UniProtKB - Q8N9N5 (BANP_HUMAN)
Protein
Protein BANP
Gene
BANP
Organism
Homo sapiens (Human)
Status
Functioni
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).By similarity1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- negative regulation of protein catabolic process Source: GO_Central
- positive regulation of transcription, DNA-templated Source: Ensembl
- protein localization to nucleus Source: GO_Central
- regulation of signal transduction by p53 class mediator Source: Reactome
Keywordsi
Molecular function | Chromatin regulator, Developmental protein, DNA-binding, Repressor |
Biological process | Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8N9N5 |
Reactomei | R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BANPAlternative name(s): BEN domain-containing protein 1 Btg3-associated nuclear protein Scaffold/matrix-associated region-1-binding protein |
Gene namesi | Name:BANP Synonyms:BEND1, SMAR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172530.19 |
HGNCi | HGNC:13450, BANP |
MIMi | 611564, gene |
neXtProti | NX_Q8N9N5 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 54971 |
OpenTargetsi | ENSG00000172530 |
PharmGKBi | PA134933411 |
Miscellaneous databases
Pharosi | Q8N9N5, Tbio |
Polymorphism and mutation databases
BioMutai | BANP |
DMDMi | 308153628 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297910 | 1 – 519 | Protein BANPAdd BLAST | 519 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 100 | PhosphoserineCombined sources | 1 | |
Cross-linki | 133 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 275 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N9N5 |
jPOSTi | Q8N9N5 |
MassIVEi | Q8N9N5 |
MaxQBi | Q8N9N5 |
PaxDbi | Q8N9N5 |
PeptideAtlasi | Q8N9N5 |
PRIDEi | Q8N9N5 |
ProteomicsDBi | 25071 72563 [Q8N9N5-1] 72564 [Q8N9N5-2] 72565 [Q8N9N5-3] 72566 [Q8N9N5-4] 72567 [Q8N9N5-5] 72568 [Q8N9N5-6] |
PTM databases
iPTMneti | Q8N9N5 |
PhosphoSitePlusi | Q8N9N5 |
Expressioni
Tissue specificityi
Down-regulated in breast cancer cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000172530, Expressed in oocyte and 231 other tissues |
ExpressionAtlasi | Q8N9N5, baseline and differential |
Genevisiblei | Q8N9N5, HS |
Organism-specific databases
HPAi | ENSG00000172530, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with TP53 and CUX1/CDP (By similarity).
Interacts with HDAC1.
Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
By similarity1 PublicationBinary interactionsi
Q8N9N5
BANP - isoform 2 [Q8N9N5-2]
BANP - isoform 7 [Q8N9N5-7]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 120308, 246 interactors |
CORUMi | Q8N9N5 |
IntActi | Q8N9N5, 209 interactors |
MINTi | Q8N9N5 |
STRINGi | 9606.ENSP00000376902 |
Miscellaneous databases
RNActi | Q8N9N5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 226 – 322 | BENPROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 152 – 342 | Interaction with CUX1 and HDAC1By similarityAdd BLAST | 191 | |
Regioni | 320 – 349 | Necessary and sufficient for TP53 activationBy similarityAdd BLAST | 30 | |
Regioni | 342 – 393 | DNA-bindingBy similarityAdd BLAST | 52 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 53 – 90 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 361 – 426 | Gln-richAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the BANP/SMAR1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRIF, Eukaryota |
GeneTreei | ENSGT00390000011116 |
HOGENOMi | CLU_037322_0_0_1 |
InParanoidi | Q8N9N5 |
OMAi | EVVQIQM |
OrthoDBi | 1401911at2759 |
PhylomeDBi | Q8N9N5 |
TreeFami | TF331908 |
Family and domain databases
InterProi | View protein in InterPro IPR042343, BANP IPR018379, BEN_domain |
PANTHERi | PTHR16243, PTHR16243, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N9N5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD
60 70 80 90 100
PSIKTICLRL DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS
110 120 130 140 150
PLGATQTCNK VRCVVPQTTV ILNNDRQNAI VAKMEDPLSN RAPDSLENVI
160 170 180 190 200
SNAVPGRRQN TIVVKVPGQE DSHHEDGESG SEASDSVSSC GQAGSQSIGS
210 220 230 240 250
NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH ISTNCRTAEK
260 270 280 290 300
MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT
310 320 330 340 350
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM
360 370 380 390 400
STPPPASELP QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV
410 420 430 440 450
PQGEQVQITQ DSEGNLQIHH VGQDGQLLEA TRIPCLLAPS VFKASSGQVL
460 470 480 490 500
QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV QYVQLAPVSD HTAGAQTAEA
510
LQPTLQPEMQ LEHGAIQIQ
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J811 | C9J811_HUMAN | Protein BANP | BANP | 194 | Annotation score: | ||
E9PJI6 | E9PJI6_HUMAN | BTG3 associated nuclear protein iso... | BANP | 128 | Annotation score: | ||
C9JF73 | C9JF73_HUMAN | Protein BANP | BANP | 119 | Annotation score: | ||
C9JTM8 | C9JTM8_HUMAN | Protein BANP | BANP | 123 | Annotation score: | ||
C9JYB6 | C9JYB6_HUMAN | Protein BANP | BANP | 95 | Annotation score: | ||
C9JGM9 | C9JGM9_HUMAN | Protein BANP | BANP | 118 | Annotation score: | ||
C9JLS0 | C9JLS0_HUMAN | Protein BANP | BANP | 56 | Annotation score: | ||
C9JLT2 | C9JLT2_HUMAN | Protein BANP | BANP | 28 | Annotation score: | ||
E9PIP2 | E9PIP2_HUMAN | BTG3 associated nuclear protein iso... | BANP | 40 | Annotation score: |
Sequence cautioni
The sequence BAC04296 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 123 | N → S in AK315535 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 338 | P → S in BAA91244 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027396 | 1 – 24 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_043558 | 24 | V → GTELWDI in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_027398 | 25 – 36 | VLENH…TDEDE → MTREFVKRSIFL in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_027399 | 54 | K → KSFLYSINQ in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_027400 | 114 – 152 | Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 39 | |
Alternative sequenceiVSP_027401 | 392 | V → VIPQ in isoform 2, isoform 4, isoform 5 and isoform 7. 2 Publications | 1 | |
Alternative sequenceiVSP_027402 | 425 – 446 | Missing in isoform 2, isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000545 mRNA Translation: BAA91244.1 AK094158 mRNA Translation: BAC04296.1 Different initiation. AK125232 mRNA Translation: BAG54171.1 AK297945 mRNA Translation: BAG60261.1 AK315089 mRNA Translation: BAG37554.1 AK315535 mRNA No translation available. AC127455 Genomic DNA No translation available. AC134312 Genomic DNA No translation available. BC009424 mRNA Translation: AAH09424.1 |
CCDSi | CCDS10966.2 [Q8N9N5-4] CCDS42215.1 [Q8N9N5-2] CCDS54052.1 [Q8N9N5-7] CCDS54053.1 [Q8N9N5-6] CCDS54054.1 [Q8N9N5-1] CCDS54055.1 [Q8N9N5-5] |
RefSeqi | NP_001167010.1, NM_001173539.1 NP_001167011.1, NM_001173540.1 [Q8N9N5-5] NP_001167012.1, NM_001173541.1 [Q8N9N5-6] NP_001167013.1, NM_001173542.1 [Q8N9N5-7] NP_001167014.1, NM_001173543.1 [Q8N9N5-1] NP_060339.2, NM_017869.3 [Q8N9N5-2] NP_524576.2, NM_079837.2 [Q8N9N5-4] |
Genome annotation databases
Ensembli | ENST00000286122; ENSP00000286122; ENSG00000172530 [Q8N9N5-1] ENST00000355022; ENSP00000347125; ENSG00000172530 [Q8N9N5-2] ENST00000393207; ENSP00000376902; ENSG00000172530 [Q8N9N5-1] ENST00000393208; ENSP00000376903; ENSG00000172530 [Q8N9N5-4] ENST00000479780; ENSP00000432508; ENSG00000172530 [Q8N9N5-6] ENST00000538234; ENSP00000444352; ENSG00000172530 [Q8N9N5-7] ENST00000626016; ENSP00000487304; ENSG00000172530 [Q8N9N5-5] |
GeneIDi | 54971 |
KEGGi | hsa:54971 |
UCSCi | uc002fkp.4, human [Q8N9N5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000545 mRNA Translation: BAA91244.1 AK094158 mRNA Translation: BAC04296.1 Different initiation. AK125232 mRNA Translation: BAG54171.1 AK297945 mRNA Translation: BAG60261.1 AK315089 mRNA Translation: BAG37554.1 AK315535 mRNA No translation available. AC127455 Genomic DNA No translation available. AC134312 Genomic DNA No translation available. BC009424 mRNA Translation: AAH09424.1 |
CCDSi | CCDS10966.2 [Q8N9N5-4] CCDS42215.1 [Q8N9N5-2] CCDS54052.1 [Q8N9N5-7] CCDS54053.1 [Q8N9N5-6] CCDS54054.1 [Q8N9N5-1] CCDS54055.1 [Q8N9N5-5] |
RefSeqi | NP_001167010.1, NM_001173539.1 NP_001167011.1, NM_001173540.1 [Q8N9N5-5] NP_001167012.1, NM_001173541.1 [Q8N9N5-6] NP_001167013.1, NM_001173542.1 [Q8N9N5-7] NP_001167014.1, NM_001173543.1 [Q8N9N5-1] NP_060339.2, NM_017869.3 [Q8N9N5-2] NP_524576.2, NM_079837.2 [Q8N9N5-4] |
3D structure databases
SMRi | Q8N9N5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120308, 246 interactors |
CORUMi | Q8N9N5 |
IntActi | Q8N9N5, 209 interactors |
MINTi | Q8N9N5 |
STRINGi | 9606.ENSP00000376902 |
PTM databases
iPTMneti | Q8N9N5 |
PhosphoSitePlusi | Q8N9N5 |
Polymorphism and mutation databases
BioMutai | BANP |
DMDMi | 308153628 |
Proteomic databases
EPDi | Q8N9N5 |
jPOSTi | Q8N9N5 |
MassIVEi | Q8N9N5 |
MaxQBi | Q8N9N5 |
PaxDbi | Q8N9N5 |
PeptideAtlasi | Q8N9N5 |
PRIDEi | Q8N9N5 |
ProteomicsDBi | 25071 72563 [Q8N9N5-1] 72564 [Q8N9N5-2] 72565 [Q8N9N5-3] 72566 [Q8N9N5-4] 72567 [Q8N9N5-5] 72568 [Q8N9N5-6] |
Protocols and materials databases
Antibodypediai | 30702, 130 antibodies |
DNASUi | 54971 |
Genome annotation databases
Organism-specific databases
CTDi | 54971 |
DisGeNETi | 54971 |
EuPathDBi | HostDB:ENSG00000172530.19 |
GeneCardsi | BANP |
HGNCi | HGNC:13450, BANP |
HPAi | ENSG00000172530, Low tissue specificity |
MIMi | 611564, gene |
neXtProti | NX_Q8N9N5 |
OpenTargetsi | ENSG00000172530 |
PharmGKBi | PA134933411 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRIF, Eukaryota |
GeneTreei | ENSGT00390000011116 |
HOGENOMi | CLU_037322_0_0_1 |
InParanoidi | Q8N9N5 |
OMAi | EVVQIQM |
OrthoDBi | 1401911at2759 |
PhylomeDBi | Q8N9N5 |
TreeFami | TF331908 |
Enzyme and pathway databases
PathwayCommonsi | Q8N9N5 |
Reactomei | R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors |
Miscellaneous databases
BioGRID-ORCSi | 54971, 595 hits in 846 CRISPR screens |
ChiTaRSi | BANP, human |
GeneWikii | BANP |
GenomeRNAii | 54971 |
Pharosi | Q8N9N5, Tbio |
PROi | PR:Q8N9N5 |
RNActi | Q8N9N5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172530, Expressed in oocyte and 231 other tissues |
ExpressionAtlasi | Q8N9N5, baseline and differential |
Genevisiblei | Q8N9N5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR042343, BANP IPR018379, BEN_domain |
PANTHERi | PTHR16243, PTHR16243, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BANP_HUMAN | |
Accessioni | Q8N9N5Primary (citable) accession number: Q8N9N5 Secondary accession number(s): A8MU25 Q9NWY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM