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UniProtKB - Q8N9N5 (BANP_HUMAN)

Protein

Protein BANP

Gene

BANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • p53 binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein BANP
Alternative name(s):
BEN domain-containing protein 1
Btg3-associated nuclear protein
Scaffold/matrix-associated region-1-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BANP
Synonyms:BEND1, SMAR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000172530.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:13450 BANP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611564 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N9N5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		54971

Open Targets

More...OpenTargetsi		ENSG00000172530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134933411

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BANP

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153628

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002979101 – 519Protein BANPAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N9N5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N9N5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N9N5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N9N5

PeptideAtlas

More...PeptideAtlasi		Q8N9N5

PRoteomics IDEntifications database

More...PRIDEi		Q8N9N5

ProteomicsDB human proteome resource

More...ProteomicsDBi		72563
72564 [Q8N9N5-2]
72565 [Q8N9N5-3]
72566 [Q8N9N5-4]
72567 [Q8N9N5-5]
72568 [Q8N9N5-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N9N5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N9N5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Down-regulated in breast cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172530 Expressed in 218 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...CleanExi		HS_BANP

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N9N5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N9N5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA047164

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ADAM15Q134443EBI-744695,EBI-77818
AFG1LQ8WV933EBI-744695,EBI-2865743
ALAS2P225573EBI-744695,EBI-2115743
ALAS2P22557-25EBI-11524452,EBI-12257000
BAG5Q9UL153EBI-744695,EBI-356517
BANPA0A0S2Z5G43EBI-11524452,EBI-16429704
BANPB4DE544EBI-11524452,EBI-16429313
BANPE9PJI63EBI-11524452,EBI-16437731
BLZF1Q9H2G93EBI-11524452,EBI-2548012
C1orf94Q6P1W53EBI-744695,EBI-946029
C22orf39Q6P5X53EBI-744695,EBI-7317823
CAMK2DQ135573EBI-744695,EBI-351018
CCDC26Q8TAB73EBI-744695,EBI-10271580
CDKN1BP465273EBI-11524452,EBI-519280
CDX4O146273EBI-16429296,EBI-10181162
CEP76Q8TAP63EBI-16429296,EBI-742887
CFAP206Q8IYR03EBI-744695,EBI-749051
COL10A1Q036924EBI-11524452,EBI-2528309
CRXO431865EBI-11524452,EBI-748171
DCDC2BA2VCK23EBI-744695,EBI-10173222
DLX3O604793EBI-16429296,EBI-3908248
DNAJA4Q8WW22-23EBI-744695,EBI-10277181
EPHA10Q5JZY3-33EBI-744695,EBI-10244652
FAM117BQ6P1L53EBI-744695,EBI-3893327
FAM71CQ8NEG03EBI-744695,EBI-752049
FAM90A1Q86YD73EBI-744695,EBI-6658203
FHL2Q141925EBI-11524452,EBI-701903
FHL5Q5TD973EBI-16429296,EBI-750641
FOXM1Q080503EBI-16429296,EBI-866480
FOXM1Q08050-23EBI-16429296,EBI-5237510
FOXR1Q6PIV23EBI-744695,EBI-10253815
GFM2Q969S93EBI-744695,EBI-2371750
HSFY2Q96LI63EBI-16429296,EBI-3957665
ISCUQ9H1K13EBI-744695,EBI-1047335
L3MBTL3Q96JM73EBI-744695,EBI-2686809
LENG1Q96BZ83EBI-744695,EBI-726510
LGALS14Q8TCE93EBI-744695,EBI-10274069
LMO2P257913EBI-744695,EBI-739696
LMO3Q8TAP43EBI-744695,EBI-742259
LMO4P619683EBI-744695,EBI-2798728
LSM2Q9Y3333EBI-744695,EBI-347416
MAP2K1Q027503EBI-744695,EBI-492564
MAXP612443EBI-744695,EBI-751711
MDFIQ997505EBI-11524452,EBI-724076
MEOX1P502213EBI-11524452,EBI-2864512
MEOX2Q6FHY53EBI-16429296,EBI-16439278
MGC4677Q53S703EBI-744695,EBI-10242717
MRPL28Q130843EBI-744695,EBI-723426
NEDD9Q145114EBI-744695,EBI-2108053
NMNAT1Q9HAN96EBI-11524452,EBI-3917542
NRIP2Q9BQI93EBI-744695,EBI-3913975
PHF21AQ96BD53EBI-744695,EBI-745085
PHF21BA0A0S2Z6153EBI-11524452,EBI-16434035
PHF21BQ96EK2-33EBI-11524452,EBI-16437793
PID1Q7Z2X43EBI-744695,EBI-10256685
PIM1P113093EBI-744695,EBI-696621
POGZQ7Z3K37EBI-11524452,EBI-1389308
POLDIP3Q8WUT13EBI-744695,EBI-10276663
POLR2LP628753EBI-744695,EBI-359527
PPIBP232843EBI-744695,EBI-359252
PPICP458773EBI-744695,EBI-953909
PPIFP304053EBI-744695,EBI-5544229
PRKAB2O437413EBI-744695,EBI-1053424
PRKCHQ9BVQ03EBI-744695,EBI-10299920
PRR20EP864783EBI-16429296,EBI-12700196
PSMD9O002333EBI-744695,EBI-750973
RAB3IPQ96QF03EBI-744695,EBI-747844
RAB3IPQ96QF0-75EBI-11524452,EBI-11984839
RBM39Q14498-33EBI-744695,EBI-6654703
RBPMSQ930623EBI-744695,EBI-740322
RELQ04864-25EBI-11524452,EBI-10829018
SH3RF2Q08AM83EBI-744695,EBI-10225873
SH3RF2Q8TEC53EBI-744695,EBI-2130111
SLC16A3O154273EBI-744695,EBI-7600166
SNRPBP14678-23EBI-744695,EBI-372475
SP2Q020864EBI-744695,EBI-8651703
SP4Q024463EBI-11524452,EBI-10198587
SPACA6W5XKT83EBI-744695,EBI-10176265
tmp_locus_54Q53NU33EBI-744695,EBI-10242677
TNXBP221054EBI-744695,EBI-2821024
TOX4O948425EBI-11524452,EBI-948613
TP53P046373EBI-744695,EBI-366083
TRAF2Q129334EBI-744695,EBI-355744
TRAF4Q9BUZ47EBI-11524452,EBI-3650647
TROAPQ128153EBI-744695,EBI-2349743
XAGE1EQ9HD643EBI-744695,EBI-2340004
ZC2HC1CQ53FD03EBI-744695,EBI-740767
ZMIZ2Q8NF643EBI-16429296,EBI-745786
ZMIZ2Q8NF64-23EBI-744695,EBI-10182121
ZNF488Q96MN93EBI-744695,EBI-948288
ZNF581Q9P0T43EBI-744695,EBI-745520

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120308, 133 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8N9N5

Protein interaction database and analysis system

More...IntActi		Q8N9N5, 197 interactors

Molecular INTeraction database

More...MINTi		Q8N9N5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286122

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8N9N5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N9N5

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini226 – 322BENPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 342Interaction with CUX1 and HDAC1By similarityAdd BLAST191
Regioni320 – 349Necessary and sufficient for TP53 activationBy similarityAdd BLAST30
Regioni342 – 393DNA-bindingBy similarityAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili53 – 90Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi361 – 426Gln-richAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BANP/SMAR1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IGMM Eukaryota
ENOG410Z2PJ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011116

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000015355

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107493

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N9N5

Identification of Orthologs from Complete Genome Data

More...OMAi		VQIHRIG

Database of Orthologous Groups

More...OrthoDBi		1401911at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N9N5

TreeFam database of animal gene trees

More...TreeFami		TF331908

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018379 BEN_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10523 BEN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01025 BEN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51457 BEN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N9N5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD 
        60         70         80         90        100
PSIKTICLRL DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS 
       110        120        130        140        150
PLGATQTCNK VRCVVPQTTV ILNNDRQNAI VAKMEDPLSN RAPDSLENVI 
       160        170        180        190        200
SNAVPGRRQN TIVVKVPGQE DSHHEDGESG SEASDSVSSC GQAGSQSIGS 
       210        220        230        240        250
NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH ISTNCRTAEK 
       260        270        280        290        300
MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT 
       310        320        330        340        350
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM 
       360        370        380        390        400
STPPPASELP QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV 
       410        420        430        440        450
PQGEQVQITQ DSEGNLQIHH VGQDGQLLEA TRIPCLLAPS VFKASSGQVL 
       460        470        480        490        500
QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV QYVQLAPVSD HTAGAQTAEA 
       510 
LQPTLQPEMQ LEHGAIQIQ
Length:519
Mass (Da):56,494
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i521C53F367A3A29E
GO
Isoform 2 (identifier: Q8N9N5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ
     425-446: Missing.

Show »
Length:469
Mass (Da):51,243
Checksum:i9E4B4A8C287A4A34
GO
Isoform 3 (identifier: Q8N9N5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     25-36: VLENHVVTDEDE → MTREFVKRSIFL
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,404
Checksum:i4C86E6B4AFD4B689
GO
Isoform 4 (identifier: Q8N9N5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Show »
Length:491
Mass (Da):53,527
Checksum:iBA171D3BA87F731B
GO
Isoform 5 (identifier: Q8N9N5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → GTELWDI
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):54,243
Checksum:i377684337AFFEF27
GO
Isoform 6 (identifier: Q8N9N5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Show »
Length:466
Mass (Da):50,905
Checksum:i4704286351630810
GO
Isoform 7 (identifier: Q8N9N5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     392-392: V → VIPQ
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,502
Checksum:i80ACD475B6F32D74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJI6E9PJI6_HUMAN
BTG3 associated nuclear protein iso...
BANP
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYB6C9JYB6_HUMAN
Protein BANP
BANP
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF73C9JF73_HUMAN
Protein BANP
BANP
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGM9C9JGM9_HUMAN
Protein BANP
BANP
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTM8C9JTM8_HUMAN
Protein BANP
BANP
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J811C9J811_HUMAN
Protein BANP
BANP
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIP2E9PIP2_HUMAN
BTG3 associated nuclear protein iso...
BANP
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLT2C9JLT2_HUMAN
Protein BANP
BANP
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLS0C9JLS0_HUMAN
Protein BANP
BANP
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04296 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123N → S in AK315535 (PubMed:14702039).Curated1
Sequence conflicti338P → S in BAA91244 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0273961 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04355824V → GTELWDI in isoform 5. 1 Publication1
Alternative sequenceiVSP_02739825 – 36VLENH…TDEDE → MTREFVKRSIFL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02739954K → KSFLYSINQ in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027400114 – 152Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_027401392V → VIPQ in isoform 2, isoform 4, isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027402425 – 446Missing in isoform 2, isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000545 mRNA Translation: BAA91244.1
AK094158 mRNA Translation: BAC04296.1 Different initiation.
AK125232 mRNA Translation: BAG54171.1
AK297945 mRNA Translation: BAG60261.1
AK315089 mRNA Translation: BAG37554.1
AK315535 mRNA No translation available.
AC127455 Genomic DNA No translation available.
AC134312 Genomic DNA No translation available.
BC009424 mRNA Translation: AAH09424.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10966.2 [Q8N9N5-4]
CCDS42215.1 [Q8N9N5-2]
CCDS54052.1 [Q8N9N5-7]
CCDS54053.1 [Q8N9N5-6]
CCDS54054.1 [Q8N9N5-1]
CCDS54055.1 [Q8N9N5-5]

NCBI Reference Sequences

More...RefSeqi		NP_001167010.1, NM_001173539.1
NP_001167011.1, NM_001173540.1 [Q8N9N5-5]
NP_001167012.1, NM_001173541.1 [Q8N9N5-6]
NP_001167013.1, NM_001173542.1 [Q8N9N5-7]
NP_001167014.1, NM_001173543.1 [Q8N9N5-1]
NP_060339.2, NM_017869.3 [Q8N9N5-2]
NP_524576.2, NM_079837.2 [Q8N9N5-4]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.461705

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286122; ENSP00000286122; ENSG00000172530 [Q8N9N5-1]
ENST00000355022; ENSP00000347125; ENSG00000172530 [Q8N9N5-2]
ENST00000393207; ENSP00000376902; ENSG00000172530 [Q8N9N5-1]
ENST00000393208; ENSP00000376903; ENSG00000172530 [Q8N9N5-4]
ENST00000479780; ENSP00000432508; ENSG00000172530 [Q8N9N5-6]
ENST00000538234; ENSP00000444352; ENSG00000172530 [Q8N9N5-7]
ENST00000626016; ENSP00000487304; ENSG00000172530 [Q8N9N5-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54971

UCSC genome browser

More...UCSCi		uc002fkp.4 human [Q8N9N5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000545 mRNA Translation: BAA91244.1
AK094158 mRNA Translation: BAC04296.1 Different initiation.
AK125232 mRNA Translation: BAG54171.1
AK297945 mRNA Translation: BAG60261.1
AK315089 mRNA Translation: BAG37554.1
AK315535 mRNA No translation available.
AC127455 Genomic DNA No translation available.
AC134312 Genomic DNA No translation available.
BC009424 mRNA Translation: AAH09424.1
CCDSiCCDS10966.2 [Q8N9N5-4]
CCDS42215.1 [Q8N9N5-2]
CCDS54052.1 [Q8N9N5-7]
CCDS54053.1 [Q8N9N5-6]
CCDS54054.1 [Q8N9N5-1]
CCDS54055.1 [Q8N9N5-5]
RefSeqiNP_001167010.1, NM_001173539.1
NP_001167011.1, NM_001173540.1 [Q8N9N5-5]
NP_001167012.1, NM_001173541.1 [Q8N9N5-6]
NP_001167013.1, NM_001173542.1 [Q8N9N5-7]
NP_001167014.1, NM_001173543.1 [Q8N9N5-1]
NP_060339.2, NM_017869.3 [Q8N9N5-2]
NP_524576.2, NM_079837.2 [Q8N9N5-4]
UniGeneiHs.461705

3D structure databases

ProteinModelPortaliQ8N9N5
SMRiQ8N9N5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120308, 133 interactors
CORUMiQ8N9N5
IntActiQ8N9N5, 197 interactors
MINTiQ8N9N5
STRINGi9606.ENSP00000286122

PTM databases

iPTMnetiQ8N9N5
PhosphoSitePlusiQ8N9N5

Polymorphism and mutation databases

BioMutaiBANP
DMDMi308153628

Proteomic databases

EPDiQ8N9N5
jPOSTiQ8N9N5
MaxQBiQ8N9N5
PaxDbiQ8N9N5
PeptideAtlasiQ8N9N5
PRIDEiQ8N9N5
ProteomicsDBi72563
72564 [Q8N9N5-2]
72565 [Q8N9N5-3]
72566 [Q8N9N5-4]
72567 [Q8N9N5-5]
72568 [Q8N9N5-6]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		54971
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286122; ENSP00000286122; ENSG00000172530 [Q8N9N5-1]
ENST00000355022; ENSP00000347125; ENSG00000172530 [Q8N9N5-2]
ENST00000393207; ENSP00000376902; ENSG00000172530 [Q8N9N5-1]
ENST00000393208; ENSP00000376903; ENSG00000172530 [Q8N9N5-4]
ENST00000479780; ENSP00000432508; ENSG00000172530 [Q8N9N5-6]
ENST00000538234; ENSP00000444352; ENSG00000172530 [Q8N9N5-7]
ENST00000626016; ENSP00000487304; ENSG00000172530 [Q8N9N5-5]
GeneIDi54971
KEGGihsa:54971
UCSCiuc002fkp.4 human [Q8N9N5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54971
DisGeNETi54971
EuPathDBiHostDB:ENSG00000172530.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		BANP
HGNCiHGNC:13450 BANP
HPAiHPA047164
MIMi611564 gene
neXtProtiNX_Q8N9N5
OpenTargetsiENSG00000172530
PharmGKBiPA134933411

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IGMM Eukaryota
ENOG410Z2PJ LUCA
GeneTreeiENSGT00390000011116
HOGENOMiHOG000015355
HOVERGENiHBG107493
InParanoidiQ8N9N5
OMAiVQIHRIG
OrthoDBi1401911at2759
PhylomeDBiQ8N9N5
TreeFamiTF331908

Enzyme and pathway databases

ReactomeiR-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BANP human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BANP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54971

Protein Ontology

More...PROi		PR:Q8N9N5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172530 Expressed in 218 organ(s), highest expression level in oocyte
CleanExiHS_BANP
ExpressionAtlasiQ8N9N5 baseline and differential
GenevisibleiQ8N9N5 HS

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBANP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9N5
Secondary accession number(s): A8MU25
, A8MX25, B2RCF7, B4DNJ9, F5GZM0, Q96GJ7, Q9NWY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: January 16, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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