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UniProtKB - Q8N9N5 (BANP_HUMAN)

Protein

Protein BANP

Gene

BANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).By similarity1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • p53 binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BANP
Alternative name(s):
BEN domain-containing protein 1
Btg3-associated nuclear protein
Scaffold/matrix-associated region-1-binding protein
Gene namesi
Name:BANP
Synonyms:BEND1, SMAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000172530.19
HGNCiHGNC:13450 BANP
MIMi611564 gene
neXtProtiNX_Q8N9N5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi54971
OpenTargetsiENSG00000172530
PharmGKBiPA134933411

Polymorphism and mutation databases

BioMutaiBANP
DMDMi308153628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979101 – 519Protein BANPAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N9N5
MaxQBiQ8N9N5
PaxDbiQ8N9N5
PeptideAtlasiQ8N9N5
PRIDEiQ8N9N5
ProteomicsDBi72563
72564 [Q8N9N5-2]
72565 [Q8N9N5-3]
72566 [Q8N9N5-4]
72567 [Q8N9N5-5]
72568 [Q8N9N5-6]

PTM databases

iPTMnetiQ8N9N5
PhosphoSitePlusiQ8N9N5

Expressioni

Tissue specificityi

Down-regulated in breast cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000172530 Expressed in 218 organ(s), highest expression level in oocyte
CleanExiHS_BANP
ExpressionAtlasiQ8N9N5 baseline and differential
GenevisibleiQ8N9N5 HS

Organism-specific databases

HPAiHPA047164

Interactioni

Subunit structurei

Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAM15Q134443EBI-744695,EBI-77818
AFG1LQ8WV933EBI-744695,EBI-2865743
ALAS2P225573EBI-744695,EBI-2115743
ALAS2P22557-25EBI-11524452,EBI-12257000
BAG5Q9UL153EBI-744695,EBI-356517
BANPA0A0S2Z5G43EBI-11524452,EBI-16429704
BANPB4DE544EBI-11524452,EBI-16429313
BANPE9PJI63EBI-11524452,EBI-16437731
BLZF1Q9H2G93EBI-11524452,EBI-2548012
C1orf94Q6P1W53EBI-11524452,EBI-946029
C22orf39Q6P5X53EBI-744695,EBI-7317823
CAMK2DQ135573EBI-744695,EBI-351018
CCDC26Q8TAB73EBI-744695,EBI-10271580
CDKN1BP465273EBI-11524452,EBI-519280
CDX4O146273EBI-16429296,EBI-10181162
CEP76Q8TAP63EBI-16429296,EBI-742887
CFAP206Q8IYR03EBI-744695,EBI-749051
COL10A1Q036924EBI-11524452,EBI-2528309
CRXO431865EBI-11524452,EBI-748171
DCDC2BA2VCK23EBI-744695,EBI-10173222
DLX3O604793EBI-11524452,EBI-3908248
DNAJA4Q8WW22-23EBI-744695,EBI-10277181
EPHA10Q5JZY3-33EBI-744695,EBI-10244652
FAM117BQ6P1L53EBI-744695,EBI-3893327
FAM71CQ8NEG03EBI-744695,EBI-752049
FAM90A1Q86YD73EBI-744695,EBI-6658203
FHL2Q141925EBI-11524452,EBI-701903
FHL5Q5TD973EBI-16429296,EBI-750641
FOXM1Q080503EBI-11524452,EBI-866480
FOXM1Q08050-23EBI-11524452,EBI-5237510
FOXR1Q6PIV23EBI-744695,EBI-10253815
GFM2Q969S93EBI-744695,EBI-2371750
HSFY2Q96LI63EBI-16429296,EBI-3957665
ISCUQ9H1K13EBI-744695,EBI-1047335
L3MBTL3Q96JM73EBI-744695,EBI-2686809
LENG1Q96BZ83EBI-744695,EBI-726510
LGALS14Q8TCE93EBI-744695,EBI-10274069
LMO2P257913EBI-744695,EBI-739696
LMO3Q8TAP43EBI-744695,EBI-742259
LMO4P619683EBI-744695,EBI-2798728
LSM2Q9Y3333EBI-744695,EBI-347416
MAP2K1Q027503EBI-744695,EBI-492564
MAXP612443EBI-744695,EBI-751711
MDFIQ997505EBI-11524452,EBI-724076
MEOX1P502213EBI-16429296,EBI-2864512
MEOX2Q6FHY53EBI-11524452,EBI-16439278
MGC4677Q53S703EBI-744695,EBI-10242717
MRPL28Q130843EBI-744695,EBI-723426
NEDD9Q145114EBI-744695,EBI-2108053
NMNAT1Q9HAN96EBI-11524452,EBI-3917542
NRIP2Q9BQI93EBI-744695,EBI-3913975
PHF21AQ96BD53EBI-744695,EBI-745085
PHF21BA0A0S2Z6153EBI-11524452,EBI-16434035
PHF21BQ96EK2-33EBI-11524452,EBI-16437793
PID1Q7Z2X43EBI-744695,EBI-10256685
PIM1P113093EBI-744695,EBI-696621
POGZQ7Z3K37EBI-11524452,EBI-1389308
POLDIP3Q8WUT13EBI-744695,EBI-10276663
POLR2LP628753EBI-744695,EBI-359527
PPIBP232843EBI-744695,EBI-359252
PPICP458773EBI-744695,EBI-953909
PPIFP304053EBI-744695,EBI-5544229
PRKAB2O437413EBI-744695,EBI-1053424
PRKCHQ9BVQ03EBI-744695,EBI-10299920
PRR20EP864783EBI-16429296,EBI-12700196
PSMD9O002333EBI-744695,EBI-750973
RAB3IPQ96QF03EBI-744695,EBI-747844
RAB3IPQ96QF0-75EBI-11524452,EBI-11984839
RBM39Q14498-33EBI-744695,EBI-6654703
RBPMSQ930623EBI-744695,EBI-740322
RELQ04864-25EBI-11524452,EBI-10829018
SH3RF2Q08AM83EBI-744695,EBI-10225873
SH3RF2Q8TEC53EBI-744695,EBI-2130111
SLC16A3O154273EBI-744695,EBI-7600166
SNRPBP14678-23EBI-744695,EBI-372475
SP2Q020864EBI-744695,EBI-8651703
SP4Q024463EBI-11524452,EBI-10198587
SPACA6W5XKT83EBI-744695,EBI-10176265
tmp_locus_54Q53NU33EBI-744695,EBI-10242677
TNXBP221054EBI-744695,EBI-2821024
TOX4O948425EBI-11524452,EBI-948613
TP53P046373EBI-744695,EBI-366083
TRAF2Q129334EBI-744695,EBI-355744
TRAF4Q9BUZ47EBI-11524452,EBI-3650647
TROAPQ128153EBI-744695,EBI-2349743
XAGE1EQ9HD643EBI-744695,EBI-2340004
ZC2HC1CQ53FD03EBI-744695,EBI-740767
ZMIZ2Q8NF643EBI-16429296,EBI-745786
ZMIZ2Q8NF64-23EBI-744695,EBI-10182121
ZNF488Q96MN93EBI-744695,EBI-948288
ZNF581Q9P0T43EBI-744695,EBI-745520

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120308, 133 interactors
CORUMiQ8N9N5
IntActiQ8N9N5, 197 interactors
MINTiQ8N9N5
STRINGi9606.ENSP00000286122

Structurei

3D structure databases

ProteinModelPortaliQ8N9N5
SMRiQ8N9N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 322BENPROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 342Interaction with CUX1 and HDAC1By similarityAdd BLAST191
Regioni320 – 349Necessary and sufficient for TP53 activationBy similarityAdd BLAST30
Regioni342 – 393DNA-bindingBy similarityAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 90Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi361 – 426Gln-richAdd BLAST66

Sequence similaritiesi

Belongs to the BANP/SMAR1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGMM Eukaryota
ENOG410Z2PJ LUCA
GeneTreeiENSGT00390000011116
HOGENOMiHOG000015355
HOVERGENiHBG107493
InParanoidiQ8N9N5
OMAiIISNAVP
OrthoDBiEOG091G0JD3
PhylomeDBiQ8N9N5
TreeFamiTF331908

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N9N5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSEHDLADV VQIAVEDLSP DHPVVLENHV VTDEDEPALK RQRLEINCQD 
        60         70         80         90        100
PSIKTICLRL DSIEAKLQAL EATCKSLEEK LDLVTNKQHS PIQVPMVAGS 
       110        120        130        140        150
PLGATQTCNK VRCVVPQTTV ILNNDRQNAI VAKMEDPLSN RAPDSLENVI 
       160        170        180        190        200
SNAVPGRRQN TIVVKVPGQE DSHHEDGESG SEASDSVSSC GQAGSQSIGS 
       210        220        230        240        250
NVTLITLNSE EDYPNGTWLG DENNPEMRVR CAIIPSDMLH ISTNCRTAEK 
       260        270        280        290        300
MALTLLDYLF HREVQAVSNL SGQGKHGKKQ LDPLTIYGIR CHLFYKFGIT 
       310        320        330        340        350
ESDWYRIKQS IDSKCRTAWR RKQRGQSLAV KSFSRRTPNS SSYCPSEPMM 
       360        370        380        390        400
STPPPASELP QPQPQPQALH YALANAQQVQ IHQIGEDGQV QVGHLHIAQV 
       410        420        430        440        450
PQGEQVQITQ DSEGNLQIHH VGQDGQLLEA TRIPCLLAPS VFKASSGQVL 
       460        470        480        490        500
QGAQLIAVAS SDPAAAGVDG SPLQGSDIQV QYVQLAPVSD HTAGAQTAEA 
       510 
LQPTLQPEMQ LEHGAIQIQ
Length:519
Mass (Da):56,494
Last modified:October 5, 2010 - v3
Checksum:i521C53F367A3A29E
GO
Isoform 2 (identifier: Q8N9N5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ
     425-446: Missing.

Show »
Length:469
Mass (Da):51,243
Checksum:i9E4B4A8C287A4A34
GO
Isoform 3 (identifier: Q8N9N5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     25-36: VLENHVVTDEDE → MTREFVKRSIFL
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,404
Checksum:i4C86E6B4AFD4B689
GO
Isoform 4 (identifier: Q8N9N5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Show »
Length:491
Mass (Da):53,527
Checksum:iBA171D3BA87F731B
GO
Isoform 5 (identifier: Q8N9N5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: V → GTELWDI
     54-54: K → KSFLYSINQ
     114-152: Missing.
     392-392: V → VIPQ

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):54,243
Checksum:i377684337AFFEF27
GO
Isoform 6 (identifier: Q8N9N5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     114-152: Missing.
     425-446: Missing.

Show »
Length:466
Mass (Da):50,905
Checksum:i4704286351630810
GO
Isoform 7 (identifier: Q8N9N5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: K → KSFLYSINQ
     392-392: V → VIPQ
     425-446: Missing.

Note: No experimental confirmation available.
Show »
Length:508
Mass (Da):55,502
Checksum:i80ACD475B6F32D74
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJI6E9PJI6_HUMAN
BTG3 associated nuclear protein iso...
BANP
128Annotation score:
C9JF73C9JF73_HUMAN
Protein BANP
BANP
119Annotation score:
C9JGM9C9JGM9_HUMAN
Protein BANP
BANP
118Annotation score:
C9JYB6C9JYB6_HUMAN
Protein BANP
BANP
95Annotation score:
C9JTM8C9JTM8_HUMAN
Protein BANP
BANP
123Annotation score:
C9J811C9J811_HUMAN
Protein BANP
BANP
194Annotation score:
E9PIP2E9PIP2_HUMAN
BTG3 associated nuclear protein iso...
BANP
40Annotation score:
C9JLS0C9JLS0_HUMAN
Protein BANP
BANP
56Annotation score:
C9JLT2C9JLT2_HUMAN
Protein BANP
BANP
28Annotation score:

Sequence cautioni

The sequence BAC04296 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123N → S in AK315535 (PubMed:14702039).Curated1
Sequence conflicti338P → S in BAA91244 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273961 – 24Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_04355824V → GTELWDI in isoform 5. 1 Publication1
Alternative sequenceiVSP_02739825 – 36VLENH…TDEDE → MTREFVKRSIFL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02739954K → KSFLYSINQ in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027400114 – 152Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_027401392V → VIPQ in isoform 2, isoform 4, isoform 5 and isoform 7. 2 Publications1
Alternative sequenceiVSP_027402425 – 446Missing in isoform 2, isoform 3, isoform 6 and isoform 7. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000545 mRNA Translation: BAA91244.1
AK094158 mRNA Translation: BAC04296.1 Different initiation.
AK125232 mRNA Translation: BAG54171.1
AK297945 mRNA Translation: BAG60261.1
AK315089 mRNA Translation: BAG37554.1
AK315535 mRNA No translation available.
AC127455 Genomic DNA No translation available.
AC134312 Genomic DNA No translation available.
BC009424 mRNA Translation: AAH09424.1
CCDSiCCDS10966.2 [Q8N9N5-4]
CCDS42215.1 [Q8N9N5-2]
CCDS54052.1 [Q8N9N5-7]
CCDS54053.1 [Q8N9N5-6]
CCDS54054.1 [Q8N9N5-1]
CCDS54055.1 [Q8N9N5-5]
RefSeqiNP_001167010.1, NM_001173539.1
NP_001167011.1, NM_001173540.1 [Q8N9N5-5]
NP_001167012.1, NM_001173541.1 [Q8N9N5-6]
NP_001167013.1, NM_001173542.1 [Q8N9N5-7]
NP_001167014.1, NM_001173543.1 [Q8N9N5-1]
NP_060339.2, NM_017869.3 [Q8N9N5-2]
NP_524576.2, NM_079837.2 [Q8N9N5-4]
UniGeneiHs.461705

Genome annotation databases

EnsembliENST00000286122; ENSP00000286122; ENSG00000172530 [Q8N9N5-1]
ENST00000355022; ENSP00000347125; ENSG00000172530 [Q8N9N5-2]
ENST00000393207; ENSP00000376902; ENSG00000172530 [Q8N9N5-1]
ENST00000393208; ENSP00000376903; ENSG00000172530 [Q8N9N5-4]
ENST00000479780; ENSP00000432508; ENSG00000172530 [Q8N9N5-6]
ENST00000538234; ENSP00000444352; ENSG00000172530 [Q8N9N5-7]
ENST00000626016; ENSP00000487304; ENSG00000172530 [Q8N9N5-5]
GeneIDi54971
KEGGihsa:54971
UCSCiuc002fkp.4 human [Q8N9N5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBANP_HUMAN
AccessioniPrimary (citable) accession number: Q8N9N5
Secondary accession number(s): A8MU25
, A8MX25, B2RCF7, B4DNJ9, F5GZM0, Q96GJ7, Q9NWY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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