UniProtKB - Q8N9Z9 (LMTD1_HUMAN)
Protein
Lamin tail domain-containing protein 1
Gene
LMNTD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- cell population proliferation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8N9Z9 |
Names & Taxonomyi
Protein namesi | Recommended name: Lamin tail domain-containing protein 1Alternative name(s): Intermediate filament tail domain-containing protein 1 |
Gene namesi | Name:LMNTD1 Synonyms:IFLTD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26683, LMNTD1 |
neXtProti | NX_Q8N9Z9 |
VEuPathDBi | HostDB:ENSG00000152936.10 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Nucleus
- nuclear envelope Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Intermediate filamentPathology & Biotechi
Organism-specific databases
DisGeNETi | 160492 |
OpenTargetsi | ENSG00000152936 |
PharmGKBi | PA162391895 |
Miscellaneous databases
Pharosi | Q8N9Z9, Tdark |
Genetic variation databases
BioMutai | LMNTD1 |
DMDMi | 296434538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317247 | 1 – 388 | Lamin tail domain-containing protein 1Add BLAST | 388 |
Proteomic databases
PaxDbi | Q8N9Z9 |
PeptideAtlasi | Q8N9Z9 |
PRIDEi | Q8N9Z9 |
ProteomicsDBi | 72615 [Q8N9Z9-1] 72616 [Q8N9Z9-2] 72617 [Q8N9Z9-3] 72618 [Q8N9Z9-4] 72619 [Q8N9Z9-5] |
PTM databases
iPTMneti | Q8N9Z9 |
PhosphoSitePlusi | Q8N9Z9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152936, Expressed in right uterine tube and 83 other tissues |
ExpressionAtlasi | Q8N9Z9, baseline and differential |
Genevisiblei | Q8N9Z9, HS |
Organism-specific databases
HPAi | ENSG00000152936, Tissue enhanced (brain, fallopian tube, pituitary gland, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127760, 3 interactors |
IntActi | Q8N9Z9, 1 interactor |
STRINGi | 9606.ENSP00000407353 |
Miscellaneous databases
RNActi | Q8N9Z9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 136 – 254 | LTDPROSITE-ProRule annotationAdd BLAST | 119 |
Sequence similaritiesi
Belongs to the intermediate filament family.Curated
Phylogenomic databases
eggNOGi | KOG0977, Eukaryota |
GeneTreei | ENSGT00910000144343 |
HOGENOMi | CLU_048894_1_0_1 |
InParanoidi | Q8N9Z9 |
OMAi | GMPLGYY |
OrthoDBi | 716378at2759 |
PhylomeDBi | Q8N9Z9 |
TreeFami | TF338357 |
Family and domain databases
Gene3Di | 2.60.40.1260, 1 hit |
InterProi | View protein in InterPro IPR001322, Lamin_tail_dom IPR036415, Lamin_tail_dom_sf IPR042840, LMNTD1 |
PANTHERi | PTHR47012, PTHR47012, 1 hit |
Pfami | View protein in Pfam PF00932, LTD, 1 hit |
SUPFAMi | SSF74853, SSF74853, 1 hit |
PROSITEi | View protein in PROSITE PS51841, LTD, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N9Z9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLEGSWINRR EDKLGVYSLV HFSPKMLGSV ATTLPLSSSN SSGMPLGYYL
60 70 80 90 100
SSPQISRVTI STTGQLTSKA TVGSCSRVEN SLDASPFSVP KKQDESPMIG
110 120 130 140 150
DGEDYFLSLF GDSKKLTAHS NYTQKTLKYF SMILEEVGQF TSSSLGDVEI
160 170 180 190 200
AEVNVKGLFV KLINSSLDKE MAIGDHILQQ NVNGQTISLY RFLPNIVMQA
210 220 230 240 250
NSTVTVWAAA SEAKHQPPSD FLWKEQDKFR ASPDCITILC KPNGQAIAWY
260 270 280 290 300
TPIHWKQAWE KLDADVEFNR CSVVSPTFRK RVFQWTASTA TITKEKQDQP
310 320 330 340 350
KKDISNYQVE QAQVLLKREK EIPPTVFPNR SPWCQNPYVS AHPYCPLIEP
360 370 380
HNTSTAGGRL DRQPRTRSTR PNRASGSKKK KTSESQKQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H8G2 | F5H8G2_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 143 | Annotation score: | ||
H0YFE3 | H0YFE3_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 105 | Annotation score: | ||
H0YFH5 | H0YFH5_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 163 | Annotation score: | ||
F5H3Q3 | F5H3Q3_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 165 | Annotation score: | ||
F5H719 | F5H719_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 170 | Annotation score: | ||
F5H5I3 | F5H5I3_HUMAN | Lamin tail domain-containing protei... | LMNTD1 | 72 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | R → K in BAC04132 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 381 | K → E in BAG59389 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049809 | 264 | A → T. Corresponds to variant dbSNP:rs35450203Ensembl. | 1 | |
Natural variantiVAR_049810 | 267 | E → G. Corresponds to variant dbSNP:rs34326830Ensembl. | 1 | |
Natural variantiVAR_049811 | 289 | T → A. Corresponds to variant dbSNP:rs34732786Ensembl. | 1 | |
Natural variantiVAR_049812 | 290 | A → T. Corresponds to variant dbSNP:rs34074522Ensembl. | 1 | |
Natural variantiVAR_049813 | 366 | T → S3 PublicationsCorresponds to variant dbSNP:rs1479500Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030922 | 1 – 97 | Missing in isoform 2. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_040489 | 1 – 63 | Missing in isoform 3. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_040490 | 1 – 9 | MLEGSWINR → MKDTQDIQEASKAMQNKVHE QEDKNEKQKQ in isoform 4 and isoform 5. 1 Publication | 9 | |
Alternative sequenceiVSP_040491 | 64 – 83 | GQLTS…ENSLD → MQQPVRAGDIGVSRVQTHHN in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_040492 | 206 – 245 | Missing in isoform 4. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093323 mRNA Translation: BAC04132.1 AK296816 mRNA Translation: BAG59389.1 AK302292 mRNA Translation: BAG63632.1 AK310411 mRNA No translation available. AC022367 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96516.1 BC037957 mRNA Translation: AAH37957.1 |
CCDSi | CCDS44847.1 [Q8N9Z9-3] CCDS44848.1 [Q8N9Z9-4] CCDS44849.1 [Q8N9Z9-5] CCDS58218.1 [Q8N9Z9-2] CCDS8704.1 [Q8N9Z9-1] |
RefSeqi | NP_001139199.1, NM_001145727.2 [Q8N9Z9-3] NP_001139200.1, NM_001145728.2 [Q8N9Z9-5] NP_001139201.1, NM_001145729.1 [Q8N9Z9-4] NP_001243195.1, NM_001256266.1 [Q8N9Z9-2] NP_689803.2, NM_152590.3 [Q8N9Z9-1] XP_011518877.1, XM_011520575.1 [Q8N9Z9-5] XP_011518878.1, XM_011520576.2 [Q8N9Z9-5] XP_011518879.1, XM_011520577.2 [Q8N9Z9-5] XP_011518880.1, XM_011520578.2 [Q8N9Z9-5] XP_011518882.1, XM_011520580.1 [Q8N9Z9-4] XP_016874380.1, XM_017018891.1 [Q8N9Z9-5] |
Genome annotation databases
Ensembli | ENST00000282881; ENSP00000282881; ENSG00000152936 [Q8N9Z9-1] ENST00000413632; ENSP00000393150; ENSG00000152936 [Q8N9Z9-4] ENST00000445693; ENSP00000407043; ENSG00000152936 [Q8N9Z9-3] ENST00000458174; ENSP00000407353; ENSG00000152936 [Q8N9Z9-5] ENST00000539744; ENSP00000443132; ENSG00000152936 [Q8N9Z9-2] |
GeneIDi | 160492 |
KEGGi | hsa:160492 |
UCSCi | uc001rgs.3, human [Q8N9Z9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093323 mRNA Translation: BAC04132.1 AK296816 mRNA Translation: BAG59389.1 AK302292 mRNA Translation: BAG63632.1 AK310411 mRNA No translation available. AC022367 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96516.1 BC037957 mRNA Translation: AAH37957.1 |
CCDSi | CCDS44847.1 [Q8N9Z9-3] CCDS44848.1 [Q8N9Z9-4] CCDS44849.1 [Q8N9Z9-5] CCDS58218.1 [Q8N9Z9-2] CCDS8704.1 [Q8N9Z9-1] |
RefSeqi | NP_001139199.1, NM_001145727.2 [Q8N9Z9-3] NP_001139200.1, NM_001145728.2 [Q8N9Z9-5] NP_001139201.1, NM_001145729.1 [Q8N9Z9-4] NP_001243195.1, NM_001256266.1 [Q8N9Z9-2] NP_689803.2, NM_152590.3 [Q8N9Z9-1] XP_011518877.1, XM_011520575.1 [Q8N9Z9-5] XP_011518878.1, XM_011520576.2 [Q8N9Z9-5] XP_011518879.1, XM_011520577.2 [Q8N9Z9-5] XP_011518880.1, XM_011520578.2 [Q8N9Z9-5] XP_011518882.1, XM_011520580.1 [Q8N9Z9-4] XP_016874380.1, XM_017018891.1 [Q8N9Z9-5] |
3D structure databases
SMRi | Q8N9Z9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127760, 3 interactors |
IntActi | Q8N9Z9, 1 interactor |
STRINGi | 9606.ENSP00000407353 |
PTM databases
iPTMneti | Q8N9Z9 |
PhosphoSitePlusi | Q8N9Z9 |
Genetic variation databases
BioMutai | LMNTD1 |
DMDMi | 296434538 |
Proteomic databases
PaxDbi | Q8N9Z9 |
PeptideAtlasi | Q8N9Z9 |
PRIDEi | Q8N9Z9 |
ProteomicsDBi | 72615 [Q8N9Z9-1] 72616 [Q8N9Z9-2] 72617 [Q8N9Z9-3] 72618 [Q8N9Z9-4] 72619 [Q8N9Z9-5] |
Protocols and materials databases
Antibodypediai | 42350, 110 antibodies |
Genome annotation databases
Ensembli | ENST00000282881; ENSP00000282881; ENSG00000152936 [Q8N9Z9-1] ENST00000413632; ENSP00000393150; ENSG00000152936 [Q8N9Z9-4] ENST00000445693; ENSP00000407043; ENSG00000152936 [Q8N9Z9-3] ENST00000458174; ENSP00000407353; ENSG00000152936 [Q8N9Z9-5] ENST00000539744; ENSP00000443132; ENSG00000152936 [Q8N9Z9-2] |
GeneIDi | 160492 |
KEGGi | hsa:160492 |
UCSCi | uc001rgs.3, human [Q8N9Z9-1] |
Organism-specific databases
CTDi | 160492 |
DisGeNETi | 160492 |
GeneCardsi | LMNTD1 |
HGNCi | HGNC:26683, LMNTD1 |
HPAi | ENSG00000152936, Tissue enhanced (brain, fallopian tube, pituitary gland, testis) |
neXtProti | NX_Q8N9Z9 |
OpenTargetsi | ENSG00000152936 |
PharmGKBi | PA162391895 |
VEuPathDBi | HostDB:ENSG00000152936.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0977, Eukaryota |
GeneTreei | ENSGT00910000144343 |
HOGENOMi | CLU_048894_1_0_1 |
InParanoidi | Q8N9Z9 |
OMAi | GMPLGYY |
OrthoDBi | 716378at2759 |
PhylomeDBi | Q8N9Z9 |
TreeFami | TF338357 |
Enzyme and pathway databases
PathwayCommonsi | Q8N9Z9 |
Miscellaneous databases
BioGRID-ORCSi | 160492, 5 hits in 977 CRISPR screens |
ChiTaRSi | LMNTD1, human |
GenomeRNAii | 160492 |
Pharosi | Q8N9Z9, Tdark |
PROi | PR:Q8N9Z9 |
RNActi | Q8N9Z9, protein |
Gene expression databases
Bgeei | ENSG00000152936, Expressed in right uterine tube and 83 other tissues |
ExpressionAtlasi | Q8N9Z9, baseline and differential |
Genevisiblei | Q8N9Z9, HS |
Family and domain databases
Gene3Di | 2.60.40.1260, 1 hit |
InterProi | View protein in InterPro IPR001322, Lamin_tail_dom IPR036415, Lamin_tail_dom_sf IPR042840, LMNTD1 |
PANTHERi | PTHR47012, PTHR47012, 1 hit |
Pfami | View protein in Pfam PF00932, LTD, 1 hit |
SUPFAMi | SSF74853, SSF74853, 1 hit |
PROSITEi | View protein in PROSITE PS51841, LTD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LMTD1_HUMAN | |
Accessioni | Q8N9Z9Primary (citable) accession number: Q8N9Z9 Secondary accession number(s): B4DL27, B4DY70, Q8IY38 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families