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UniProtKB - Q8NAC3 (I17RC_HUMAN)

Entry version 150 (10 Feb 2021)
Sequence version 2 (05 May 2009)
Previous versions | rss
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Protein

Interleukin-17 receptor C

Gene

IL17RC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity).By similarity4 Publications
Receptor for both IL17A and IL17F.1 Publication
Does not bind IL17A or IL17F.1 Publication
Does not bind IL17A or IL17F.1 Publication
Receptor for both IL17A and IL17F.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NAC3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-448424, Interleukin-17 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8NAC3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17 receptor C
Short name:
IL-17 receptor C
Short name:
IL-17RC
Alternative name(s):
Interleukin-17 receptor homolog
Short name:
IL17Rhom
Interleukin-17 receptor-like protein
Short name:
IL-17RL
ZcytoR14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL17RC
ORF Names:UNQ6118/PRO20040/PRO38901
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18358, IL17RC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610925, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NAC3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163702.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 538ExtracellularSequence analysisAdd BLAST518
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 791CytoplasmicSequence analysisAdd BLAST232

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Candidiasis, familial, 9 (CANDF9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		84818

MalaCards human disease database

More...MalaCardsi		IL17RC
MIMi616445, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163702

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1334, Chronic mucocutaneous candidiasis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134986616

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NAC3, Tclin

Chemistry databases

DrugCentral

More...DrugCentrali		Q8NAC3

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL17RC

Domain mapping of disease mutations (DMDM)

More...DMDMi		229462881

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001103421 – 791Interleukin-17 receptor CAdd BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi265 ↔ 277Combined sources1 Publication
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi341 ↔ 391Combined sources1 Publication
Disulfide bondi343 ↔ 359Combined sources1 Publication
Disulfide bondi400 ↔ 409Combined sources1 Publication
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi439 ↔ 453Combined sources1 Publication
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi481 ↔ 488Combined sources1 Publication
Disulfide bondi515 ↔ 529Combined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8NAC3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NAC3

PeptideAtlas

More...PeptideAtlasi		Q8NAC3

PRoteomics IDEntifications database

More...PRIDEi		Q8NAC3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20526
20554
72669 [Q8NAC3-1]
72670 [Q8NAC3-2]
72671 [Q8NAC3-3]
72672 [Q8NAC3-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8NAC3, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NAC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NAC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By HGF and VEGF.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163702, Expressed in adenohypophysis and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NAC3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NAC3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163702, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (PubMed:32187518). Heterodimer with IL17RA (PubMed:16785495, PubMed:18684971). Heterodimerization with IL17RA is independent of the cytoplasmic tail (By similarity). Associates with non-glycosylated IL17RA constitutively (By similarity). Binding of IL17A and IL17F induces association with glycosylated IL17RA (By similarity). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518, PubMed:28827714). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (PubMed:32187518). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RC chain can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:28827714).

Interacts (through SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (PubMed:24120361).

By similarity5 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124278, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q8NAC3, 45 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000295981

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NAC3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NAC3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini583 – 735SEFIRPROSITE-ProRule annotationAdd BLAST153

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYE0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026893_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NAC3

Identification of Orthologs from Complete Genome Data

More...OMAi		CLWSDSL

Database of Orthologous Groups

More...OrthoDBi		297610at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NAC3

TreeFam database of animal gene trees

More...TreeFami		TF335852

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom

The PANTHER Classification System

More...PANTHERi		PTHR15583, PTHR15583, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51534, SEFIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NAC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVPWFLLSL ALGRSPVVLS LERLVGPQDA THCSPVSLEP WGDEERLRVQ 
        60         70         80         90        100
FLAQQSLSLA PVTAATARTA LSGLSGADGR REERGRGKSW VCLSLGGSGN 
       110        120        130        140        150
TEPQKKGLSC RLWDSDILCL PGDIVPAPGP VLAPTHLQTE LVLRCQKETD 
       160        170        180        190        200
CDLCLRVAVH LAVHGHWEEP EDEEKFGGAA DSGVEEPRNA SLQAQVVLSF 
       210        220        230        240        250
QAYPTARCVL LEVQVPAALV QFGQSVGSVV YDCFEAALGS EVRIWSYTQP 
       260        270        280        290        300
RYEKELNHTQ QLPDCRGLEV WNSIPSCWAL PWLNVSADGD NVHLVLNVSE 
       310        320        330        340        350
EQHFGLSLYW NQVQGPPKPR WHKNLTGPQI ITLNHTDLVP CLCIQVWPLE 
       360        370        380        390        400
PDSVRTNICP FREDPRAHQN LWQAARLQLL TLQSWLLDAP CSLPAEAALC 
       410        420        430        440        450
WRAPGGDPCQ PLVPPLSWEN VTVDKVLEFP LLKGHPNLCV QVNSSEKLQL 
       460        470        480        490        500
QECLWADSLG PLKDDVLLLE TRGPQDNRSL CALEPSGCTS LPSKASTRAA 
       510        520        530        540        550
RLGEYLLQDL QSGQCLQLWD DDLGALWACP MDKYIHKRWA LVWLACLLFA 
       560        570        580        590        600
AALSLILLLK KDHAKGWLRL LKQDVRSGAA ARGRAALLLY SADDSGFERL 
       610        620        630        640        650
VGALASALCQ LPLRVAVDLW SRRELSAQGP VAWFHAQRRQ TLQEGGVVVL 
       660        670        680        690        700
LFSPGAVALC SEWLQDGVSG PGAHGPHDAF RASLSCVLPD FLQGRAPGSY 
       710        720        730        740        750
VGACFDRLLH PDAVPALFRT VPVFTLPSQL PDFLGALQQP RAPRSGRLQE 
       760        770        780        790 
RAEQVSRALQ PALDSYFHPP GTPAPGRGVG PGAGPGAGDG T
Length:791
Mass (Da):86,240
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9A4032C17ECD4AF
GO
Isoform 2 (identifier: Q8NAC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.

Show »
Length:720
Mass (Da):78,689
Checksum:i598203CD77A72647
GO
Isoform 3 (identifier: Q8NAC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.

Show »
Length:705
Mass (Da):76,942
Checksum:iE665E2494E795EFF
GO
Isoform 4 (identifier: Q8NAC3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
     579-624: AAARGRAALL...VAVDLWSRRE → GEWEQALGGG...PRGSAPLLSR
     625-791: Missing.

Show »
Length:538
Mass (Da):59,100
Checksum:i55E6359DA6A5AF4B
GO
Isoform 5 (identifier: Q8NAC3-5) [UniParc]FASTAAdd to basket
Also known as: IL17RC1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     566-578: Missing.

Show »
Length:707
Mass (Da):77,179
Checksum:i3BED07CC5C11A8B3
GO
Isoform 6 (identifier: Q8NAC3-6) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta7,121 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
     425-441: Missing.

Show »
Length:688
Mass (Da):75,025
Checksum:iA3A8A825FDD77893
GO
Isoform 7 (identifier: Q8NAC3-7) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta121 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     425-441: Missing.
     566-578: Missing.

Show »
Length:690
Mass (Da):75,262
Checksum:i8998AD766D1D6A62
GO
Isoform 8 (identifier: Q8NAC3-8) [UniParc]FASTAAdd to basket
Also known as: IL17RC-delta71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     36-106: Missing.
     264-278: Missing.
     566-578: Missing.

Show »
Length:692
Mass (Da):75,432
Checksum:i08389B2672D4B996
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSZ3C9JSZ3_HUMAN
Interleukin-17 receptor C
IL17RC
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DI24B4DI24_HUMAN
Interleukin-17 receptor C
IL17RC
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0M1C9K0M1_HUMAN
Interleukin-17 receptor C
IL17RC
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD65F8WD65_HUMAN
Interleukin-17 receptor C
IL17RC
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB43F8WB43_HUMAN
Interleukin-17 receptor C
IL17RC
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE27F8WE27_HUMAN
Interleukin-17 receptor C
IL17RC
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEG5F8WEG5_HUMAN
Interleukin-17 receptor C
IL17RC
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8K3Q5A8K3Q5_HUMAN
Interleukin-17 receptor C
IL17RC
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V177G3V177_HUMAN
Interleukin 17 receptor C, isoform ...
IL17RC hCG_1995707
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC09F8WC09_HUMAN
Interleukin-17 receptor C
IL17RC
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti241E → G in AAQ89199 (PubMed:12975309).1
Sequence conflicti378Q → R in ABV44615 (PubMed:17911633).Curated1
Sequence conflicti378Q → R in ABV44616 (PubMed:17911633).Curated1
Sequence conflicti378Q → R in ABV44617 (PubMed:17911633).Curated1
Sequence conflicti378Q → R in BD292072 (Ref. 2) Curated1
Sequence conflicti378Q → R in AAM77569 (Ref. 3) Curated1
Sequence conflicti378Q → R in AAQ89199 (PubMed:12975309).Curated1
Sequence conflicti378Q → R in AAQ89456 (PubMed:12975309).Curated1
Sequence conflicti378Q → R in BAC04001 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022680182S → L2 PublicationsCorresponds to variant dbSNP:rs708567Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01413836 – 106Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8. 3 Publications1 PublicationAdd BLAST71
Alternative sequenceiVSP_014139264 – 278Missing in isoform 3, isoform 4, isoform 6 and isoform 8. 2 Publications1 PublicationAdd BLAST15
Alternative sequenceiVSP_047291425 – 441Missing in isoform 6 and isoform 7. Curated1 PublicationAdd BLAST17
Alternative sequenceiVSP_047292566 – 578Missing in isoform 5, isoform 7 and isoform 8. Curated1 PublicationAdd BLAST13
Alternative sequenceiVSP_014140579 – 624AAARG…WSRRE → GEWEQALGGGPPPGSQACAS SPLPSPSVFSGSGRQGPRGS APLLSR in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_014141625 – 791Missing in isoform 4. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EF676032 mRNA Translation: ABV44615.1
EF676033 mRNA Translation: ABV44616.1
EF676034 mRNA Translation: ABV44617.1
BD292072 mRNA No translation available.
AF458065 mRNA Translation: AAM77569.1
AY358840 mRNA Translation: AAQ89199.1
AY359098 mRNA Translation: AAQ89456.1
AK092907 mRNA Translation: BAC04001.1
AC018809 Genomic DNA No translation available.
BC006411 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2590.1 [Q8NAC3-1]
CCDS2591.2 [Q8NAC3-3]
CCDS46746.1 [Q8NAC3-2]
CCDS56240.1 [Q8NAC3-5]
CCDS56241.1 [Q8NAC3-6]
CCDS74898.1 [Q8NAC3-7]

NCBI Reference Sequences

More...RefSeqi		NP_001190192.1, NM_001203263.1 [Q8NAC3-5]
NP_001190193.1, NM_001203264.1 [Q8NAC3-7]
NP_001190194.1, NM_001203265.1 [Q8NAC3-6]
NP_116121.2, NM_032732.5 [Q8NAC3-3]
NP_703190.1, NM_153460.3 [Q8NAC3-2]
NP_703191.1, NM_153461.3 [Q8NAC3-1]
XP_016862835.1, XM_017007346.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295981; ENSP00000295981; ENSG00000163702 [Q8NAC3-1]
ENST00000383812; ENSP00000373323; ENSG00000163702 [Q8NAC3-3]
ENST00000403601; ENSP00000384969; ENSG00000163702 [Q8NAC3-2]
ENST00000413608; ENSP00000396064; ENSG00000163702 [Q8NAC3-5]
ENST00000416074; ENSP00000395315; ENSG00000163702 [Q8NAC3-7]
ENST00000455057; ENSP00000407894; ENSG00000163702 [Q8NAC3-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84818

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84818

UCSC genome browser

More...UCSCi		uc003btz.4, human [Q8NAC3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF676032 mRNA Translation: ABV44615.1
EF676033 mRNA Translation: ABV44616.1
EF676034 mRNA Translation: ABV44617.1
BD292072 mRNA No translation available.
AF458065 mRNA Translation: AAM77569.1
AY358840 mRNA Translation: AAQ89199.1
AY359098 mRNA Translation: AAQ89456.1
AK092907 mRNA Translation: BAC04001.1
AC018809 Genomic DNA No translation available.
BC006411 mRNA No translation available.
CCDSiCCDS2590.1 [Q8NAC3-1]
CCDS2591.2 [Q8NAC3-3]
CCDS46746.1 [Q8NAC3-2]
CCDS56240.1 [Q8NAC3-5]
CCDS56241.1 [Q8NAC3-6]
CCDS74898.1 [Q8NAC3-7]
RefSeqiNP_001190192.1, NM_001203263.1 [Q8NAC3-5]
NP_001190193.1, NM_001203264.1 [Q8NAC3-7]
NP_001190194.1, NM_001203265.1 [Q8NAC3-6]
NP_116121.2, NM_032732.5 [Q8NAC3-3]
NP_703190.1, NM_153460.3 [Q8NAC3-2]
NP_703191.1, NM_153461.3 [Q8NAC3-1]
XP_016862835.1, XM_017007346.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HG4X-ray3.32B95-538[»]
6HG9X-ray3.62B95-538[»]
6HGAX-ray2.60B279-538[»]
SMRiQ8NAC3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124278, 53 interactors
IntActiQ8NAC3, 45 interactors
STRINGi9606.ENSP00000295981

Chemistry databases

DrugCentraliQ8NAC3

PTM databases

GlyGeniQ8NAC3, 9 sites
iPTMnetiQ8NAC3
PhosphoSitePlusiQ8NAC3

Genetic variation databases

BioMutaiIL17RC
DMDMi229462881

Proteomic databases

jPOSTiQ8NAC3
PaxDbiQ8NAC3
PeptideAtlasiQ8NAC3
PRIDEiQ8NAC3
ProteomicsDBi20526
20554
72669 [Q8NAC3-1]
72670 [Q8NAC3-2]
72671 [Q8NAC3-3]
72672 [Q8NAC3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10412, 315 antibodies

Genome annotation databases

EnsembliENST00000295981; ENSP00000295981; ENSG00000163702 [Q8NAC3-1]
ENST00000383812; ENSP00000373323; ENSG00000163702 [Q8NAC3-3]
ENST00000403601; ENSP00000384969; ENSG00000163702 [Q8NAC3-2]
ENST00000413608; ENSP00000396064; ENSG00000163702 [Q8NAC3-5]
ENST00000416074; ENSP00000395315; ENSG00000163702 [Q8NAC3-7]
ENST00000455057; ENSP00000407894; ENSG00000163702 [Q8NAC3-6]
GeneIDi84818
KEGGihsa:84818
UCSCiuc003btz.4, human [Q8NAC3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84818
DisGeNETi84818

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL17RC
HGNCiHGNC:18358, IL17RC
HPAiENSG00000163702, Low tissue specificity
MalaCardsiIL17RC
MIMi610925, gene
616445, phenotype
neXtProtiNX_Q8NAC3
OpenTargetsiENSG00000163702
Orphaneti1334, Chronic mucocutaneous candidiasis
PharmGKBiPA134986616
VEuPathDBiHostDB:ENSG00000163702.18

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYE0, Eukaryota
GeneTreeiENSGT00730000111286
HOGENOMiCLU_026893_1_0_1
InParanoidiQ8NAC3
OMAiCLWSDSL
OrthoDBi297610at2759
PhylomeDBiQ8NAC3
TreeFamiTF335852

Enzyme and pathway databases

PathwayCommonsiQ8NAC3
ReactomeiR-HSA-448424, Interleukin-17 signaling
SIGNORiQ8NAC3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84818, 6 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL17RC, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IL17RC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84818
PharosiQ8NAC3, Tclin

Protein Ontology

More...PROi		PR:Q8NAC3
RNActiQ8NAC3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163702, Expressed in adenohypophysis and 207 other tissues
ExpressionAtlasiQ8NAC3, baseline and differential
GenevisibleiQ8NAC3, HS

Family and domain databases

InterProiView protein in InterPro
IPR039465, IL-17_rcpt-like
IPR027841, IL-17_rcpt_C/E_N
IPR013568, SEFIR_dom
PANTHERiPTHR15583, PTHR15583, 1 hit
PfamiView protein in Pfam
PF15037, IL17_R_N, 1 hit
PF08357, SEFIR, 1 hit
PROSITEiView protein in PROSITE
PS51534, SEFIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI17RC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NAC3
Secondary accession number(s): A8BWC1
, A8BWC9, A8BWD5, E9PHG1, E9PHJ6, Q6UVY3, Q6UWD4, Q8NFS1, Q9BR97
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: May 5, 2009
Last modified: February 10, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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