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Entry version 144 (12 Aug 2020)
Sequence version 2 (20 May 2008)
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Protein

Protein Atg16l2

Gene

ATG16L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.By similarity

Miscellaneous

Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies in mouse suggest that ATG16L2 is not essential for canonical autophagy.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NAA4

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8NAA4

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Atg16l2Curated
Alternative name(s):
APG16-like 2
Autophagy-related protein 16-2
WD repeat-containing protein 80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG16L2
Synonyms:WDR80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168010.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25464, ATG16L2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618716, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NAA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89849

Open Targets

More...
OpenTargetsi
ENSG00000168010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672575

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NAA4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATG16L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189027648

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371101 – 619Protein Atg16l2Add BLAST619

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8NAA4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NAA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NAA4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8NAA4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NAA4

PeptideAtlas

More...
PeptideAtlasi
Q8NAA4

PRoteomics IDEntifications database

More...
PRIDEi
Q8NAA4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72661 [Q8NAA4-1]
72662 [Q8NAA4-2]
72663 [Q8NAA4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NAA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NAA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168010, Expressed in blood and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NAA4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NAA4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168010, Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Heterooligomer with ATG16L1.

Interacts with ATG5. Self-oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2.

Interacts with RAB33B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124620, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-354, ATG12-ATG5-ATG16L2 complex

Protein interaction database and analysis system

More...
IntActi
Q8NAA4, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8NAA4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NAA4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NAA4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati334 – 373WD 1Sequence analysisAdd BLAST40
Repeati378 – 417WD 2Sequence analysisAdd BLAST40
Repeati420 – 454WD 3Sequence analysisAdd BLAST35
Repeati455 – 498WD 4Sequence analysisAdd BLAST44
Repeati500 – 539WD 5Sequence analysisAdd BLAST40
Repeati546 – 585WD 6Sequence analysisAdd BLAST40
Repeati589 – 619WD 7Sequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili116 – 227Sequence analysisAdd BLAST112

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat ATG16 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0288, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NAA4

KEGG Orthology (KO)

More...
KOi
K20868

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NAA4

TreeFam database of animal gene trees

More...
TreeFami
TF315541

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013923, Autophagy-rel_prot_16
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08614, ATG16, 1 hit
PF00400, WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 3 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NAA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL
60 70 80 90 100
DKFSKKLQPE PNSVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL
110 120 130 140 150
RLVCGEMAYQ VVEKGAALGT LESELQQRQS RLAALEARVA QLREARAQQA
160 170 180 190 200
QQVEEWRAQN AVQRAAYEAL RAHVGLREAA LRRLQEEARD LLERLVQRKA
210 220 230 240 250
RAAAERNLRN ERRERAKQAR VSQELKKAAK RTVSISEGPD TLGDGMRERR
260 270 280 290 300
ETLALAPEPE PLEKEACEKW KRPFRSASAT SLTLSHCVDV VKGLLDFKKR
310 320 330 340 350
RGHSIGGAPE QRYQIIPVCV AARLPTRAQD VLDAHLSEVN AVRFGPNSSL
360 370 380 390 400
LATGGADRLI HLWNVVGSRL EANQTLEGAG GSITSVDFDP SGYQVLAATY
410 420 430 440 450
NQAAQLWKVG EAQSKETLSG HKDKVTAAKF KLTRHQAVTG SRDRTVKEWD
460 470 480 490 500
LGRAYCSRTI NVLSYCNDVV CGDHIIISGH NDQKIRFWDS RGPHCTQVIP
510 520 530 540 550
VQGRVTSLSL SHDQLHLLSC SRDNTLKVID LRVSNIRQVF RADGFKCGSD
560 570 580 590 600
WTKAVFSPDR SYALAGSCDG ALYIWDVDTG KLESRLQGPH CAAVNAVAWC
610
YSGSHMVSVD QGRKVVLWQ
Length:619
Mass (Da):68,998
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F2962AA3C6BB850
GO
Isoform 2 (identifier: Q8NAA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:513
Mass (Da):56,955
Checksum:iBC41BEBE478C9F55
GO
Isoform 3 (identifier: Q8NAA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     276-619: Missing.

Show »
Length:275
Mass (Da):31,445
Checksum:i09BEED7D259D9E04
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YF72H0YF72_HUMAN
Autophagy-related protein 16-2
ATG16L2
450Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFG0H0YFG0_HUMAN
Autophagy-related protein 16-2
ATG16L2
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG67H0YG67_HUMAN
Autophagy-related protein 16-2
ATG16L2
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YG45H0YG45_HUMAN
Autophagy-related protein 16-2
ATG16L2
397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWZ9F5GWZ9_HUMAN
Autophagy-related protein 16-2
ATG16L2
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWM4F5GWM4_HUMAN
Autophagy-related protein 16-2
ATG16L2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7B6F5H7B6_HUMAN
Autophagy-related protein 16-2
ATG16L2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGJ8H0YGJ8_HUMAN
Autophagy-related protein 16-2
ATG16L2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGE3H0YGE3_HUMAN
Autophagy-related protein 16-2
ATG16L2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFZ7H0YFZ7_HUMAN
Autophagy-related protein 16-2
ATG16L2
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124E → G in BAC03485 (PubMed:14702039).Curated1
Sequence conflicti256A → V in AAH36713 (PubMed:15489334).Curated1
Sequence conflicti343R → G in BAC03485 (PubMed:14702039).Curated1
Sequence conflicti492G → E in BAC04021 (PubMed:14702039).Curated1
Sequence conflicti508L → R in CAH56355 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043605220R → W. Corresponds to variant dbSNP:rs11235604Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0339041 – 106Missing in isoform 2. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_033905276 – 619Missing in isoform 3. 1 PublicationAdd BLAST344

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093017 mRNA Translation: BAC04021.1
AK090597 mRNA Translation: BAC03485.1
CH471076 Genomic DNA Translation: EAW74876.1
CH471076 Genomic DNA Translation: EAW74874.1
BC036713 mRNA Translation: AAH36713.1
BC137489 mRNA Translation: AAI37490.1
BC137490 mRNA Translation: AAI37491.1
BC142718 mRNA Translation: AAI42719.1
BC146660 mRNA Translation: AAI46661.1
AL832974 mRNA Translation: CAH56355.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31634.1 [Q8NAA4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001305695.1, NM_001318766.1 [Q8NAA4-2]
NP_203746.1, NM_033388.1 [Q8NAA4-1]
XP_011543635.1, XM_011545333.1 [Q8NAA4-2]
XP_011543636.1, XM_011545334.1 [Q8NAA4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321297; ENSP00000326340; ENSG00000168010 [Q8NAA4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
89849

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:89849

UCSC genome browser

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UCSCi
uc001otd.4, human [Q8NAA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093017 mRNA Translation: BAC04021.1
AK090597 mRNA Translation: BAC03485.1
CH471076 Genomic DNA Translation: EAW74876.1
CH471076 Genomic DNA Translation: EAW74874.1
BC036713 mRNA Translation: AAH36713.1
BC137489 mRNA Translation: AAI37490.1
BC137490 mRNA Translation: AAI37491.1
BC142718 mRNA Translation: AAI42719.1
BC146660 mRNA Translation: AAI46661.1
AL832974 mRNA Translation: CAH56355.1
CCDSiCCDS31634.1 [Q8NAA4-1]
RefSeqiNP_001305695.1, NM_001318766.1 [Q8NAA4-2]
NP_203746.1, NM_033388.1 [Q8NAA4-1]
XP_011543635.1, XM_011545333.1 [Q8NAA4-2]
XP_011543636.1, XM_011545334.1 [Q8NAA4-2]

3D structure databases

SMRiQ8NAA4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124620, 6 interactors
ComplexPortaliCPX-354, ATG12-ATG5-ATG16L2 complex
IntActiQ8NAA4, 6 interactors
MINTiQ8NAA4
STRINGi9606.ENSP00000326340

Protein family/group databases

TCDBi9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ8NAA4
PhosphoSitePlusiQ8NAA4

Polymorphism and mutation databases

BioMutaiATG16L2
DMDMi189027648

Proteomic databases

EPDiQ8NAA4
jPOSTiQ8NAA4
MassIVEiQ8NAA4
MaxQBiQ8NAA4
PaxDbiQ8NAA4
PeptideAtlasiQ8NAA4
PRIDEiQ8NAA4
ProteomicsDBi72661 [Q8NAA4-1]
72662 [Q8NAA4-2]
72663 [Q8NAA4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30896, 182 antibodies

Genome annotation databases

EnsembliENST00000321297; ENSP00000326340; ENSG00000168010 [Q8NAA4-1]
GeneIDi89849
KEGGihsa:89849
UCSCiuc001otd.4, human [Q8NAA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
89849
DisGeNETi89849
EuPathDBiHostDB:ENSG00000168010.10

GeneCards: human genes, protein and diseases

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GeneCardsi
ATG16L2
HGNCiHGNC:25464, ATG16L2
HPAiENSG00000168010, Tissue enhanced (bone marrow, lymphoid tissue)
MIMi618716, gene
neXtProtiNX_Q8NAA4
OpenTargetsiENSG00000168010
PharmGKBiPA142672575

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0288, Eukaryota
GeneTreeiENSGT00940000153936
InParanoidiQ8NAA4
KOiK20868
PhylomeDBiQ8NAA4
TreeFamiTF315541

Enzyme and pathway databases

PathwayCommonsiQ8NAA4
SignaLinkiQ8NAA4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
89849, 3 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATG16L2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
89849
PharosiQ8NAA4, Tbio

Protein Ontology

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PROi
PR:Q8NAA4
RNActiQ8NAA4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168010, Expressed in blood and 185 other tissues
ExpressionAtlasiQ8NAA4, baseline and differential
GenevisibleiQ8NAA4, HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR013923, Autophagy-rel_prot_16
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08614, ATG16, 1 hit
PF00400, WD40, 4 hits
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 3 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA16L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NAA4
Secondary accession number(s): A5PL30
, B2RPK5, Q658V4, Q6PID3, Q8NBG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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