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Entry version 138 (12 Aug 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Protein chibby homolog 2

Gene

CBY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8NA61

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein chibby homolog 2Curated
Alternative name(s):
Spermatid-associated protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CBY2Imported
Synonyms:SPERT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174015.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30720, CBY2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618614, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NA61

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
220082

Open Targets

More...
OpenTargetsi
ENSG00000174015

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NA61, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPERT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003072911 – 448Protein chibby homolog 2Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei148PhosphoserineBy similarity1
Modified residuei150PhosphoserineBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei338PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NA61

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NA61

PeptideAtlas

More...
PeptideAtlasi
Q8NA61

PRoteomics IDEntifications database

More...
PRIDEi
Q8NA61

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
72645 [Q8NA61-1]
72646 [Q8NA61-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NA61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NA61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000174015, Expressed in left testis and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NA61, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NA61, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174015, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds to NEK1 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8NA61
With#Exp.IntAct
ACTN1 [P12814]3EBI-741724,EBI-351710
ARHGEF40 - isoform 2 [Q8TER5-2]3EBI-741724,EBI-10275150
ARMC7 [Q9H6L4]3EBI-741724,EBI-742909
C19orf44 [Q9H6X5]3EBI-741724,EBI-7112211
C1orf109 [Q9NX04]3EBI-741724,EBI-8643161
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-741724,EBI-10247802
CCDC198 [Q9NVL8]3EBI-741724,EBI-10238351
CCNG1 [P51959]3EBI-741724,EBI-3905829
CDC23 [Q9UJX2]3EBI-741724,EBI-396137
CEP44 [Q9C0F1]4EBI-741724,EBI-744115
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-741724,EBI-10181988
CEP95 [Q96GE4]3EBI-741724,EBI-372775
CHCHD3 [Q9NX63]3EBI-741724,EBI-743375
CHIC2 [Q9UKJ5]3EBI-741724,EBI-741528
CKS1B [P61024]3EBI-741724,EBI-456371
CNNM3 [Q8NE01]3EBI-741724,EBI-741032
CTNNAL1 [Q9UBT7]3EBI-741724,EBI-514206
DUSP14 [O95147]3EBI-741724,EBI-3922653
DZIP1L [Q8IYY4]3EBI-741724,EBI-10264440
EIF4E2 [O60573]3EBI-741724,EBI-398610
ELOA [Q14241]3EBI-741724,EBI-742350
ENKD1 [Q9H0I2]3EBI-741724,EBI-744099
FAM161A [Q3B820]3EBI-741724,EBI-719941
FRS3 [O43559]3EBI-741724,EBI-725515
GOLGA6L2 - isoform 2 [Q8N9W4-2]3EBI-741724,EBI-10268729
HAUS1 [Q96CS2]3EBI-741724,EBI-2514791
KIFC3 [Q9BVG8]5EBI-741724,EBI-2125614
KLC3 [Q6P597]3EBI-741724,EBI-1643885
LATS1 [Q6PJG3]3EBI-741724,EBI-10253976
LENG1 [Q96BZ8]3EBI-741724,EBI-726510
LMO1 [P25800]3EBI-741724,EBI-8639312
LMO2 [P25791]3EBI-741724,EBI-739696
LMO3 [Q8TAP4]3EBI-741724,EBI-742259
MED28 [Q9H204]3EBI-741724,EBI-514199
METTL17 [Q9H7H0]4EBI-741724,EBI-749353
MLH1 [P40692]6EBI-741724,EBI-744248
MOS [P00540]3EBI-741724,EBI-1757866
PID1 [Q7Z2X4]3EBI-741724,EBI-10256685
PIN1 [Q13526]3EBI-741724,EBI-714158
PLEKHN1 [Q494U1]3EBI-741724,EBI-10241513
PPP1R18 [Q6NYC8]3EBI-741724,EBI-2557469
RPL9P9 [P32969]3EBI-741724,EBI-358122
RTP5 [Q14D33]3EBI-741724,EBI-10217913
RUNX1T1 - isoform 4 [Q06455-4]3EBI-741724,EBI-10224192
SCNM1 [Q9BWG6]3EBI-741724,EBI-748391
SH3RF2 [Q08AM8]3EBI-741724,EBI-10225873
SYCE1 [Q8N0S2]3EBI-741724,EBI-6872807
TCEANC [Q8N8B7]3EBI-741724,EBI-954696
TEX11 [Q8IYF3]3EBI-741724,EBI-742397
TRIM42 [Q8IWZ5]3EBI-741724,EBI-5235829
TSGA10 [Q9BZW7]3EBI-741724,EBI-744794
TXLNA [P40222]3EBI-741724,EBI-359793
TXLNB [Q8N3L3]3EBI-741724,EBI-6116822
ZC2HC1C [Q53FD0]3EBI-741724,EBI-740767
ZMAT2 [Q96NC0]3EBI-741724,EBI-2682299
ZNF564 [Q8TBZ8]3EBI-741724,EBI-10273713
ZNF581 [Q9P0T4]3EBI-741724,EBI-745520
ZNF655 [Q8N720]4EBI-741724,EBI-625509
B2R6J33EBI-741724,EBI-10175524
CBY2 - isoform 2 [Q8NA61-2]
With#Exp.IntAct
AIMP2 [Q13155]5EBI-11524851,EBI-745226
BEX3 [Q00994]3EBI-11524851,EBI-741753
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-11524851,EBI-12061599
C1orf109 [Q9NX04]3EBI-11524851,EBI-8643161
itself5EBI-11524851,EBI-11524851
CCDC146 [Q8IYE0]3EBI-11524851,EBI-10749669
CCDC185 [Q8N715]3EBI-11524851,EBI-740814
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-11524851,EBI-10961624
CCHCR1 - isoform 3 [Q8TD31-3]5EBI-11524851,EBI-10175300
CDC37 [Q16543]3EBI-11524851,EBI-295634
CDK18 [Q07002]3EBI-11524851,EBI-746238
CEP55 [Q53EZ4]3EBI-11524851,EBI-747776
CKS1B [P61024]3EBI-11524851,EBI-456371
CNNM3 [Q8NE01]3EBI-11524851,EBI-741032
CYTH4 [Q9UIA0]3EBI-11524851,EBI-11521003
DTNB - isoform 5 [O60941-5]3EBI-11524851,EBI-11984733
DZIP1L [Q8IYY4]5EBI-11524851,EBI-10264440
EFCAB3 - isoform 2 [Q8N7B9-2]3EBI-11524851,EBI-11958551
ENKD1 [Q9H0I2]3EBI-11524851,EBI-744099
FAM161A [Q3B820]5EBI-11524851,EBI-719941
FAM92A - isoform 3 [A1XBS5-3]3EBI-11524851,EBI-12348777
FARS2 [O95363]3EBI-11524851,EBI-2513774
FBXO17 [Q96EF6]3EBI-11524851,EBI-2510157
GADD45GIP1 [Q8TAE8]3EBI-11524851,EBI-372506
GOLGA6A [Q9NYA3]3EBI-11524851,EBI-11163335
HSF2BP [O75031]3EBI-11524851,EBI-7116203
ING5 [Q8WYH8]6EBI-11524851,EBI-488533
ISCU [Q9H1K1]3EBI-11524851,EBI-1047335
KIAA0408 [Q6ZU52]5EBI-11524851,EBI-739493
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-11524851,EBI-14069005
LNX1 [Q8TBB1]7EBI-11524851,EBI-739832
MCRS1 [Q96EZ8]3EBI-11524851,EBI-348259
MED28 [Q9H204]3EBI-11524851,EBI-514199
METTL17 - isoform 2 [Q9H7H0-2]3EBI-11524851,EBI-11098807
MGC50722 [Q8IVT4]3EBI-11524851,EBI-14086479
MLH1 [P40692]11EBI-11524851,EBI-744248
MMAB [Q96EY8]3EBI-11524851,EBI-7825413
MOS [P00540]3EBI-11524851,EBI-1757866
NEK6 - isoform 4 [Q9HC98-4]3EBI-11524851,EBI-11750983
NME7 [Q9Y5B8]3EBI-11524851,EBI-744782
OIP5 [O43482]3EBI-11524851,EBI-536879
PIN1 [Q13526]3EBI-11524851,EBI-714158
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-11524851,EBI-12014286
POLR1C [O15160]5EBI-11524851,EBI-1055079
PPFIA3 [O75145]3EBI-11524851,EBI-1763225
PPP1R13B [Q96KQ4]3EBI-11524851,EBI-1105153
PRPF18 [Q99633]3EBI-11524851,EBI-2798416
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-11524851,EBI-1504830
RNF6 [A0A0S2Z4G9]3EBI-11524851,EBI-16428950
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-11524851,EBI-11984663
SCNM1 [Q9BWG6]5EBI-11524851,EBI-748391
SNAPC5 - isoform 2 [O75971-2]5EBI-11524851,EBI-12004298
SSX3 [Q99909]3EBI-11524851,EBI-10295431
SYCE1 [Q8N0S2]7EBI-11524851,EBI-6872807
SYT17 [Q9BSW7]3EBI-11524851,EBI-745392
TCEA2 [Q15560]3EBI-11524851,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11524851,EBI-11955057
TCHP [Q9BT92]3EBI-11524851,EBI-740781
TEX11 - isoform 3 [Q8IYF3-3]3EBI-11524851,EBI-11523345
TRIML2 [Q8N7C3]3EBI-11524851,EBI-11059915
TSGA10IP [Q3SY00]3EBI-11524851,EBI-10241197
TXK [P42681]3EBI-11524851,EBI-7877438
TXLNA [P40222]3EBI-11524851,EBI-359793
USHBP1 [Q8N6Y0]3EBI-11524851,EBI-739895
WDYHV1 [Q96HA8]5EBI-11524851,EBI-741158
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-11524851,EBI-8656416
ZNF250 - isoform 3 [P15622-3]3EBI-11524851,EBI-10177272
ZNF417 [Q8TAU3]3EBI-11524851,EBI-740727
ZNF564 [Q8TBZ8]3EBI-11524851,EBI-10273713
ZNF572 [Q7Z3I7]3EBI-11524851,EBI-10172590
ZNF581 [Q9P0T4]3EBI-11524851,EBI-745520
ZNF688 [A0A0S2Z5X4]3EBI-11524851,EBI-16429014
ZNF764 [Q96H86]3EBI-11524851,EBI-745775
ZNF785 [A8K8V0]3EBI-11524851,EBI-3925400

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128627, 97 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NA61, 130 interactors

Molecular INTeraction database

More...
MINTi
Q8NA61

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309189

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8NA61, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NA61

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 198Sequence analysisAdd BLAST35
Coiled coili242 – 267Sequence analysisAdd BLAST26
Coiled coili356 – 414Sequence analysisAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chibby family. SPERT subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S6IZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041289_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NA61

KEGG Orthology (KO)

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KOi
K23403

Identification of Orthologs from Complete Genome Data

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OMAi
WSIWEEN

Database of Orthologous Groups

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OrthoDBi
1015941at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NA61

TreeFam database of animal gene trees

More...
TreeFami
TF324419

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07429, Cby_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028118, Chibby_fam
IPR026655, SPERT

The PANTHER Classification System

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PANTHERi
PTHR21533:SF13, PTHR21533:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14645, Chibby, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NA61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL
60 70 80 90 100
PQRGTAEPFP RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL
110 120 130 140 150
DPMERPMSQA DLELDYNPPR VQLSDEMFVF QDGRWVNENC RLQSPYFSPS
160 170 180 190 200
ASFHHKLHHK RLAKECMLQE ENKSLREENK ALREENRMLS KENKILQVFW
210 220 230 240 250
EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR GKEDSTLQLL
260 270 280 290 300
REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ
310 320 330 340 350
GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP
360 370 380 390 400
DGCQPLQLLR EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL
410 420 430 440
WENNKLKLQQ KLVIDTVTEV TARMEMLIEE LYAFMPARSQ DPKKPSRV
Length:448
Mass (Da):51,570
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD59271CFE59F8863
GO
Isoform 2 (identifier: Q8NA61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-52: TRSESLEIPISVVLPQ → MQPEGLKCRMEESNAE

Show »
Length:412
Mass (Da):47,289
Checksum:i6EC3B47EF08CDE10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLB4E9PLB4_HUMAN
Protein chibby homolog 2
CBY2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054064329K → E. Corresponds to variant dbSNP:rs7317245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0286731 – 36Missing in isoform 2. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_02867437 – 52TRSES…VVLPQ → MQPEGLKCRMEESNAE in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK093129 mRNA Translation: BAC04067.1
AK292350 mRNA Translation: BAF85039.1
AL139320 Genomic DNA No translation available.
BC027609 mRNA Translation: AAH27609.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS66540.1 [Q8NA61-2]
CCDS9399.1 [Q8NA61-1]

NCBI Reference Sequences

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RefSeqi
NP_001273270.1, NM_001286341.1
NP_001273271.1, NM_001286342.1 [Q8NA61-2]
NP_689932.1, NM_152719.2 [Q8NA61-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310521; ENSP00000309189; ENSG00000174015 [Q8NA61-1]
ENST00000378966; ENSP00000368249; ENSG00000174015 [Q8NA61-2]
ENST00000610924; ENSP00000480148; ENSG00000174015 [Q8NA61-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
220082

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:220082

UCSC genome browser

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UCSCi
uc001van.3, human [Q8NA61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093129 mRNA Translation: BAC04067.1
AK292350 mRNA Translation: BAF85039.1
AL139320 Genomic DNA No translation available.
BC027609 mRNA Translation: AAH27609.1
CCDSiCCDS66540.1 [Q8NA61-2]
CCDS9399.1 [Q8NA61-1]
RefSeqiNP_001273270.1, NM_001286341.1
NP_001273271.1, NM_001286342.1 [Q8NA61-2]
NP_689932.1, NM_152719.2 [Q8NA61-1]

3D structure databases

SMRiQ8NA61
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128627, 97 interactors
IntActiQ8NA61, 130 interactors
MINTiQ8NA61
STRINGi9606.ENSP00000309189

PTM databases

iPTMnetiQ8NA61
PhosphoSitePlusiQ8NA61

Polymorphism and mutation databases

BioMutaiSPERT
DMDMi74751135

Proteomic databases

MassIVEiQ8NA61
PaxDbiQ8NA61
PeptideAtlasiQ8NA61
PRIDEiQ8NA61
ProteomicsDBi72645 [Q8NA61-1]
72646 [Q8NA61-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
42238, 55 antibodies

Genome annotation databases

EnsembliENST00000310521; ENSP00000309189; ENSG00000174015 [Q8NA61-1]
ENST00000378966; ENSP00000368249; ENSG00000174015 [Q8NA61-2]
ENST00000610924; ENSP00000480148; ENSG00000174015 [Q8NA61-2]
GeneIDi220082
KEGGihsa:220082
UCSCiuc001van.3, human [Q8NA61-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
220082
DisGeNETi220082
EuPathDBiHostDB:ENSG00000174015.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CBY2
HGNCiHGNC:30720, CBY2
HPAiENSG00000174015, Tissue enriched (testis)
MIMi618614, gene
neXtProtiNX_Q8NA61
OpenTargetsiENSG00000174015
PharmGKBiPA144596272

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S6IZ, Eukaryota
GeneTreeiENSGT00940000153137
HOGENOMiCLU_041289_0_0_1
InParanoidiQ8NA61
KOiK23403
OMAiWSIWEEN
OrthoDBi1015941at2759
PhylomeDBiQ8NA61
TreeFamiTF324419

Enzyme and pathway databases

PathwayCommonsiQ8NA61

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
220082, 0 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
220082
PharosiQ8NA61, Tdark

Protein Ontology

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PROi
PR:Q8NA61
RNActiQ8NA61, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174015, Expressed in left testis and 38 other tissues
ExpressionAtlasiQ8NA61, baseline and differential
GenevisibleiQ8NA61, HS

Family and domain databases

CDDicd07429, Cby_like, 1 hit
InterProiView protein in InterPro
IPR028118, Chibby_fam
IPR026655, SPERT
PANTHERiPTHR21533:SF13, PTHR21533:SF13, 1 hit
PfamiView protein in Pfam
PF14645, Chibby, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBY2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NA61
Secondary accession number(s): A8K8I5, Q8NHV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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