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UniProtKB - Q8NA54 (IQUB_HUMAN)

Entry version 140 (07 Apr 2021)
Sequence version 2 (06 Feb 2007)
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Protein

IQ and ubiquitin-like domain-containing protein

Gene

IQUB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play roles in cilia formation and/or maintenance.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8NA54

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQ and ubiquitin-like domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQUB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21995, IQUB

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8NA54

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164675.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		154865

Open Targets

More...OpenTargetsi		ENSG00000164675

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162392258

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8NA54, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IQUB

Domain mapping of disease mutations (DMDM)

More...DMDMi		125950212

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002746011 – 791IQ and ubiquitin-like domain-containing proteinAdd BLAST791

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8NA54

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8NA54

PeptideAtlas

More...PeptideAtlasi		Q8NA54

PRoteomics IDEntifications database

More...PRIDEi		Q8NA54

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72638 [Q8NA54-1]
72639 [Q8NA54-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8NA54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8NA54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164675, Expressed in sperm and 115 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8NA54, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8NA54, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164675, Tissue enhanced (pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZMYND10.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8NA54
With#Exp.IntAct
ALX4 [Q9H161]3EBI-10220600,EBI-11317841
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-10220600,EBI-12224467
ANKRD23 [Q86SG2]3EBI-10220600,EBI-5661893
BHLHB9 [Q6PI77]3EBI-10220600,EBI-11519926
BLZF1 [Q9H2G9]6EBI-10220600,EBI-2548012
CALCOCO2 [Q13137]3EBI-10220600,EBI-739580
CEP70 [Q8NHQ1]3EBI-10220600,EBI-739624
CEP76 [Q8TAP6]3EBI-10220600,EBI-742887
CHAT - isoform R [P28329-3]3EBI-10220600,EBI-25837549
COL26A1 - isoform 2 [Q96A83-2]3EBI-10220600,EBI-21553822
CYSRT1 [A8MQ03]3EBI-10220600,EBI-3867333
DIP2A - isoform 4 [Q14689-4]3EBI-10220600,EBI-12019962
DNAJB6 - isoform B [O75190-2]3EBI-10220600,EBI-12593112
DNALI1 [O14645]3EBI-10220600,EBI-395638
DNM2 - isoform 2 [P50570-2]3EBI-10220600,EBI-10968534
DYNLL1 [P63167]3EBI-10220600,EBI-349105
EYA2 - isoform 2 [O00167-2]3EBI-10220600,EBI-12807776
FGFR3 [P22607]3EBI-10220600,EBI-348399
GDAP1 [Q8TB36]3EBI-10220600,EBI-11110431
GFAP [P14136]3EBI-10220600,EBI-744302
GOLGA2 [Q08379]3EBI-10220600,EBI-618309
GSN [P06396]3EBI-10220600,EBI-351506
HRAS [P01112]3EBI-10220600,EBI-350145
HSPB1 [P04792]3EBI-10220600,EBI-352682
IHO1 [Q8IYA8]4EBI-10220600,EBI-8638439
JPH3 [Q8WXH2]3EBI-10220600,EBI-1055254
KATNAL1 [Q9BW62]3EBI-10220600,EBI-743591
KIF1B - isoform 2 [O60333-2]3EBI-10220600,EBI-10975473
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-10220600,EBI-14069005
KLF11 [O14901]3EBI-10220600,EBI-948266
KRT40 [Q6A162]3EBI-10220600,EBI-10171697
KRT75 [O95678]3EBI-10220600,EBI-2949715
KRT76 [Q01546]3EBI-10220600,EBI-2952745
KRTAP10-7 [P60409]3EBI-10220600,EBI-10172290
KRTAP10-9 [P60411]3EBI-10220600,EBI-10172052
KRTAP12-2 [P59991]3EBI-10220600,EBI-10176379
KRTAP12-4 [P60329]6EBI-10220600,EBI-10176396
LHX3 - isoform B [Q9UBR4-2]3EBI-10220600,EBI-12039345
LMNA [P02545]3EBI-10220600,EBI-351935
MAGEA6 [P43360]3EBI-10220600,EBI-1045155
MDFI [Q99750]3EBI-10220600,EBI-724076
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-10220600,EBI-11022007
PIH1D2 [Q8WWB5]3EBI-10220600,EBI-10232538
PKP3 [Q9Y446]3EBI-10220600,EBI-2880227
POU6F2 [P78424]3EBI-10220600,EBI-12029004
PRDM6 [Q9NQX0]3EBI-10220600,EBI-11320284
PRKN - isoform 5 [O60260-5]3EBI-10220600,EBI-21251460
PRR23D1 [E9PI22]3EBI-10220600,EBI-23335840
RHOH [Q15669]3EBI-10220600,EBI-1244971
RNF11 [Q9Y3C5]3EBI-10220600,EBI-396669
SAXO1 [Q8IYX7]3EBI-10220600,EBI-3957636
SMN2 [Q16637]6EBI-10220600,EBI-395421
SORBS3 [O60504]3EBI-10220600,EBI-741237
SPRED1 [Q7Z699]6EBI-10220600,EBI-5235340
SYCE1 [Q8N0S2]3EBI-10220600,EBI-6872807
TOR1A - isoform 2 [O14656-2]3EBI-10220600,EBI-25847109
TP53BP2 [Q05BL1]3EBI-10220600,EBI-11952721
TRAF2 [Q12933]3EBI-10220600,EBI-355744
TRAF6 [Q9Y4K3]3EBI-10220600,EBI-359276
TRIM23 [P36406]7EBI-10220600,EBI-740098
TRIM27 [P14373]3EBI-10220600,EBI-719493
TRIM42 [Q8IWZ5]3EBI-10220600,EBI-5235829
TRIM50 [Q86XT4]3EBI-10220600,EBI-9867283
TRIM54 [Q9BYV2]4EBI-10220600,EBI-2130429
WFS1 [O76024]3EBI-10220600,EBI-720609
ZNF143 [P52747]3EBI-10220600,EBI-2849334
ZNF410 - isoform 3 [Q86VK4-3]3EBI-10220600,EBI-11741890
ZNF526 [Q8TF50]3EBI-10220600,EBI-11035148
ZRANB1 [Q9UGI0]3EBI-10220600,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127562, 61 interactors

Protein interaction database and analysis system

More...IntActi		Q8NA54, 75 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000417769

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8NA54, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1791
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8NA54

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8NA54

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 207Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77
Domaini338 – 367IQAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRQT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014326

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014415_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8NA54

Identification of Orthologs from Complete Genome Data

More...OMAi		IVPGKYQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8NA54

TreeFam database of animal gene trees

More...TreeFami		TF323180

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037695, IQUB
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR21074, PTHR21074, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00240, ubiquitin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NA54-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNQQEKYEA QNIVNSTEES DDAFDTVTIP VPSEEPQESD QTEEHESGIE 
        60         70         80         90        100
QFSESHAIHV EEQSDQSFSS LEPDNEQLME EVISPRQVSY TPQHHEKQYA 
       110        120        130        140        150
MQRPNDDSLA FLDKIKSVKE SLQESVEDSL ATVKVVLIPV GQEIVIPFKV 
       160        170        180        190        200
DTILKYLKDH FSHLLGIPHS VLQIRYSGKI LKNNETLVQH GVKPQEIVQV 
       210        220        230        240        250
EIFSTNPDLY PVRRIDGLTD VSQIITVTVQ TGLDQYQQVP VEIVKSDFHK 
       260        270        280        290        300
PFLGGFRHKV TGVEYHNAGT QTVPKRIPER LSIFCRDTQT VFQKKNLQQT 
       310        320        330        340        350
TNTTSTQMTN IGVYVSNMTD KLVTPGKYFS AAEYHAQRLK AVIVIQTYYR 
       360        370        380        390        400
QWHAKIFVEN LRRQKSLRLE WETQQELRKI REKEEWIKLD YHRRHNPKTN 
       410        420        430        440        450
EDFEFLYNAL EFWRQEELTR INQSFTGAER KAALCELLEK ETQIIASIGR 
       460        470        480        490        500
HRYIAYMANQ EAAIQAFLDK CSAPKIWRTP NGKTIEMDTQ FTIRARELQN 
       510        520        530        540        550
IYKCIMLKNI SQDERLDVLL TLKHTVKEHE CKLTQEILEL IDREVDLMMR 
       560        570        580        590        600
GVKHHNLEGL RKRIATLFFH YIKTPLFNPE VAKYLKVPQD PLKFYKKIYF 
       610        620        630        640        650
CHSCQLYLPS TEFSVSSTSR RIYRCRNCIN LQNEAQKRES FLKYKCLLQQ 
       660        670        680        690        700
LYYTEADYED DSKIAFLMQL QDIQYLTENI WASQSVLSAC DNLSDLVMVR 
       710        720        730        740        750
WNKSLEWSPW NCILLTKDEA AAHLKLTSIE EGYERSFIHK IKHKHILAKN 
       760        770        780        790 
YFSQVPVLAS FILDDGEIDE IRWKYHSDTT PKIIESQRPP H
Length:791
Mass (Da):92,581
Last modified:February 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D16F8BF4BAED522
GO
Isoform 2 (identifier: Q8NA54-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     587-680: VPQDPLKFYK...QDIQYLTENI → MGGEYLSMAL
     681-791: Missing.

Show »
Length:596
Mass (Da):69,382
Checksum:i0F99A639616E100E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1A4Z1A1A4Z1_HUMAN
IQ and ubiquitin-like domain-contai...
IQUB
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4Q → R in BAC04074 (PubMed:14702039).Curated1
Sequence conflicti252F → S in BAC04074 (PubMed:14702039).Curated1
Sequence conflicti343I → T in BAC04074 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030332126V → M1 PublicationCorresponds to variant dbSNP:rs10255061Ensembl.1
Natural variantiVAR_030333691D → N. Corresponds to variant dbSNP:rs17146009Ensembl.1
Natural variantiVAR_036291735R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1525626Ensembl.1
Natural variantiVAR_030334735R → P. Corresponds to variant dbSNP:rs1525626Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022830587 – 680VPQDP…LTENI → MGGEYLSMAL in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_022831681 – 791Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093153 mRNA Translation: BAC04074.1
AK093393 mRNA Translation: BAC04153.1
CH236947 Genomic DNA Translation: EAL24336.1
BC026173 mRNA Translation: AAH26173.1
BC036121 mRNA Translation: AAH36121.1
BC091520 mRNA Translation: AAH91520.1
BC128181 mRNA Translation: AAI28182.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5787.1 [Q8NA54-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269784.1, NM_001282855.1 [Q8NA54-1]
NP_001308222.1, NM_001321293.1 [Q8NA54-1]
NP_849149.3, NM_178827.4 [Q8NA54-1]
XP_005250218.1, XM_005250161.3 [Q8NA54-1]
XP_011514135.1, XM_011515833.2 [Q8NA54-1]
XP_011514136.1, XM_011515834.2 [Q8NA54-1]
XP_016867260.1, XM_017011771.1 [Q8NA54-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000324698; ENSP00000324882; ENSG00000164675 [Q8NA54-1]
ENST00000466202; ENSP00000417769; ENSG00000164675 [Q8NA54-1]
ENST00000484508; ENSP00000417285; ENSG00000164675 [Q8NA54-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		154865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:154865

UCSC genome browser

More...UCSCi		uc003vkn.4, human [Q8NA54-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093153 mRNA Translation: BAC04074.1
AK093393 mRNA Translation: BAC04153.1
CH236947 Genomic DNA Translation: EAL24336.1
BC026173 mRNA Translation: AAH26173.1
BC036121 mRNA Translation: AAH36121.1
BC091520 mRNA Translation: AAH91520.1
BC128181 mRNA Translation: AAI28182.1
CCDSiCCDS5787.1 [Q8NA54-1]
RefSeqiNP_001269784.1, NM_001282855.1 [Q8NA54-1]
NP_001308222.1, NM_001321293.1 [Q8NA54-1]
NP_849149.3, NM_178827.4 [Q8NA54-1]
XP_005250218.1, XM_005250161.3 [Q8NA54-1]
XP_011514135.1, XM_011515833.2 [Q8NA54-1]
XP_011514136.1, XM_011515834.2 [Q8NA54-1]
XP_016867260.1, XM_017011771.1 [Q8NA54-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAFNMR-A123-227[»]
SMRiQ8NA54
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127562, 61 interactors
IntActiQ8NA54, 75 interactors
STRINGi9606.ENSP00000417769

PTM databases

iPTMnetiQ8NA54
PhosphoSitePlusiQ8NA54

Genetic variation databases

BioMutaiIQUB
DMDMi125950212

Proteomic databases

MassIVEiQ8NA54
PaxDbiQ8NA54
PeptideAtlasiQ8NA54
PRIDEiQ8NA54
ProteomicsDBi72638 [Q8NA54-1]
72639 [Q8NA54-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17626, 22 antibodies

Genome annotation databases

EnsembliENST00000324698; ENSP00000324882; ENSG00000164675 [Q8NA54-1]
ENST00000466202; ENSP00000417769; ENSG00000164675 [Q8NA54-1]
ENST00000484508; ENSP00000417285; ENSG00000164675 [Q8NA54-2]
GeneIDi154865
KEGGihsa:154865
UCSCiuc003vkn.4, human [Q8NA54-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		154865
DisGeNETi154865

GeneCards: human genes, protein and diseases

More...GeneCardsi		IQUB
HGNCiHGNC:21995, IQUB
HPAiENSG00000164675, Tissue enhanced (pituitary gland, testis)
neXtProtiNX_Q8NA54
OpenTargetsiENSG00000164675
PharmGKBiPA162392258
VEuPathDBiHostDB:ENSG00000164675.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRQT, Eukaryota
GeneTreeiENSGT00390000014326
HOGENOMiCLU_014415_0_0_1
InParanoidiQ8NA54
OMAiIVPGKYQ
PhylomeDBiQ8NA54
TreeFamiTF323180

Enzyme and pathway databases

PathwayCommonsiQ8NA54

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		154865, 5 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IQUB, human
EvolutionaryTraceiQ8NA54

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		154865
PharosiQ8NA54, Tdark

Protein Ontology

More...PROi		PR:Q8NA54
RNActiQ8NA54, protein

Gene expression databases

BgeeiENSG00000164675, Expressed in sperm and 115 other tissues
ExpressionAtlasiQ8NA54, baseline and differential
GenevisibleiQ8NA54, HS

Family and domain databases

InterProiView protein in InterPro
IPR037695, IQUB
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR21074, PTHR21074, 1 hit
PfamiView protein in Pfam
PF00240, ubiquitin, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053, UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQUB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NA54
Secondary accession number(s): A4D0X0
, Q49AL6, Q4G189, Q5BJD9, Q6NUH6, Q8N9Y2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 7, 2021
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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