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Protein

Zinc finger protein 383

Gene

ZNF383

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 383
Gene namesi
Name:ZNF383
ORF Names:HSD17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188283.11
HGNCiHGNC:18609 ZNF383
neXtProtiNX_Q8NA42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188283
PharmGKBiPA134903145

Polymorphism and mutation databases

BioMutaiZNF383
DMDMi74760056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475501 – 475Zinc finger protein 383Add BLAST475

Proteomic databases

MaxQBiQ8NA42
PaxDbiQ8NA42
PeptideAtlasiQ8NA42
PRIDEiQ8NA42
ProteomicsDBi72635

PTM databases

iPTMnetiQ8NA42
PhosphoSitePlusiQ8NA42

Expressioni

Tissue specificityi

Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.1 Publication

Developmental stagei

In tissues from a six months embryo, highly expressed in heart, testis and skeletal muscle, lower expression levels in kidney, intestines and prostate.1 Publication

Gene expression databases

BgeeiENSG00000188283 Expressed in 146 organ(s), highest expression level in cerebellar vermis
CleanExiHS_ZNF383
ExpressionAtlasiQ8NA42 baseline and differential
GenevisibleiQ8NA42 HS

Organism-specific databases

HPAiHPA063945

Interactioni

Protein-protein interaction databases

BioGridi127849, 2 interactors
IntActiQ8NA42, 5 interactors
STRINGi9606.ENSP00000340132

Structurei

3D structure databases

ProteinModelPortaliQ8NA42
SMRiQ8NA42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Domaini

The KRAB domain is responsible for the transcriptional repressor activity.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NA42
KOiK09228
OMAiTHEYMPT
OrthoDBiEOG091G02KC
PhylomeDBiQ8NA42

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8NA42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYG NLVSMGLYTP
60 70 80 90 100
KPQVISLLEQ GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC
110 120 130 140 150
QREIMGLTKH GLEYSSFGDV LEYRSHLAKQ LGYPNGHFSQ EIFTPEYMPT
160 170 180 190 200
FIQQTFLTLH QIINNEDRPY ECKKCGKAFS QNSQFIQHQR IHIGEKSYEC
210 220 230 240 250
KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY LSQHQRIHTG
260 270 280 290 300
KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYECKVCGKA FTKSSQLFQH
310 320 330 340 350
ARIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG
360 370 380 390 400
SALTNHQRIH TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG
410 420 430 440 450
KAFTQNSQLF QHQRIHTDEK PYECNECGKA FNKCSNLTRH LRIHTGEKPY
460 470
NCKECGKAFS SGSDLIRHQG IHTNK
Length:475
Mass (Da):54,613
Last modified:October 1, 2002 - v1
Checksum:i2F47070F5C2E582B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJN0K7EJN0_HUMAN
Zinc finger protein 383
ZNF383
114Annotation score:
K7ELW4K7ELW4_HUMAN
Zinc finger protein 383
ZNF383
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11V → A in AAP20067 (Ref. 2) Curated1
Sequence conflicti114Y → H in AAP20067 (Ref. 2) Curated1
Sequence conflicti443I → V in AAP20067 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438646 mRNA Translation: AAR14184.1
AY260141 mRNA Translation: AAP20067.1
AK093182 mRNA Translation: BAC04086.1
CCDSiCCDS12501.1
RefSeqiNP_001332876.1, NM_001345947.1
NP_001332877.1, NM_001345948.1
NP_001332878.1, NM_001345949.1
NP_689817.1, NM_152604.2
XP_005258642.1, XM_005258585.2
XP_011524888.1, XM_011526586.2
XP_011524889.1, XM_011526587.2
XP_011524890.1, XM_011526588.2
XP_011524891.1, XM_011526589.2
XP_011524892.1, XM_011526590.2
XP_016881911.1, XM_017026422.1
XP_016881912.1, XM_017026423.1
XP_016881913.1, XM_017026424.1
UniGeneiHs.590975

Genome annotation databases

EnsembliENST00000352998; ENSP00000340132; ENSG00000188283
ENST00000589413; ENSP00000464871; ENSG00000188283
ENST00000590503; ENSP00000466101; ENSG00000188283
GeneIDi163087
KEGGihsa:163087
UCSCiuc002oft.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY438646 mRNA Translation: AAR14184.1
AY260141 mRNA Translation: AAP20067.1
AK093182 mRNA Translation: BAC04086.1
CCDSiCCDS12501.1
RefSeqiNP_001332876.1, NM_001345947.1
NP_001332877.1, NM_001345948.1
NP_001332878.1, NM_001345949.1
NP_689817.1, NM_152604.2
XP_005258642.1, XM_005258585.2
XP_011524888.1, XM_011526586.2
XP_011524889.1, XM_011526587.2
XP_011524890.1, XM_011526588.2
XP_011524891.1, XM_011526589.2
XP_011524892.1, XM_011526590.2
XP_016881911.1, XM_017026422.1
XP_016881912.1, XM_017026423.1
XP_016881913.1, XM_017026424.1
UniGeneiHs.590975

3D structure databases

ProteinModelPortaliQ8NA42
SMRiQ8NA42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127849, 2 interactors
IntActiQ8NA42, 5 interactors
STRINGi9606.ENSP00000340132

PTM databases

iPTMnetiQ8NA42
PhosphoSitePlusiQ8NA42

Polymorphism and mutation databases

BioMutaiZNF383
DMDMi74760056

Proteomic databases

MaxQBiQ8NA42
PaxDbiQ8NA42
PeptideAtlasiQ8NA42
PRIDEiQ8NA42
ProteomicsDBi72635

Protocols and materials databases

DNASUi163087
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352998; ENSP00000340132; ENSG00000188283
ENST00000589413; ENSP00000464871; ENSG00000188283
ENST00000590503; ENSP00000466101; ENSG00000188283
GeneIDi163087
KEGGihsa:163087
UCSCiuc002oft.2 human

Organism-specific databases

CTDi163087
EuPathDBiHostDB:ENSG00000188283.11
GeneCardsiZNF383
HGNCiHGNC:18609 ZNF383
HPAiHPA063945
neXtProtiNX_Q8NA42
OpenTargetsiENSG00000188283
PharmGKBiPA134903145
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8NA42
KOiK09228
OMAiTHEYMPT
OrthoDBiEOG091G02KC
PhylomeDBiQ8NA42

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii163087
PROiPR:Q8NA42

Gene expression databases

BgeeiENSG00000188283 Expressed in 146 organ(s), highest expression level in cerebellar vermis
CleanExiHS_ZNF383
ExpressionAtlasiQ8NA42 baseline and differential
GenevisibleiQ8NA42 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN383_HUMAN
AccessioniPrimary (citable) accession number: Q8NA42
Secondary accession number(s): Q6X2C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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