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Protein

Mitoguardin 1

Gene

MIGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.1 Publication

Caution

It is uncertain whether Met-1 or Met-33 is the initiator.Curated

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoguardin 11 Publication
Alternative name(s):
Protein FAM73ACurated
Gene namesi
Name:MIGA11 PublicationImported
Synonyms:FAM73AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000180488.14
HGNCiHGNC:24741 MIGA1
neXtProtiNX_Q8NAN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180488
PharmGKBiPA142671836

Polymorphism and mutation databases

BioMutaiFAM73A
DMDMi74729966

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856461 – 632Mitoguardin 1Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289PhosphoserineBy similarity1
Modified residuei293PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NAN2
MaxQBiQ8NAN2
PaxDbiQ8NAN2
PeptideAtlasiQ8NAN2
PRIDEiQ8NAN2
ProteomicsDBi72682
72683 [Q8NAN2-2]

PTM databases

iPTMnetiQ8NAN2
PhosphoSitePlusiQ8NAN2

Expressioni

Gene expression databases

BgeeiENSG00000180488 Expressed in 204 organ(s), highest expression level in brain
CleanExiHS_FAM73A
ExpressionAtlasiQ8NAN2 baseline and differential
GenevisibleiQ8NAN2 HS

Organism-specific databases

HPAiHPA017589

Interactioni

Subunit structurei

Homodimer and heterodimer; forms heterodimers with MIGA2 (PubMed:26711011). Interacts with PLD6/MitoPLD (PubMed:26711011).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131945, 19 interactors
IntActiQ8NAN2, 3 interactors
STRINGi9606.ENSP00000359827

Structurei

3D structure databases

ProteinModelPortaliQ8NAN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mitoguardin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3831 Eukaryota
ENOG410Y4ER LUCA
GeneTreeiENSGT00390000008565
HOVERGENiHBG106606
InParanoidiQ8NAN2
PhylomeDBiQ8NAN2
TreeFamiTF313896

Family and domain databases

InterProiView protein in InterPro
IPR019392 Miga
PANTHERiPTHR21508 PTHR21508, 1 hit
PfamiView protein in Pfam
PF10265 Miga, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NAN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDCCSAPGI SWEAGVGRPA VPGLELQIRR GAMSEETVSE SQFSLKTAAL
60 70 80 90 100
RVFDLPLTWY YSLSQIKFSP VAKKLFVVTA VSAISVIFLA HHFKRKRGKK
110 120 130 140 150
KGKILPWEPE HLILEYTKRA ASDKGSSCSS SRQNLTLSLS STKDKGSQVC
160 170 180 190 200
NYANGGLFSK YSGSAQSLAS VQSVNSCHSC ACGNSNSWDK ADEDDIKLVN
210 220 230 240 250
IPVTTPENLY LMGMELFEEA LRRWEQALTF RNRQAEDEAC GSIKLGAGDA
260 270 280 290 300
IAEENVDDII STEFIHKLEA LLQRAYRLQE EFEATLGASD PNSLADDIDK
310 320 330 340 350
DTDITMKGNV EDFGLRDTLS IASTDSFASA AELAEHREVR HTYSLESLCH
360 370 380 390 400
CPFYEEAMHL VEEGKIYSRV LRTEMLECLG DSDFLAKLHC IRQAFQVILS
410 420 430 440 450
ESANRIFLAE SGRKILSALI VKARKNPKKF EDVFDEMIYF LEQTDHWGST
460 470 480 490 500
EMELAARGVK NLNFYDVVLD FILMDSFEDL ENPPTSIQNV VNNRWLNSSF
510 520 530 540 550
KETAVASSCW SVLKQKRQQM KIPDGFFAHF YAICEHISPV LAWGFLGPRN
560 570 580 590 600
SLYDLCCFFK NQVLLFLKDI FDFEKVRYSS TETLAEDLMQ LLIRRTELLM
610 620 630
AYLEADALRH TSSCLSSHGH VMSTGLLEAK VQ
Length:632
Mass (Da):71,006
Last modified:October 1, 2002 - v1
Checksum:iEB717ACABAF8DD83
GO
Isoform 2 (identifier: Q8NAN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-384: TEMLECLGDSDF → YHFSFVYVYEGY
     385-632: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):42,689
Checksum:iB4BED956530BF946
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7S1F8W7S1_HUMAN
Mitoguardin 1
MIGA1
633Annotation score:
A0A2R8YE40A0A2R8YE40_HUMAN
Mitoguardin 1
MIGA1
601Annotation score:
A0A2R8YF99A0A2R8YF99_HUMAN
Mitoguardin 1
MIGA1
600Annotation score:
A0A2R8YDC7A0A2R8YDC7_HUMAN
Mitoguardin 1
MIGA1
585Annotation score:
A0A2R8YFQ8A0A2R8YFQ8_HUMAN
Mitoguardin 1
MIGA1
503Annotation score:
A0A2R8YGK2A0A2R8YGK2_HUMAN
Mitoguardin 1
MIGA1
604Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024878373 – 384TEMLE…GDSDF → YHFSFVYVYEGY in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_024879385 – 632Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092412 mRNA Translation: BAC03880.1
BX537792 mRNA Translation: CAD97844.1
BX641170 mRNA Translation: CAE46075.1
BC130387 mRNA Translation: AAI30388.1
CCDSiCCDS681.1 [Q8NAN2-1]
RefSeqiNP_001257313.1, NM_001270384.1
NP_940951.1, NM_198549.3 [Q8NAN2-1]
UniGeneiHs.437755

Genome annotation databases

EnsembliENST00000370791; ENSP00000359827; ENSG00000180488 [Q8NAN2-1]
ENST00000643143; ENSP00000495281; ENSG00000180488 [Q8NAN2-1]
GeneIDi374986
KEGGihsa:374986
UCSCiuc001dhx.5 human [Q8NAN2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092412 mRNA Translation: BAC03880.1
BX537792 mRNA Translation: CAD97844.1
BX641170 mRNA Translation: CAE46075.1
BC130387 mRNA Translation: AAI30388.1
CCDSiCCDS681.1 [Q8NAN2-1]
RefSeqiNP_001257313.1, NM_001270384.1
NP_940951.1, NM_198549.3 [Q8NAN2-1]
UniGeneiHs.437755

3D structure databases

ProteinModelPortaliQ8NAN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131945, 19 interactors
IntActiQ8NAN2, 3 interactors
STRINGi9606.ENSP00000359827

PTM databases

iPTMnetiQ8NAN2
PhosphoSitePlusiQ8NAN2

Polymorphism and mutation databases

BioMutaiFAM73A
DMDMi74729966

Proteomic databases

EPDiQ8NAN2
MaxQBiQ8NAN2
PaxDbiQ8NAN2
PeptideAtlasiQ8NAN2
PRIDEiQ8NAN2
ProteomicsDBi72682
72683 [Q8NAN2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370791; ENSP00000359827; ENSG00000180488 [Q8NAN2-1]
ENST00000643143; ENSP00000495281; ENSG00000180488 [Q8NAN2-1]
GeneIDi374986
KEGGihsa:374986
UCSCiuc001dhx.5 human [Q8NAN2-1]

Organism-specific databases

CTDi374986
EuPathDBiHostDB:ENSG00000180488.14
GeneCardsiMIGA1
H-InvDBiHIX0000717
HGNCiHGNC:24741 MIGA1
HPAiHPA017589
neXtProtiNX_Q8NAN2
OpenTargetsiENSG00000180488
PharmGKBiPA142671836
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3831 Eukaryota
ENOG410Y4ER LUCA
GeneTreeiENSGT00390000008565
HOVERGENiHBG106606
InParanoidiQ8NAN2
PhylomeDBiQ8NAN2
TreeFamiTF313896

Enzyme and pathway databases

ReactomeiR-HSA-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiMIGA1 human
GenomeRNAii374986
PROiPR:Q8NAN2

Gene expression databases

BgeeiENSG00000180488 Expressed in 204 organ(s), highest expression level in brain
CleanExiHS_FAM73A
ExpressionAtlasiQ8NAN2 baseline and differential
GenevisibleiQ8NAN2 HS

Family and domain databases

InterProiView protein in InterPro
IPR019392 Miga
PANTHERiPTHR21508 PTHR21508, 1 hit
PfamiView protein in Pfam
PF10265 Miga, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMIGA1_HUMAN
AccessioniPrimary (citable) accession number: Q8NAN2
Secondary accession number(s): Q6MZG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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