UniProtKB - Q8NA54 (IQUB_HUMAN)
Protein
IQ and ubiquitin-like domain-containing protein
Gene
IQUB
Organism
Homo sapiens (Human)
Status
Functioni
May play roles in cilia formation and/or maintenance.By similarity
GO - Biological processi
- cilium assembly Source: Ensembl
- smoothened signaling pathway Source: Ensembl
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q8NA54 |
Names & Taxonomyi
Protein namesi | Recommended name: IQ and ubiquitin-like domain-containing protein |
Gene namesi | Name:IQUB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164675.10 |
HGNCi | HGNC:21995, IQUB |
neXtProti | NX_Q8NA54 |
Subcellular locationi
Other locations
- acrosomal vesicle Source: Ensembl
- motile cilium Source: Ensembl
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 154865 |
OpenTargetsi | ENSG00000164675 |
PharmGKBi | PA162392258 |
Miscellaneous databases
Pharosi | Q8NA54, Tdark |
Polymorphism and mutation databases
BioMutai | IQUB |
DMDMi | 125950212 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274601 | 1 – 791 | IQ and ubiquitin-like domain-containing proteinAdd BLAST | 791 |
Proteomic databases
MassIVEi | Q8NA54 |
PaxDbi | Q8NA54 |
PeptideAtlasi | Q8NA54 |
PRIDEi | Q8NA54 |
ProteomicsDBi | 72638 [Q8NA54-1] 72639 [Q8NA54-2] |
PTM databases
iPTMneti | Q8NA54 |
PhosphoSitePlusi | Q8NA54 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164675, Expressed in sperm and 115 other tissues |
ExpressionAtlasi | Q8NA54, baseline and differential |
Genevisiblei | Q8NA54, HS |
Organism-specific databases
HPAi | ENSG00000164675, Tissue enhanced (pituitary gland, testis) |
Interactioni
Subunit structurei
Interacts with ZMYND10.
1 PublicationBinary interactionsi
Hide detailsQ8NA54
Protein-protein interaction databases
BioGRIDi | 127562, 59 interactors |
IntActi | Q8NA54, 55 interactors |
STRINGi | 9606.ENSP00000417769 |
Miscellaneous databases
RNActi | Q8NA54, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8NA54 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8NA54 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 131 – 207 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 338 – 367 | IQAdd BLAST | 30 |
Phylogenomic databases
eggNOGi | ENOG502QRQT, Eukaryota |
GeneTreei | ENSGT00390000014326 |
HOGENOMi | CLU_014415_0_0_1 |
InParanoidi | Q8NA54 |
OMAi | IVPGKYQ |
PhylomeDBi | Q8NA54 |
TreeFami | TF323180 |
Family and domain databases
InterProi | View protein in InterPro IPR037695, IQUB IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR21074, PTHR21074, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8NA54-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE
60 70 80 90 100
QFSESHAIHV EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA
110 120 130 140 150
MQRPNDDSLA FLDKIKSVKE SLQESVEDSL ATVKVVLIPV GQEIVIPFKV
160 170 180 190 200
DTILKYLKDH FSHLLGIPHS VLQIRYSGKI LKNNETLVQH GVKPQEIVQV
210 220 230 240 250
EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP VEIVKSDFHK
260 270 280 290 300
PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT
310 320 330 340 350
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR
360 370 380 390 400
QWHAKIFVEN LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN
410 420 430 440 450
EDFEFLYNAL EFWRQEELTR INQSFTGAER KAALCELLEK ETQIIASIGR
460 470 480 490 500
HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP NGKTIEMDTQ FTIRARELQN
510 520 530 540 550
IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL IDREVDLMMR
560 570 580 590 600
GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF
610 620 630 640 650
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ
660 670 680 690 700
LYYTEADYED DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR
710 720 730 740 750
WNKSLEWSPW NCILLTKDEA AAHLKLTSIE EGYERSFIHK IKHKHILAKN
760 770 780 790
YFSQVPVLAS FILDDGEIDE IRWKYHSDTT PKIIESQRPP H
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA1A4Z1 | A1A4Z1_HUMAN | IQ and ubiquitin-like domain-contai... | IQUB | 421 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | Q → R in BAC04074 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 252 | F → S in BAC04074 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 343 | I → T in BAC04074 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030332 | 126 | V → M1 PublicationCorresponds to variant dbSNP:rs10255061Ensembl. | 1 | |
Natural variantiVAR_030333 | 691 | D → N. Corresponds to variant dbSNP:rs17146009Ensembl. | 1 | |
Natural variantiVAR_036291 | 735 | R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1525626Ensembl. | 1 | |
Natural variantiVAR_030334 | 735 | R → P. Corresponds to variant dbSNP:rs1525626Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022830 | 587 – 680 | VPQDP…LTENI → MGGEYLSMAL in isoform 2. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_022831 | 681 – 791 | Missing in isoform 2. 1 PublicationAdd BLAST | 111 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093153 mRNA Translation: BAC04074.1 AK093393 mRNA Translation: BAC04153.1 CH236947 Genomic DNA Translation: EAL24336.1 BC026173 mRNA Translation: AAH26173.1 BC036121 mRNA Translation: AAH36121.1 BC091520 mRNA Translation: AAH91520.1 BC128181 mRNA Translation: AAI28182.1 |
CCDSi | CCDS5787.1 [Q8NA54-1] |
RefSeqi | NP_001269784.1, NM_001282855.1 [Q8NA54-1] NP_001308222.1, NM_001321293.1 [Q8NA54-1] NP_849149.3, NM_178827.4 [Q8NA54-1] XP_005250218.1, XM_005250161.3 [Q8NA54-1] XP_011514135.1, XM_011515833.2 [Q8NA54-1] XP_011514136.1, XM_011515834.2 [Q8NA54-1] XP_016867260.1, XM_017011771.1 [Q8NA54-1] |
Genome annotation databases
Ensembli | ENST00000324698; ENSP00000324882; ENSG00000164675 [Q8NA54-1] ENST00000466202; ENSP00000417769; ENSG00000164675 [Q8NA54-1] ENST00000484508; ENSP00000417285; ENSG00000164675 [Q8NA54-2] |
GeneIDi | 154865 |
KEGGi | hsa:154865 |
UCSCi | uc003vkn.4, human [Q8NA54-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093153 mRNA Translation: BAC04074.1 AK093393 mRNA Translation: BAC04153.1 CH236947 Genomic DNA Translation: EAL24336.1 BC026173 mRNA Translation: AAH26173.1 BC036121 mRNA Translation: AAH36121.1 BC091520 mRNA Translation: AAH91520.1 BC128181 mRNA Translation: AAI28182.1 |
CCDSi | CCDS5787.1 [Q8NA54-1] |
RefSeqi | NP_001269784.1, NM_001282855.1 [Q8NA54-1] NP_001308222.1, NM_001321293.1 [Q8NA54-1] NP_849149.3, NM_178827.4 [Q8NA54-1] XP_005250218.1, XM_005250161.3 [Q8NA54-1] XP_011514135.1, XM_011515833.2 [Q8NA54-1] XP_011514136.1, XM_011515834.2 [Q8NA54-1] XP_016867260.1, XM_017011771.1 [Q8NA54-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DAF | NMR | - | A | 123-227 | [»] | |
SMRi | Q8NA54 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 127562, 59 interactors |
IntActi | Q8NA54, 55 interactors |
STRINGi | 9606.ENSP00000417769 |
PTM databases
iPTMneti | Q8NA54 |
PhosphoSitePlusi | Q8NA54 |
Polymorphism and mutation databases
BioMutai | IQUB |
DMDMi | 125950212 |
Proteomic databases
MassIVEi | Q8NA54 |
PaxDbi | Q8NA54 |
PeptideAtlasi | Q8NA54 |
PRIDEi | Q8NA54 |
ProteomicsDBi | 72638 [Q8NA54-1] 72639 [Q8NA54-2] |
Protocols and materials databases
Antibodypediai | 17626, 22 antibodies |
Genome annotation databases
Ensembli | ENST00000324698; ENSP00000324882; ENSG00000164675 [Q8NA54-1] ENST00000466202; ENSP00000417769; ENSG00000164675 [Q8NA54-1] ENST00000484508; ENSP00000417285; ENSG00000164675 [Q8NA54-2] |
GeneIDi | 154865 |
KEGGi | hsa:154865 |
UCSCi | uc003vkn.4, human [Q8NA54-1] |
Organism-specific databases
CTDi | 154865 |
DisGeNETi | 154865 |
EuPathDBi | HostDB:ENSG00000164675.10 |
GeneCardsi | IQUB |
HGNCi | HGNC:21995, IQUB |
HPAi | ENSG00000164675, Tissue enhanced (pituitary gland, testis) |
neXtProti | NX_Q8NA54 |
OpenTargetsi | ENSG00000164675 |
PharmGKBi | PA162392258 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRQT, Eukaryota |
GeneTreei | ENSGT00390000014326 |
HOGENOMi | CLU_014415_0_0_1 |
InParanoidi | Q8NA54 |
OMAi | IVPGKYQ |
PhylomeDBi | Q8NA54 |
TreeFami | TF323180 |
Enzyme and pathway databases
PathwayCommonsi | Q8NA54 |
Miscellaneous databases
BioGRID-ORCSi | 154865, 5 hits in 843 CRISPR screens |
ChiTaRSi | IQUB, human |
EvolutionaryTracei | Q8NA54 |
GenomeRNAii | 154865 |
Pharosi | Q8NA54, Tdark |
PROi | PR:Q8NA54 |
RNActi | Q8NA54, protein |
Gene expression databases
Bgeei | ENSG00000164675, Expressed in sperm and 115 other tissues |
ExpressionAtlasi | Q8NA54, baseline and differential |
Genevisiblei | Q8NA54, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037695, IQUB IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR21074, PTHR21074, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IQUB_HUMAN | |
Accessioni | Q8NA54Primary (citable) accession number: Q8NA54 Secondary accession number(s): A4D0X0 Q8N9Y2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations