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Entry version 133 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

Lethal(3)malignant brain tumor-like protein 4

Gene

L3MBTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri370 – 414CCHHC-typePROSITE-ProRule annotationAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 4
Short name:
H-l(3)mbt-like protein 4
Short name:
L(3)mbt-like protein 4
Short name:
L3mbt-like 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L3MBTL4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26677 L3MBTL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617135 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NA19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91133

Open Targets

More...
OpenTargetsi
ENSG00000154655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134935795

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8NA19

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1287624

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
L3MBTL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434577

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370771 – 623Lethal(3)malignant brain tumor-like protein 4Add BLAST623

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8NA19

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NA19

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NA19

PeptideAtlas

More...
PeptideAtlasi
Q8NA19

PRoteomics IDEntifications database

More...
PRIDEi
Q8NA19

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72622 [Q8NA19-1]
72623 [Q8NA19-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NA19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NA19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154655 Expressed in 138 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NA19 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NA19 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA064194
HPA069042

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NINLQ9Y2I63EBI-8833581,EBI-719716

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124797, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8NA19, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382976

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8NA19

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8NA19

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati52 – 152MBT 1Add BLAST101
Repeati160 – 260MBT 2Add BLAST101
Repeati269 – 364MBT 3Add BLAST96
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 607SAMPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 414CCHHC-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3766 Eukaryota
ENOG410Y4AQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158264

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231019

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NA19

Identification of Orthologs from Complete Genome Data

More...
OMAi
RPAGWCK

Database of Orthologous Groups

More...
OrthoDBi
63195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NA19

TreeFam database of animal gene trees

More...
TreeFami
TF316498

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2H2C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
PF01530 zf-C2HC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NA19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKQPNRKRKL NMDSKERLDQ DGRLEQAEEE KKPKDSTTPL SHVPSAAAQG
60 70 80 90 100
AWSWEWYLKE QKAVAAPVEL FSKDQSFPEH ENGFQIGMRL EGIDPRHPSV
110 120 130 140 150
FCVLSVAEVC GYRLRLHFDG YLSCYDFWTN AGSPDIHPVG WCEKTKHELH
160 170 180 190 200
IPKGYRKDKF VWMDYLKACK LQNAPKKLFR NRSPNGPMSK EFQVGMKLEA
210 220 230 240 250
VDRKNPSLVC VATIADIVED RLLVHFDNWD DSYDYWCDVN SPYVQPVGWC
260 270 280 290 300
QENGRTLIAP QGYPNPENFS WTEYLEATQT NAVPAKVFKM RLPHGFLPNM
310 320 330 340 350
KLEVVDKRNP RLIRVATIVD VDDQRVKVHF DGWDHKYDYW VEADSPDIHP
360 370 380 390 400
IGWCDVTGHP LEVPQRTNDL KILPGQAVCP TPGCRGIGHI RGPRYSGHHS
410 420 430 440 450
AFGCPYSDMN LKKEATLHDR LREQTQANLE SDSSHSKSKS LCSLNFNGKH
460 470 480 490 500
EKVNSQPRLV QQAKCLKIKG KEDIDLDNLF RVLVLHPRGL EYSVEQAQQV
510 520 530 540 550
LHQSVSMSTV SAHPFRDLPL GREQHCKLLP GVADIRASQV ARWTVDEVAE
560 570 580 590 600
FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ TDIVKVMKIK LGPALKIYNS
610 620
ILMFRHSQEL PEEDIASGQE VRG
Length:623
Mass (Da):71,122
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBD7FC6004599B10
GO
Isoform 2 (identifier: Q8NA19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-534: VLVLHPRGLE...HCKLLPGVAD → GRVRWLMPVI...KLARRGGGCL
     535-623: Missing.

Note: No experimental confirmation available.
Show »
Length:534
Mass (Da):61,256
Checksum:iA84D557682793483
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9S8F8W9S8_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL4
614Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRN7J3KRN7_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL4
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLK8J3QLK8_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL4
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS41J3KS41_HUMAN
Lethal(3)malignant brain tumor-like...
L3MBTL4
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti504S → P in BAC04111 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060435489G → S. Corresponds to variant dbSNP:rs12958879Ensembl.1
Natural variantiVAR_060436618G → D1 PublicationCorresponds to variant dbSNP:rs3737353Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033863482 – 534VLVLH…PGVAD → GRVRWLMPVIPALWEAEAGR SRDQEIKTILANAVKPRLYQ KYKKLARRGGGCL in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_033864535 – 623Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093255 mRNA Translation: BAC04111.1
AP000874 Genomic DNA No translation available.
AP001021 Genomic DNA No translation available.
AP005060 Genomic DNA No translation available.
AP005228 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01639.1
CH471113 Genomic DNA Translation: EAX01640.1
BC039316 mRNA Translation: AAH39316.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11839.2 [Q8NA19-1]

NCBI Reference Sequences

More...
RefSeqi
NP_775735.2, NM_173464.3 [Q8NA19-1]
XP_011524063.1, XM_011525761.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400104; ENSP00000382975; ENSG00000154655 [Q8NA19-2]
ENST00000400105; ENSP00000382976; ENSG00000154655 [Q8NA19-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91133

UCSC genome browser

More...
UCSCi
uc002kmz.4 human [Q8NA19-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093255 mRNA Translation: BAC04111.1
AP000874 Genomic DNA No translation available.
AP001021 Genomic DNA No translation available.
AP005060 Genomic DNA No translation available.
AP005228 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01639.1
CH471113 Genomic DNA Translation: EAX01640.1
BC039316 mRNA Translation: AAH39316.1
CCDSiCCDS11839.2 [Q8NA19-1]
RefSeqiNP_775735.2, NM_173464.3 [Q8NA19-1]
XP_011524063.1, XM_011525761.1

3D structure databases

SMRiQ8NA19
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124797, 10 interactors
IntActiQ8NA19, 11 interactors
STRINGi9606.ENSP00000382976

Chemistry databases

BindingDBiQ8NA19
ChEMBLiCHEMBL1287624

PTM databases

iPTMnetiQ8NA19
PhosphoSitePlusiQ8NA19

Polymorphism and mutation databases

BioMutaiL3MBTL4
DMDMi296434577

Proteomic databases

jPOSTiQ8NA19
MassIVEiQ8NA19
PaxDbiQ8NA19
PeptideAtlasiQ8NA19
PRIDEiQ8NA19
ProteomicsDBi72622 [Q8NA19-1]
72623 [Q8NA19-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8NA19

Genome annotation databases

EnsembliENST00000400104; ENSP00000382975; ENSG00000154655 [Q8NA19-2]
ENST00000400105; ENSP00000382976; ENSG00000154655 [Q8NA19-1]
GeneIDi91133
KEGGihsa:91133
UCSCiuc002kmz.4 human [Q8NA19-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91133
DisGeNETi91133

GeneCards: human genes, protein and diseases

More...
GeneCardsi
L3MBTL4
HGNCiHGNC:26677 L3MBTL4
HPAiHPA064194
HPA069042
MIMi617135 gene
neXtProtiNX_Q8NA19
OpenTargetsiENSG00000154655
PharmGKBiPA134935795

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00940000158264
HOGENOMiHOG000231019
InParanoidiQ8NA19
OMAiRPAGWCK
OrthoDBi63195at2759
PhylomeDBiQ8NA19
TreeFamiTF316498

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
L3MBTL4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91133
PharosiQ8NA19

Protein Ontology

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PROi
PR:Q8NA19

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000154655 Expressed in 138 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ8NA19 baseline and differential
GenevisibleiQ8NA19 HS

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2H2C
PfamiView protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
PF01530 zf-C2HC, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMBL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NA19
Secondary accession number(s): A8MTL8, Q8IXS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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