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UniProtKB - Q8N9V7 (TOPZ1_HUMAN)

Entry version 100 (10 Feb 2021)
Sequence version 3 (11 Jan 2011)
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Protein

Protein TOPAZ1

Gene

TOPAZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N9V7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1By similarity
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPAZ1
Synonyms:C3orf77
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24746, TOPAZ1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614412, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N9V7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173769.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		375337

Open Targets

More...OpenTargetsi		ENSG00000173769

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165696874

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N9V7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TOPAZ1

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373461

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206001 – 1692Protein TOPAZ1Add BLAST1692

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N9V7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N9V7

PeptideAtlas

More...PeptideAtlasi		Q8N9V7

PRoteomics IDEntifications database

More...PRIDEi		Q8N9V7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72592

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N9V7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N9V7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173769, Expressed in testis and 4 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173769, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131973, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q8N9V7, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000310303

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N9V7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPIV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012495

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N9V7

Identification of Orthologs from Complete Genome Data

More...OMAi		NIFMEYY

Database of Orthologous Groups

More...OrthoDBi		347766at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N9V7

TreeFam database of animal gene trees

More...TreeFami		TF338635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom

The PANTHER Classification System

More...PANTHERi		PTHR35671, PTHR35671, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N9V7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRPPPLGPT TASGPEGNVR NLQKRQAPGP GAAGGCGPEA GGCRENKQKR 
        60         70         80         90        100
RMVARATPGR GEVESDKSVA ASGAGKAARR QVEGRRGPVS PSDSSDPRGL 
       110        120        130        140        150
EAAKEAELPL QTERHTKEKR KVTEASSDDP QPGLDLVRKE SLTSSESFQT 
       160        170        180        190        200
VECLQSLGKE SIIEGIKRRI RNKKLKSLEN PPLKITENEA TQNIKVEFQD 
       210        220        230        240        250
ELYKNTPKYS CNILSPEVEN NSVLKLRDCN CFPHSKGCND ENNLPYKPDG 
       260        270        280        290        300
GCMHVAENFS KKENLRSLAE KSDTNSIPQL LQTEENVMGV NKLLPEESDL 
       310        320        330        340        350
YQSKTNGLLS CLQHEKNKYS IEESSVGRKP RKRMKLSEKA DETVTEMNFS 
       360        370        380        390        400
NEYNKSELML QENQMIADGK EAETKSPLNV LRKVSHNTVS LMDHLLSVPE 
       410        420        430        440        450
TVEKETSSEH HVNAVFQKTI EPLLKEETEN ASEPLGYESM ASKEDFKSMK 
       460        470        480        490        500
SFIGKSPNEY HIERRSSRED LRSASEELKL SCQRTIPMTG KRTWPYYSCA 
       510        520        530        540        550
RISAWCWKKA SLPESSYFLR GSQESCRQVD VPKHQTNQTH LTDSKLLLQS 
       560        570        580        590        600
SLTETNTESS SKEKLDSNSN CLSSVSAVEP TLMVIKEPII KDDKKIKSEE 
       610        620        630        640        650
LSRRGSEVIS NTTEDTQLTS ETQSLTGNKK KARGNLTKLN LTATSKDGQE 
       660        670        680        690        700
ANNSAGKTIH RKACIAQQTF IVPDLVKILN TGRLTNFKIP LLKNKSEKRK 
       710        720        730        740        750
EVNAKSSERE AYSPLELLDN LSGADVRQNR SKENVSMMML GPQTLSIRNS 
       760        770        780        790        800
VTPVQASSDS FYNKKSYSIS PSFTKQGNNS KPSNHVSEPG NIVSNKEVAS 
       810        820        830        840        850
LTVENNAFSC DPGYVEKSPS FCCNEQETFR PVSSEVRGRK ITKNFSEVGF 
       860        870        880        890        900
PDILKAYEDD VLLIDVIQDD PDLFGVSNEG ELSFTSEVPK ISQEPNVAGE 
       910        920        930        940        950
HQSTDSKYME TPVKKEPSDD LRELPVLDCG WIKPDICASN SAESEIKRDP 
       960        970        980        990       1000
KDVNTSLGEV ANETSENETL GDFSEQIKGS DLDEKHRFTD KVITKEEKEN 
      1010       1020       1030       1040       1050
IYEVCKSKDS RNADFMVGEC QFAVPVPKPL CLLVPPLNLS GRQEDTILNT 
      1060       1070       1080       1090       1100
WMNDFRFLGK HSVLKLQNPE TCEIFKREKN VGVFQKSLGL MIPYKYCKFH 
      1110       1120       1130       1140       1150
FNTLRGCERP LCKFAHVPEQ GDEKVCMDVF KKYININELC LLQRAVNIFM 
      1160       1170       1180       1190       1200
EYYRKFPPGV YFDLQVLNDL LNSLLKHCLL KEVFQIVNLS IMVKMLPSLK 
      1210       1220       1230       1240       1250
ILLNIFEYVA TMKLRNAVPA LIDIFCKLVE AGMVLDPEHF NYIVKLLYQV 
      1260       1270       1280       1290       1300
QASKQEITAV LEMKSRLQMR RFKKNWKCDL DSALNKLEHC KEKGDWTKLG 
      1310       1320       1330       1340       1350
KLYINVKMGC EKFADFQTFC ACIAETLTKN YEDERPDIPF CEFAETVSKD 
      1360       1370       1380       1390       1400
PQNSKVDKGV LGRIGISAMY FYHKLLQWSK GRKVLEKLYE LKIHFTSLKG 
      1410       1420       1430       1440       1450
LIGPEKLASR CQIVNVAAEI FLKSGSLDGA IWVMRESEWI INTPLWPCDR 
      1460       1470       1480       1490       1500
LDVLNRHNLL CTIAHEILAK SLYRQTFEVL QNLPGFQNSQ ETVEVSQYSL 
      1510       1520       1530       1540       1550
LFNKLLGSCI ESSSLGMSSS VAEFMISKSI PIDFSFLRRL ITSLGRSRLW 
      1560       1570       1580       1590       1600
LKARAHYKSA LSLGCYPPLE GNLYRKLLLI PSYLSEIEML LAIEIFMVSN 
      1610       1620       1630       1640       1650
ASSIQSPGTS TQILQIVLKR CEDNQSRSND DYQAAVERLI MAARISDPKL 
      1660       1670       1680       1690 
FVKHMTVNVN KEQVYSLEHC SALKWLKENM KWAGKVWLFS NH
Length:1,692
Mass (Da):190,927
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3857B608D4033D44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22L → H in BAC04180 (PubMed:14702039).Curated1
Sequence conflicti802T → P in BX648094 (PubMed:17974005).Curated1
Sequence conflicti1537L → P in BX648094 (PubMed:17974005).Curated1
Sequence conflicti1666S → I in AI208289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03922443C → R1 PublicationCorresponds to variant dbSNP:rs9833423Ensembl.1
Natural variantiVAR_03922588P → Q1 PublicationCorresponds to variant dbSNP:rs7645375Ensembl.1
Natural variantiVAR_039226196V → I. Corresponds to variant dbSNP:rs9284879Ensembl.1
Natural variantiVAR_039227483Q → R. Corresponds to variant dbSNP:rs17076541Ensembl.1
Natural variantiVAR_039228673P → A. Corresponds to variant dbSNP:rs17646517Ensembl.1
Natural variantiVAR_039229796K → E. Corresponds to variant dbSNP:rs17076545Ensembl.1
Natural variantiVAR_0392301352Q → R. Corresponds to variant dbSNP:rs11921568EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC104187 Genomic DNA No translation available.
AK093476 mRNA Translation: BAC04180.1
BX648094 mRNA No translation available.
AI208289 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46809.1

NCBI Reference Sequences

More...RefSeqi		NP_001138502.1, NM_001145030.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309765; ENSP00000310303; ENSG00000173769

Database of genes from NCBI RefSeq genomes

More...GeneIDi		375337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:375337

UCSC genome browser

More...UCSCi		uc003cna.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104187 Genomic DNA No translation available.
AK093476 mRNA Translation: BAC04180.1
BX648094 mRNA No translation available.
AI208289 mRNA No translation available.
CCDSiCCDS46809.1
RefSeqiNP_001138502.1, NM_001145030.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131973, 4 interactors
IntActiQ8N9V7, 1 interactor
STRINGi9606.ENSP00000310303

PTM databases

iPTMnetiQ8N9V7
PhosphoSitePlusiQ8N9V7

Genetic variation databases

BioMutaiTOPAZ1
DMDMi317373461

Proteomic databases

EPDiQ8N9V7
PaxDbiQ8N9V7
PeptideAtlasiQ8N9V7
PRIDEiQ8N9V7
ProteomicsDBi72592

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		64655, 24 antibodies

Genome annotation databases

EnsembliENST00000309765; ENSP00000310303; ENSG00000173769
GeneIDi375337
KEGGihsa:375337
UCSCiuc003cna.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		375337
DisGeNETi375337

GeneCards: human genes, protein and diseases

More...GeneCardsi		TOPAZ1
HGNCiHGNC:24746, TOPAZ1
HPAiENSG00000173769, Tissue enriched (testis)
MIMi614412, gene
neXtProtiNX_Q8N9V7
OpenTargetsiENSG00000173769
PharmGKBiPA165696874
VEuPathDBiHostDB:ENSG00000173769.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPIV, Eukaryota
GeneTreeiENSGT00390000012495
HOGENOMiCLU_003190_0_0_1
InParanoidiQ8N9V7
OMAiNIFMEYY
OrthoDBi347766at2759
PhylomeDBiQ8N9V7
TreeFamiTF338635

Enzyme and pathway databases

PathwayCommonsiQ8N9V7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		375337, 7 hits in 871 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		375337
PharosiQ8N9V7, Tdark

Protein Ontology

More...PROi		PR:Q8N9V7
RNActiQ8N9V7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173769, Expressed in testis and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
PANTHERiPTHR35671, PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9V7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: February 10, 2021
This is version 100 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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