP KLQCELCDGD KAVGAGNQGR
1010 1020 1030 1040 1050
PHRHLTSRPY ACELCAKQFQ SPSTLKMHMR CHTGEKPYQC KTCGRCFSVQ
1060 1070 1080 1090 1100
GNLQKHERIH LGLKEFVCQY CNKAFTLNET LKIHERIHTG EKRYHCQFCF
1110 1120 1130 1140 1150
QRFLYLSTKR NHEQRHIREH NGKGYACFQC PKICKTAAAL GMHQKKHLFK
1160 1170 1180 1190
SPSQQEKIGD VCHENSNPLE NQHFIGSEDN DQKDNIQTGV ENVVL
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBC4 | D6RBC4_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 771 | Annotation score: | ||
A0A1B0GV48 | A0A1B0GV48_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 725 | Annotation score: | ||
D6R9I1 | D6R9I1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 210 | Annotation score: | ||
D6RE69 | D6RE69_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 150 | Annotation score: | ||
D6RHD1 | D6RHD1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 118 | Annotation score: | ||
D6RJE1 | D6RJE1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 146 | Annotation score: | ||
D6R9U6 | D6R9U6_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 111 | Annotation score: | ||
D6RAC4 | D6RAC4_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 69 | Annotation score: | ||
D6RC86 | D6RC86_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 94 | Annotation score: | ||
D6RGK1 | D6RGK1_HUMAN | Zinc finger and BTB domain-containi... | ZBTB38 | 108 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence BAC03868 differs from that shown. Reason: Frameshift.Curated
Polymorphismi
Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIMi:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052917 | 319 | S → A. Corresponds to variant dbSNP:rs16851435Ensembl. | 1 | |
Natural variantiVAR_052918 | 615 | T → M. Corresponds to variant dbSNP:rs17787670Ensembl. | 1 | |
Natural variantiVAR_052919 | 809 | A → T. Corresponds to variant dbSNP:rs3732867EnsemblClinVar. | 1 | |
Natural variantiVAR_079610 | 1067 | V → I Found in patients with pathologic myopia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202147729Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010184 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79004.1 CH471052 Genomic DNA Translation: EAW79005.1 AK092355 mRNA Translation: BAC03868.1 Frameshift. |
CCDSi | CCDS43157.1 |
RefSeqi | NP_001073881.2, NM_001080412.2 XP_005247314.1, XM_005247257.1 XP_005247315.1, XM_005247258.1 XP_005247318.1, XM_005247261.3 XP_011510913.1, XM_011512611.1 XP_016861541.1, XM_017006052.1 XP_016861542.1, XM_017006053.1 XP_016861543.1, XM_017006054.1 XP_016861544.1, XM_017006055.1 XP_016861545.1, XM_017006056.1 XP_016861546.1, XM_017006057.1 XP_016861547.1, XM_017006058.1 XP_016861548.1, XM_017006059.1 XP_016861549.1, XM_017006060.1 XP_016861550.1, XM_017006061.1 |
Genome annotation databases
Ensembli | ENST00000321464; ENSP00000372635; ENSG00000177311 ENST00000441582; ENSP00000406955; ENSG00000177311 ENST00000514251; ENSP00000426387; ENSG00000177311 ENST00000637056; ENSP00000490041; ENSG00000177311 |
GeneIDi | 253461 |
KEGGi | hsa:253461 |
UCSCi | uc062olr.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC010184 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79004.1 CH471052 Genomic DNA Translation: EAW79005.1 AK092355 mRNA Translation: BAC03868.1 Frameshift. |
CCDSi | CCDS43157.1 |
RefSeqi | NP_001073881.2, NM_001080412.2 XP_005247314.1, XM_005247257.1 XP_005247315.1, XM_005247258.1 XP_005247318.1, XM_005247261.3 XP_011510913.1, XM_011512611.1 XP_016861541.1, XM_017006052.1 XP_016861542.1, XM_017006053.1 XP_016861543.1, XM_017006054.1 XP_016861544.1, XM_017006055.1 XP_016861545.1, XM_017006056.1 XP_016861546.1, XM_017006057.1 XP_016861547.1, XM_017006058.1 XP_016861548.1, XM_017006059.1 XP_016861549.1, XM_017006060.1 XP_016861550.1, XM_017006061.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6E93 | X-ray | 1.75 | A | 1006-1124 | [»] | |
6E94 | X-ray | 1.59 | A | 1006-1124 | [»] | |
SASBDBi | Q8NAP3 | |||||
SMRi | Q8NAP3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128969, 140 interactors |
IntActi | Q8NAP3, 29 interactors |
MINTi | Q8NAP3 |
STRINGi | 9606.ENSP00000426387 |
PTM databases
iPTMneti | Q8NAP3 |
PhosphoSitePlusi | Q8NAP3 |
Polymorphism and mutation databases
BioMutai | ZBTB38 |
DMDMi | 68566212 |
Proteomic databases
EPDi | Q8NAP3 |
jPOSTi | Q8NAP3 |
MassIVEi | Q8NAP3 |
MaxQBi | Q8NAP3 |
PaxDbi | Q8NAP3 |
PeptideAtlasi | Q8NAP3 |
PRIDEi | Q8NAP3 |
ProteomicsDBi | 72688 |
Protocols and materials databases
Antibodypediai | 8856, 175 antibodies |
Genome annotation databases
Ensembli | ENST00000321464; ENSP00000372635; ENSG00000177311 ENST00000441582; ENSP00000406955; ENSG00000177311 ENST00000514251; ENSP00000426387; ENSG00000177311 ENST00000637056; ENSP00000490041; ENSG00000177311 |
GeneIDi | 253461 |
KEGGi | hsa:253461 |
UCSCi | uc062olr.1, human |
Organism-specific databases
CTDi | 253461 |
DisGeNETi | 253461 |
EuPathDBi | HostDB:ENSG00000177311.10 |
GeneCardsi | ZBTB38 |
HGNCi | HGNC:26636, ZBTB38 |
HPAi | ENSG00000177311, Low tissue specificity |
MIMi | 612218, gene 612221, phenotype |
neXtProti | NX_Q8NAP3 |
OpenTargetsi | ENSG00000177311 |
PharmGKBi | PA142670542 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161449 |
InParanoidi | Q8NAP3 |
OMAi | KEHENRS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8NAP3 |
TreeFami | TF333100 |
Enzyme and pathway databases
PathwayCommonsi | Q8NAP3 |
Miscellaneous databases
BioGRID-ORCSi | 253461, 6 hits in 866 CRISPR screens |
ChiTaRSi | ZBTB38, human |
GenomeRNAii | 253461 |
Pharosi | Q8NAP3, Tbio |
PROi | PR:Q8NAP3 |
RNActi | Q8NAP3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177311, Expressed in intestine and 250 other tissues |
ExpressionAtlasi | Q8NAP3, baseline and differential |
Genevisiblei | Q8NAP3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT38_HUMAN | |
Accessioni | Q8NAP3Primary (citable) accession number: Q8NAP3 Secondary accession number(s): D3DNF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations