We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q8NA61 (CBY2_HUMAN)
Protein
Protein chibby homolog 2
Gene
CBY2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
Enzyme and pathway databases
PathwayCommonsi | Q8NA61 |
SignaLinki | Q8NA61 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein chibby homolog 2CuratedAlternative name(s): Spermatid-associated protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30720, CBY2 |
MIMi | 618614, gene |
neXtProti | NX_Q8NA61 |
VEuPathDBi | HostDB:ENSG00000174015 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 220082 |
OpenTargetsi | ENSG00000174015 |
PharmGKBi | PA144596272 |
Miscellaneous databases
Pharosi | Q8NA61, Tbio |
Genetic variation databases
BioMutai | SPERT |
DMDMi | 74751135 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307291 | 1 – 448 | Protein chibby homolog 2Add BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineBy similarity | 1 | |
Modified residuei | 86 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Modified residuei | 97 | PhosphoserineBy similarity | 1 | |
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 144 | PhosphoserineBy similarity | 1 | |
Modified residuei | 148 | PhosphoserineBy similarity | 1 | |
Modified residuei | 150 | PhosphoserineBy similarity | 1 | |
Modified residuei | 212 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 335 | PhosphoserineBy similarity | 1 | |
Modified residuei | 338 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q8NA61 |
PaxDbi | Q8NA61 |
PeptideAtlasi | Q8NA61 |
PRIDEi | Q8NA61 |
ProteomicsDBi | 72645 [Q8NA61-1] 72646 [Q8NA61-2] |
PTM databases
iPTMneti | Q8NA61 |
PhosphoSitePlusi | Q8NA61 |
Expressioni
Tissue specificityi
Testis-specific.1 Publication
Gene expression databases
Bgeei | ENSG00000174015, Expressed in left testis and 39 other tissues |
ExpressionAtlasi | Q8NA61, baseline and differential |
Genevisiblei | Q8NA61, HS |
Organism-specific databases
HPAi | ENSG00000174015, Tissue enriched (testis) |
Interactioni
Subunit structurei
Homodimer. Binds to NEK1 (By similarity).
By similarityBinary interactionsi
Q8NA61
CBY2 - isoform 2 [Q8NA61-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 128627, 144 interactors |
IntActi | Q8NA61, 130 interactors |
MINTi | Q8NA61 |
STRINGi | 9606.ENSP00000309189 |
Miscellaneous databases
RNActi | Q8NA61, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 323 | DisorderedSequence analysisAdd BLAST | 54 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 164 – 198 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 242 – 267 | Sequence analysisAdd BLAST | 26 | |
Coiled coili | 356 – 414 | Sequence analysisAdd BLAST | 59 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S6IZ, Eukaryota |
GeneTreei | ENSGT00940000153137 |
HOGENOMi | CLU_041289_0_0_1 |
InParanoidi | Q8NA61 |
OMAi | WSIWEEN |
OrthoDBi | 1015941at2759 |
PhylomeDBi | Q8NA61 |
TreeFami | TF324419 |
Family and domain databases
CDDi | cd07429, Cby_like, 1 hit |
InterProi | View protein in InterPro IPR028118, Chibby_fam IPR026655, SPERT |
PANTHERi | PTHR21533:SF13, PTHR21533:SF13, 1 hit |
Pfami | View protein in Pfam PF14645, Chibby, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NA61-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPLECSECF GDQLLHRTYT WQLTLHSRPN YTRKRDTRSE SLEIPISVVL
60 70 80 90 100
PQRGTAEPFP RLHNLYSTPR CAQQAALPRL SRRMASQHSY PLNRFSSVPL
110 120 130 140 150
DPMERPMSQA DLELDYNPPR VQLSDEMFVF QDGRWVNENC RLQSPYFSPS
160 170 180 190 200
ASFHHKLHHK RLAKECMLQE ENKSLREENK ALREENRMLS KENKILQVFW
210 220 230 240 250
EEHKASLGRE ESRAPSPLLH KDSASLEVVK KDHVALQVPR GKEDSTLQLL
260 270 280 290 300
REENRALQQL LEQKQAYWAQ AEDTAAPAEE SKPAPSPHEE PCSPGLLQDQ
310 320 330 340 350
GSGLSSRFEE PKGPPARQED SKELRALRKM VSNMSGPSGE EEAKVGPGLP
360 370 380 390 400
DGCQPLQLLR EMRQALQALL KENRLLQEEN RTLQVLRAEH RGFQEENKAL
410 420 430 440
WENNKLKLQQ KLVIDTVTEV TARMEMLIEE LYAFMPARSQ DPKKPSRV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PLB4 | E9PLB4_HUMAN | Protein chibby homolog 2 | CBY2 | 160 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054064 | 329 | K → E. Corresponds to variant dbSNP:rs7317245Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028673 | 1 – 36 | Missing in isoform 2. 2 PublicationsAdd BLAST | 36 | |
Alternative sequenceiVSP_028674 | 37 – 52 | TRSES…VVLPQ → MQPEGLKCRMEESNAE in isoform 2. 2 PublicationsAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093129 mRNA Translation: BAC04067.1 AK292350 mRNA Translation: BAF85039.1 AL139320 Genomic DNA No translation available. BC027609 mRNA Translation: AAH27609.1 |
CCDSi | CCDS66540.1 [Q8NA61-2] CCDS9399.1 [Q8NA61-1] |
RefSeqi | NP_001273270.1, NM_001286341.1 NP_001273271.1, NM_001286342.1 [Q8NA61-2] NP_689932.1, NM_152719.2 [Q8NA61-1] |
Genome annotation databases
Ensembli | ENST00000310521; ENSP00000309189; ENSG00000174015 ENST00000378966; ENSP00000368249; ENSG00000174015 [Q8NA61-2] ENST00000610924; ENSP00000480148; ENSG00000174015 [Q8NA61-2] |
GeneIDi | 220082 |
KEGGi | hsa:220082 |
MANE-Selecti | ENST00000310521.6; ENSP00000309189.1; NM_152719.3; NP_689932.1 |
UCSCi | uc001van.3, human [Q8NA61-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093129 mRNA Translation: BAC04067.1 AK292350 mRNA Translation: BAF85039.1 AL139320 Genomic DNA No translation available. BC027609 mRNA Translation: AAH27609.1 |
CCDSi | CCDS66540.1 [Q8NA61-2] CCDS9399.1 [Q8NA61-1] |
RefSeqi | NP_001273270.1, NM_001286341.1 NP_001273271.1, NM_001286342.1 [Q8NA61-2] NP_689932.1, NM_152719.2 [Q8NA61-1] |
3D structure databases
SMRi | Q8NA61 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128627, 144 interactors |
IntActi | Q8NA61, 130 interactors |
MINTi | Q8NA61 |
STRINGi | 9606.ENSP00000309189 |
PTM databases
iPTMneti | Q8NA61 |
PhosphoSitePlusi | Q8NA61 |
Genetic variation databases
BioMutai | SPERT |
DMDMi | 74751135 |
Proteomic databases
MassIVEi | Q8NA61 |
PaxDbi | Q8NA61 |
PeptideAtlasi | Q8NA61 |
PRIDEi | Q8NA61 |
ProteomicsDBi | 72645 [Q8NA61-1] 72646 [Q8NA61-2] |
Protocols and materials databases
Antibodypediai | 42238, 65 antibodies from 15 providers |
DNASUi | 220082 |
Genome annotation databases
Ensembli | ENST00000310521; ENSP00000309189; ENSG00000174015 ENST00000378966; ENSP00000368249; ENSG00000174015 [Q8NA61-2] ENST00000610924; ENSP00000480148; ENSG00000174015 [Q8NA61-2] |
GeneIDi | 220082 |
KEGGi | hsa:220082 |
MANE-Selecti | ENST00000310521.6; ENSP00000309189.1; NM_152719.3; NP_689932.1 |
UCSCi | uc001van.3, human [Q8NA61-1] |
Organism-specific databases
CTDi | 220082 |
DisGeNETi | 220082 |
GeneCardsi | CBY2 |
HGNCi | HGNC:30720, CBY2 |
HPAi | ENSG00000174015, Tissue enriched (testis) |
MIMi | 618614, gene |
neXtProti | NX_Q8NA61 |
OpenTargetsi | ENSG00000174015 |
PharmGKBi | PA144596272 |
VEuPathDBi | HostDB:ENSG00000174015 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6IZ, Eukaryota |
GeneTreei | ENSGT00940000153137 |
HOGENOMi | CLU_041289_0_0_1 |
InParanoidi | Q8NA61 |
OMAi | WSIWEEN |
OrthoDBi | 1015941at2759 |
PhylomeDBi | Q8NA61 |
TreeFami | TF324419 |
Enzyme and pathway databases
PathwayCommonsi | Q8NA61 |
SignaLinki | Q8NA61 |
Miscellaneous databases
BioGRID-ORCSi | 220082, 5 hits in 1035 CRISPR screens |
GenomeRNAii | 220082 |
Pharosi | Q8NA61, Tbio |
PROi | PR:Q8NA61 |
RNActi | Q8NA61, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174015, Expressed in left testis and 39 other tissues |
ExpressionAtlasi | Q8NA61, baseline and differential |
Genevisiblei | Q8NA61, HS |
Family and domain databases
CDDi | cd07429, Cby_like, 1 hit |
InterProi | View protein in InterPro IPR028118, Chibby_fam IPR026655, SPERT |
PANTHERi | PTHR21533:SF13, PTHR21533:SF13, 1 hit |
Pfami | View protein in Pfam PF14645, Chibby, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CBY2_HUMAN | |
Accessioni | Q8NA61Primary (citable) accession number: Q8NA61 Secondary accession number(s): A8K8I5, Q8NHV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families