UniProtKB - Q8N9I5 (FADS6_HUMAN)
Protein
Fatty acid desaturase 6
Gene
FADS6
Organism
Homo sapiens (Human)
Status
Functioni
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q8N9I5 |
SignaLinki | Q8N9I5 |
UniPathwayi | UPA00199 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:FADS6 ORF Names:FP18279 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30459, FADS6 |
neXtProti | NX_Q8N9I5 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 283985 |
PharmGKBi | PA134883572 |
Miscellaneous databases
Pharosi | Q8N9I5, Tdark |
Polymorphism and mutation databases
BioMutai | FADS6 |
DMDMi | 190359479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341546 | 1 – 356 | Fatty acid desaturase 6Add BLAST | 356 |
Proteomic databases
PaxDbi | Q8N9I5 |
PeptideAtlasi | Q8N9I5 |
PRIDEi | Q8N9I5 |
ProteomicsDBi | 72543 [Q8N9I5-1] 72544 [Q8N9I5-2] |
PTM databases
iPTMneti | Q8N9I5 |
PhosphoSitePlusi | Q8N9I5 |
Interactioni
Binary interactionsi
Hide detailsQ8N9I5
Protein-protein interaction databases
BioGRIDi | 129719, 19 interactors |
IntActi | Q8N9I5, 20 interactors |
STRINGi | 9606.ENSP00000481684 |
Miscellaneous databases
RNActi | Q8N9I5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 6 | 1 | 6 | |
Repeati | 7 – 12 | 2 | 6 | |
Repeati | 13 – 18 | 3 | 6 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 18 | 3 X 6 AA tandem repeat of M-E-P-T-E-PAdd BLAST | 18 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 102 – 106 | Histidine box-1 | 5 | |
Motifi | 139 – 143 | Histidine box-2 | 5 | |
Motifi | 292 – 296 | Histidine box-3 | 5 |
Sequence similaritiesi
Belongs to the fatty acid desaturase type 1 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ1J, Eukaryota |
InParanoidi | Q8N9I5 |
OrthoDBi | 1379984at2759 |
PhylomeDBi | Q8N9I5 |
TreeFami | TF333083 |
Family and domain databases
InterProi | View protein in InterPro IPR005804, FA_desaturase_dom |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N9I5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPTEPMEPT EPMEPTEPME PARSAHRGGE ALLRELEVLV QDVVRTSSWW
60 70 80 90 100
ERHGVDCAIL ALSLFALPAG FLCLRWENAL VFASGITILG VCHYTLTVKG
110 120 130 140 150
SHLATHGALT ESKRWSKIWL LFFVEVCTAF TAEHATHGHV KMHHAYTNVV
160 170 180 190 200
GLGDSSTWRL PCLNRYVYMF LAPFLLPIAT PLVAVERLRK VELGTALRTL
210 220 230 240 250
ALISLGLYSH YWLLLNVSGF KNPSSALGCM FLTRSLLAHP YLHVNIFQHI
260 270 280 290 300
GLPMFSRDNK PRRIHMMSLG VLNLARLPVL DWAFGHSIIS CHVEHHLFPR
310 320 330 340 350
LSDNMCLKVK PVVSQFLREK QLPYNEDSYL ARFQLFLRRY EEFMVQAPPI
TELVGL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WYB9 | A0A087WYB9_HUMAN | Fatty acid desaturase 6 | FADS6 | 368 | Annotation score: | ||
J3QRK6 | J3QRK6_HUMAN | Fatty acid desaturase 6 | FADS6 | 219 | Annotation score: | ||
A0A087WU67 | A0A087WU67_HUMAN | Fatty acid desaturase 6 | FADS6 hCG_2043034 | 350 | Annotation score: | ||
A0A087WWN9 | A0A087WWN9_HUMAN | Fatty acid desaturase 6 | FADS6 | 123 | Annotation score: |
Sequence cautioni
The sequence BAC04349 differs from that shown. The N-terminus contains a duplication of the repeated 'MEPTEP' sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 310 | K → E in BAC04349 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034320 | 1 – 18 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY203929 mRNA Translation: AAP34452.1 AK094411 mRNA Translation: BAC04349.1 Sequence problems. BC117230 mRNA Translation: AAI17231.2 |
RefSeqi | NP_835229.3, NM_178128.5 |
Genome annotation databases
GeneIDi | 283985 |
KEGGi | hsa:283985 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY203929 mRNA Translation: AAP34452.1 AK094411 mRNA Translation: BAC04349.1 Sequence problems. BC117230 mRNA Translation: AAI17231.2 |
RefSeqi | NP_835229.3, NM_178128.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129719, 19 interactors |
IntActi | Q8N9I5, 20 interactors |
STRINGi | 9606.ENSP00000481684 |
PTM databases
iPTMneti | Q8N9I5 |
PhosphoSitePlusi | Q8N9I5 |
Polymorphism and mutation databases
BioMutai | FADS6 |
DMDMi | 190359479 |
Proteomic databases
PaxDbi | Q8N9I5 |
PeptideAtlasi | Q8N9I5 |
PRIDEi | Q8N9I5 |
ProteomicsDBi | 72543 [Q8N9I5-1] 72544 [Q8N9I5-2] |
Genome annotation databases
GeneIDi | 283985 |
KEGGi | hsa:283985 |
Organism-specific databases
CTDi | 283985 |
DisGeNETi | 283985 |
GeneCardsi | FADS6 |
HGNCi | HGNC:30459, FADS6 |
neXtProti | NX_Q8N9I5 |
PharmGKBi | PA134883572 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ1J, Eukaryota |
InParanoidi | Q8N9I5 |
OrthoDBi | 1379984at2759 |
PhylomeDBi | Q8N9I5 |
TreeFami | TF333083 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
PathwayCommonsi | Q8N9I5 |
SignaLinki | Q8N9I5 |
Miscellaneous databases
BioGRID-ORCSi | 283985, 6 hits in 839 CRISPR screens |
GenomeRNAii | 283985 |
Pharosi | Q8N9I5, Tdark |
PROi | PR:Q8N9I5 |
RNActi | Q8N9I5, protein |
Family and domain databases
InterProi | View protein in InterPro IPR005804, FA_desaturase_dom |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FADS6_HUMAN | |
Accessioni | Q8N9I5Primary (citable) accession number: Q8N9I5 Secondary accession number(s): Q17RQ7, Q6XYE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM