Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 114 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Putative protein CASTOR 3

Gene

CASTOR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Product of a dubious CDS prediction. The transcript contains several 3' non-coding exons. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NAP1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative protein CASTOR 3Curated
Alternative name(s):
STAG3 opposite strand transcript proteinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASTOR3Imported
Synonyms:GATSImported, STAG3OS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000239521.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29954, CASTOR3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NAP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
352954

Open Targets

More...
OpenTargetsi
ENSG00000239521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NAP1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GATS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74729973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258921 – 163Putative protein CASTOR 3Add BLAST163

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NAP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NAP1

PeptideAtlas

More...
PeptideAtlasi
Q8NAP1

PRoteomics IDEntifications database

More...
PRIDEi
Q8NAP1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72687

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NAP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NAP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239521, Expressed in corpus callosum and 160 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NAP1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000239521, Tissue enhanced (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131583, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NAP1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389760

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NAP1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NAP1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GATS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QV83, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006208

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_125526_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NAP1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEFTILW

Database of Orthologous Groups

More...
OrthoDBi
1166424at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NAP1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040778, CASTOR1_N
IPR027795, CASTOR_ACT_dom
IPR026249, CASTOR_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13840, ACT_7, 1 hit
PF18700, Castor1_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02078, GATSLIKEFMLY

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NAP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCRGRGAGG RWNSTSWSTG CKLPASPRRV SRCSPTGLIK LAFLFSKTRC
60 70 80 90 100
KFFSLTETPE DYTIIVDEEG FLELPSSEHL SVADATWLAL NVVSGGGSFS
110 120 130 140 150
SSQPIGMTKI AKSVIAPLAD QNISVFMLST YQTDFILVLK RDLPFVTHTL
160
SSEFTILWSV ARL
Length:163
Mass (Da):17,846
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9BDF3D07A30E637
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33723 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH53367 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH65200 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78E → G in AAH44886 (PubMed:15489334).Curated1
Sequence conflicti82V → A in CAH18327 (PubMed:17974005).Curated1
Sequence conflicti90L → P in CAH18327 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK092358 mRNA Translation: BAC03870.1
AK290039 mRNA Translation: BAF82728.1
AK290237 mRNA Translation: BAF82926.1
AK290510 mRNA Translation: BAF83199.1
CR749506 mRNA Translation: CAH18327.1
CH471091 Genomic DNA Translation: EAW76563.1
CH471091 Genomic DNA Translation: EAW76564.1
CH471091 Genomic DNA Translation: EAW76565.1
BC033723 mRNA Translation: AAH33723.1 Different initiation.
BC044886 mRNA Translation: AAH44886.2
BC053367 mRNA Translation: AAH53367.1 Different initiation.
BC065200 mRNA Translation: AAH65200.1 Different initiation.
BC090867 mRNA Translation: AAH90867.1

NCBI Reference Sequences

More...
RefSeqi
NP_849153.3, NM_178831.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000436886; ENSP00000389760; ENSG00000239521

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
352954

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:352954

UCSC genome browser

More...
UCSCi
uc003uua.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092358 mRNA Translation: BAC03870.1
AK290039 mRNA Translation: BAF82728.1
AK290237 mRNA Translation: BAF82926.1
AK290510 mRNA Translation: BAF83199.1
CR749506 mRNA Translation: CAH18327.1
CH471091 Genomic DNA Translation: EAW76563.1
CH471091 Genomic DNA Translation: EAW76564.1
CH471091 Genomic DNA Translation: EAW76565.1
BC033723 mRNA Translation: AAH33723.1 Different initiation.
BC044886 mRNA Translation: AAH44886.2
BC053367 mRNA Translation: AAH53367.1 Different initiation.
BC065200 mRNA Translation: AAH65200.1 Different initiation.
BC090867 mRNA Translation: AAH90867.1
RefSeqiNP_849153.3, NM_178831.6

3D structure databases

SMRiQ8NAP1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131583, 4 interactors
IntActiQ8NAP1, 6 interactors
STRINGi9606.ENSP00000389760

PTM databases

iPTMnetiQ8NAP1
PhosphoSitePlusiQ8NAP1

Polymorphism and mutation databases

BioMutaiGATS
DMDMi74729973

Proteomic databases

MassIVEiQ8NAP1
PaxDbiQ8NAP1
PeptideAtlasiQ8NAP1
PRIDEiQ8NAP1
ProteomicsDBi72687

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
75889, 9 antibodies

Genome annotation databases

EnsembliENST00000436886; ENSP00000389760; ENSG00000239521
GeneIDi352954
KEGGihsa:352954
UCSCiuc003uua.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
352954
DisGeNETi352954
EuPathDBiHostDB:ENSG00000239521.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASTOR3
HGNCiHGNC:29954, CASTOR3
HPAiENSG00000239521, Tissue enhanced (brain, skeletal muscle)
neXtProtiNX_Q8NAP1
OpenTargetsiENSG00000239521
PharmGKBiPA164720213

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QV83, Eukaryota
GeneTreeiENSGT00390000006208
HOGENOMiCLU_125526_0_0_1
InParanoidiQ8NAP1
OMAiSEFTILW
OrthoDBi1166424at2759
PhylomeDBiQ8NAP1

Enzyme and pathway databases

PathwayCommonsiQ8NAP1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
352954, 60 hits in 837 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASTOR3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
352954
PharosiQ8NAP1, Tdark
RNActiQ8NAP1, protein

Gene expression databases

BgeeiENSG00000239521, Expressed in corpus callosum and 160 other tissues
GenevisibleiQ8NAP1, HS

Family and domain databases

InterProiView protein in InterPro
IPR040778, CASTOR1_N
IPR027795, CASTOR_ACT_dom
IPR026249, CASTOR_fam
PfamiView protein in Pfam
PF13840, ACT_7, 1 hit
PF18700, Castor1_N, 1 hit
PRINTSiPR02078, GATSLIKEFMLY

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAST3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NAP1
Secondary accession number(s): D6W5V0
, Q68D93, Q6P198, Q6PII7, Q7Z720, Q86UK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again