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Protein

THAP domain-containing protein 8

Gene

THAP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 85THAP-typePROSITE-ProRule annotationAdd BLAST85

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 8
Gene namesi
Name:THAP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161277.10
HGNCiHGNC:23191 THAP8
MIMi612536 gene
neXtProtiNX_Q8NA92

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161277
PharmGKBiPA134973337

Polymorphism and mutation databases

BioMutaiTHAP8
DMDMi29839559

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686501 – 274THAP domain-containing protein 8Add BLAST274

Proteomic databases

MaxQBiQ8NA92
PaxDbiQ8NA92
PeptideAtlasiQ8NA92
PRIDEiQ8NA92
ProteomicsDBi72658

PTM databases

iPTMnetiQ8NA92
PhosphoSitePlusiQ8NA92

Expressioni

Gene expression databases

BgeeiENSG00000161277 Expressed in 133 organ(s), highest expression level in gastrocnemius
CleanExiHS_THAP8
ExpressionAtlasiQ8NA92 baseline and differential
GenevisibleiQ8NA92 HS

Organism-specific databases

HPAiHPA064056
HPA070139

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TFIP11Q9UBB93EBI-717429,EBI-1105213

Protein-protein interaction databases

BioGridi128269, 9 interactors
IntActiQ8NA92, 7 interactors
STRINGi9606.ENSP00000292894

Structurei

3D structure databases

ProteinModelPortaliQ8NA92
SMRiQ8NA92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 85THAP-typePROSITE-ProRule annotationAdd BLAST85

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J6A3 Eukaryota
ENOG4111Z0Y LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000154565
HOVERGENiHBG079251
InParanoidiQ8NA92
OMAiFQWRWGV
OrthoDBiEOG091G034R
PhylomeDBiQ8NA92
TreeFamiTF330127

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026522 THAP8
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF13 PTHR23080:SF13, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NA92-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKYCRAPNC SNTAGRLGAD NRPVSFYKFP LKDGPRLQAW LQHMGCEHWV
60 70 80 90 100
PSCHQHLCSE HFTPSCFQWR WGVRYLRPDA VPSIFSRGPP AKSQRRTRST
110 120 130 140 150
QKPVSPPPPL QKNTPLPQSP AIPVSGPVRL VVLGPTSGSP KTVATMLLTP
160 170 180 190 200
LAPAPTPERS QPEVPAQQAQ TGLGPVLGAL QRRVRRLQRC QERHQAQLQA
210 220 230 240 250
LERLAQQLHG ESLLARARRG LQRLTTAQTL GPEESQTFTI ICGGPDIAMV
260 270
LAQDPAPATV DAKPELLDTR IPSA
Length:274
Mass (Da):30,082
Last modified:October 1, 2002 - v1
Checksum:iED820002E426E81A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHW1E5RHW1_HUMAN
THAP domain-containing protein 8
THAP8
65Annotation score:
U3KQ16U3KQ16_HUMAN
THAP domain-containing protein 8
THAP8
41Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03455270R → H. Corresponds to variant dbSNP:rs3810449Ensembl.1
Natural variantiVAR_020264112K → R. Corresponds to variant dbSNP:rs3810450Ensembl.1
Natural variantiVAR_034553157P → S1 PublicationCorresponds to variant dbSNP:rs34250145Ensembl.1
Natural variantiVAR_052288185R → Q1 PublicationCorresponds to variant dbSNP:rs10421966Ensembl.1
Natural variantiVAR_052289189R → W1 PublicationCorresponds to variant dbSNP:rs10420353Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057453 mRNA Translation: BAB71493.1
AK093048 mRNA Translation: BAC04034.1
BC046207 mRNA Translation: AAH46207.1
BC072416 mRNA Translation: AAH72416.1
CCDSiCCDS33000.1
RefSeqiNP_689871.1, NM_152658.2
UniGeneiHs.350209

Genome annotation databases

EnsembliENST00000292894; ENSP00000292894; ENSG00000161277
GeneIDi199745
KEGGihsa:199745
UCSCiuc002oda.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057453 mRNA Translation: BAB71493.1
AK093048 mRNA Translation: BAC04034.1
BC046207 mRNA Translation: AAH46207.1
BC072416 mRNA Translation: AAH72416.1
CCDSiCCDS33000.1
RefSeqiNP_689871.1, NM_152658.2
UniGeneiHs.350209

3D structure databases

ProteinModelPortaliQ8NA92
SMRiQ8NA92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128269, 9 interactors
IntActiQ8NA92, 7 interactors
STRINGi9606.ENSP00000292894

PTM databases

iPTMnetiQ8NA92
PhosphoSitePlusiQ8NA92

Polymorphism and mutation databases

BioMutaiTHAP8
DMDMi29839559

Proteomic databases

MaxQBiQ8NA92
PaxDbiQ8NA92
PeptideAtlasiQ8NA92
PRIDEiQ8NA92
ProteomicsDBi72658

Protocols and materials databases

DNASUi199745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292894; ENSP00000292894; ENSG00000161277
GeneIDi199745
KEGGihsa:199745
UCSCiuc002oda.1 human

Organism-specific databases

CTDi199745
EuPathDBiHostDB:ENSG00000161277.10
GeneCardsiTHAP8
HGNCiHGNC:23191 THAP8
HPAiHPA064056
HPA070139
MIMi612536 gene
neXtProtiNX_Q8NA92
OpenTargetsiENSG00000161277
PharmGKBiPA134973337
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6A3 Eukaryota
ENOG4111Z0Y LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000154565
HOVERGENiHBG079251
InParanoidiQ8NA92
OMAiFQWRWGV
OrthoDBiEOG091G034R
PhylomeDBiQ8NA92
TreeFamiTF330127

Miscellaneous databases

GenomeRNAii199745
PROiPR:Q8NA92
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161277 Expressed in 133 organ(s), highest expression level in gastrocnemius
CleanExiHS_THAP8
ExpressionAtlasiQ8NA92 baseline and differential
GenevisibleiQ8NA92 HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026522 THAP8
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF13 PTHR23080:SF13, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP8_HUMAN
AccessioniPrimary (citable) accession number: Q8NA92
Secondary accession number(s): Q0P5Z7, Q96M21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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