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Protein

Protein FAM181A

Gene

FAM181A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM181A
Gene namesi
Name:FAM181A
Synonyms:C14orf152
ORF Names:HSD-31, HSD31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000140067.6
HGNCiHGNC:20491 FAM181A
neXtProtiNX_Q8N9Y4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140067
PharmGKBiPA162387582

Polymorphism and mutation databases

BioMutaiFAM181A
DMDMi152032205

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899511 – 354Protein FAM181AAdd BLAST354

Proteomic databases

EPDiQ8N9Y4
PaxDbiQ8N9Y4
PeptideAtlasiQ8N9Y4
PRIDEiQ8N9Y4
ProteomicsDBi72608
72609 [Q8N9Y4-2]

PTM databases

iPTMnetiQ8N9Y4
PhosphoSitePlusiQ8N9Y4

Expressioni

Gene expression databases

BgeeiENSG00000140067 Expressed in 49 organ(s), highest expression level in right testis
CleanExiHS_FAM181A
ExpressionAtlasiQ8N9Y4 baseline and differential
GenevisibleiQ8N9Y4 HS

Organism-specific databases

HPAiHPA001603

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000267594

Structurei

3D structure databases

ProteinModelPortaliQ8N9Y4
SMRiQ8N9Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM181 family.Curated

Phylogenomic databases

eggNOGiENOG410IF5J Eukaryota
ENOG4111HR9 LUCA
GeneTreeiENSGT00510000049499
HOGENOMiHOG000112456
HOVERGENiHBG094428
InParanoidiQ8N9Y4
OMAiQKVYRPV
OrthoDBiEOG091G0DJF
PhylomeDBiQ8N9Y4
TreeFamiTF333276

Family and domain databases

InterProiView protein in InterPro
IPR029359 FAM181
PANTHERiPTHR33766 PTHR33766, 1 hit
PfamiView protein in Pfam
PF15238 FAM181, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N9Y4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLEERRSSG ERNDAAPTNH RRPGEKRAST AKQVSSVPFL GAAGHQQSLP
60 70 80 90 100
SSWKASCSGP LVMASDSDVK MLLNFVNLAS SDIKAALDKS APCRRSVDHR
110 120 130 140 150
KYLQKQLKRF SQKYSRLPRG LPGRAAEPYL KRGSEDRPRR LLLDLGPDSS
160 170 180 190 200
PGGGGGCKEK VLRNPYREEC LAKEQLPQRQ HPEAAQPGQV PMRKRQLPAS
210 220 230 240 250
FWEEPRPTHS YHVGLEGGLG PREGPPYEGK KNCKGLEPLG PETTLVSMSP
260 270 280 290 300
RALAEKEPLK MPGVSLVGRV NAWSCCPFQY HGQPIYPGPL GALPQSPVPS
310 320 330 340 350
LGLWRKSPAF PGELAHLCKD VDGLGQKVCR PVVLKPIPTK PAVPPPIFNV

FGYL
Note: No experimental confirmation available.
Length:354
Mass (Da):38,724
Last modified:May 29, 2007 - v3
Checksum:iD1BB76A980617249
GO
Isoform 2 (identifier: Q8N9Y4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:292
Mass (Da):32,127
Checksum:iB1003054FF20D07D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5K4G3V5K4_HUMAN
Protein FAM181A
FAM181A
232Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164N → S in BAC04151 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02283428A → T1 PublicationCorresponds to variant dbSNP:rs10141024Ensembl.1
Natural variantiVAR_057822162L → M. Corresponds to variant dbSNP:rs34220325Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145491 – 62Missing in isoform 2. 3 PublicationsAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255795 mRNA Translation: AAP15252.1
AK093387 mRNA Translation: BAC04151.1
AK315393 mRNA Translation: BAG37786.1
AL132642 Genomic DNA No translation available.
BC009073 mRNA Translation: AAH09073.1
CCDSiCCDS55939.1 [Q8N9Y4-2]
CCDS9914.1 [Q8N9Y4-1]
RefSeqiNP_001194000.1, NM_001207071.1 [Q8N9Y4-2]
NP_001194001.1, NM_001207072.1 [Q8N9Y4-2]
NP_001194002.1, NM_001207073.1 [Q8N9Y4-2]
NP_001194003.1, NM_001207074.1 [Q8N9Y4-2]
NP_612353.3, NM_138344.4 [Q8N9Y4-1]
UniGeneiHs.525550

Genome annotation databases

EnsembliENST00000267594; ENSP00000267594; ENSG00000140067 [Q8N9Y4-1]
ENST00000556222; ENSP00000451678; ENSG00000140067 [Q8N9Y4-2]
ENST00000557000; ENSP00000451445; ENSG00000140067 [Q8N9Y4-2]
ENST00000557719; ENSP00000451802; ENSG00000140067 [Q8N9Y4-2]
ENST00000611800; ENSP00000478780; ENSG00000273533 [Q8N9Y4-2]
ENST00000617881; ENSP00000479410; ENSG00000273533 [Q8N9Y4-1]
ENST00000620448; ENSP00000478207; ENSG00000273533 [Q8N9Y4-2]
ENST00000626058; ENSP00000486422; ENSG00000273533 [Q8N9Y4-2]
GeneIDi90050
KEGGihsa:90050
UCSCiuc001ybz.3 human [Q8N9Y4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY255795 mRNA Translation: AAP15252.1
AK093387 mRNA Translation: BAC04151.1
AK315393 mRNA Translation: BAG37786.1
AL132642 Genomic DNA No translation available.
BC009073 mRNA Translation: AAH09073.1
CCDSiCCDS55939.1 [Q8N9Y4-2]
CCDS9914.1 [Q8N9Y4-1]
RefSeqiNP_001194000.1, NM_001207071.1 [Q8N9Y4-2]
NP_001194001.1, NM_001207072.1 [Q8N9Y4-2]
NP_001194002.1, NM_001207073.1 [Q8N9Y4-2]
NP_001194003.1, NM_001207074.1 [Q8N9Y4-2]
NP_612353.3, NM_138344.4 [Q8N9Y4-1]
UniGeneiHs.525550

3D structure databases

ProteinModelPortaliQ8N9Y4
SMRiQ8N9Y4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000267594

PTM databases

iPTMnetiQ8N9Y4
PhosphoSitePlusiQ8N9Y4

Polymorphism and mutation databases

BioMutaiFAM181A
DMDMi152032205

Proteomic databases

EPDiQ8N9Y4
PaxDbiQ8N9Y4
PeptideAtlasiQ8N9Y4
PRIDEiQ8N9Y4
ProteomicsDBi72608
72609 [Q8N9Y4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267594; ENSP00000267594; ENSG00000140067 [Q8N9Y4-1]
ENST00000556222; ENSP00000451678; ENSG00000140067 [Q8N9Y4-2]
ENST00000557000; ENSP00000451445; ENSG00000140067 [Q8N9Y4-2]
ENST00000557719; ENSP00000451802; ENSG00000140067 [Q8N9Y4-2]
ENST00000611800; ENSP00000478780; ENSG00000273533 [Q8N9Y4-2]
ENST00000617881; ENSP00000479410; ENSG00000273533 [Q8N9Y4-1]
ENST00000620448; ENSP00000478207; ENSG00000273533 [Q8N9Y4-2]
ENST00000626058; ENSP00000486422; ENSG00000273533 [Q8N9Y4-2]
GeneIDi90050
KEGGihsa:90050
UCSCiuc001ybz.3 human [Q8N9Y4-1]

Organism-specific databases

CTDi90050
EuPathDBiHostDB:ENSG00000140067.6
GeneCardsiFAM181A
HGNCiHGNC:20491 FAM181A
HPAiHPA001603
neXtProtiNX_Q8N9Y4
OpenTargetsiENSG00000140067
PharmGKBiPA162387582
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5J Eukaryota
ENOG4111HR9 LUCA
GeneTreeiENSGT00510000049499
HOGENOMiHOG000112456
HOVERGENiHBG094428
InParanoidiQ8N9Y4
OMAiQKVYRPV
OrthoDBiEOG091G0DJF
PhylomeDBiQ8N9Y4
TreeFamiTF333276

Miscellaneous databases

GenomeRNAii90050
PROiPR:Q8N9Y4

Gene expression databases

BgeeiENSG00000140067 Expressed in 49 organ(s), highest expression level in right testis
CleanExiHS_FAM181A
ExpressionAtlasiQ8N9Y4 baseline and differential
GenevisibleiQ8N9Y4 HS

Family and domain databases

InterProiView protein in InterPro
IPR029359 FAM181
PANTHERiPTHR33766 PTHR33766, 1 hit
PfamiView protein in Pfam
PF15238 FAM181, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF181A_HUMAN
AccessioniPrimary (citable) accession number: Q8N9Y4
Secondary accession number(s): B2RD39, Q96GY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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