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Entry version 131 (16 Oct 2019)
Sequence version 2 (11 Jan 2011)
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Protein

Tandem C2 domains nuclear protein

Gene

TC2N

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tandem C2 domains nuclear protein
Alternative name(s):
Membrane targeting tandem C2 domain-containing protein 1
Tandem C2 protein in nucleus
Short name:
Tac2-N
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TC2N
Synonyms:C14orf47, MTAC2D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19859 TC2N

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N9U0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
123036

Open Targets

More...
OpenTargetsi
ENSG00000165929

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N9U0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TC2N

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373282

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724141 – 490Tandem C2 domains nuclear proteinAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei83PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei174PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei218PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N9U0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N9U0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N9U0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N9U0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N9U0

PeptideAtlas

More...
PeptideAtlasi
Q8N9U0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N9U0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72584 [Q8N9U0-1]
72585 [Q8N9U0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N9U0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N9U0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8N9U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165929 Expressed in 162 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N9U0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N9U0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027549

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125812, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N9U0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387882

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N9U0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini353 – 456C2PROSITE-ProRule annotationAdd BLAST104

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi447 – 449Nuclear localization signalSequence analysis3

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1028 Eukaryota
ENOG410XRME LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009196

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133064

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N9U0

KEGG Orthology (KO)

More...
KOi
K17287

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKETVTN

Database of Orthologous Groups

More...
OrthoDBi
729490at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N9U0

TreeFam database of animal gene trees

More...
TreeFami
TF317035

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08684 C2A_Tac2-N, 1 hit
cd08692 C2B_Tac2-N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037786 C2A_Tac2-N
IPR037788 C2B_Tac2-N
IPR030542 Tac2-N

The PANTHER Classification System

More...
PANTHERi
PTHR46887 PTHR46887, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N9U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEFIKSCC GGCFYGETEK HNFSVERDFK AAVPNSQNAT ISVPPLTSVS
60 70 80 90 100
VKPQLGCTED YLLSKLPSDG KEVPFVVPKF KLSYIQPRTQ ETPSHLEELE
110 120 130 140 150
GSARASFGDR KVELSSSSQH GPSYDVYNPF YMYQHISPDL SRRFPPRSEV
160 170 180 190 200
KRLYGSVCDL RTNKLPGSPG LSKSMFDLTN SSQRFIQRHD SLSSVPSSSS
210 220 230 240 250
SRKNSQGSNR SLDTITLSGD ERDFGRLNVK LFYNSSVEQI WITVLQCRDL
260 270 280 290 300
SWPSSYGDTP TVSIKGILTL PKPVHFKSSA KEGSNAIEFM ETFVFAIKLQ
310 320 330 340 350
NLQTVRLVFK IQTQTPRKKT IGECSMSLRT LSTQEMDYSL DITPPSKISV
360 370 380 390 400
CHAELELGTC FQAVNSRIQL QILEARYLPS SSTPLTLSFF VKVGMFSSGE
410 420 430 440 450
LIYKKKTRLL KASNGRVKWG ETMIFPLIQS EKEIVFLIKL YSRSSVRRKH
460 470 480 490
FVGQIWISED SNNIEAVNQW KETVINPEKV VIRWHKLNPS
Length:490
Mass (Da):55,284
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5606E022D6584200
GO
Isoform 2 (identifier: Q8N9U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-349: Missing.

Note: No experimental confirmation available.
Show »
Length:426
Mass (Da):47,948
Checksum:iD86D1D04A985223D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ73H0YJ73_HUMAN
Tandem C2 domains nuclear protein
TC2N
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60D → G in BAC86538 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051405151K → T2 PublicationsCorresponds to variant dbSNP:rs2402073Ensembl.1
Natural variantiVAR_051406172S → N. Corresponds to variant dbSNP:rs8020529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008572286 – 349Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093876 mRNA Translation: BAC04238.1
AK126359 mRNA Translation: BAC86538.1
AL121839 Genomic DNA No translation available.
BC040503 mRNA Translation: AAH40503.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73679.1 [Q8N9U0-2]
CCDS9897.1 [Q8N9U0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001122067.1, NM_001128595.2 [Q8N9U0-1]
NP_001122068.1, NM_001128596.2 [Q8N9U0-1]
NP_001276063.1, NM_001289134.1 [Q8N9U0-2]
NP_689545.1, NM_152332.5 [Q8N9U0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340892; ENSP00000343199; ENSG00000165929 [Q8N9U0-1]
ENST00000360594; ENSP00000353802; ENSG00000165929 [Q8N9U0-1]
ENST00000435962; ENSP00000387882; ENSG00000165929 [Q8N9U0-1]
ENST00000556018; ENSP00000451317; ENSG00000165929 [Q8N9U0-2]
ENST00000610758; ENSP00000483305; ENSG00000276776 [Q8N9U0-1]
ENST00000620359; ENSP00000478127; ENSG00000276776 [Q8N9U0-1]
ENST00000632584; ENSP00000487608; ENSG00000276776 [Q8N9U0-1]
ENST00000634120; ENSP00000488431; ENSG00000276776 [Q8N9U0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
123036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:123036

UCSC genome browser

More...
UCSCi
uc001xzt.6 human [Q8N9U0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093876 mRNA Translation: BAC04238.1
AK126359 mRNA Translation: BAC86538.1
AL121839 Genomic DNA No translation available.
BC040503 mRNA Translation: AAH40503.1
CCDSiCCDS73679.1 [Q8N9U0-2]
CCDS9897.1 [Q8N9U0-1]
RefSeqiNP_001122067.1, NM_001128595.2 [Q8N9U0-1]
NP_001122068.1, NM_001128596.2 [Q8N9U0-1]
NP_001276063.1, NM_001289134.1 [Q8N9U0-2]
NP_689545.1, NM_152332.5 [Q8N9U0-1]

3D structure databases

SMRiQ8N9U0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125812, 5 interactors
IntActiQ8N9U0, 2 interactors
STRINGi9606.ENSP00000387882

PTM databases

iPTMnetiQ8N9U0
PhosphoSitePlusiQ8N9U0
SwissPalmiQ8N9U0

Polymorphism and mutation databases

BioMutaiTC2N
DMDMi317373282

Proteomic databases

EPDiQ8N9U0
jPOSTiQ8N9U0
MassIVEiQ8N9U0
MaxQBiQ8N9U0
PaxDbiQ8N9U0
PeptideAtlasiQ8N9U0
PRIDEiQ8N9U0
ProteomicsDBi72584 [Q8N9U0-1]
72585 [Q8N9U0-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
123036

Genome annotation databases

EnsembliENST00000340892; ENSP00000343199; ENSG00000165929 [Q8N9U0-1]
ENST00000360594; ENSP00000353802; ENSG00000165929 [Q8N9U0-1]
ENST00000435962; ENSP00000387882; ENSG00000165929 [Q8N9U0-1]
ENST00000556018; ENSP00000451317; ENSG00000165929 [Q8N9U0-2]
ENST00000610758; ENSP00000483305; ENSG00000276776 [Q8N9U0-1]
ENST00000620359; ENSP00000478127; ENSG00000276776 [Q8N9U0-1]
ENST00000632584; ENSP00000487608; ENSG00000276776 [Q8N9U0-1]
ENST00000634120; ENSP00000488431; ENSG00000276776 [Q8N9U0-2]
GeneIDi123036
KEGGihsa:123036
UCSCiuc001xzt.6 human [Q8N9U0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
123036
DisGeNETi123036

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TC2N
HGNCiHGNC:19859 TC2N
HPAiHPA027549
neXtProtiNX_Q8N9U0
OpenTargetsiENSG00000165929
PharmGKBiPA162405395

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00390000009196
HOGENOMiHOG000133064
InParanoidiQ8N9U0
KOiK17287
OMAiWKETVTN
OrthoDBi729490at2759
PhylomeDBiQ8N9U0
TreeFamiTF317035

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TC2N human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TC2N

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
123036
PharosiQ8N9U0

Protein Ontology

More...
PROi
PR:Q8N9U0

Gene expression databases

BgeeiENSG00000165929 Expressed in 162 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ8N9U0 baseline and differential
GenevisibleiQ8N9U0 HS

Family and domain databases

CDDicd08684 C2A_Tac2-N, 1 hit
cd08692 C2B_Tac2-N, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037786 C2A_Tac2-N
IPR037788 C2B_Tac2-N
IPR030542 Tac2-N
PANTHERiPTHR46887 PTHR46887, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAC2N_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9U0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: October 16, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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