Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - Q8NA82 (MARHA_HUMAN)

Entry version 150 (07 Apr 2021)
Sequence version 3 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Probable E3 ubiquitin-protein ligase MARCHF10

Gene

MARCHF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri651 – 721RING-CH-typePROSITE-ProRule annotationAdd BLAST71

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NA82

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase MARCHF10 (EC:2.3.2.27)
Alternative name(s):
Membrane-associated RING finger protein 10
Membrane-associated RING-CH protein X
Short name:
MARCH-X
RING finger protein 190
RING-type E3 ubiquitin transferase MARCHF10Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARCHF10Imported
Synonyms:MARCH10, RNF190
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26655, MARCHF10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613337, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NA82

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173838.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		162333

Open Targets

More...OpenTargetsi		ENSG00000173838

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395028

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NA82, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MARCH10

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439307

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002616261 – 808Probable E3 ubiquitin-protein ligase MARCHF10Add BLAST808

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NA82

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NA82

PeptideAtlas

More...PeptideAtlasi		Q8NA82

PRoteomics IDEntifications database

More...PRIDEi		Q8NA82

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72656

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NA82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NA82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173838, Expressed in right testis and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NA82, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NA82, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173838, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127813, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q8NA82, 10 interactors

Molecular INTeraction database

More...MINTi		Q8NA82

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000463080

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NA82, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NA82

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi575 – 581Poly-Ser7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri651 – 721RING-CH-typePROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1609, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063836

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021725_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NA82

Database of Orthologous Groups

More...OrthoDBi		517602at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NA82

TreeFam database of animal gene trees

More...TreeFami		TF330816

Family and domain databases

Conserved Domains Database

More...CDDi		cd16813, RING_CH-C4HC3_MARCH10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042583, MARCH10_RING_CH-C4HC3
IPR011016, Znf_RING-CH
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12906, RINGv, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00744, RINGv, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51292, ZF_RING_CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8NA82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHDARDRQK FFSDVQYLRD MQHKVDSEYQ ACLRRQEYRR DPNEKKRDQF 
        60         70         80         90        100
WGQETSFERS RFSSRSSSKQ SSSEEDALTE PRSSIKISAF KCDSKLPAID 
       110        120        130        140        150
QTSVKQKHKS TMTVRKAEKV DPSEPSPADQ APMVLLRKRK PNLRRFTVSP 
       160        170        180        190        200
ESHSPRASGD RSRQKQQWPA KVPVPRGADQ VVQQEGLMCN TKLKRPNQER 
       210        220        230        240        250
RNLVPSSQPM TENAPDRAKK GDPSAPSQSE LHPALSQAFQ GKNSPQVLSE 
       260        270        280        290        300
FSGPPLTPTT VGGPRKASFR FRDEDFYSIL SLNSRRESDD TEEETQSEEC 
       310        320        330        340        350
LWVGVRSPCS PSHHKRSRFG GTSTPQAKNK NFEENAENCR GHSSRRSEPS 
       360        370        380        390        400
HGSLRISNAM EPATERPSAG QRLSQDPGLP DRESATEKDR GGSENAKKSP 
       410        420        430        440        450
LSWDTKSEPR QEVGVNAENV WSDCISVEHR PGTHDSEGYW KDYLNSSQNS 
       460        470        480        490        500
LDYFISGRPI SPRSSVNSSY NPPASFMHSA LRDDIPVDLS MSSTSVHSSD 
       510        520        530        540        550
SEGNSGFHVC QPLSPIRNRT PFASAENHNY FPVNSAHEFA VREAEDTTLT 
       560        570        580        590        600
SQPQGAPLYT DLLLNPQGNL SLVDSSSSSP SRMNSEGHLH VSGSLQENTP 
       610        620        630        640        650
FTFFAVSHFP NQNDNGSRMA ASGFTDEKET SKIKADPEKL KKLQESLLEE 
       660        670        680        690        700
DSEEEGDLCR ICQIAGGSPS NPLLEPCGCV GSLQFVHQEC LKKWLKVKIT 
       710        720        730        740        750
SGADLGAVKT CEMCKQGLLV DLGDFNMIEF YQKHQQSQAQ NELMNSGLYL 
       760        770        780        790        800
VLLLHLYEQR FAELMRLNHN QVERERLSRN YPQPRTEENE NSELGDGNEG 

SISQSQVV
Length:808
Mass (Da):90,511
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i456C2D2A93AAE8B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1Q5G3V1Q5_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10 RNF190, hCG_2039713
799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTN9J3KTN9_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10 RNF190, hCG_2039713
846Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRH7J3QRH7_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
693Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTK3J3KTK3_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLJ2J3QLJ2_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35021 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC05079 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti734H → Y in BAC05079 (PubMed:14702039).Curated1
Sequence conflicti791N → S in AAH35021 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029461241G → E1 PublicationCorresponds to variant dbSNP:rs17853369Ensembl.1
Natural variantiVAR_029462319F → S1 PublicationCorresponds to variant dbSNP:rs9891498Ensembl.1
Natural variantiVAR_029463742E → K. Corresponds to variant dbSNP:rs16946335Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093076 mRNA Translation: BAC04044.1
AK097506 mRNA Translation: BAC05079.1 Different initiation.
AC005821 Genomic DNA No translation available.
AC068512 Genomic DNA No translation available.
AC080038 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94337.1
CH471109 Genomic DNA Translation: EAW94338.1
BC035021 mRNA Translation: AAH35021.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11635.1

NCBI Reference Sequences

More...RefSeqi		NP_001094345.1, NM_001100875.2
NP_001275708.1, NM_001288779.1
NP_001275709.1, NM_001288780.1
NP_689811.2, NM_152598.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311269; ENSP00000311496; ENSG00000173838
ENST00000456609; ENSP00000416177; ENSG00000173838

Database of genes from NCBI RefSeq genomes

More...GeneIDi		162333

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:162333

UCSC genome browser

More...UCSCi		uc002jag.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093076 mRNA Translation: BAC04044.1
AK097506 mRNA Translation: BAC05079.1 Different initiation.
AC005821 Genomic DNA No translation available.
AC068512 Genomic DNA No translation available.
AC080038 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94337.1
CH471109 Genomic DNA Translation: EAW94338.1
BC035021 mRNA Translation: AAH35021.1 Sequence problems.
CCDSiCCDS11635.1
RefSeqiNP_001094345.1, NM_001100875.2
NP_001275708.1, NM_001288779.1
NP_001275709.1, NM_001288780.1
NP_689811.2, NM_152598.3

3D structure databases

SMRiQ8NA82
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127813, 8 interactors
IntActiQ8NA82, 10 interactors
MINTiQ8NA82
STRINGi9606.ENSP00000463080

PTM databases

iPTMnetiQ8NA82
PhosphoSitePlusiQ8NA82

Genetic variation databases

BioMutaiMARCH10
DMDMi296439307

Proteomic databases

MassIVEiQ8NA82
PaxDbiQ8NA82
PeptideAtlasiQ8NA82
PRIDEiQ8NA82
ProteomicsDBi72656

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18645, 197 antibodies

Genome annotation databases

EnsembliENST00000311269; ENSP00000311496; ENSG00000173838
ENST00000456609; ENSP00000416177; ENSG00000173838
GeneIDi162333
KEGGihsa:162333
UCSCiuc002jag.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		162333
DisGeNETi162333

GeneCards: human genes, protein and diseases

More...GeneCardsi		MARCHF10
HGNCiHGNC:26655, MARCHF10
HPAiENSG00000173838, Tissue enriched (testis)
MIMi613337, gene
neXtProtiNX_Q8NA82
OpenTargetsiENSG00000173838
PharmGKBiPA162395028
VEuPathDBiHostDB:ENSG00000173838.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1609, Eukaryota
GeneTreeiENSGT00530000063836
HOGENOMiCLU_021725_0_0_1
InParanoidiQ8NA82
OrthoDBi517602at2759
PhylomeDBiQ8NA82
TreeFamiTF330816

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ8NA82

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		162333, 8 hits in 961 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MARCH10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		162333
PharosiQ8NA82, Tbio

Protein Ontology

More...PROi		PR:Q8NA82
RNActiQ8NA82, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173838, Expressed in right testis and 110 other tissues
ExpressionAtlasiQ8NA82, baseline and differential
GenevisibleiQ8NA82, HS

Family and domain databases

CDDicd16813, RING_CH-C4HC3_MARCH10, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR042583, MARCH10_RING_CH-C4HC3
IPR011016, Znf_RING-CH
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12906, RINGv, 1 hit
SMARTiView protein in SMART
SM00744, RINGv, 1 hit
PROSITEiView protein in PROSITE
PS51292, ZF_RING_CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARHA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NA82
Secondary accession number(s): D3DU09, Q8IYS7, Q8N7Z7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again