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Protein

Transmembrane protein 102

Gene

TMEM102

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.1 Publication

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 102
Alternative name(s):
Common beta-chain associated protein
Short name:
CBAP
Gene namesi
Name:TMEM102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181284.2
HGNCiHGNC:26722 TMEM102
MIMi613936 gene
neXtProtiNX_Q8N9M5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 260ExtracellularSequence analysisAdd BLAST260
Transmembranei261 – 278HelicalSequence analysisAdd BLAST18
Topological domaini279 – 508CytoplasmicSequence analysisAdd BLAST230

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181284
PharmGKBiPA142670751

Polymorphism and mutation databases

BioMutaiTMEM102
DMDMi74729725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636481 – 508Transmembrane protein 102Add BLAST508

Proteomic databases

EPDiQ8N9M5
MaxQBiQ8N9M5
PaxDbiQ8N9M5
PeptideAtlasiQ8N9M5
PRIDEiQ8N9M5
ProteomicsDBi72560

PTM databases

iPTMnetiQ8N9M5
PhosphoSitePlusiQ8N9M5

Expressioni

Gene expression databases

BgeeiENSG00000181284 Expressed in 90 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TMEM102
GenevisibleiQ8N9M5 HS

Organism-specific databases

HPAiHPA024433

Interactioni

Subunit structurei

Interacts with CSF2RB; this interaction occurs preferentially in the absence of CSF2.1 Publication

Protein-protein interaction databases

BioGridi129765, 15 interactors
IntActiQ8N9M5, 2 interactors
MINTiQ8N9M5

Structurei

3D structure databases

ProteinModelPortaliQ8N9M5
SMRiQ8N9M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3963 Eukaryota
ENOG410XNRJ LUCA
GeneTreeiENSGT00530000063769
HOGENOMiHOG000154601
HOVERGENiHBG094048
InParanoidiQ8N9M5
OMAiSHSWAGP
OrthoDBiEOG091G06D0
PhylomeDBiQ8N9M5
TreeFamiTF329089

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
IPR024806 TMEM102
PANTHERiPTHR10656:SF48 PTHR10656:SF48, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N9M5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAVWGSAP WWGPPPPAPA RPLTDIDFCS GAQLQELTQL IQELGVQESW
60 70 80 90 100
SDGPKPGADL LRAKDFVFSL LGLVHRRDPR FPPQAELLLL RGGIREGSLD
110 120 130 140 150
LGHAPLGPYA RGPHYDAGFT LLVPMFSLDG TELQLDLESC YAQVCLPEMV
160 170 180 190 200
CGTPIREMWQ DCLGPPVPGA RDSIHRTESE ESSKDWQSSV DQPHSYVTEH
210 220 230 240 250
EAPVSLEKSP SDVSASESPQ HDVVDLGSTA PLKTMSSDVT KAAVESPVPK
260 270 280 290 300
PSEAREAWPT LCSAQVAAWF FATLAAVAES LIPVPGAPRL VHAARHAGFT
310 320 330 340 350
TVLLATPEPP RRLLLFDLIP VVSVAGWPEG ARSHSWAGPL ASESASFYLV
360 370 380 390 400
PGGGTERPCA SAWQLCFARQ ELALKARIPA PLLQAHAAAQ ALLRPLVAGT
410 420 430 440 450
RAAAPYLLRT LLYWACERLP ALYLARPENA GACCLGLLDE LGRVLEAGTL
460 470 480 490 500
PHYFLNGRQL RTGDDSAALL GELARLRGDP ARALRAAVEE AKVARKGGGL

AGVGGGAH
Length:508
Mass (Da):54,175
Last modified:October 1, 2002 - v1
Checksum:i27B3FDC1C30E3406
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029595110A → V. Corresponds to variant dbSNP:rs3809718Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094197 mRNA Translation: BAC04306.1
CH471108 Genomic DNA Translation: EAW90189.1
CH471108 Genomic DNA Translation: EAW90190.1
BC046189 mRNA Translation: AAH46189.1
CCDSiCCDS11104.1
RefSeqiNP_001307373.1, NM_001320444.1
NP_848613.1, NM_178518.2
UniGeneiHs.655662

Genome annotation databases

EnsembliENST00000323206; ENSP00000315387; ENSG00000181284
ENST00000396568; ENSP00000379815; ENSG00000181284
ENST00000638427; ENSP00000491063; ENSG00000284228
ENST00000639387; ENSP00000491290; ENSG00000284228
GeneIDi284114
KEGGihsa:284114
UCSCiuc002ggx.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094197 mRNA Translation: BAC04306.1
CH471108 Genomic DNA Translation: EAW90189.1
CH471108 Genomic DNA Translation: EAW90190.1
BC046189 mRNA Translation: AAH46189.1
CCDSiCCDS11104.1
RefSeqiNP_001307373.1, NM_001320444.1
NP_848613.1, NM_178518.2
UniGeneiHs.655662

3D structure databases

ProteinModelPortaliQ8N9M5
SMRiQ8N9M5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129765, 15 interactors
IntActiQ8N9M5, 2 interactors
MINTiQ8N9M5

PTM databases

iPTMnetiQ8N9M5
PhosphoSitePlusiQ8N9M5

Polymorphism and mutation databases

BioMutaiTMEM102
DMDMi74729725

Proteomic databases

EPDiQ8N9M5
MaxQBiQ8N9M5
PaxDbiQ8N9M5
PeptideAtlasiQ8N9M5
PRIDEiQ8N9M5
ProteomicsDBi72560

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323206; ENSP00000315387; ENSG00000181284
ENST00000396568; ENSP00000379815; ENSG00000181284
ENST00000638427; ENSP00000491063; ENSG00000284228
ENST00000639387; ENSP00000491290; ENSG00000284228
GeneIDi284114
KEGGihsa:284114
UCSCiuc002ggx.1 human

Organism-specific databases

CTDi284114
EuPathDBiHostDB:ENSG00000181284.2
GeneCardsiTMEM102
HGNCiHGNC:26722 TMEM102
HPAiHPA024433
MIMi613936 gene
neXtProtiNX_Q8N9M5
OpenTargetsiENSG00000181284
PharmGKBiPA142670751
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3963 Eukaryota
ENOG410XNRJ LUCA
GeneTreeiENSGT00530000063769
HOGENOMiHOG000154601
HOVERGENiHBG094048
InParanoidiQ8N9M5
OMAiSHSWAGP
OrthoDBiEOG091G06D0
PhylomeDBiQ8N9M5
TreeFamiTF329089

Miscellaneous databases

GenomeRNAii284114
PROiPR:Q8N9M5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181284 Expressed in 90 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_TMEM102
GenevisibleiQ8N9M5 HS

Family and domain databases

InterProiView protein in InterPro
IPR024810 Mab-21_dom
IPR024806 TMEM102
PANTHERiPTHR10656:SF48 PTHR10656:SF48, 1 hit
PfamiView protein in Pfam
PF03281 Mab-21, 1 hit
SMARTiView protein in SMART
SM01265 Mab-21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM102_HUMAN
AccessioniPrimary (citable) accession number: Q8N9M5
Secondary accession number(s): D3DTP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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