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Entry version 105 (13 Feb 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Protein FAM47B

Gene

FAM47B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM47B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM47B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000189132.6

Human Gene Nomenclature Database

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HGNCi
HGNC:26659 FAM47B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NA70

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000189132

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134969396

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM47B

Domain mapping of disease mutations (DMDM)

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DMDMi
71151884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870381 – 645Protein FAM47BAdd BLAST645

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8NA70

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8NA70

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NA70

PeptideAtlas

More...
PeptideAtlasi
Q8NA70

PRoteomics IDEntifications database

More...
PRIDEi
Q8NA70

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72649

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NA70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NA70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000189132 Expressed in 9 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NA70 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046829
HPA050996

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127993, 1 interactor

Protein interaction database and analysis system

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IntActi
Q8NA70, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000328307

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8NA70

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi189 – 324Pro-richAdd BLAST136

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM47 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J8EG Eukaryota
ENOG410XRKP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000165290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112475

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG076577

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NA70

Identification of Orthologs from Complete Genome Data

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OMAi
FWESCPR

Database of Orthologous Groups

More...
OrthoDBi
678383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NA70

TreeFam database of animal gene trees

More...
TreeFami
TF340932

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032743 FAM47

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14642 FAM47, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NA70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDRRPQDRP RSQGMDSKPW YCDKPPSKYF AKRKHRRLRF PPVDTQNWVF
60 70 80 90 100
VTEGMDDFRY ACQSPEDTLV CRRDEFLLPK ISLRGPQADR KSRKKKLLKK
110 120 130 140 150
AALFSELSPV QPARKAFVEE VEAQLMTKHP LAMYPNLGKD MPPDLLLQVL
160 170 180 190 200
KQLDPERKLE DAWARCEARE KTTEVPTESG KYPCGESCPR PPETPVSRLR
210 220 230 240 250
PQLPKTPVSS RRPEPPKTRV SSLRPEPPKT RVSSLHPEPP ETRASHLRVD
260 270 280 290 300
PPETGVSHLC PEPPKTLVSS VHPEPPDTGA SHLCPEPPET RVSHLHPEPP
310 320 330 340 350
ETGVSHLRPE PSKTQVSSLC PEPPEAGVSH LCLEPPNTHR VSSFLLQVLK
360 370 380 390 400
LDSEKKLEDA RARCEGQEMT TEELTKPGKY HFWESCPRPF ESRMPHLRLV
410 420 430 440 450
LPITRRMASL CLKPPKTRRV SSLCPEPTKT GASHLKELFQ EDTPSTMECV
460 470 480 490 500
SDSLQRRHTS RKLRDFKWAG DLGVNEESIS SLFDFTPECR TTDQDQKIKK
510 520 530 540 550
ANECASRLMY GMELDDMDEV EFLRIKYWDR RRRAAPHSYS AQRGRIRYGP
560 570 580 590 600
WYFEPKLGKK LRSDEPLIDP KPVLEKPDEP DILDGLYGPI AFKDFILSKG
610 620 630 640
YRMPGVIEKL FAKKGWTYDS VKTPIQRAVQ VYKYKEDVTD ASKED
Length:645
Mass (Da):73,945
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF49BACE4627E3C5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202Q → H in AAH35026 (PubMed:15489334).Curated1
Sequence conflicti220 – 221VS → AP in BAC04056 (PubMed:14702039).Curated2
Sequence conflicti299P → S in BAC04056 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK093101 mRNA Translation: BAC04056.1
AL645585 Genomic DNA No translation available.
BC035026 mRNA Translation: AAH35026.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14236.1

NCBI Reference Sequences

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RefSeqi
NP_689844.2, NM_152631.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.197801

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329357; ENSP00000328307; ENSG00000189132

Database of genes from NCBI RefSeq genomes

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GeneIDi
170062

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170062

UCSC genome browser

More...
UCSCi
uc004ddi.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093101 mRNA Translation: BAC04056.1
AL645585 Genomic DNA No translation available.
BC035026 mRNA Translation: AAH35026.1
CCDSiCCDS14236.1
RefSeqiNP_689844.2, NM_152631.2
UniGeneiHs.197801

3D structure databases

ProteinModelPortaliQ8NA70
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127993, 1 interactor
IntActiQ8NA70, 3 interactors
STRINGi9606.ENSP00000328307

PTM databases

iPTMnetiQ8NA70
PhosphoSitePlusiQ8NA70

Polymorphism and mutation databases

BioMutaiFAM47B
DMDMi71151884

Proteomic databases

EPDiQ8NA70
jPOSTiQ8NA70
PaxDbiQ8NA70
PeptideAtlasiQ8NA70
PRIDEiQ8NA70
ProteomicsDBi72649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329357; ENSP00000328307; ENSG00000189132
GeneIDi170062
KEGGihsa:170062
UCSCiuc004ddi.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170062
EuPathDBiHostDB:ENSG00000189132.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM47B
HGNCiHGNC:26659 FAM47B
HPAiHPA046829
HPA050996
neXtProtiNX_Q8NA70
OpenTargetsiENSG00000189132
PharmGKBiPA134969396

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J8EG Eukaryota
ENOG410XRKP LUCA
GeneTreeiENSGT00940000165290
HOGENOMiHOG000112475
HOVERGENiHBG076577
InParanoidiQ8NA70
OMAiFWESCPR
OrthoDBi678383at2759
PhylomeDBiQ8NA70
TreeFamiTF340932

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170062

Protein Ontology

More...
PROi
PR:Q8NA70

Gene expression databases

BgeeiENSG00000189132 Expressed in 9 organ(s), highest expression level in sperm
GenevisibleiQ8NA70 HS

Family and domain databases

InterProiView protein in InterPro
IPR032743 FAM47
PfamiView protein in Pfam
PF14642 FAM47, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA47B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NA70
Secondary accession number(s): Q5JQN5, Q6PIG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 13, 2019
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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