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Protein

Testis-expressed protein 19

Gene

TEX19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retranstoposon mobilization (PubMed:28806172).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Meiosis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 19
Gene namesi
Name:TEX19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182459.4
HGNCiHGNC:33802 TEX19
MIMi615647 gene
neXtProtiNX_Q8NA77

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi400629
OpenTargetsiENSG00000182459
PharmGKBiPA165433159

Polymorphism and mutation databases

BioMutaiTEX19
DMDMi74729854

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259621 – 164Testis-expressed protein 19Add BLAST164

Proteomic databases

PaxDbiQ8NA77
PRIDEiQ8NA77
ProteomicsDBi72654

PTM databases

PhosphoSitePlusiQ8NA77

Expressioni

Tissue specificityi

Expressed in testis. Expressed in undifferentiated embryonic stem cells.2 Publications

Inductioni

Down-regulated by gonadotropin suppression sufficient to cause marked suppression of spermatogenesis and additionally progestogen treatment.1 Publication

Gene expression databases

BgeeiENSG00000182459 Expressed in 15 organ(s), highest expression level in testis
GenevisibleiQ8NA77 HS

Organism-specific databases

HPAiHPA054577

Interactioni

Subunit structurei

Interacts with UBR2; does not lead to TEX19 degradation and stabilizes it. Interacts with piRNA-associated proteins DDX4, EDC4, MAEL, PIWIL1, PIWIL2, RANBP9 and TDRD6 (By similarity). Interacts with L1RE1 (PubMed:28806172).By similarity1 Publication

Protein-protein interaction databases

IntActiQ8NA77, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8NA77
SMRiQ8NA77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 68Interaction with LIRE11 PublicationAdd BLAST68
Regioni111 – 159Important for interaction with piRNABy similarityAdd BLAST49

Phylogenomic databases

eggNOGiENOG410IJA1 Eukaryota
ENOG41119UR LUCA
GeneTreeiENSGT00390000014279
HOGENOMiHOG000154552
InParanoidiQ8NA77
OMAiGLLTCSH
OrthoDBiEOG091G0TYV
PhylomeDBiQ8NA77
TreeFamiTF338441

Family and domain databases

InterProiView protein in InterPro
IPR029093 TEX19
PANTHERiPTHR31387 PTHR31387, 1 hit
PfamiView protein in Pfam
PF15553 TEX19, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NA77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPPVSMRYE EEGMSYLYAS WMYQLQHGDQ LSICFTCFKA AFLDFKDLLE
60 70 80 90 100
SEDWEEDNWD PELMEHTEAE SEQEGSSGME LSWGQSPGQP VQGGSEAWGP
110 120 130 140 150
GTLAAAPEGL EDAGLDPHFV PTELWPQEAV PLGLGLEDAD WTQGLPWRFE
160
ELLTCSHWPS FFPS
Length:164
Mass (Da):18,469
Last modified:October 1, 2002 - v1
Checksum:iC87C40B0E5989EEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093086 mRNA Translation: BAC04049.1
CH471099 Genomic DNA Translation: EAW89767.1
BC016939 mRNA Translation: AAH16939.1
BC036191 mRNA Translation: AAH36191.1
BC050391 mRNA Translation: AAH50391.1
BC057820 mRNA Translation: AAH57820.1
CCDSiCCDS11809.1
RefSeqiNP_997342.1, NM_207459.3
XP_016880127.1, XM_017024638.1
XP_016880128.1, XM_017024639.1
UniGeneiHs.231897

Genome annotation databases

EnsembliENST00000333437; ENSP00000331500; ENSG00000182459
GeneIDi400629
KEGGihsa:400629
UCSCiuc002keq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093086 mRNA Translation: BAC04049.1
CH471099 Genomic DNA Translation: EAW89767.1
BC016939 mRNA Translation: AAH16939.1
BC036191 mRNA Translation: AAH36191.1
BC050391 mRNA Translation: AAH50391.1
BC057820 mRNA Translation: AAH57820.1
CCDSiCCDS11809.1
RefSeqiNP_997342.1, NM_207459.3
XP_016880127.1, XM_017024638.1
XP_016880128.1, XM_017024639.1
UniGeneiHs.231897

3D structure databases

ProteinModelPortaliQ8NA77
SMRiQ8NA77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NA77, 2 interactors

PTM databases

PhosphoSitePlusiQ8NA77

Polymorphism and mutation databases

BioMutaiTEX19
DMDMi74729854

Proteomic databases

PaxDbiQ8NA77
PRIDEiQ8NA77
ProteomicsDBi72654

Protocols and materials databases

DNASUi400629
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333437; ENSP00000331500; ENSG00000182459
GeneIDi400629
KEGGihsa:400629
UCSCiuc002keq.3 human

Organism-specific databases

CTDi400629
DisGeNETi400629
EuPathDBiHostDB:ENSG00000182459.4
GeneCardsiTEX19
HGNCiHGNC:33802 TEX19
HPAiHPA054577
MIMi615647 gene
neXtProtiNX_Q8NA77
OpenTargetsiENSG00000182459
PharmGKBiPA165433159
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJA1 Eukaryota
ENOG41119UR LUCA
GeneTreeiENSGT00390000014279
HOGENOMiHOG000154552
InParanoidiQ8NA77
OMAiGLLTCSH
OrthoDBiEOG091G0TYV
PhylomeDBiQ8NA77
TreeFamiTF338441

Miscellaneous databases

GenomeRNAii400629
PROiPR:Q8NA77
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182459 Expressed in 15 organ(s), highest expression level in testis
GenevisibleiQ8NA77 HS

Family and domain databases

InterProiView protein in InterPro
IPR029093 TEX19
PANTHERiPTHR31387 PTHR31387, 1 hit
PfamiView protein in Pfam
PF15553 TEX19, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEX19_HUMAN
AccessioniPrimary (citable) accession number: Q8NA77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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