UniProtKB - Q8NA82 (MARHA_HUMAN)
Protein
Probable E3 ubiquitin-protein ligase MARCHF10
Gene
MARCHF10
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Curated
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 651 – 721 | RING-CH-typePROSITE-ProRule annotationAdd BLAST | 71 |
GO - Molecular functioni
- transferase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8NA82 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable E3 ubiquitin-protein ligase MARCHF10 (EC:2.3.2.27)Alternative name(s): Membrane-associated RING finger protein 10 Membrane-associated RING-CH protein X Short name: MARCH-X RING finger protein 190 RING-type E3 ubiquitin transferase MARCHF10Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26655, MARCHF10 |
MIMi | 613337, gene |
neXtProti | NX_Q8NA82 |
VEuPathDBi | HostDB:ENSG00000173838.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 162333 |
OpenTargetsi | ENSG00000173838 |
PharmGKBi | PA162395028 |
Miscellaneous databases
Pharosi | Q8NA82, Tbio |
Genetic variation databases
BioMutai | MARCH10 |
DMDMi | 296439307 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261626 | 1 – 808 | Probable E3 ubiquitin-protein ligase MARCHF10Add BLAST | 808 |
Proteomic databases
MassIVEi | Q8NA82 |
PaxDbi | Q8NA82 |
PeptideAtlasi | Q8NA82 |
PRIDEi | Q8NA82 |
ProteomicsDBi | 72656 |
PTM databases
iPTMneti | Q8NA82 |
PhosphoSitePlusi | Q8NA82 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173838, Expressed in right testis and 110 other tissues |
ExpressionAtlasi | Q8NA82, baseline and differential |
Genevisiblei | Q8NA82, HS |
Organism-specific databases
HPAi | ENSG00000173838, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ8NA82
Protein-protein interaction databases
BioGRIDi | 127813, 8 interactors |
IntActi | Q8NA82, 10 interactors |
MINTi | Q8NA82 |
STRINGi | 9606.ENSP00000463080 |
Miscellaneous databases
RNActi | Q8NA82, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 575 – 581 | Poly-Ser | 7 |
Domaini
The RING-CH-type zinc finger domain is required for E3 ligase activity.PROSITE-ProRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 651 – 721 | RING-CH-typePROSITE-ProRule annotationAdd BLAST | 71 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1609, Eukaryota |
GeneTreei | ENSGT00530000063836 |
HOGENOMi | CLU_021725_0_0_1 |
InParanoidi | Q8NA82 |
OrthoDBi | 517602at2759 |
PhylomeDBi | Q8NA82 |
TreeFami | TF330816 |
Family and domain databases
CDDi | cd16813, RING_CH-C4HC3_MARCH10, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR042583, MARCH10_RING_CH-C4HC3 IPR011016, Znf_RING-CH IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12906, RINGv, 1 hit |
SMARTi | View protein in SMART SM00744, RINGv, 1 hit |
PROSITEi | View protein in PROSITE PS51292, ZF_RING_CH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8NA82-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLHDARDRQK FFSDVQYLRD MQHKVDSEYQ ACLRRQEYRR DPNEKKRDQF
60 70 80 90 100
WGQETSFERS RFSSRSSSKQ SSSEEDALTE PRSSIKISAF KCDSKLPAID
110 120 130 140 150
QTSVKQKHKS TMTVRKAEKV DPSEPSPADQ APMVLLRKRK PNLRRFTVSP
160 170 180 190 200
ESHSPRASGD RSRQKQQWPA KVPVPRGADQ VVQQEGLMCN TKLKRPNQER
210 220 230 240 250
RNLVPSSQPM TENAPDRAKK GDPSAPSQSE LHPALSQAFQ GKNSPQVLSE
260 270 280 290 300
FSGPPLTPTT VGGPRKASFR FRDEDFYSIL SLNSRRESDD TEEETQSEEC
310 320 330 340 350
LWVGVRSPCS PSHHKRSRFG GTSTPQAKNK NFEENAENCR GHSSRRSEPS
360 370 380 390 400
HGSLRISNAM EPATERPSAG QRLSQDPGLP DRESATEKDR GGSENAKKSP
410 420 430 440 450
LSWDTKSEPR QEVGVNAENV WSDCISVEHR PGTHDSEGYW KDYLNSSQNS
460 470 480 490 500
LDYFISGRPI SPRSSVNSSY NPPASFMHSA LRDDIPVDLS MSSTSVHSSD
510 520 530 540 550
SEGNSGFHVC QPLSPIRNRT PFASAENHNY FPVNSAHEFA VREAEDTTLT
560 570 580 590 600
SQPQGAPLYT DLLLNPQGNL SLVDSSSSSP SRMNSEGHLH VSGSLQENTP
610 620 630 640 650
FTFFAVSHFP NQNDNGSRMA ASGFTDEKET SKIKADPEKL KKLQESLLEE
660 670 680 690 700
DSEEEGDLCR ICQIAGGSPS NPLLEPCGCV GSLQFVHQEC LKKWLKVKIT
710 720 730 740 750
SGADLGAVKT CEMCKQGLLV DLGDFNMIEF YQKHQQSQAQ NELMNSGLYL
760 770 780 790 800
VLLLHLYEQR FAELMRLNHN QVERERLSRN YPQPRTEENE NSELGDGNEG
SISQSQVV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V1Q5 | G3V1Q5_HUMAN | Probable E3 ubiquitin-protein ligas... | MARCHF10 RNF190, hCG_2039713 | 799 | Annotation score: | ||
J3KTN9 | J3KTN9_HUMAN | Probable E3 ubiquitin-protein ligas... | MARCHF10 RNF190, hCG_2039713 | 846 | Annotation score: | ||
J3QRH7 | J3QRH7_HUMAN | Probable E3 ubiquitin-protein ligas... | MARCHF10 | 693 | Annotation score: | ||
J3KTK3 | J3KTK3_HUMAN | Probable E3 ubiquitin-protein ligas... | MARCHF10 | 61 | Annotation score: | ||
J3QLJ2 | J3QLJ2_HUMAN | Probable E3 ubiquitin-protein ligas... | MARCHF10 | 164 | Annotation score: |
Sequence cautioni
The sequence AAH35021 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC05079 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 734 | H → Y in BAC05079 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 791 | N → S in AAH35021 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029461 | 241 | G → E1 PublicationCorresponds to variant dbSNP:rs17853369Ensembl. | 1 | |
Natural variantiVAR_029462 | 319 | F → S1 PublicationCorresponds to variant dbSNP:rs9891498Ensembl. | 1 | |
Natural variantiVAR_029463 | 742 | E → K. Corresponds to variant dbSNP:rs16946335Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093076 mRNA Translation: BAC04044.1 AK097506 mRNA Translation: BAC05079.1 Different initiation. AC005821 Genomic DNA No translation available. AC068512 Genomic DNA No translation available. AC080038 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94337.1 CH471109 Genomic DNA Translation: EAW94338.1 BC035021 mRNA Translation: AAH35021.1 Sequence problems. |
CCDSi | CCDS11635.1 |
RefSeqi | NP_001094345.1, NM_001100875.2 NP_001275708.1, NM_001288779.1 NP_001275709.1, NM_001288780.1 NP_689811.2, NM_152598.3 |
Genome annotation databases
Ensembli | ENST00000311269; ENSP00000311496; ENSG00000173838 ENST00000456609; ENSP00000416177; ENSG00000173838 |
GeneIDi | 162333 |
KEGGi | hsa:162333 |
UCSCi | uc002jag.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093076 mRNA Translation: BAC04044.1 AK097506 mRNA Translation: BAC05079.1 Different initiation. AC005821 Genomic DNA No translation available. AC068512 Genomic DNA No translation available. AC080038 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94337.1 CH471109 Genomic DNA Translation: EAW94338.1 BC035021 mRNA Translation: AAH35021.1 Sequence problems. |
CCDSi | CCDS11635.1 |
RefSeqi | NP_001094345.1, NM_001100875.2 NP_001275708.1, NM_001288779.1 NP_001275709.1, NM_001288780.1 NP_689811.2, NM_152598.3 |
3D structure databases
SMRi | Q8NA82 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127813, 8 interactors |
IntActi | Q8NA82, 10 interactors |
MINTi | Q8NA82 |
STRINGi | 9606.ENSP00000463080 |
PTM databases
iPTMneti | Q8NA82 |
PhosphoSitePlusi | Q8NA82 |
Genetic variation databases
BioMutai | MARCH10 |
DMDMi | 296439307 |
Proteomic databases
MassIVEi | Q8NA82 |
PaxDbi | Q8NA82 |
PeptideAtlasi | Q8NA82 |
PRIDEi | Q8NA82 |
ProteomicsDBi | 72656 |
Protocols and materials databases
Antibodypediai | 18645, 197 antibodies |
Genome annotation databases
Ensembli | ENST00000311269; ENSP00000311496; ENSG00000173838 ENST00000456609; ENSP00000416177; ENSG00000173838 |
GeneIDi | 162333 |
KEGGi | hsa:162333 |
UCSCi | uc002jag.6, human |
Organism-specific databases
CTDi | 162333 |
DisGeNETi | 162333 |
GeneCardsi | MARCHF10 |
HGNCi | HGNC:26655, MARCHF10 |
HPAi | ENSG00000173838, Tissue enriched (testis) |
MIMi | 613337, gene |
neXtProti | NX_Q8NA82 |
OpenTargetsi | ENSG00000173838 |
PharmGKBi | PA162395028 |
VEuPathDBi | HostDB:ENSG00000173838.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1609, Eukaryota |
GeneTreei | ENSGT00530000063836 |
HOGENOMi | CLU_021725_0_0_1 |
InParanoidi | Q8NA82 |
OrthoDBi | 517602at2759 |
PhylomeDBi | Q8NA82 |
TreeFami | TF330816 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8NA82 |
Miscellaneous databases
BioGRID-ORCSi | 162333, 8 hits in 961 CRISPR screens |
ChiTaRSi | MARCH10, human |
GenomeRNAii | 162333 |
Pharosi | Q8NA82, Tbio |
PROi | PR:Q8NA82 |
RNActi | Q8NA82, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173838, Expressed in right testis and 110 other tissues |
ExpressionAtlasi | Q8NA82, baseline and differential |
Genevisiblei | Q8NA82, HS |
Family and domain databases
CDDi | cd16813, RING_CH-C4HC3_MARCH10, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR042583, MARCH10_RING_CH-C4HC3 IPR011016, Znf_RING-CH IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF12906, RINGv, 1 hit |
SMARTi | View protein in SMART SM00744, RINGv, 1 hit |
PROSITEi | View protein in PROSITE PS51292, ZF_RING_CH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MARHA_HUMAN | |
Accessioni | Q8NA82Primary (citable) accession number: Q8NA82 Secondary accession number(s): D3DU09, Q8IYS7, Q8N7Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways