UniProtKB - Q8N9W6 (BOLL_HUMAN)
Protein
Protein boule-like
Gene
BOLL
Organism
Homo sapiens (Human)
Status
Functioni
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).By similarity
GO - Molecular functioni
- mRNA 3'-UTR binding Source: GO_Central
- translation activator activity Source: UniProtKB
GO - Biological processi
- 3'-UTR-mediated mRNA stabilization Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- meiotic cell cycle Source: MGI
- multicellular organism development Source: UniProtKB-KW
- positive regulation of translational initiation Source: UniProtKB
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Biological process | Differentiation, Spermatogenesis, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8N9W6 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein boule-like |
Gene namesi | Name:BOLL Synonyms:BOULE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152430.17 |
HGNCi | HGNC:14273, BOLL |
MIMi | 606165, gene |
neXtProti | NX_Q8N9W6 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 66037 |
OpenTargetsi | ENSG00000152430 |
PharmGKBi | PA25397 |
Miscellaneous databases
Pharosi | Q8N9W6, Tbio |
Polymorphism and mutation databases
BioMutai | BOLL |
DMDMi | 44887719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081494 | 1 – 283 | Protein boule-likeAdd BLAST | 283 |
Proteomic databases
MassIVEi | Q8N9W6 |
PaxDbi | Q8N9W6 |
PeptideAtlasi | Q8N9W6 |
PRIDEi | Q8N9W6 |
ProteomicsDBi | 72599 [Q8N9W6-1] 72600 [Q8N9W6-2] 72601 [Q8N9W6-3] 72602 [Q8N9W6-4] |
PTM databases
iPTMneti | Q8N9W6 |
PhosphoSitePlusi | Q8N9W6 |
Expressioni
Tissue specificityi
Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.2 Publications
Gene expression databases
Bgeei | ENSG00000152430, Expressed in testis and 80 other tissues |
ExpressionAtlasi | Q8N9W6, baseline and differential |
Genevisiblei | Q8N9W6, HS |
Organism-specific databases
HPAi | ENSG00000152430, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with DAZ1 and DAZL.
1 PublicationBinary interactionsi
Hide detailsQ8N9W6
Isoform 4 [Q8N9W6-4]
Protein-protein interaction databases
BioGRIDi | 122456, 39 interactors |
IntActi | Q8N9W6, 41 interactors |
STRINGi | 9606.ENSP00000314792 |
Miscellaneous databases
RNActi | Q8N9W6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 110 | RRMPROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 160 – 184 | DAZPROSITE-ProRule annotationAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the RRM DAZ family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00530000063480 |
HOGENOMi | CLU_077156_1_0_1 |
InParanoidi | Q8N9W6 |
OrthoDBi | 1610446at2759 |
PhylomeDBi | Q8N9W6 |
TreeFami | TF324396 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR037366, BOULE/DAZ IPR043628, DAZ_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR11176, PTHR11176, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51890, DAZ, 1 hit PS50102, RRM, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N9W6-1) [UniParc]FASTAAdd to basket
Also known as: BOULE2
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQTDSLSPSP NPVSPVPLNN PTSAPRYGTV IPNRIFVGGI DFKTNESDLR
60 70 80 90 100
KFFSQYGSVK EVKIVNDRAG VSKGYGFVTF ETQEDAQKIL QEAEKLNYKD
110 120 130 140 150
KKLNIGPAIR KQQVGIPRSS IMPAAGTMYL TTSTGYPYTY HNGVAYFHTP
160 170 180 190 200
EVTSVPPPWP SRSVCSSPVM VAQPIYQQPA YHYQATTQYL PGQWQWSVPQ
210 220 230 240 250
PSASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS VPEPYSDHGV
260 270 280
QATYHQVYAP SAITMPAPVM QPEPIKTVWS IHY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WD91 | F8WD91_HUMAN | Protein boule-like | BOLL | 87 | Annotation score: | ||
F2Z2G3 | F2Z2G3_HUMAN | Protein boule-like | BOLL | 333 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | V → A in BAC04171 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055382 | 1 – 9 | MQTDSLSPS → MTELEYPKG in isoform 5. 1 Publication | 9 | |
Alternative sequenceiVSP_009444 | 1 | M → MQTSNQM in isoform 2 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_036805 | 1 | M → METESGPQTSNQM in isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_055383 | 10 – 118 | Missing in isoform 5. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_009445 | 184 | Q → QGIKQCHTRRWMDSLLPFTK CDE in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_009446 | 277 – 283 | TVWSIHY → CGAFIIKTIGQLYSSSTDFL SNDPCVAEIQLQRTS in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272858 mRNA Translation: AAK58689.1 AM295005 mRNA Translation: CAL25726.1 AK058099 mRNA Translation: BAB71664.1 AK093453 mRNA Translation: BAC04171.1 AK097795 mRNA No translation available. AK302817 mRNA Translation: BAG64016.1 AC011997 Genomic DNA Translation: AAX93045.1 CH471063 Genomic DNA Translation: EAW70172.1 BC033674 mRNA Translation: AAH33674.1 |
CCDSi | CCDS2324.1 [Q8N9W6-3] CCDS2325.1 [Q8N9W6-1] CCDS63081.1 [Q8N9W6-5] |
RefSeqi | NP_001271287.1, NM_001284358.1 [Q8N9W6-5] NP_001271290.1, NM_001284361.1 [Q8N9W6-2] NP_001271291.1, NM_001284362.1 [Q8N9W6-4] NP_149019.1, NM_033030.5 [Q8N9W6-1] NP_932074.1, NM_197970.2 [Q8N9W6-3] |
Genome annotation databases
Ensembli | ENST00000282278; ENSP00000282278; ENSG00000152430 [Q8N9W6-5] ENST00000321801; ENSP00000314792; ENSG00000152430 [Q8N9W6-3] ENST00000392296; ENSP00000376116; ENSG00000152430 [Q8N9W6-1] ENST00000433157; ENSP00000396099; ENSG00000152430 [Q8N9W6-1] |
GeneIDi | 66037 |
KEGGi | hsa:66037 |
UCSCi | uc002uus.2, human [Q8N9W6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF272858 mRNA Translation: AAK58689.1 AM295005 mRNA Translation: CAL25726.1 AK058099 mRNA Translation: BAB71664.1 AK093453 mRNA Translation: BAC04171.1 AK097795 mRNA No translation available. AK302817 mRNA Translation: BAG64016.1 AC011997 Genomic DNA Translation: AAX93045.1 CH471063 Genomic DNA Translation: EAW70172.1 BC033674 mRNA Translation: AAH33674.1 |
CCDSi | CCDS2324.1 [Q8N9W6-3] CCDS2325.1 [Q8N9W6-1] CCDS63081.1 [Q8N9W6-5] |
RefSeqi | NP_001271287.1, NM_001284358.1 [Q8N9W6-5] NP_001271290.1, NM_001284361.1 [Q8N9W6-2] NP_001271291.1, NM_001284362.1 [Q8N9W6-4] NP_149019.1, NM_033030.5 [Q8N9W6-1] NP_932074.1, NM_197970.2 [Q8N9W6-3] |
3D structure databases
SMRi | Q8N9W6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122456, 39 interactors |
IntActi | Q8N9W6, 41 interactors |
STRINGi | 9606.ENSP00000314792 |
PTM databases
iPTMneti | Q8N9W6 |
PhosphoSitePlusi | Q8N9W6 |
Polymorphism and mutation databases
BioMutai | BOLL |
DMDMi | 44887719 |
Proteomic databases
MassIVEi | Q8N9W6 |
PaxDbi | Q8N9W6 |
PeptideAtlasi | Q8N9W6 |
PRIDEi | Q8N9W6 |
ProteomicsDBi | 72599 [Q8N9W6-1] 72600 [Q8N9W6-2] 72601 [Q8N9W6-3] 72602 [Q8N9W6-4] |
Protocols and materials databases
Antibodypediai | 19911, 457 antibodies |
DNASUi | 66037 |
Genome annotation databases
Ensembli | ENST00000282278; ENSP00000282278; ENSG00000152430 [Q8N9W6-5] ENST00000321801; ENSP00000314792; ENSG00000152430 [Q8N9W6-3] ENST00000392296; ENSP00000376116; ENSG00000152430 [Q8N9W6-1] ENST00000433157; ENSP00000396099; ENSG00000152430 [Q8N9W6-1] |
GeneIDi | 66037 |
KEGGi | hsa:66037 |
UCSCi | uc002uus.2, human [Q8N9W6-1] |
Organism-specific databases
CTDi | 66037 |
DisGeNETi | 66037 |
EuPathDBi | HostDB:ENSG00000152430.17 |
GeneCardsi | BOLL |
HGNCi | HGNC:14273, BOLL |
HPAi | ENSG00000152430, Tissue enriched (testis) |
MIMi | 606165, gene |
neXtProti | NX_Q8N9W6 |
OpenTargetsi | ENSG00000152430 |
PharmGKBi | PA25397 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00530000063480 |
HOGENOMi | CLU_077156_1_0_1 |
InParanoidi | Q8N9W6 |
OrthoDBi | 1610446at2759 |
PhylomeDBi | Q8N9W6 |
TreeFami | TF324396 |
Enzyme and pathway databases
PathwayCommonsi | Q8N9W6 |
Miscellaneous databases
BioGRID-ORCSi | 66037, 6 hits in 846 CRISPR screens |
ChiTaRSi | BOLL, human |
GeneWikii | BOLL |
GenomeRNAii | 66037 |
Pharosi | Q8N9W6, Tbio |
PROi | PR:Q8N9W6 |
RNActi | Q8N9W6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152430, Expressed in testis and 80 other tissues |
ExpressionAtlasi | Q8N9W6, baseline and differential |
Genevisiblei | Q8N9W6, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR037366, BOULE/DAZ IPR043628, DAZ_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR11176, PTHR11176, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51890, DAZ, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BOLL_HUMAN | |
Accessioni | Q8N9W6Primary (citable) accession number: Q8N9W6 Secondary accession number(s): B4DZA4 Q969U3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | March 1, 2004 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM