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Entry version 161 (17 Jun 2020)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Zinc finger protein 135

Gene

ZNF135

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 135Imported
Submitted name:
Zinc finger protein 135 (Clone pHZ-17), isoform CRA_aImported
Submitted name:
cDNA FLJ36883 fis, clone BLADE2000389, highly similar to ZINC FINGER PROTEIN 135Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF135Imported
ORF Names:hCG_2039973Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000176293.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12919 ZNF135

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000176293

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72559

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176293 Expressed in corpus callosum and 130 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 43KRABInterPro annotationAdd BLAST43
Domaini172 – 199C2H2-typeInterPro annotationAdd BLAST28
Domaini200 – 227C2H2-typeInterPro annotationAdd BLAST28
Domaini228 – 255C2H2-typeInterPro annotationAdd BLAST28
Domaini256 – 283C2H2-typeInterPro annotationAdd BLAST28
Domaini284 – 311C2H2-typeInterPro annotationAdd BLAST28
Domaini312 – 339C2H2-typeInterPro annotationAdd BLAST28
Domaini340 – 367C2H2-typeInterPro annotationAdd BLAST28
Domaini368 – 395C2H2-typeInterPro annotationAdd BLAST28
Domaini396 – 423C2H2-typeInterPro annotationAdd BLAST28
Domaini424 – 451C2H2-typeInterPro annotationAdd BLAST28
Domaini452 – 479C2H2-typeInterPro annotationAdd BLAST28
Domaini480 – 507C2H2-typeInterPro annotationAdd BLAST28
Domaini508 – 535C2H2-typeInterPro annotationAdd BLAST28
Domaini536 – 563C2H2-typeInterPro annotationAdd BLAST28
Domaini564 – 591C2H2-typeInterPro annotationAdd BLAST28
Domaini592 – 616C2H2-typeInterPro annotationAdd BLAST25

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 154DisorderedSequence analysisAdd BLAST26

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_11_1

KEGG Orthology (KO)

More...
KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N9M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDTFRLLVS VGHWLPKPNV ISLLEQEAEL WAVESRLPQG VYPDLETRPK
60 70 80 90 100
VKLSVLKQGI SEEISNSVIL VERFLWDGLW YCRGEDTEGH WEWSCESLES
110 120 130 140 150
LAVPVAFTPV KTPVLEQWQR NGFGENISLN PDLPHQPMTP ERQSPHTWGT
160 170 180 190 200
RGKREKPDLN VLQKTCVKEK PYKCQECGKA FSHSSALIEH HRTHTGERPY
210 220 230 240 250
ECHECLKGFR NSSALTKHQR IHTGEKPYKC TQCGRTFNQI APLIQHQRTH
260 270 280 290 300
TGEKPYECSE CGKSFSFRSS FSQHERTHTG EKPYECSECG KAFRQSIHLT
310 320 330 340 350
QHLRIHTGEK PYQCGECGKA FSHSSSLTKH QRIHTGEKPY ECHECGKAFT
360 370 380 390 400
QITPLIQHQR THTGEKPYEC GECGKAFSQS TLLTEHRRIH TGEKPYGCNE
410 420 430 440 450
CGKTFSHSSS LSQHERTHTG EKPYECSQCG KAFRQSTHLT QHQRIHTGEK
460 470 480 490 500
PYECNDCGKA FSHSSSLTKH QRIHTGEKPY ECNQCGRAFS QLAPLIQHQR
510 520 530 540 550
IHTGEKPYEC NQCGRAFSQS SLLIEHQRIH TKEKPYGCNE CGKSFSHSSS
560 570 580 590 600
LSQHERTHTG EKPYECHDCG KSFRQSTHLT QHRRIHTGEK PYACRDCGKA
610
FTHSSSLTKH QRTHTG
Length:616
Mass (Da):70,483
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22946EDC09BE2EA9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P52742ZN135_HUMAN
Zinc finger protein 135
ZNF135 ZNF61, ZNF78L1
658Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0N7M0R0N7_HUMAN
Zinc finger protein 135
ZNF135
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008751 Genomic DNA No translation available.
KF511281 Genomic DNA No translation available.
AK094202 mRNA Translation: BAC04309.1
CH471135 Genomic DNA Translation: EAW72552.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157999.1, NM_001164527.1
NP_001158001.1, NM_001164529.1
NP_001158002.1, NM_001164530.1
NP_001276330.1, NM_001289401.1
NP_001276331.1, NM_001289402.1
NP_003427.3, NM_003436.3
NP_009065.1, NM_007134.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000506786; ENSP00000427691; ENSG00000176293

Database of genes from NCBI RefSeq genomes

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GeneIDi
7694

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7694

UCSC genome browser

More...
UCSCi
uc002qrf.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008751 Genomic DNA No translation available.
KF511281 Genomic DNA No translation available.
AK094202 mRNA Translation: BAC04309.1
CH471135 Genomic DNA Translation: EAW72552.1
RefSeqiNP_001157999.1, NM_001164527.1
NP_001158001.1, NM_001164529.1
NP_001158002.1, NM_001164530.1
NP_001276330.1, NM_001289401.1
NP_001276331.1, NM_001289402.1
NP_003427.3, NM_003436.3
NP_009065.1, NM_007134.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi72559

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1840 77 antibodies

Genome annotation databases

EnsembliENST00000506786; ENSP00000427691; ENSG00000176293
GeneIDi7694
KEGGihsa:7694
UCSCiuc002qrf.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7694
EuPathDBiHostDB:ENSG00000176293.19
HGNCiHGNC:12919 ZNF135
OpenTargetsiENSG00000176293
PharmGKBiPA37507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000153104
HOGENOMiCLU_002678_44_11_1
KOiK09228
OrthoDBi1318335at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7694 3 hits in 809 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7694

Gene expression databases

BgeeiENSG00000176293 Expressed in corpus callosum and 130 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001909 KRAB
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8N9M3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N9M3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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